CN110191643B - 甜菊醇糖苷的生物合成生产及其工艺 - Google Patents

甜菊醇糖苷的生物合成生产及其工艺 Download PDF

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CN110191643B
CN110191643B CN201780077754.9A CN201780077754A CN110191643B CN 110191643 B CN110191643 B CN 110191643B CN 201780077754 A CN201780077754 A CN 201780077754A CN 110191643 B CN110191643 B CN 110191643B
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reb
rebaudioside
udp
cell
steviol
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CN110191643A (zh
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毛国红
J.E.维克
M.巴滕
D.卞
Y.罗
Y.吴
B.张
X.余
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Conagen Inc
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Conagen Inc
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    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/256—Polyterpene radicals
    • A—HUMAN NECESSITIES
    • A21—BAKING; EDIBLE DOUGHS
    • A21D—TREATMENT OF FLOUR OR DOUGH FOR BAKING, e.g. BY ADDITION OF MATERIALS; BAKING; BAKERY PRODUCTS
    • A21D13/00—Finished or partly finished bakery products
    • A21D13/06—Products with modified nutritive value, e.g. with modified starch content
    • A21D13/062—Products with modified nutritive value, e.g. with modified starch content with modified sugar content; Sugar-free products
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G4/00—Chewing gum
    • A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
    • A23G4/10—Chewing gum characterised by the composition containing organic or inorganic compounds characterised by the carbohydrates used, e.g. polysaccharides
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
    • A23L2/52—Adding ingredients
    • A23L2/60—Sweeteners
    • A—HUMAN NECESSITIES
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    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/30—Artificial sweetening agents
    • A—HUMAN NECESSITIES
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    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/30—Artificial sweetening agents
    • A23L27/33—Artificial sweetening agents containing sugars or derivatives
    • A23L27/36—Terpene glycosides
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    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
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    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C12N9/1062—Sucrose synthase (2.4.1.13)
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    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1081—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
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    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405—Glucanases
    • C12N9/2434—Glucanases acting on beta-1,4-glucosidic bonds
    • C12N9/2445—Beta-glucosidase (3.2.1.21)
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    • C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
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    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
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CN201780077754.9A 2016-10-14 2017-10-13 甜菊醇糖苷的生物合成生产及其工艺 Active CN110191643B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662408179P 2016-10-14 2016-10-14
US62/408179 2016-10-14
US201762555809P 2017-09-08 2017-09-08
US62/555809 2017-09-08
PCT/US2017/056457 WO2018071744A1 (en) 2016-10-14 2017-10-13 Biosynthetic production of steviol glycosides and processes therefore

Publications (2)

Publication Number Publication Date
CN110191643A CN110191643A (zh) 2019-08-30
CN110191643B true CN110191643B (zh) 2023-06-06

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US (4) US11098315B2 (https=)
EP (1) EP3525598B1 (https=)
JP (2) JP7177048B2 (https=)
KR (1) KR102540615B1 (https=)
CN (1) CN110191643B (https=)
AU (1) AU2017341798B2 (https=)
BR (1) BR112019007504B1 (https=)
CA (1) CA3039105C (https=)
ES (1) ES2964976T3 (https=)
HU (1) HUE064754T2 (https=)
MX (1) MX2019004368A (https=)
RU (1) RU2019114181A (https=)
WO (1) WO2018071744A1 (https=)

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DK3200615T3 (da) * 2014-10-03 2019-08-19 Conagen Inc Kaloriefrie sødestoffer og fremgangsmåder til syntetisering
CN110191643B (zh) 2016-10-14 2023-06-06 科纳根公司 甜菊醇糖苷的生物合成生产及其工艺
AU2017345605B2 (en) * 2016-10-20 2022-04-14 The Coca-Cola Company Diterpene glycosides isolated from Stevia, compositions and methods
JP2019534027A (ja) * 2016-11-14 2019-11-28 ピュアサークル ユーエスエー インコーポレイテッド ステビア由来分子、そのような分子を得る方法、及びその使用
MX2019010537A (es) * 2017-03-06 2019-11-21 Conagen Inc Produccion biosintetica del rebaudiosido d4 de glucosido de esteviol a partir del rebaudiosido e.
MX2019015404A (es) * 2017-06-30 2020-07-20 Conagen Inc Hidrólisis de glucósidos de esteviol por beta-glucosidasa.
CN111868252B (zh) 2018-03-12 2025-06-03 科纳根公司 甜菊糖苷莱苞迪苷j和莱苞迪苷n的生物合成生产
WO2019177634A1 (en) * 2018-03-16 2019-09-19 Purecircle Usa Inc. High-purity steviol glycosides
WO2019178541A1 (en) * 2018-03-16 2019-09-19 Purecircle Usa Inc. High-purity steviol glycosides
WO2021226417A1 (en) * 2020-05-07 2021-11-11 The Coca-Cola Company Beverages comprising rebaudioside am and rebaudioside m with enhanced flavor
WO2021252814A1 (en) * 2020-06-11 2021-12-16 Corn Products Development, Inc. Production and uses of oligosaccharides and steviol glycosides
WO2024068511A1 (en) * 2022-09-28 2024-04-04 Société des Produits Nestlé S.A. Diterpenoid derivatives as inhibitors of sglt2

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CN103732753A (zh) * 2011-08-08 2014-04-16 埃沃尔瓦公司 甜菊醇糖苷类的重组生产
CN103974628A (zh) * 2012-05-22 2014-08-06 谱赛科有限责任公司 高纯度的甜菊醇糖苷
CN105051195A (zh) * 2013-02-06 2015-11-11 埃沃尔瓦公司 用于提高莱鲍迪苷d和莱鲍迪苷m之产生的方法
WO2016073740A1 (en) * 2014-11-05 2016-05-12 Manus Biosynthesis, Inc. Microbial production of steviol glycosides
WO2016120486A1 (en) * 2015-01-30 2016-08-04 Evolva Sa Production of steviol glycosides in recombinant hosts

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TWI657746B (zh) 2013-06-19 2019-05-01 美商科納根股份有限公司 含有甜葉菊苷ｅ之可食用產品及使用其製備和強化可食用產品之甜味的方法
ES2709439T3 (es) 2013-11-01 2019-04-16 Conagen Inc Producción recombinante de glucósidos de esteviol
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