CN1099752A - 新型酰氨烷基-和亚氨烷基-哌嗪 - Google Patents
新型酰氨烷基-和亚氨烷基-哌嗪 Download PDFInfo
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- CN1099752A CN1099752A CN93118820A CN93118820A CN1099752A CN 1099752 A CN1099752 A CN 1099752A CN 93118820 A CN93118820 A CN 93118820A CN 93118820 A CN93118820 A CN 93118820A CN 1099752 A CN1099752 A CN 1099752A
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- 238000000034 method Methods 0.000 claims abstract description 27
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- 229910052799 carbon Inorganic materials 0.000 claims description 31
- 125000005843 halogen group Chemical group 0.000 claims description 28
- 239000002253 acid Substances 0.000 claims description 25
- 239000000203 mixture Substances 0.000 claims description 24
- -1 CF 3 Chemical group 0.000 claims description 21
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 21
- 125000000217 alkyl group Chemical group 0.000 claims description 20
- 238000006243 chemical reaction Methods 0.000 claims description 13
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 13
- 125000003545 alkoxy group Chemical group 0.000 claims description 12
- 125000000623 heterocyclic group Chemical group 0.000 claims description 12
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 12
- 238000002360 preparation method Methods 0.000 claims description 12
- 239000003814 drug Substances 0.000 claims description 11
- 125000002837 carbocyclic group Chemical group 0.000 claims description 10
- 150000003839 salts Chemical class 0.000 claims description 10
- 125000003118 aryl group Chemical group 0.000 claims description 9
- 239000013067 intermediate product Substances 0.000 claims description 9
- HZVOZRGWRWCICA-UHFFFAOYSA-N methanediyl Chemical compound [CH2] HZVOZRGWRWCICA-UHFFFAOYSA-N 0.000 claims description 9
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- 239000013543 active substance Substances 0.000 claims description 8
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- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
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- 239000012279 sodium borohydride Substances 0.000 description 1
- 229910000033 sodium borohydride Inorganic materials 0.000 description 1
- BEOOHQFXGBMRKU-UHFFFAOYSA-N sodium cyanoborohydride Chemical compound [Na+].[B-]C#N BEOOHQFXGBMRKU-UHFFFAOYSA-N 0.000 description 1
- JVBXVOWTABLYPX-UHFFFAOYSA-L sodium dithionite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])=O JVBXVOWTABLYPX-UHFFFAOYSA-L 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
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- IIACRCGMVDHOTQ-UHFFFAOYSA-M sulfamate Chemical compound NS([O-])(=O)=O IIACRCGMVDHOTQ-UHFFFAOYSA-M 0.000 description 1
- 229950000244 sulfanilic acid Drugs 0.000 description 1
- YBBRCQOCSYXUOC-UHFFFAOYSA-N sulfuryl dichloride Chemical compound ClS(Cl)(=O)=O YBBRCQOCSYXUOC-UHFFFAOYSA-N 0.000 description 1
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- 239000000454 talc Substances 0.000 description 1
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- 229910052623 talc Inorganic materials 0.000 description 1
- 125000006633 tert-butoxycarbonylamino group Chemical group 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/20—Spiro-condensed ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/62—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles
- C07D209/66—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles with oxygen atoms in positions 1 and 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Priority Applications (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9201138A SE9201138D0 (sv) | 1992-04-09 | 1992-04-09 | Novel phthalimidoalkylpiperazines |
| JP5518225A JPH06508378A (ja) | 1992-04-09 | 1993-04-06 | 新規アミドアルキル−およびイミドアルキル−ピペラジン類 |
| CA002109816A CA2109816A1 (en) | 1992-04-09 | 1993-04-06 | Novel amidoalkyl- and imidoalkyl-piperazines |
| HU9303520A HUT68891A (en) | 1992-04-09 | 1993-04-06 | Novel amidoalkyl- and imidoalkyl-piperazines |
| PCT/SE1993/000295 WO1993021179A1 (en) | 1992-04-09 | 1993-04-06 | Novel amidoalkyl- and imidoalkyl-piperazines |
| CZ932701A CZ270193A3 (en) | 1992-04-09 | 1993-04-06 | Novel amidoalkyl- and imidoalkyl piperazines |
| EP93909109A EP0594813A1 (en) | 1992-04-09 | 1993-04-06 | Novel amidoalkyl- and imidoalkyl-piperazines |
| AU39643/93A AU665825B2 (en) | 1992-04-09 | 1993-04-06 | Novel amidoalkyl- and imidoalkyl-piperazines |
| SK1389-93A SK138993A3 (en) | 1992-04-09 | 1993-04-06 | Amidoalkyl - and imidoalkylpiperazines |
| SI9300191A SI9300191A (sl) | 1992-04-09 | 1993-04-09 | Novi amidoalkil- in imidoalkil-piperazini |
| CN93118820A CN1099752A (zh) | 1992-04-09 | 1993-08-31 | 新型酰氨烷基-和亚氨烷基-哌嗪 |
| NO934426A NO180794C (no) | 1992-04-09 | 1993-12-06 | Nye amidoalkyl- og imidoalkylpiperaziner samt farmasöytisk preparat inneholdende slike forbindelser |
| NO934426D NO934426D0 (no) | 1992-04-09 | 1993-12-06 | Nye amidoalkyl- og imidoalkylpipera-ziner |
| BG98281A BG98281A (en) | 1992-04-09 | 1993-12-08 | Amidoalkyl- and imidoalkylpiperazines |
| FI935494A FI935494A (fi) | 1992-04-09 | 1993-12-08 | Nya amidolakyl- och imidoalkylpiperaziner |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9201138A SE9201138D0 (sv) | 1992-04-09 | 1992-04-09 | Novel phthalimidoalkylpiperazines |
| CN93118820A CN1099752A (zh) | 1992-04-09 | 1993-08-31 | 新型酰氨烷基-和亚氨烷基-哌嗪 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1099752A true CN1099752A (zh) | 1995-03-08 |
Family
ID=36869961
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN93118820A Pending CN1099752A (zh) | 1992-04-09 | 1993-08-31 | 新型酰氨烷基-和亚氨烷基-哌嗪 |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0594813A1 (xx) |
| JP (1) | JPH06508378A (xx) |
| CN (1) | CN1099752A (xx) |
| AU (1) | AU665825B2 (xx) |
| BG (1) | BG98281A (xx) |
| CA (1) | CA2109816A1 (xx) |
| CZ (1) | CZ270193A3 (xx) |
| FI (1) | FI935494A (xx) |
| HU (1) | HUT68891A (xx) |
| NO (2) | NO934426D0 (xx) |
| SE (1) | SE9201138D0 (xx) |
| SI (1) | SI9300191A (xx) |
| SK (1) | SK138993A3 (xx) |
| WO (1) | WO1993021179A1 (xx) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1948298B (zh) * | 2006-11-09 | 2010-09-01 | 东南大学 | 一种多巴胺d3受体部分激动剂及其应用 |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1266582B1 (it) * | 1993-07-30 | 1997-01-09 | Recordati Chem Pharm | Derivati (di)azacicloesanici e diazacicloeptanici |
| US5395835A (en) * | 1994-03-24 | 1995-03-07 | Warner-Lambert Company | Naphthalamides as central nervous system agents |
| GB9411099D0 (en) * | 1994-06-03 | 1994-07-27 | Wyeth John & Brother Ltd | Piperazine derivatives |
| FR2742149B1 (fr) * | 1995-12-11 | 1998-02-13 | Inst Nat Sante Rech Med | Nouveaux derives de 2-naphtamides et leurs applications therapeutiques |
| US5703235A (en) * | 1996-03-21 | 1997-12-30 | Neurogen Corporation | N-Aminoalkyl-2-anthracenecarboxamides; new dopamine receptor subtype specific ligands |
| US5763609A (en) | 1996-03-21 | 1998-06-09 | Neurogen Corporation | Certain pyrrolo pyridine-3-carboxamides; a new class of gaba brain receptor ligands |
| IL126411A0 (en) * | 1996-04-05 | 1999-05-09 | Sod Conseils Rech Applic | Alpha1-Adrenergic receptor antagonists |
| HU227543B1 (en) * | 2001-09-28 | 2011-08-29 | Richter Gedeon Nyrt | N-[4-(2-piperazin- and 2-piperidin-1-yl-ethyl)-cyclohexyl]-sulfon- and sulfamides, process for their preparation, their use and pharmaceutical compositions containing them |
| HUP0103987A3 (en) * | 2001-09-28 | 2004-11-29 | Richter Gedeon Vegyeszet | Phenylpiperazinylalkyl carboxylic acid amid derivatives, process for their preparation, pharmaceutical compositions containing them and their intermediates |
| MXPA05000033A (es) * | 2002-07-04 | 2005-04-08 | Sanol Arznei Schwarz Gmbh | Utilizacion de carboxamida de heteroareno como ligandos de dopamina-d3 para el tratamiento de enfermedades de cns. |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3398151A (en) * | 1966-02-01 | 1968-08-20 | Mead Johnson & Co | Azaspirodecanediones and azaspiroundecanediones |
| US3488352A (en) * | 1966-10-11 | 1970-01-06 | Shulton Inc | Basically substituted alkoxy anthranilamides,their corresponding 2-nitro compounds and derivatives thereof |
| US3505338A (en) * | 1966-11-25 | 1970-04-07 | American Cyanamid Co | Thiophenecarbonylalkylene-diamines |
| FR1537901A (fr) * | 1967-07-19 | 1968-08-30 | Bruneau & Cie Lab | Dérivés amidés d'acides halogéno et nitro benzoïques et leur préparation |
| US3558777A (en) * | 1968-06-21 | 1971-01-26 | Mead Johnson & Co | Pharmacologic processes and compositions containing azaspirodecanediones and azaspiroundecanediones |
| US3465080A (en) * | 1968-10-07 | 1969-09-02 | American Cyanamid Co | Therapeutic compositions containing morpholinoalkylene - indoles and methods of administering such in the treatment of depression |
| JPS504650B2 (xx) * | 1971-09-03 | 1975-02-22 | ||
| US3940397A (en) * | 1974-11-13 | 1976-02-24 | E. R. Squibb & Sons, Inc. | 2-[(Substituted-piperazinyl)alkyl]-1H-benz[de]isoquinoline-1,3(2H)-diones |
| NL8005133A (nl) * | 1980-09-12 | 1982-04-01 | Duphar Int Res | Fenylpiperazinederivaten met antiagressieve werking. |
| US4361565A (en) * | 1981-12-28 | 1982-11-30 | Mead Johnson & Company | 2-[4-[(4,4-Dialkyl-2,6-piperidinedion-1-yl)butyl]-1-piperazinyl]pyridines |
| DE3529872A1 (de) * | 1985-08-21 | 1987-02-26 | Kali Chemie Pharma Gmbh | Neue tetraoxoverbindungen |
| US4892943A (en) * | 1985-10-16 | 1990-01-09 | American Home Products Corporation | Fused bicyclic imides with psychotropic activity |
| IL90279A (en) * | 1988-05-24 | 1995-03-30 | American Home Prod | History of piperazinyl carboxamide, their preparation and the pharmaceutical preparations containing them |
| DE68918832T2 (de) * | 1988-12-28 | 1995-02-09 | Suntory Ltd | Benzoxazepinderivate. |
| US4939137A (en) * | 1989-06-28 | 1990-07-03 | Ortho Pharmaceutical Corporation | Ring-fused thienopyrimidinedione derivatives |
| EP0507863A4 (en) * | 1989-12-28 | 1993-07-07 | Virginia Commonwealth University | Sigma receptor ligands and the use thereof |
| US5143923B1 (en) * | 1991-04-29 | 1993-11-02 | Hoechst-Roussel Pharmaceuticals Incorporated | Benzoisothiazole-and benzisoxazole-3-carboxamides |
| IT1251144B (it) * | 1991-07-30 | 1995-05-04 | Boehringer Ingelheim Italia | Derivati del benzimidazolone |
-
1992
- 1992-04-09 SE SE9201138A patent/SE9201138D0/xx unknown
-
1993
- 1993-04-06 HU HU9303520A patent/HUT68891A/hu unknown
- 1993-04-06 CZ CZ932701A patent/CZ270193A3/cs unknown
- 1993-04-06 SK SK1389-93A patent/SK138993A3/sk unknown
- 1993-04-06 CA CA002109816A patent/CA2109816A1/en not_active Abandoned
- 1993-04-06 WO PCT/SE1993/000295 patent/WO1993021179A1/en not_active Application Discontinuation
- 1993-04-06 EP EP93909109A patent/EP0594813A1/en not_active Withdrawn
- 1993-04-06 AU AU39643/93A patent/AU665825B2/en not_active Ceased
- 1993-04-06 JP JP5518225A patent/JPH06508378A/ja active Pending
- 1993-04-09 SI SI9300191A patent/SI9300191A/sl unknown
- 1993-08-31 CN CN93118820A patent/CN1099752A/zh active Pending
- 1993-12-06 NO NO934426D patent/NO934426D0/no unknown
- 1993-12-06 NO NO934426A patent/NO180794C/no unknown
- 1993-12-08 BG BG98281A patent/BG98281A/xx unknown
- 1993-12-08 FI FI935494A patent/FI935494A/fi not_active Application Discontinuation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1948298B (zh) * | 2006-11-09 | 2010-09-01 | 东南大学 | 一种多巴胺d3受体部分激动剂及其应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2109816A1 (en) | 1993-10-28 |
| EP0594813A1 (en) | 1994-05-04 |
| SI9300191A (sl) | 1993-12-31 |
| NO934426L (no) | 1993-12-06 |
| FI935494A0 (fi) | 1993-12-08 |
| BG98281A (en) | 1994-09-30 |
| SE9201138D0 (sv) | 1992-04-09 |
| SK138993A3 (en) | 1994-11-09 |
| NO180794C (no) | 1997-06-25 |
| AU665825B2 (en) | 1996-01-18 |
| WO1993021179A1 (en) | 1993-10-28 |
| HUT68891A (en) | 1995-08-28 |
| NO934426D0 (no) | 1993-12-06 |
| AU3964393A (en) | 1993-11-18 |
| FI935494A (fi) | 1993-12-08 |
| NO180794B (no) | 1997-03-17 |
| CZ270193A3 (en) | 1994-08-17 |
| JPH06508378A (ja) | 1994-09-22 |
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