MA46878A - Composés de benzodiazolium en tant qu'inhibiteurs d'enac - Google Patents

Composés de benzodiazolium en tant qu'inhibiteurs d'enac

Info

Publication number
MA46878A
MA46878A MA046878A MA46878A MA46878A MA 46878 A MA46878 A MA 46878A MA 046878 A MA046878 A MA 046878A MA 46878 A MA46878 A MA 46878A MA 46878 A MA46878 A MA 46878A
Authority
MA
Morocco
Prior art keywords
benzodiazolium
compounds
enac inhibitors
enac
inhibitors
Prior art date
Application number
MA046878A
Other languages
English (en)
French (fr)
Inventor
Jonathan David Hargrave
Duncan Alexander Hay
Clive Mccarthy
Thomas Beauregard Schofield
Naomi Went
Original Assignee
Enterprise Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enterprise Therapeutics Ltd filed Critical Enterprise Therapeutics Ltd
Publication of MA46878A publication Critical patent/MA46878A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/12—Mucolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
MA046878A 2016-11-22 2017-11-22 Composés de benzodiazolium en tant qu'inhibiteurs d'enac MA46878A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1619694.1A GB201619694D0 (en) 2016-11-22 2016-11-22 Compounds

Publications (1)

Publication Number Publication Date
MA46878A true MA46878A (fr) 2019-10-02

Family

ID=57993838

Family Applications (1)

Application Number Title Priority Date Filing Date
MA046878A MA46878A (fr) 2016-11-22 2017-11-22 Composés de benzodiazolium en tant qu'inhibiteurs d'enac

Country Status (20)

Country Link
US (4) US10941149B2 (enExample)
EP (1) EP3544981B1 (enExample)
JP (1) JP6980014B2 (enExample)
KR (1) KR102517273B1 (enExample)
CN (1) CN110214141B (enExample)
AU (1) AU2017364308B2 (enExample)
CA (1) CA3043132A1 (enExample)
DK (1) DK3544981T3 (enExample)
EA (1) EA039607B1 (enExample)
ES (1) ES2890226T3 (enExample)
GB (1) GB201619694D0 (enExample)
HU (1) HUE055692T2 (enExample)
IL (1) IL266745B (enExample)
MA (1) MA46878A (enExample)
MX (1) MX389496B (enExample)
PL (1) PL3544981T3 (enExample)
PT (1) PT3544981T (enExample)
TW (1) TWI756305B (enExample)
WO (1) WO2018096325A1 (enExample)
ZA (1) ZA201902710B (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201610854D0 (en) 2016-06-21 2016-08-03 Entpr Therapeutics Ltd Compounds
GB201619694D0 (en) 2016-11-22 2017-01-04 Entpr Therapeutics Ltd Compounds
GB201717051D0 (en) 2017-10-17 2017-11-29 Enterprise Therapeutics Ltd Compounds
GB201801355D0 (en) 2018-01-26 2018-03-14 Enterprise Therapeutics Ltd Compounds
GB201808093D0 (en) * 2018-05-18 2018-07-04 Enterprise Therapeutics Ltd Compounds
KR20220050126A (ko) 2019-06-12 2022-04-22 티엠이엠16에이 리미티드 호흡기 질환을 치료하기 위한 화합물
GB201908453D0 (en) 2019-06-12 2019-07-24 Enterprise Therapeutics Ltd Compounds for treating respiratory disease
GB201910608D0 (en) * 2019-07-24 2019-09-04 Enterprise Therapeutics Ltd Compounds
TW202237090A (zh) 2020-12-11 2022-10-01 英商Ｔｍｅｍ16Ａ有限公司 治療呼吸道疾病之化合物
CN118852442A (zh) 2023-04-26 2024-10-29 上海麦科思生物医药有限公司 抗ptk7抗体及其用途
GB202406247D0 (en) 2024-05-03 2024-06-19 Enterprise Therapeutics Ltd Compounds and pharmaceutical compositions

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GB0526240D0 (en) 2005-12-22 2006-02-01 Novartis Ag Organic compounds
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WO2009019506A1 (en) 2007-08-03 2009-02-12 Astrazeneca Ab Heterocyclyc sulfonamides having edg-1 antagonistic activity
BRPI0820669A2 (pt) 2007-12-10 2020-08-04 Novartis Ag compostos orgânicos
WO2009139948A1 (en) 2008-02-26 2009-11-19 Johnson Michael R Poly aromatic sodium channel blockers
MX2010012441A (es) 2008-05-13 2010-12-06 Novartis Ag Derivados de acido 3,5-diamino-6-cloro-pirazin-2-carboxilico y su uso como bloqueadores del canal de sodio epitelial para el tratamiento de enfermedades de las vias respiratorias.
KR20110040818A (ko) 2008-06-10 2011-04-20 노파르티스 아게 상피 나트륨 채널 차단제로서의 피라진 유도체
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US8372845B2 (en) 2010-09-17 2013-02-12 Novartis Ag Pyrazine derivatives as enac blockers
AR086745A1 (es) 2011-06-27 2014-01-22 Parion Sciences Inc 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida
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US10155749B2 (en) * 2015-01-12 2018-12-18 Boehringer Ingelheim International Gmbh Substituted benzimidazolium compounds useful in the treatment of respiratory diseases
EP3245200B1 (en) 2015-01-12 2021-03-10 Boehringer Ingelheim International GmbH 2-(pyrazin-2-ylcarbonylaminomethyl)benzimidazolium compounds as epithelial sodium channel inhibitors
EP3245202B1 (en) 2015-01-12 2020-03-11 Boehringer Ingelheim International GmbH Tetrasubstituted benzimidazolium compounds useful in the treatment of respiratory diseases
MX2018002006A (es) 2015-08-20 2018-06-19 Boehringer Ingelheim Int Benzamidas apareadas novedosas.
EP3298022B1 (en) 2015-08-20 2019-06-05 Boehringer Ingelheim International GmbH Novel annelated phenoxyacetamides
GB201610854D0 (en) 2016-06-21 2016-08-03 Entpr Therapeutics Ltd Compounds
GB201619694D0 (en) * 2016-11-22 2017-01-04 Entpr Therapeutics Ltd Compounds

Also Published As

Publication number Publication date
AU2017364308A1 (en) 2019-05-23
US20210147432A1 (en) 2021-05-20
CN110214141B (zh) 2022-05-31
US10941149B2 (en) 2021-03-09
KR102517273B1 (ko) 2023-04-03
US12371436B2 (en) 2025-07-29
BR112019009864A2 (pt) 2019-08-27
HUE055692T2 (hu) 2021-12-28
AU2017364308B2 (en) 2021-03-11
US20190315757A1 (en) 2019-10-17
MX2019005934A (es) 2019-11-12
US11739094B2 (en) 2023-08-29
EA039607B1 (ru) 2022-02-16
PL3544981T3 (pl) 2021-12-20
ZA201902710B (en) 2021-10-27
US20250304590A1 (en) 2025-10-02
DK3544981T3 (da) 2021-09-20
NZ753048A (en) 2024-09-27
US20240067653A1 (en) 2024-02-29
TWI756305B (zh) 2022-03-01
JP2019535747A (ja) 2019-12-12
CA3043132A1 (en) 2018-05-31
IL266745B (en) 2021-12-01
ES2890226T3 (es) 2022-01-18
GB201619694D0 (en) 2017-01-04
CN110214141A (zh) 2019-09-06
WO2018096325A1 (en) 2018-05-31
JP6980014B2 (ja) 2021-12-15
TW201833111A (zh) 2018-09-16
PT3544981T (pt) 2021-09-23
EP3544981B1 (en) 2021-06-23
IL266745A (en) 2019-07-31
EA201991253A1 (ru) 2019-11-29
MX389496B (es) 2025-03-20
EP3544981A1 (en) 2019-10-02
KR20190084076A (ko) 2019-07-15

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