BR112019005464A2 - antagonistas de trpv4 - Google Patents

antagonistas de trpv4

Info

Publication number
BR112019005464A2
BR112019005464A2 BR112019005464A BR112019005464A BR112019005464A2 BR 112019005464 A2 BR112019005464 A2 BR 112019005464A2 BR 112019005464 A BR112019005464 A BR 112019005464A BR 112019005464 A BR112019005464 A BR 112019005464A BR 112019005464 A2 BR112019005464 A2 BR 112019005464A2
Authority
BR
Brazil
Prior art keywords
trpv4 antagonists
trpv4
antagonists
pharmaceutical compositions
relates
Prior art date
Application number
BR112019005464A
Other languages
English (en)
Inventor
Griffin Lawhorn Brian
W Budzik Brian
A Brooks Carl
J Behm David
J Brnardic Edward
Ye Guosen
R Patterson Jaclyn
V Thomas James
M Matthews Jay
Jeffrey Mcatee John
E Pero Joseph
Roscoe Terrell Lamont
S Barton Linda
Robert Sender Matthew
Sanchez Robert
Original Assignee
Glaxosmithkline Ip No 2 Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Ip No 2 Ltd filed Critical Glaxosmithkline Ip No 2 Ltd
Publication of BR112019005464A2 publication Critical patent/BR112019005464A2/pt

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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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Abstract

a presente invenção refere-se a análogos de sulfonamida de pirrolidina, composições farmacêuticas contendo-os e seu uso como antagonistas de trpv4.
BR112019005464A 2016-09-20 2017-09-20 antagonistas de trpv4 BR112019005464A2 (pt)

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