RU2753490C2 - Модуляторы ror-гамма - Google Patents

Модуляторы ror-гамма Download PDF

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Publication number
RU2753490C2
RU2753490C2 RU2019115059A RU2019115059A RU2753490C2 RU 2753490 C2 RU2753490 C2 RU 2753490C2 RU 2019115059 A RU2019115059 A RU 2019115059A RU 2019115059 A RU2019115059 A RU 2019115059A RU 2753490 C2 RU2753490 C2 RU 2753490C2
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RU
Russia
Prior art keywords
compound
formula
alkyl
och
another embodiment
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RU2019115059A
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English (en)
Russian (ru)
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RU2019115059A3 (enExample
RU2019115059A (ru
Inventor
Раджу Мохан
Джон НУСС
Джэйсон ХАРРИС
Original Assignee
Эскальер Байосайенсес, Бв
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Publication of RU2019115059A publication Critical patent/RU2019115059A/ru
Publication of RU2019115059A3 publication Critical patent/RU2019115059A3/ru
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Details Of Television Scanning (AREA)
  • Processing Of Color Television Signals (AREA)
  • Picture Signal Circuits (AREA)
RU2019115059A 2016-10-27 2017-10-27 Модуляторы ror-гамма RU2753490C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662413907P 2016-10-27 2016-10-27
US62/413,907 2016-10-27
PCT/US2017/058755 WO2018081558A1 (en) 2016-10-27 2017-10-27 Ror-gamma modulators

Publications (3)

Publication Number Publication Date
RU2019115059A RU2019115059A (ru) 2020-11-27
RU2019115059A3 RU2019115059A3 (enExample) 2020-12-18
RU2753490C2 true RU2753490C2 (ru) 2021-08-17

Family

ID=62024021

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2019115059A RU2753490C2 (ru) 2016-10-27 2017-10-27 Модуляторы ror-гамма

Country Status (14)

Country Link
US (5) US10905687B2 (enExample)
EP (1) EP3532062B1 (enExample)
JP (1) JP7027437B2 (enExample)
KR (1) KR102598775B1 (enExample)
CN (1) CN110139652B (enExample)
AU (1) AU2017348345B2 (enExample)
BR (1) BR112019008548A2 (enExample)
CA (1) CA3042080A1 (enExample)
ES (1) ES2928904T3 (enExample)
IL (1) IL266261B (enExample)
MX (1) MX392163B (enExample)
PH (1) PH12019500949A1 (enExample)
RU (1) RU2753490C2 (enExample)
WO (1) WO2018081558A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2928904T3 (es) 2016-10-27 2022-11-23 Escalier Biosciences Bv Moduladores de ROR-gamma
JP2021517563A (ja) 2018-03-12 2021-07-26 エスカリア バイオサイエンシーズ，ビーブイ 二環式ＲＯＲγモジュレーター
EA202092051A1 (ru) 2018-03-12 2021-03-04 Эскальер Байосайенсес Б.В. Спироциклические модуляторы ror-гамма
AU2020378005A1 (en) * 2019-11-05 2022-05-26 Dermira, Inc. ROR gamma T inhibitors and topical uses thereof
IL298928A (en) * 2020-06-30 2023-02-01 Dermira Inc RORγt INHIBITORS AND TOPICAL USES THEREOF
CN111892599B (zh) * 2020-08-14 2023-01-13 黄芳 一种2,5-二氮杂双环[2.2.2]辛烷-2-羧酸叔丁酯的合成方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6432957B1 (en) * 2001-06-29 2002-08-13 Kowa Co., Ltd. Piperazine derivative
WO2004032933A1 (ja) * 2002-10-11 2004-04-22 Kowa Co., Ltd. 癌の処置方法
US20100029621A1 (en) * 2008-05-15 2010-02-04 Andrew John Cooke Hexafluoroisopropanol derivatives
US20140031330A1 (en) * 2012-07-11 2014-01-30 Genentech, Inc. ARYL SULTAM DERIVATIVES AS RORc MODULATORS
US20140187554A1 (en) * 2011-05-16 2014-07-03 The Scripps Research Institute Modulators of the nuclear hormone receptor ror
RU2014115796A (ru) * 2011-09-19 2015-10-27 Этх Цюрих Модуляторы ror-гамма

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP1100166A2 (en) * 2011-03-29 2012-12-28 Sanofi Sa Reductive amination process for preparation of dronedarone using amine intermediary compound
CN107614062A (zh) * 2015-03-12 2018-01-19 加利福尼亚大学董事会 用RORγ抑制剂治疗癌症的方法
ES2928904T3 (es) 2016-10-27 2022-11-23 Escalier Biosciences Bv Moduladores de ROR-gamma

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6432957B1 (en) * 2001-06-29 2002-08-13 Kowa Co., Ltd. Piperazine derivative
WO2004032933A1 (ja) * 2002-10-11 2004-04-22 Kowa Co., Ltd. 癌の処置方法
US20100029621A1 (en) * 2008-05-15 2010-02-04 Andrew John Cooke Hexafluoroisopropanol derivatives
US20140187554A1 (en) * 2011-05-16 2014-07-03 The Scripps Research Institute Modulators of the nuclear hormone receptor ror
RU2014115796A (ru) * 2011-09-19 2015-10-27 Этх Цюрих Модуляторы ror-гамма
US20140031330A1 (en) * 2012-07-11 2014-01-30 Genentech, Inc. ARYL SULTAM DERIVATIVES AS RORc MODULATORS

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
В. Г. Беликов "Фармацевтическая химия". Глава 2.6 "Связь между химической структурой, свойствами веществ и их действием на организм". - М.: МЕДпресс-информ, 2007, с. 27-29. *
Фиалков Ю. Я. "Растворитель как средство управления химическим процессом", Издательство "Химия", 1990, с. 240. *
Фиалков Ю. Я. "Растворитель как средство управления химическим процессом", Издательство "Химия", 1990, с. 240. В. Г. Беликов "Фармацевтическая химия". Глава 2.6 "Связь между химической структурой, свойствами веществ и их действием на организм". - М.: МЕДпресс-информ, 2007, с. 27-29. *

Also Published As

Publication number Publication date
EP3532062A1 (en) 2019-09-04
MX2019004973A (es) 2019-09-19
IL266261A (en) 2019-06-30
RU2019115059A3 (enExample) 2020-12-18
IL266261B (en) 2022-07-01
AU2017348345A1 (en) 2019-05-30
MX392163B (es) 2025-03-21
US10905687B2 (en) 2021-02-02
KR20190096979A (ko) 2019-08-20
US20220175765A1 (en) 2022-06-09
CN110139652A (zh) 2019-08-16
AU2017348345B2 (en) 2022-01-27
US20230277527A1 (en) 2023-09-07
ES2928904T3 (es) 2022-11-23
RU2019115059A (ru) 2020-11-27
EP3532062B1 (en) 2022-07-20
BR112019008548A2 (pt) 2019-09-17
WO2018081558A1 (en) 2018-05-03
EP3532062A4 (en) 2020-04-15
JP7027437B2 (ja) 2022-03-01
US20240216361A1 (en) 2024-07-04
US20190269674A1 (en) 2019-09-05
CA3042080A1 (en) 2018-05-03
JP2019535813A (ja) 2019-12-12
PH12019500949A1 (en) 2019-08-05
CN110139652B (zh) 2022-10-11
KR102598775B1 (ko) 2023-11-03
US20210069182A1 (en) 2021-03-11

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