CN109963945A - 单一向导rna、crispr/cas9系统及其使用方法 - Google Patents

单一向导rna、crispr/cas9系统及其使用方法 Download PDF

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CN109963945A
CN109963945A CN201780064151.5A CN201780064151A CN109963945A CN 109963945 A CN109963945 A CN 109963945A CN 201780064151 A CN201780064151 A CN 201780064151A CN 109963945 A CN109963945 A CN 109963945A
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sequence
mutation
dna
artificial sequence
snp
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Chinese (zh)
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T.摩尔
A.内斯比特
D.考特尼
K.克里斯蒂
G.李
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Avellino Lab USA Inc
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Avellino Lab USA Inc
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CN201780064151.5A 2016-08-20 2017-08-21 单一向导rna、crispr/cas9系统及其使用方法 Pending CN109963945A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201662377586P 2016-08-20 2016-08-20
US62/377,586 2016-08-20
US201762462808P 2017-02-23 2017-02-23
US62/462,808 2017-02-23
US201762501750P 2017-05-05 2017-05-05
US62/501,750 2017-05-05
PCT/US2017/047861 WO2018039145A1 (en) 2016-08-20 2017-08-21 Single guide rna, crispr/cas9 systems, and methods of use thereof

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CN109963945A true CN109963945A (zh) 2019-07-02

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US (1) US20190185850A1 (enExample)
EP (1) EP3500677A4 (enExample)
JP (3) JP2019524149A (enExample)
KR (2) KR20230155013A (enExample)
CN (1) CN109963945A (enExample)
WO (1) WO2018039145A1 (enExample)

Cited By (4)

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CN110499335A (zh) * 2019-08-08 2019-11-26 复旦大学 CRISPR/SauriCas9基因编辑系统及其应用
CN110551763A (zh) * 2019-08-08 2019-12-10 复旦大学 CRISPR/SlutCas9基因编辑系统及其应用
CN116286823A (zh) * 2023-04-04 2023-06-23 尧唐(上海)生物科技有限公司 靶向TGFBI基因的sgRNA、载体及其应用
CN119464347A (zh) * 2024-11-26 2025-02-18 扬州大学 基于CRISPR-Cas9系统的噬菌体基因组编辑载体及其编辑方法和应用

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US20150044192A1 (en) 2013-08-09 2015-02-12 President And Fellows Of Harvard College Methods for identifying a target site of a cas9 nuclease
US9359599B2 (en) 2013-08-22 2016-06-07 President And Fellows Of Harvard College Engineered transcription activator-like effector (TALE) domains and uses thereof
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JP6929865B2 (ja) 2015-11-13 2021-09-01 タラ ムーア 角膜ジストロフィーの治療方法
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GB2568182A (en) 2016-08-03 2019-05-08 Harvard College Adenosine nucleobase editors and uses thereof
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US20190185850A1 (en) * 2016-08-20 2019-06-20 Avellino Lab Usa, Inc. Single guide rna/crispr/cas9 systems, and methods of use thereof
WO2020225754A1 (en) * 2019-05-06 2020-11-12 Mcmullen Tara Crispr gene editing for autosomal dominant diseases
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CN110914310A (zh) 2017-03-10 2020-03-24 哈佛大学的校长及成员们 胞嘧啶至鸟嘌呤碱基编辑器
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WO2018209320A1 (en) 2017-05-12 2018-11-15 President And Fellows Of Harvard College Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation
EP3636754A4 (en) * 2017-06-07 2021-03-17 The University Of Tokyo GENE THERAPY FOR GRANULAR CORNEAL DYSTROPHY
JP2020534795A (ja) 2017-07-28 2020-12-03 プレジデント アンド フェローズ オブ ハーバード カレッジ ファージによって支援される連続的進化（ｐａｃｅ）を用いて塩基編集因子を進化させるための方法および組成物
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AU2020240109A1 (en) 2019-03-19 2021-09-30 President And Fellows Of Harvard College Methods and compositions for editing nucleotide sequences
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