JP6980014B2 - ＥＮａＣ阻害剤としてのベンゾジアゾリウム化合物 - Google Patents

ＥＮａＣ阻害剤としてのベンゾジアゾリウム化合物 Download PDF

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JP6980014B2
JP6980014B2 JP2019527365A JP2019527365A JP6980014B2 JP 6980014 B2 JP6980014 B2 JP 6980014B2 JP 2019527365 A JP2019527365 A JP 2019527365A JP 2019527365 A JP2019527365 A JP 2019527365A JP 6980014 B2 JP6980014 B2 JP 6980014B2
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amino
methyl
benzodiazole
pyrazine
ium
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JP2019535747A (ja
JP2019535747A5 (enExample
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マッカーティー クリーブ
デビッド ハルグレイブ ジョナサン
アレクサンダー ヘイ ダンカン
ボーレガード スコフィールド トーマス
ウェント ナオミ
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エンタープライズ セラピューティクス リミテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/12—Mucolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2019527365A 2016-11-22 2017-11-22 ＥＮａＣ阻害剤としてのベンゾジアゾリウム化合物 Active JP6980014B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1619694.1A GB201619694D0 (en) 2016-11-22 2016-11-22 Compounds
GB1619694.1 2016-11-22
PCT/GB2017/053499 WO2018096325A1 (en) 2016-11-22 2017-11-22 Benzodiazolium compounds as enac inhibitors

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JP2019535747A JP2019535747A (ja) 2019-12-12
JP2019535747A5 JP2019535747A5 (enExample) 2021-05-06
JP6980014B2 true JP6980014B2 (ja) 2021-12-15

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US (4) US10941149B2 (enExample)
EP (1) EP3544981B1 (enExample)
JP (1) JP6980014B2 (enExample)
KR (1) KR102517273B1 (enExample)
CN (1) CN110214141B (enExample)
AU (1) AU2017364308B2 (enExample)
CA (1) CA3043132A1 (enExample)
DK (1) DK3544981T3 (enExample)
EA (1) EA039607B1 (enExample)
ES (1) ES2890226T3 (enExample)
GB (1) GB201619694D0 (enExample)
HU (1) HUE055692T2 (enExample)
IL (1) IL266745B (enExample)
MA (1) MA46878A (enExample)
MX (1) MX389496B (enExample)
PL (1) PL3544981T3 (enExample)
PT (1) PT3544981T (enExample)
TW (1) TWI756305B (enExample)
WO (1) WO2018096325A1 (enExample)
ZA (1) ZA201902710B (enExample)

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GB201717051D0 (en) 2017-10-17 2017-11-29 Enterprise Therapeutics Ltd Compounds
GB201801355D0 (en) 2018-01-26 2018-03-14 Enterprise Therapeutics Ltd Compounds
GB201808093D0 (en) 2018-05-18 2018-07-04 Enterprise Therapeutics Ltd Compounds
CN114269721B (zh) 2019-06-12 2024-12-20 Tmem16A有限公司 用于治疗呼吸系统疾病的化合物
GB201908453D0 (en) 2019-06-12 2019-07-24 Enterprise Therapeutics Ltd Compounds for treating respiratory disease
GB201910608D0 (en) * 2019-07-24 2019-09-04 Enterprise Therapeutics Ltd Compounds
AR124316A1 (es) 2020-12-11 2023-03-15 Tmem16A Ltd Compuestos para tratar una enfermedad respiratoria
CN118852442A (zh) 2023-04-26 2024-10-29 上海麦科思生物医药有限公司 抗ptk7抗体及其用途
GB202406247D0 (en) 2024-05-03 2024-06-19 Enterprise Therapeutics Ltd Compounds and pharmaceutical compositions

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TW201833111A (zh) 2018-09-16
ES2890226T3 (es) 2022-01-18
JP2019535747A (ja) 2019-12-12
PT3544981T (pt) 2021-09-23
IL266745B (en) 2021-12-01
AU2017364308A1 (en) 2019-05-23
EA201991253A1 (ru) 2019-11-29
DK3544981T3 (da) 2021-09-20
MX389496B (es) 2025-03-20
HUE055692T2 (hu) 2021-12-28
MX2019005934A (es) 2019-11-12
US20250304590A1 (en) 2025-10-02
PL3544981T3 (pl) 2021-12-20
BR112019009864A2 (pt) 2019-08-27
EP3544981A1 (en) 2019-10-02
KR20190084076A (ko) 2019-07-15
CN110214141B (zh) 2022-05-31
AU2017364308B2 (en) 2021-03-11
US20210147432A1 (en) 2021-05-20
KR102517273B1 (ko) 2023-04-03
MA46878A (fr) 2019-10-02
US20190315757A1 (en) 2019-10-17
IL266745A (en) 2019-07-31
US20240067653A1 (en) 2024-02-29
CN110214141A (zh) 2019-09-06
TWI756305B (zh) 2022-03-01
US10941149B2 (en) 2021-03-09
WO2018096325A1 (en) 2018-05-31
US12371436B2 (en) 2025-07-29
ZA201902710B (en) 2021-10-27
GB201619694D0 (en) 2017-01-04
EP3544981B1 (en) 2021-06-23
US11739094B2 (en) 2023-08-29
CA3043132A1 (en) 2018-05-31
EA039607B1 (ru) 2022-02-16
NZ753048A (en) 2024-09-27

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