CN110198732A - 一种促进胰岛素受体底物-2表达的方法 - Google Patents

一种促进胰岛素受体底物-2表达的方法 Download PDF

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Publication number
CN110198732A
CN110198732A CN201780078168.6A CN201780078168A CN110198732A CN 110198732 A CN110198732 A CN 110198732A CN 201780078168 A CN201780078168 A CN 201780078168A CN 110198732 A CN110198732 A CN 110198732A
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plasminogen
subject
expression
diabetic subjects
effective amount
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Chinese (zh)
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李季男
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Tailunji International Co ltd
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Tailunji International Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/484—Plasmin (3.4.21.7)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
CN201780078168.6A 2016-12-15 2017-06-19 一种促进胰岛素受体底物-2表达的方法 Pending CN110198732A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CNPCT/CN2016/110171 2016-12-15
CNPCT/CN2016/110171 2016-12-15
PCT/CN2017/089069 WO2018107708A1 (zh) 2016-12-15 2017-06-19 一种促进胰岛素受体底物-2表达的方法

Publications (1)

Publication Number Publication Date
CN110198732A true CN110198732A (zh) 2019-09-03

Family

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Family Applications (4)

Application Number Title Priority Date Filing Date
CN201780078124.3A Pending CN110139667A (zh) 2016-12-15 2017-06-19 一种使胰高血糖素、胰岛素恢复正常平衡的方法
CN201780078168.6A Pending CN110198732A (zh) 2016-12-15 2017-06-19 一种促进胰岛素受体底物-2表达的方法
CN201780078122.4A Pending CN110366426A (zh) 2016-12-15 2017-06-19 一种促进胰岛素分泌的方法
CN201780078131.3A Pending CN110121357A (zh) 2016-12-15 2017-06-19 一种治疗糖尿病的新方法

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CN201780078124.3A Pending CN110139667A (zh) 2016-12-15 2017-06-19 一种使胰高血糖素、胰岛素恢复正常平衡的方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
CN201780078122.4A Pending CN110366426A (zh) 2016-12-15 2017-06-19 一种促进胰岛素分泌的方法
CN201780078131.3A Pending CN110121357A (zh) 2016-12-15 2017-06-19 一种治疗糖尿病的新方法

Country Status (9)

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US (4) US11311607B2 (enExample)
EP (4) EP3556390B1 (enExample)
JP (6) JP7554557B2 (enExample)
CN (4) CN110139667A (enExample)
CA (4) CA3047177A1 (enExample)
DK (1) DK3556383T5 (enExample)
ES (1) ES2981141T3 (enExample)
TW (7) TWI763680B (enExample)
WO (7) WO2018107705A1 (enExample)

Families Citing this family (8)

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WO2017101870A1 (zh) 2015-12-18 2017-06-22 深圳瑞健生命科学研究院有限公司 一种预防或治疗糖尿病性视网膜病变的方法
CN109069567A (zh) 2015-12-18 2018-12-21 泰伦基国际有限公司 一种预防或治疗糖尿病性神经损伤及其相关病症的方法
CN108778307A (zh) 2015-12-18 2018-11-09 泰伦基国际有限公司 一种预防和治疗糖尿病肾病的方法
EP3391902B1 (en) 2015-12-18 2023-10-18 Talengen International Limited Plasminogen for use in the treatment of diabetic angiocardiopathy
TWI763680B (zh) 2016-12-15 2022-05-11 大陸商深圳瑞健生命科學硏究院有限公司 纖溶酶原在製備藥物中的用途
EP3556380A4 (en) 2016-12-15 2020-05-13 Talengen International Limited METHOD FOR PREVENTING AND TREATING FABRIC OF TISSUE AND ORGAN
ES3036897T3 (en) 2017-06-19 2025-09-25 Talengen Int Ltd Plasminogen for use in treating parkinson's and alzheimer's disease
CN111411072B (zh) * 2020-03-09 2022-10-11 同济大学 SLC30A8基因表达下调的抗糖尿病胰岛β细胞及其应用

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TWI763680B (zh) 2022-05-11
CA3047173A1 (en) 2018-06-21
EP3556390A1 (en) 2019-10-23
TW201822803A (zh) 2018-07-01
TW201822804A (zh) 2018-07-01
CA3047176A1 (en) 2018-06-21
EP3556383B1 (en) 2024-04-10
JP2020502150A (ja) 2020-01-23
TW201822808A (zh) 2018-07-01
TW201822801A (zh) 2018-07-01
CA3047172A1 (en) 2018-06-21
JP7175270B2 (ja) 2022-11-18
CA3047177A1 (en) 2018-06-21
EP3556390A4 (en) 2020-09-09
EP3556384A1 (en) 2019-10-23
WO2018107708A1 (zh) 2018-06-21
TW201822807A (zh) 2018-07-01
JP7554048B2 (ja) 2024-09-19
US20190307861A1 (en) 2019-10-10
JP2020502140A (ja) 2020-01-23
CN110139667A (zh) 2019-08-16
EP3556383A4 (en) 2020-09-09
TW201822802A (zh) 2018-07-01
DK3556383T5 (da) 2024-09-02
DK3556383T3 (da) 2024-05-13
WO2018107704A1 (zh) 2018-06-21
TWI763681B (zh) 2022-05-11
US20190314465A1 (en) 2019-10-17
EP3556384B1 (en) 2024-04-10
WO2018107702A1 (zh) 2018-06-21
WO2018107705A1 (zh) 2018-06-21
EP3556392A1 (en) 2019-10-23
ES2981141T3 (es) 2024-10-07
CN110121357A (zh) 2019-08-13
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