PH12019500949A1 - Ror-gamma modulators - Google Patents
Ror-gamma modulatorsInfo
- Publication number
- PH12019500949A1 PH12019500949A1 PH12019500949A PH12019500949A PH12019500949A1 PH 12019500949 A1 PH12019500949 A1 PH 12019500949A1 PH 12019500949 A PH12019500949 A PH 12019500949A PH 12019500949 A PH12019500949 A PH 12019500949A PH 12019500949 A1 PH12019500949 A1 PH 12019500949A1
- Authority
- PH
- Philippines
- Prior art keywords
- ror
- modulators
- gamma modulators
- disorders
- gamma
- Prior art date
Links
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 102000005962 receptors Human genes 0.000 abstract 2
- 108020003175 receptors Proteins 0.000 abstract 2
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000002500 effect on skin Effects 0.000 abstract 1
- 102000004164 orphan nuclear receptors Human genes 0.000 abstract 1
- 108090000629 orphan nuclear receptors Proteins 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229930002330 retinoic acid Natural products 0.000 abstract 1
- 229960001727 tretinoin Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/08—Antiseborrheics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Dermatology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Processing Of Color Television Signals (AREA)
- Picture Signal Circuits (AREA)
- Details Of Television Scanning (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662413907P | 2016-10-27 | 2016-10-27 | |
| PCT/US2017/058755 WO2018081558A1 (en) | 2016-10-27 | 2017-10-27 | Ror-gamma modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PH12019500949A1 true PH12019500949A1 (en) | 2019-08-05 |
Family
ID=62024021
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH12019500949A PH12019500949A1 (en) | 2016-10-27 | 2019-04-26 | Ror-gamma modulators |
Country Status (14)
| Country | Link |
|---|---|
| US (5) | US10905687B2 (enExample) |
| EP (1) | EP3532062B1 (enExample) |
| JP (1) | JP7027437B2 (enExample) |
| KR (1) | KR102598775B1 (enExample) |
| CN (1) | CN110139652B (enExample) |
| AU (1) | AU2017348345B2 (enExample) |
| BR (1) | BR112019008548A2 (enExample) |
| CA (1) | CA3042080A1 (enExample) |
| ES (1) | ES2928904T3 (enExample) |
| IL (1) | IL266261B (enExample) |
| MX (1) | MX392163B (enExample) |
| PH (1) | PH12019500949A1 (enExample) |
| RU (1) | RU2753490C2 (enExample) |
| WO (1) | WO2018081558A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX392163B (es) | 2016-10-27 | 2025-03-21 | Escalier Biosciences Bv | Moduladores de ror gamma. |
| US11242350B2 (en) | 2018-03-12 | 2022-02-08 | Escalier Biosciences B.V. | Spirocyclic ROR-gamma modulators |
| US11230555B2 (en) | 2018-03-12 | 2022-01-25 | Escalier Biosciences B.V. | Bicyclic RORγ modulators |
| US20220409643A1 (en) * | 2019-11-05 | 2022-12-29 | Dermira, Inc. | ROR Gamma T Inhibitors and Topical Uses Thereof |
| BR112022027083A2 (pt) * | 2020-06-30 | 2023-03-14 | Dermira Inc | Inibidores de rorgamat e usos tópicos dos mesmos |
| CN111892599B (zh) * | 2020-08-14 | 2023-01-13 | 黄芳 | 一种2,5-二氮杂双环[2.2.2]辛烷-2-羧酸叔丁酯的合成方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6432957B1 (en) * | 2001-06-29 | 2002-08-13 | Kowa Co., Ltd. | Piperazine derivative |
| WO2004032933A1 (ja) * | 2002-10-11 | 2004-04-22 | Kowa Co., Ltd. | 癌の処置方法 |
| TW201006816A (en) | 2008-05-15 | 2010-02-16 | Organon Nv | Hexafluoroisopropanol derivatives |
| HUP1100166A2 (en) * | 2011-03-29 | 2012-12-28 | Sanofi Sa | Reductive amination process for preparation of dronedarone using amine intermediary compound |
| US9586928B2 (en) | 2011-05-16 | 2017-03-07 | The Scripps Research Institute | Modulators of the nuclear hormone receptor ROR |
| JP2014526494A (ja) * | 2011-09-19 | 2014-10-06 | イーティーエイチ・チューリッヒ | ＲＯＲγ修飾剤 |
| TW201408652A (zh) * | 2012-07-11 | 2014-03-01 | Hoffmann La Roche | 作爲ＲＯＲｃ調節劑之芳基磺內醯胺衍生物 |
| WO2016145298A1 (en) * | 2015-03-12 | 2016-09-15 | The Regents Of The University Of California | METHODS FOR TREATING CANCER WITH RORgamma INHIBITORS |
| MX392163B (es) | 2016-10-27 | 2025-03-21 | Escalier Biosciences Bv | Moduladores de ror gamma. |
-
2017
- 2017-10-27 MX MX2019004973A patent/MX392163B/es unknown
- 2017-10-27 JP JP2019544789A patent/JP7027437B2/ja not_active Expired - Fee Related
- 2017-10-27 CA CA3042080A patent/CA3042080A1/en active Pending
- 2017-10-27 RU RU2019115059A patent/RU2753490C2/ru active
- 2017-10-27 US US16/344,919 patent/US10905687B2/en not_active Expired - Fee Related
- 2017-10-27 WO PCT/US2017/058755 patent/WO2018081558A1/en not_active Ceased
- 2017-10-27 ES ES17865163T patent/ES2928904T3/es active Active
- 2017-10-27 AU AU2017348345A patent/AU2017348345B2/en not_active Ceased
- 2017-10-27 BR BR112019008548A patent/BR112019008548A2/pt not_active Application Discontinuation
- 2017-10-27 IL IL266261A patent/IL266261B/en unknown
- 2017-10-27 KR KR1020197015082A patent/KR102598775B1/ko active Active
- 2017-10-27 CN CN201780081203.XA patent/CN110139652B/zh not_active Expired - Fee Related
- 2017-10-27 EP EP17865163.4A patent/EP3532062B1/en not_active Not-in-force
-
2019
- 2019-04-26 PH PH12019500949A patent/PH12019500949A1/en unknown
-
2020
- 2020-11-23 US US17/102,105 patent/US20210069182A1/en not_active Abandoned
-
2022
- 2022-02-15 US US17/672,496 patent/US20220175765A1/en not_active Abandoned
-
2023
- 2023-05-11 US US18/315,908 patent/US20230277527A1/en not_active Abandoned
- 2023-12-28 US US18/399,265 patent/US20240216361A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP3532062A1 (en) | 2019-09-04 |
| CA3042080A1 (en) | 2018-05-03 |
| IL266261A (en) | 2019-06-30 |
| AU2017348345A1 (en) | 2019-05-30 |
| AU2017348345B2 (en) | 2022-01-27 |
| US20210069182A1 (en) | 2021-03-11 |
| JP7027437B2 (ja) | 2022-03-01 |
| JP2019535813A (ja) | 2019-12-12 |
| EP3532062A4 (en) | 2020-04-15 |
| US20240216361A1 (en) | 2024-07-04 |
| EP3532062B1 (en) | 2022-07-20 |
| US20190269674A1 (en) | 2019-09-05 |
| US10905687B2 (en) | 2021-02-02 |
| CN110139652B (zh) | 2022-10-11 |
| MX2019004973A (es) | 2019-09-19 |
| IL266261B (en) | 2022-07-01 |
| MX392163B (es) | 2025-03-21 |
| RU2019115059A3 (enExample) | 2020-12-18 |
| US20220175765A1 (en) | 2022-06-09 |
| KR20190096979A (ko) | 2019-08-20 |
| KR102598775B1 (ko) | 2023-11-03 |
| BR112019008548A2 (pt) | 2019-09-17 |
| WO2018081558A1 (en) | 2018-05-03 |
| CN110139652A (zh) | 2019-08-16 |
| RU2019115059A (ru) | 2020-11-27 |
| ES2928904T3 (es) | 2022-11-23 |
| RU2753490C2 (ru) | 2021-08-17 |
| US20230277527A1 (en) | 2023-09-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PH12019500949A1 (en) | Ror-gamma modulators | |
| CL2018003142A1 (es) | Moduladores de la vía de estrés integrada | |
| SG10201808104RA (en) | Cenicriviroc for the treatment of fibrosis | |
| PH12015502621A1 (en) | Estrogen receptor modulator and uses thereof | |
| MX2020001555A (es) | Preparaciones terapéuticas de glicanos y métodos relacionados con estas. | |
| BR112019001923A2 (pt) | moduladores de nmda de espiro-lactama e métodos de sua utilização | |
| EA201890725A1 (ru) | Агонисты фарнезоидного х-рецептора и их применение | |
| WO2016172658A3 (en) | Microbiome regulators and related uses thereof | |
| MX2018009752A (es) | 1,2,3,-triazoles sustituidos como moduladores de nmda selectivos de nr2b. | |
| NZ737399A (en) | Ccr2 modulators | |
| CL2016001364A1 (es) | Moduladores de ror gamma (rory) | |
| MY188139A (en) | Sodium channel modulators for the treatment of pain | |
| MX2014002668A (es) | Tratamiento de enfermedades relacionadas con subunidades alfa de canales de sonido regulados por voltaje (scnxa) con moleculas pequeñas. | |
| MX385357B (es) | Compuestos de tetrahidroquinolinona sustituidos como moduladores de ror gamma | |
| MX2018000352A (es) | 4-azaindoles sustituidos y su uso como moduladores del receptor glun2b. | |
| MX2019010949A (es) | Moduladores de somatostatina y usos de los mismos. | |
| MX2014010537A (es) | Moduladores de receptor x del higado (lxr) para el tratamiento de enfermedades, trastornos y condiciones dermicas. | |
| MX378098B (es) | Derivados de piperazina como moduladores de ror?. | |
| BR112019001768A2 (pt) | moduladores do receptor de spiro-lactamas nmda e usos dos mesmos | |
| EA201692007A1 (ru) | Соединения изоиндолинона в качестве модуляторов gpr119 для лечения диабета, ожирения, дислипидемии и связанных с ними нарушений | |
| EA201691808A1 (ru) | Кортикостероидные композиции для местного применения | |
| PH12017500494A1 (en) | Methyl-and trifluoromethyl-substituted pyrrolopyridine modulators of rorc2 and methods of use thereof | |
| BR112019001921A2 (pt) | moduladores do receptor nmda de espiro-lactama e seus usos | |
| MX387731B (es) | Composiciones farmacéuticas orales de mesalazina. | |
| PH12016502331A1 (en) | Novel compounds |