TWI763680B - 纖溶酶原在製備藥物中的用途 - Google Patents

纖溶酶原在製備藥物中的用途

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Publication number
TWI763680B
TWI763680B TW106120481A TW106120481A TWI763680B TW I763680 B TWI763680 B TW I763680B TW 106120481 A TW106120481 A TW 106120481A TW 106120481 A TW106120481 A TW 106120481A TW I763680 B TWI763680 B TW I763680B
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TW
Taiwan
Prior art keywords
plasminogen
mice
group
pbs
insulin
Prior art date
Application number
TW106120481A
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English (en)
Chinese (zh)
Other versions
TW201822801A (zh
Inventor
李季男
Original Assignee
大陸商深圳瑞健生命科學硏究院有限公司
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Publication of TW201822801A publication Critical patent/TW201822801A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/484—Plasmin (3.4.21.7)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
TW106120481A 2016-12-15 2017-06-19 纖溶酶原在製備藥物中的用途 TWI763680B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CNPCT/CN2016/110171 2016-12-15
WOPCT/CN2016/110171 2016-12-15

Publications (2)

Publication Number Publication Date
TW201822801A TW201822801A (zh) 2018-07-01
TWI763680B true TWI763680B (zh) 2022-05-11

Family

ID=62557852

Family Applications (7)

Application Number Title Priority Date Filing Date
TW106120481A TWI763680B (zh) 2016-12-15 2017-06-19 纖溶酶原在製備藥物中的用途
TW106120494A TWI669130B (zh) 2016-12-15 2017-06-19 纖溶酶原在製備用於治療糖尿病的藥物上的用途
TW106120485A TWI642442B (zh) 2016-12-15 2017-06-19 纖溶酶原在製備降低胰高血糖素分泌的藥物上的用途
TW106120480A TWI738799B (zh) 2016-12-15 2017-06-19 纖溶酶原在製備藥物中的用途
TW106120484A TW201822803A (zh) 2016-12-15 2017-06-19 一種抑制胰島β細胞凋亡的方法
TW106120493A TWI763681B (zh) 2016-12-15 2017-06-19 纖溶酶原在製備藥物中的用途
TW106120482A TWI644682B (zh) 2016-12-15 2017-06-19 一種纖溶酶原在製備促進胰島細胞損傷修復的藥物上的用途

Family Applications After (6)

Application Number Title Priority Date Filing Date
TW106120494A TWI669130B (zh) 2016-12-15 2017-06-19 纖溶酶原在製備用於治療糖尿病的藥物上的用途
TW106120485A TWI642442B (zh) 2016-12-15 2017-06-19 纖溶酶原在製備降低胰高血糖素分泌的藥物上的用途
TW106120480A TWI738799B (zh) 2016-12-15 2017-06-19 纖溶酶原在製備藥物中的用途
TW106120484A TW201822803A (zh) 2016-12-15 2017-06-19 一種抑制胰島β細胞凋亡的方法
TW106120493A TWI763681B (zh) 2016-12-15 2017-06-19 纖溶酶原在製備藥物中的用途
TW106120482A TWI644682B (zh) 2016-12-15 2017-06-19 一種纖溶酶原在製備促進胰島細胞損傷修復的藥物上的用途

Country Status (9)

Country Link
US (4) US20190307861A1 (enExample)
EP (4) EP3556390B1 (enExample)
JP (6) JP7175270B2 (enExample)
CN (4) CN110121357A (enExample)
CA (4) CA3047177A1 (enExample)
DK (1) DK3556383T5 (enExample)
ES (1) ES2981141T3 (enExample)
TW (7) TWI763680B (enExample)
WO (7) WO2018107708A1 (enExample)

Families Citing this family (8)

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JP6682008B2 (ja) 2015-12-18 2020-04-15 タレンゲン インターナショナル リミテッドＴａｌｅｎｇｅｎ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｌｉｍｉｔｅｄ 糖尿病性腎症を予防及び治療するための方法
US10709771B2 (en) 2015-12-18 2020-07-14 Talengen International Limited Method for preventing or treating diabetic retinopathy
WO2017101871A1 (zh) 2015-12-18 2017-06-22 深圳瑞健生命科学研究院有限公司 一种预防和治疗心血管病的新方法
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EP3556390B1 (en) * 2016-12-15 2024-04-03 Talengen International Limited Plasminogen for use in treating diabetes
US20190314466A1 (en) 2016-12-15 2019-10-17 Talengen International Limited Method for preventing and treating skin fibrosis
TWI714862B (zh) * 2017-06-19 2021-01-01 大陸商深圳瑞健生命科學硏究院有限公司 一種調控glp-1/glp-1r的方法和藥物
CN111411072B (zh) * 2020-03-09 2022-10-11 同济大学 SLC30A8基因表达下调的抗糖尿病胰岛β细胞及其应用

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CA3008694C (en) 2015-12-18 2022-11-29 Talengen International Limited Use of plasminogen for preventing or treating diabetic nerve injury and related disorders thereof
DK3395359T5 (da) 2015-12-18 2024-09-23 Talengen Int Ltd Plasminogen til anvendelse til forebyggelse eller behandling af akut trombose og kronisk trombose
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EP3556390B1 (en) * 2016-12-15 2024-04-03 Talengen International Limited Plasminogen for use in treating diabetes
US20190328850A1 (en) 2016-12-15 2019-10-31 Talengen International Limited Method for preventing and treating lipid metabolism disorders and related diseases thereof
EP3725326A4 (en) 2017-12-15 2021-03-03 Talengen International Limited METHODS AND MEDICINAL PRODUCTS FOR THE PREVENTION OR TREATMENT OF OSTEOARTHRITIS

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WO2018107703A1 (zh) 2018-06-21
JP2020502140A (ja) 2020-01-23
JP7175270B2 (ja) 2022-11-18
EP3556390A4 (en) 2020-09-09
EP3556390A1 (en) 2019-10-23
ES2981141T3 (es) 2024-10-07
CN110139667A (zh) 2019-08-16
EP3556383B1 (en) 2024-04-10
EP3556384A4 (en) 2020-09-23
EP3556390B1 (en) 2024-04-03
WO2018107706A1 (zh) 2018-06-21
EP3556384A1 (en) 2019-10-23
WO2018107701A1 (zh) 2018-06-21
TW201822803A (zh) 2018-07-01
CN110198732A (zh) 2019-09-03
EP3556384B1 (en) 2024-04-10
TWI738799B (zh) 2021-09-11
TWI644682B (zh) 2018-12-21
JP2020502151A (ja) 2020-01-23
TWI642442B (zh) 2018-12-01
US11311607B2 (en) 2022-04-26
WO2018107702A1 (zh) 2018-06-21
TW201822804A (zh) 2018-07-01
EP3556383A1 (en) 2019-10-23
TW201822807A (zh) 2018-07-01
US20190314465A1 (en) 2019-10-17
EP3556392B1 (en) 2024-04-17
CA3047176C (en) 2021-11-30
JP2022166026A (ja) 2022-11-01
JP2020502150A (ja) 2020-01-23
US20190314463A1 (en) 2019-10-17
CA3047173A1 (en) 2018-06-21
TW201822800A (zh) 2018-07-01
WO2018107704A1 (zh) 2018-06-21
CN110121357A (zh) 2019-08-13
CA3047176A1 (en) 2018-06-21
TWI669130B (zh) 2019-08-21
US11129880B2 (en) 2021-09-28
CN110366426A (zh) 2019-10-22
WO2018107708A1 (zh) 2018-06-21
CA3047172A1 (en) 2018-06-21
TW201822808A (zh) 2018-07-01
JP7554048B2 (ja) 2024-09-19
TW201822802A (zh) 2018-07-01
JP2020510628A (ja) 2020-04-09
JP2022166028A (ja) 2022-11-01
US20190314464A1 (en) 2019-10-17
DK3556383T5 (da) 2024-09-02
US20190307861A1 (en) 2019-10-10
EP3556392A1 (en) 2019-10-23
JP7554557B2 (ja) 2024-09-20
EP3556383A4 (en) 2020-09-09
JP7171572B2 (ja) 2022-11-15
TWI763681B (zh) 2022-05-11
DK3556383T3 (da) 2024-05-13
TW201822801A (zh) 2018-07-01
EP3556392A4 (en) 2020-09-23
WO2018107705A1 (zh) 2018-06-21
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