CN110139652B - ROR-γ调节剂 - Google Patents

ROR-γ调节剂 Download PDF

Info

Publication number
CN110139652B
CN110139652B CN201780081203.XA CN201780081203A CN110139652B CN 110139652 B CN110139652 B CN 110139652B CN 201780081203 A CN201780081203 A CN 201780081203A CN 110139652 B CN110139652 B CN 110139652B
Authority
CN
China
Prior art keywords
formula
compounds
alkyl
compound
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201780081203.XA
Other languages
English (en)
Chinese (zh)
Other versions
CN110139652A (zh
Inventor
拉朱·莫汉
约翰·努斯
詹森·哈里斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Escalier Biosciences BV
Original Assignee
Escalier Biosciences BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Escalier Biosciences BV filed Critical Escalier Biosciences BV
Publication of CN110139652A publication Critical patent/CN110139652A/zh
Application granted granted Critical
Publication of CN110139652B publication Critical patent/CN110139652B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Processing Of Color Television Signals (AREA)
  • Picture Signal Circuits (AREA)
  • Details Of Television Scanning (AREA)
CN201780081203.XA 2016-10-27 2017-10-27 ROR-γ调节剂 Expired - Fee Related CN110139652B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662413907P 2016-10-27 2016-10-27
US62/413,907 2016-10-27
PCT/US2017/058755 WO2018081558A1 (en) 2016-10-27 2017-10-27 Ror-gamma modulators

Publications (2)

Publication Number Publication Date
CN110139652A CN110139652A (zh) 2019-08-16
CN110139652B true CN110139652B (zh) 2022-10-11

Family

ID=62024021

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780081203.XA Expired - Fee Related CN110139652B (zh) 2016-10-27 2017-10-27 ROR-γ调节剂

Country Status (14)

Country Link
US (5) US10905687B2 (enExample)
EP (1) EP3532062B1 (enExample)
JP (1) JP7027437B2 (enExample)
KR (1) KR102598775B1 (enExample)
CN (1) CN110139652B (enExample)
AU (1) AU2017348345B2 (enExample)
BR (1) BR112019008548A2 (enExample)
CA (1) CA3042080A1 (enExample)
ES (1) ES2928904T3 (enExample)
IL (1) IL266261B (enExample)
MX (1) MX392163B (enExample)
PH (1) PH12019500949A1 (enExample)
RU (1) RU2753490C2 (enExample)
WO (1) WO2018081558A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7027437B2 (ja) 2016-10-27 2022-03-01 エスカリア バイオサイエンシーズ，ビーブイ ＲＯＲ－γモジュレーター
EP3765009A4 (en) 2018-03-12 2021-11-10 Escalier Biosciences, BV BICYCLIC ROR-GAMMA MODULATORS
BR112020018718A2 (pt) 2018-03-12 2021-03-09 Escalier Biosciences B.V. Moduladores de ror-gama espirocíclicos
AU2020378005A1 (en) * 2019-11-05 2022-05-26 Dermira, Inc. ROR gamma T inhibitors and topical uses thereof
AU2021300281A1 (en) * 2020-06-30 2023-02-02 Dermira, Inc. RORγt inhibitors and topical uses thereof
CN111892599B (zh) * 2020-08-14 2023-01-13 黄芳 一种2,5-二氮杂双环[2.2.2]辛烷-2-羧酸叔丁酯的合成方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016145298A1 (en) * 2015-03-12 2016-09-15 The Regents Of The University Of California METHODS FOR TREATING CANCER WITH RORgamma INHIBITORS

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6432957B1 (en) 2001-06-29 2002-08-13 Kowa Co., Ltd. Piperazine derivative
AU2003280558A1 (en) * 2002-10-11 2004-05-04 Kowa Co., Ltd. Method for treatment of cancer
TW201006816A (en) 2008-05-15 2010-02-16 Organon Nv Hexafluoroisopropanol derivatives
HUP1100166A2 (en) * 2011-03-29 2012-12-28 Sanofi Sa Reductive amination process for preparation of dronedarone using amine intermediary compound
WO2012158784A2 (en) 2011-05-16 2012-11-22 Theodore Mark Kamenecka Modulators of the nuclear hormone receptor ror
AU2012311599B2 (en) * 2011-09-19 2017-07-06 Eth Zurich Ror gamma modulators
AR092348A1 (es) 2012-07-11 2015-04-15 Hoffmann La Roche DERIVADOS DE ARIL-SULTAMO COMO MODULADORES DE RORc
JP7027437B2 (ja) 2016-10-27 2022-03-01 エスカリア バイオサイエンシーズ，ビーブイ ＲＯＲ－γモジュレーター

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016145298A1 (en) * 2015-03-12 2016-09-15 The Regents Of The University Of California METHODS FOR TREATING CANCER WITH RORgamma INHIBITORS

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Identification of SR2211: A Potent Synthetic RORγ-Selective Modulator;Naresh Kumar et al.;《American Chemical Society》;20120131;第7卷;672-677 *

Also Published As

Publication number Publication date
MX392163B (es) 2025-03-21
US20190269674A1 (en) 2019-09-05
WO2018081558A1 (en) 2018-05-03
AU2017348345B2 (en) 2022-01-27
MX2019004973A (es) 2019-09-19
US20240216361A1 (en) 2024-07-04
US20220175765A1 (en) 2022-06-09
ES2928904T3 (es) 2022-11-23
IL266261B (en) 2022-07-01
JP2019535813A (ja) 2019-12-12
RU2753490C2 (ru) 2021-08-17
US10905687B2 (en) 2021-02-02
CA3042080A1 (en) 2018-05-03
RU2019115059A (ru) 2020-11-27
CN110139652A (zh) 2019-08-16
RU2019115059A3 (enExample) 2020-12-18
KR20190096979A (ko) 2019-08-20
BR112019008548A2 (pt) 2019-09-17
AU2017348345A1 (en) 2019-05-30
PH12019500949A1 (en) 2019-08-05
IL266261A (en) 2019-06-30
KR102598775B1 (ko) 2023-11-03
JP7027437B2 (ja) 2022-03-01
US20230277527A1 (en) 2023-09-07
EP3532062A1 (en) 2019-09-04
US20210069182A1 (en) 2021-03-11
EP3532062B1 (en) 2022-07-20
EP3532062A4 (en) 2020-04-15

Similar Documents

Publication Publication Date Title
US20230277527A1 (en) Ror-gamma modulators
US12252471B2 (en) Isoquinoline compounds and their use in treating AhR imbalance
JP6378630B2 (ja) 皮膚の疾患、障害、および異常の治療のための肝臓ｘ受容体（ｌｘｒ）調節因子
US9981913B2 (en) Liver X receptor (LXR) modulators
AU2007238816B2 (en) Methods for modulating formation and progression of cellulite
HK40012522A (en) Ror-gamma modulators
HK40012522B (en) Ror-gamma modulators
CH639092A5 (fr) 2,3-dihydroimidazo(1,2-c)pyrimidines substituees.
US9408793B2 (en) Selective compounds inhibiting CYP26A1 useful in cosmetic and pharmaceutical compositions
KR20160037530A (ko) 피페리딘-2,5-디온의 제조방법 및 이를 포함하는 약학적 조성물

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 40012522

Country of ref document: HK

GR01 Patent grant
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20221011

CF01 Termination of patent right due to non-payment of annual fee