CN109952289B - Trpv4拮抗剂 - Google Patents
Trpv4拮抗剂 Download PDFInfo
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- CN109952289B CN109952289B CN201780057993.8A CN201780057993A CN109952289B CN 109952289 B CN109952289 B CN 109952289B CN 201780057993 A CN201780057993 A CN 201780057993A CN 109952289 B CN109952289 B CN 109952289B
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- sulfonyl
- hydroxy
- hydroxymethyl
- oxy
- pyrrolidin
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
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| US201662396991P | 2016-09-20 | 2016-09-20 | |
| US62/396,991 | 2016-09-20 | ||
| US201762482296P | 2017-04-06 | 2017-04-06 | |
| US62/482,296 | 2017-04-06 | ||
| PCT/IB2017/055700 WO2018055524A1 (en) | 2016-09-20 | 2017-09-20 | Trpv4 antagonists |
Publications (2)
| Publication Number | Publication Date |
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| CN109952289A CN109952289A (zh) | 2019-06-28 |
| CN109952289B true CN109952289B (zh) | 2022-12-09 |
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| EP3515889A1 (en) | 2016-09-20 | 2019-07-31 | GlaxoSmithKline Intellectual Property (No. 2) Limited | Trpv4 antagonists |
| JP7106528B2 (ja) | 2016-09-20 | 2022-07-26 | グラクソスミスクライン、インテレクチュアル、プロパティー、(ナンバー2)、リミテッド | Trpv4拮抗薬 |
| TW201825458A (zh) * | 2016-09-20 | 2018-07-16 | 英商葛蘭素史克智慧財產(第二)有限公司 | Trpv4拮抗劑 |
| CN108836972A (zh) * | 2018-08-16 | 2018-11-20 | 青岛大学 | Ws6对trp通道的作用 |
| JP6994061B2 (ja) | 2019-02-15 | 2022-01-14 | ノバルティス アーゲー | 4-(7-ヒドロキシ-2-イソプロピル-4-オキソ-4h-キナゾリン-3-イル)-ベンゾニトリルの製剤 |
| TWI878266B (zh) | 2019-02-15 | 2025-04-01 | 愛爾蘭商博士倫愛爾蘭有限公司 | 治療眼表痛之方法 |
| CA3157279A1 (en) * | 2019-11-21 | 2021-05-27 | Paul Richard Sebahar | Trpv4 receptor ligands |
| US20230339934A1 (en) | 2020-04-30 | 2023-10-26 | Raqualia Pharma Inc. | Pyrimidin-4(3h)-one derivatives as trpv4 antagonists |
| WO2021233752A1 (en) | 2020-05-19 | 2021-11-25 | Bayer Aktiengesellschaft | Trpa1 antagonists for the treatment of diseases associated with pain and inflammation |
| EP4178982A1 (en) | 2020-07-13 | 2023-05-17 | Precirix N.V. | Antibody fragment against folr1 |
| TW202216143A (zh) | 2020-07-16 | 2022-05-01 | 日商拉夸里亞創藥股份有限公司 | 作為眼疾病的治療藥之trpv4抑制藥 |
| CN112574090B (zh) * | 2020-11-23 | 2022-04-29 | 浙大城市学院 | 一种含硫的多取代吡咯类化合物及其制备方法 |
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| AU2023264245A1 (en) | 2022-05-02 | 2024-12-19 | Precirix N.V. | Pre-targeting |
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| CN103896946A (zh) * | 2012-12-28 | 2014-07-02 | 浙江导明医药科技有限公司 | 用于预防及治疗多种自身免疫疾病的新化合物 |
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| WO2007082262A2 (en) * | 2006-01-11 | 2007-07-19 | Smithkline Beecham Corporation | Novel compounds |
| CN103896946A (zh) * | 2012-12-28 | 2014-07-02 | 浙江导明医药科技有限公司 | 用于预防及治疗多种自身免疫疾病的新化合物 |
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| SI3515887T1 (sl) | 2021-11-30 |
| CN109952289A (zh) | 2019-06-28 |
| EP3515887A1 (en) | 2019-07-31 |
| RS62317B1 (sr) | 2021-09-30 |
| PT3515887T (pt) | 2021-09-27 |
| BR112019005464A2 (pt) | 2019-06-04 |
| LT3515887T (lt) | 2021-12-10 |
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| EP3515887B1 (en) | 2021-07-07 |
| ES2890986T3 (es) | 2022-01-25 |
| HRP20211457T1 (hr) | 2021-12-24 |
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