GB201619694D0 - Compounds - Google Patents
CompoundsInfo
- Publication number
- GB201619694D0 GB201619694D0 GBGB1619694.1A GB201619694A GB201619694D0 GB 201619694 D0 GB201619694 D0 GB 201619694D0 GB 201619694 A GB201619694 A GB 201619694A GB 201619694 D0 GB201619694 D0 GB 201619694D0
- Authority
- GB
- United Kingdom
- Prior art keywords
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 150000001875 compounds Chemical class 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/12—Mucolytics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Pulmonology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (25)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1619694.1A GB201619694D0 (en) | 2016-11-22 | 2016-11-22 | Compounds |
| PT178079000T PT3544981T (pt) | 2016-11-22 | 2017-11-22 | Compostos de benzodiazólio como inibidores do enac |
| CA3043132A CA3043132A1 (en) | 2016-11-22 | 2017-11-22 | Benzodiazolium compounds as enac inhibitors |
| MX2019005934A MX389496B (es) | 2016-11-22 | 2017-11-22 | Compuestos de benzodiazolio como inhibidores del canal de sodio epitelial (enac) |
| CN201780084165.3A CN110214141B (zh) | 2016-11-22 | 2017-11-22 | 作为ENaC抑制剂的苯并二唑鎓化合物 |
| KR1020197016141A KR102517273B1 (ko) | 2016-11-22 | 2017-11-22 | ENaC 억제제로서의 벤조디아졸륨 화합물 |
| EA201991253A EA039607B1 (ru) | 2016-11-22 | 2017-11-22 | Бензодиазолиевые соединения в качестве ингибиторов enac |
| US16/462,794 US10941149B2 (en) | 2016-11-22 | 2017-11-22 | Substituted benzodiazoliums as ENaC inhibitors |
| PL17807900T PL3544981T3 (pl) | 2016-11-22 | 2017-11-22 | Związki benzodiazolium jako inhibitory enac |
| AU2017364308A AU2017364308B2 (en) | 2016-11-22 | 2017-11-22 | Benzodiazolium compounds as ENaC inhibitors |
| EP17807900.0A EP3544981B1 (en) | 2016-11-22 | 2017-11-22 | Benzodiazolium compounds as enac inhibitors |
| DK17807900.0T DK3544981T3 (da) | 2016-11-22 | 2017-11-22 | Benzodiazoliumforbindelser som enac-inhibitorer |
| TW106140573A TWI756305B (zh) | 2016-11-22 | 2017-11-22 | 化合物 |
| BR112019009864-0A BR112019009864B1 (pt) | 2016-11-22 | 2017-11-22 | Compostos de benzodiazolínio, composição farmacêutica e produto compreendendo os referidos compostos, seus processos de fabricação e uso |
| PCT/GB2017/053499 WO2018096325A1 (en) | 2016-11-22 | 2017-11-22 | Benzodiazolium compounds as enac inhibitors |
| JP2019527365A JP6980014B2 (ja) | 2016-11-22 | 2017-11-22 | ＥＮａＣ阻害剤としてのベンゾジアゾリウム化合物 |
| MA046878A MA46878A (fr) | 2016-11-22 | 2017-11-22 | Composés de benzodiazolium en tant qu'inhibiteurs d'enac |
| ES17807900T ES2890226T3 (es) | 2016-11-22 | 2017-11-22 | Compuestos de benzodiazolio como inhibidores del ENaC |
| HUE17807900A HUE055692T2 (hu) | 2016-11-22 | 2017-11-22 | A benzodiazolium-vegyületek mint ENAC gátlók |
| NZ753048A NZ753048B2 (en) | 2017-11-22 | Benzodiazolium compounds as enac inhibitors | |
| ZA2019/02710A ZA201902710B (en) | 2016-11-22 | 2019-04-30 | Benzodiazolium compounds as enac inhibitors |
| IL266745A IL266745B (en) | 2016-11-22 | 2019-05-20 | Benzodiazolonium compounds as enac inhibitors |
| US17/103,559 US11739094B2 (en) | 2016-11-22 | 2020-11-24 | Substituted benzodiazoliums as ENaC inhibitors |
| US18/345,840 US12371436B2 (en) | 2016-11-22 | 2023-06-30 | Substituted benzodiazoliums as ENaC inhibitors |
| US19/235,076 US20250304590A1 (en) | 2016-11-22 | 2025-06-11 | Benzodiazolium compounds as enac inhibitors |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1619694.1A GB201619694D0 (en) | 2016-11-22 | 2016-11-22 | Compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB201619694D0 true GB201619694D0 (en) | 2017-01-04 |
Family
ID=57993838
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GBGB1619694.1A Ceased GB201619694D0 (en) | 2016-11-22 | 2016-11-22 | Compounds |
Country Status (20)
| Country | Link |
|---|---|
| US (4) | US10941149B2 (enExample) |
| EP (1) | EP3544981B1 (enExample) |
| JP (1) | JP6980014B2 (enExample) |
| KR (1) | KR102517273B1 (enExample) |
| CN (1) | CN110214141B (enExample) |
| AU (1) | AU2017364308B2 (enExample) |
| CA (1) | CA3043132A1 (enExample) |
| DK (1) | DK3544981T3 (enExample) |
| EA (1) | EA039607B1 (enExample) |
| ES (1) | ES2890226T3 (enExample) |
| GB (1) | GB201619694D0 (enExample) |
| HU (1) | HUE055692T2 (enExample) |
| IL (1) | IL266745B (enExample) |
| MA (1) | MA46878A (enExample) |
| MX (1) | MX389496B (enExample) |
| PL (1) | PL3544981T3 (enExample) |
| PT (1) | PT3544981T (enExample) |
| TW (1) | TWI756305B (enExample) |
| WO (1) | WO2018096325A1 (enExample) |
| ZA (1) | ZA201902710B (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201610854D0 (en) | 2016-06-21 | 2016-08-03 | Entpr Therapeutics Ltd | Compounds |
| GB201619694D0 (en) | 2016-11-22 | 2017-01-04 | Entpr Therapeutics Ltd | Compounds |
| GB201717051D0 (en) | 2017-10-17 | 2017-11-29 | Enterprise Therapeutics Ltd | Compounds |
| GB201801355D0 (en) | 2018-01-26 | 2018-03-14 | Enterprise Therapeutics Ltd | Compounds |
| GB201808093D0 (en) | 2018-05-18 | 2018-07-04 | Enterprise Therapeutics Ltd | Compounds |
| GB201908453D0 (en) | 2019-06-12 | 2019-07-24 | Enterprise Therapeutics Ltd | Compounds for treating respiratory disease |
| MX2021015214A (es) | 2019-06-12 | 2022-04-06 | Tmem16A Ltd | Compuestos para tratar enfermedad respiratoria. |
| GB201910608D0 (en) * | 2019-07-24 | 2019-09-04 | Enterprise Therapeutics Ltd | Compounds |
| CN116745267A (zh) | 2020-12-11 | 2023-09-12 | 跨膜蛋白16A有限公司 | 用于治疗呼吸系统疾病的苯并咪唑衍生物 |
| CN118852442A (zh) | 2023-04-26 | 2024-10-29 | 上海麦科思生物医药有限公司 | 抗ptk7抗体及其用途 |
| GB202406247D0 (en) | 2024-05-03 | 2024-06-19 | Enterprise Therapeutics Ltd | Compounds and pharmaceutical compositions |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6858615B2 (en) | 2002-02-19 | 2005-02-22 | Parion Sciences, Inc. | Phenyl guanidine sodium channel blockers |
| US6858614B2 (en) | 2002-02-19 | 2005-02-22 | Parion Sciences, Inc. | Phenolic guanidine sodium channel blockers |
| US6903105B2 (en) | 2003-02-19 | 2005-06-07 | Parion Sciences, Inc. | Sodium channel blockers |
| CA2534682C (en) | 2003-08-18 | 2013-02-26 | Parion Sciences, Inc. | Capped pyrazinoylguanidine sodium channel blockers |
| KR20060115348A (ko) | 2003-08-18 | 2006-11-08 | 패리온 사이언스 인코퍼레이티드 | 지방족 피라지노일구아니딘 나트륨 채널 차단제 |
| US20050090505A1 (en) | 2003-08-18 | 2005-04-28 | Johnson Michael R. | Methods of reducing risk of infection from pathogens |
| AU2004264441A1 (en) | 2003-08-18 | 2005-02-24 | Parion Sciences, Inc. | Cyclic pyrazinoylguanidine sodium channel blockers |
| US7745442B2 (en) | 2003-08-20 | 2010-06-29 | Parion Sciences, Inc. | Methods of reducing risk of infection from pathogens |
| NZ547109A (en) * | 2003-10-28 | 2010-03-26 | Vertex Pharma | Benzimidazoles useful as modulators of ion channels |
| US7399766B2 (en) | 2004-08-18 | 2008-07-15 | Parion Sciences, Inc. | Soluble amide & ester pyrazinoylguanidine sodium channel blockers |
| BRPI0608581A2 (pt) * | 2005-03-14 | 2010-01-19 | Transtech Pharma Inc | derivados de benzazol, composiÇÕes e mÉtodos de uso como inibidores de b-secretase |
| US7807834B2 (en) | 2005-08-03 | 2010-10-05 | Parion Sciences, Inc. | Capped pyrazinoylguanidine sodium channel blockers |
| GB0526240D0 (en) | 2005-12-22 | 2006-02-01 | Novartis Ag | Organic compounds |
| GB0526244D0 (en) | 2005-12-22 | 2006-02-01 | Novartis Ag | Organic compounds |
| WO2008124491A1 (en) | 2007-04-03 | 2008-10-16 | Parion Sciences, Inc. | Pyrazinoylguanidine compounds for use taste modulators |
| AU2008248598B2 (en) | 2007-05-07 | 2011-11-17 | Novartis Ag | Organic compounds |
| WO2009019506A1 (en) | 2007-08-03 | 2009-02-12 | Astrazeneca Ab | Heterocyclyc sulfonamides having edg-1 antagonistic activity |
| CN101939054B (zh) | 2007-12-10 | 2014-10-29 | 诺华股份有限公司 | 有机化合物 |
| AU2009246799B2 (en) | 2008-02-26 | 2014-02-27 | Parion Sciences, Inc. | Poly aromatic pyrazinoylguanidine sodium channel blockers |
| JP2011520831A (ja) | 2008-05-13 | 2011-07-21 | ノバルティス アーゲー | ３，５−ジアミノ−６−クロロ−ピラジン−２−カルボン酸誘導体および気道疾患処置用上皮性ナトリウムチャネルブロッカーとしてのその使用 |
| ES2535736T3 (es) | 2008-06-10 | 2015-05-14 | Novartis Ag | Derivados de pirazina como bloqueadores de los canales de sodio epitelial |
| WO2011028740A1 (en) | 2009-09-03 | 2011-03-10 | Glaxo Group Limited | ENaC BLOCKERS |
| WO2011079087A1 (en) | 2009-12-23 | 2011-06-30 | Glaxo Group Limited | Enac blockers |
| US8247436B2 (en) | 2010-03-19 | 2012-08-21 | Novartis Ag | Pyridine and pyrazine derivative for the treatment of CF |
| TW201204353A (en) * | 2010-06-08 | 2012-02-01 | Vertex Pharma | Formulations of (R)-1-(2,2-difluorobenzo[D][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide |
| US8372845B2 (en) | 2010-09-17 | 2013-02-12 | Novartis Ag | Pyrazine derivatives as enac blockers |
| AR086745A1 (es) | 2011-06-27 | 2014-01-22 | Parion Sciences Inc | 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida |
| AU2012331274B2 (en) | 2011-11-02 | 2017-06-08 | Boehringer Ingelheim International Gmbh | Heterocyclic compounds, medicaments containing said compounds, use thereof and processes for the preparation thereof |
| US8859559B2 (en) | 2011-12-20 | 2014-10-14 | Boehringer Ingelheim International Gmbh | Substituted pyrazines and their use in the treatment of disease |
| SI2855435T1 (sl) | 2012-05-29 | 2018-09-28 | Parion Sciences Inc. | Dendrimeru podobni amino amidi, ki imajo delovanje blokatorja natrijevih kanalov za zdravljenje suhih oči in drugih mukoznih bolezni |
| EP2897940B1 (en) | 2012-09-24 | 2019-05-01 | Boehringer Ingelheim International GmbH | Heterocyclic compounds, medicaments containing said compounds, use thereof and processes for the preparation thereof |
| CA2896686A1 (en) | 2012-12-17 | 2014-06-26 | Parion Sciences, Inc. | 3,5-diamino-6-chloro-n-(n-(4-phenylbutyl)carbamimidoyl) pyrazine-2- carboxamide compounds |
| SI2931713T1 (sl) | 2012-12-17 | 2017-03-31 | Parion Sciences, Inc. | Derivati kloro-pirazin karboksamida uporabni za zdravljenje bolezni favoriziranih z nezadostno hidracijo sluznice |
| EP2931712B8 (en) | 2012-12-17 | 2018-05-23 | Parion Sciences, Inc. | 3,5-diamino-6-chloro-n-(n-(4-phenylbutyl)carbamimidoyl) pyrazine-2- carboxamide compounds |
| JP6353032B2 (ja) | 2013-04-30 | 2018-07-04 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ジアミノピラジン化合物、前記化合物を含有する医薬、その使用、およびその調製方法 |
| WO2015003083A1 (en) | 2013-07-02 | 2015-01-08 | The California Institute For Biomedical Research | Compounds for treatment of cystic fibrosis |
| JP6449870B2 (ja) | 2013-07-08 | 2019-01-09 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 肺および気道の疾患を処置するための上皮性ナトリウムチャネルの阻害剤としてのアミロライド型化合物 |
| EP3022198B1 (en) | 2013-07-15 | 2019-09-11 | Boehringer Ingelheim International GmbH | Novel 5-substituted benzimidazolium compounds |
| WO2015007519A1 (en) | 2013-07-15 | 2015-01-22 | Boehringer Ingelheim International Gmbh | Novel benzimidazolium compounds |
| EP3022197B1 (en) | 2013-07-15 | 2017-09-06 | Boehringer Ingelheim International GmbH | Novel tetra- and pentasubstituted benzimidazolium compounds |
| JP6449880B2 (ja) | 2013-08-08 | 2019-01-09 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規ピラジンアミド化合物 |
| US20180002312A1 (en) | 2015-01-12 | 2018-01-04 | Boehringer Ingelheim International Gmbh | Tetra- and pentasubstituted benzimidazolium compounds useful in the treatment of respiratory diseases |
| JP6667538B2 (ja) | 2015-01-12 | 2020-03-18 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 呼吸器系疾患の治療に有用な置換ベンズイミダゾリウム化合物 |
| US9981954B2 (en) | 2015-01-12 | 2018-05-29 | Boehringer Ingelheim International Gmbh | 2-(pyrazin-2-ylcarbonylaminomethyl) benzimidazolium compounds as epithelial sodium channel inhibitors |
| EP3245199B1 (en) * | 2015-01-12 | 2020-01-01 | Boehringer Ingelheim International GmbH | Substituted benzimidazolium compounds useful in the treatment of respiratory diseases |
| CA2995881A1 (en) | 2015-08-20 | 2017-02-23 | Boehringer Ingelheim International Gmbh | Novel annelated benzamides |
| AU2015406100B2 (en) | 2015-08-20 | 2020-04-23 | Boehringer Ingelheim International Gmbh | Novel annelated phenoxyacetamides |
| GB201610854D0 (en) * | 2016-06-21 | 2016-08-03 | Entpr Therapeutics Ltd | Compounds |
| GB201619694D0 (en) * | 2016-11-22 | 2017-01-04 | Entpr Therapeutics Ltd | Compounds |
-
2016
- 2016-11-22 GB GBGB1619694.1A patent/GB201619694D0/en not_active Ceased
-
2017
- 2017-11-22 WO PCT/GB2017/053499 patent/WO2018096325A1/en not_active Ceased
- 2017-11-22 TW TW106140573A patent/TWI756305B/zh active
- 2017-11-22 EP EP17807900.0A patent/EP3544981B1/en active Active
- 2017-11-22 PT PT178079000T patent/PT3544981T/pt unknown
- 2017-11-22 MX MX2019005934A patent/MX389496B/es unknown
- 2017-11-22 MA MA046878A patent/MA46878A/fr unknown
- 2017-11-22 JP JP2019527365A patent/JP6980014B2/ja active Active
- 2017-11-22 KR KR1020197016141A patent/KR102517273B1/ko active Active
- 2017-11-22 HU HUE17807900A patent/HUE055692T2/hu unknown
- 2017-11-22 PL PL17807900T patent/PL3544981T3/pl unknown
- 2017-11-22 DK DK17807900.0T patent/DK3544981T3/da active
- 2017-11-22 ES ES17807900T patent/ES2890226T3/es active Active
- 2017-11-22 AU AU2017364308A patent/AU2017364308B2/en active Active
- 2017-11-22 CA CA3043132A patent/CA3043132A1/en active Pending
- 2017-11-22 CN CN201780084165.3A patent/CN110214141B/zh active Active
- 2017-11-22 US US16/462,794 patent/US10941149B2/en active Active
- 2017-11-22 EA EA201991253A patent/EA039607B1/ru unknown
-
2019
- 2019-04-30 ZA ZA2019/02710A patent/ZA201902710B/en unknown
- 2019-05-20 IL IL266745A patent/IL266745B/en unknown
-
2020
- 2020-11-24 US US17/103,559 patent/US11739094B2/en active Active
-
2023
- 2023-06-30 US US18/345,840 patent/US12371436B2/en active Active
-
2025
- 2025-06-11 US US19/235,076 patent/US20250304590A1/en active Pending
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AT | Applications terminated before publication under section 16(1) |