SMT202100561T1 - Antagonisti di trpv4 - Google Patents
Antagonisti di trpv4Info
- Publication number
- SMT202100561T1 SMT202100561T1 SM20210561T SMT202100561T SMT202100561T1 SM T202100561 T1 SMT202100561 T1 SM T202100561T1 SM 20210561 T SM20210561 T SM 20210561T SM T202100561 T SMT202100561 T SM T202100561T SM T202100561 T1 SMT202100561 T1 SM T202100561T1
- Authority
- SM
- San Marino
- Prior art keywords
- trpv4 antagonists
- trpv4
- antagonists
- Prior art date
Links
- 101150098315 TRPV4 gene Proteins 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
Classifications
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07—ORGANIC CHEMISTRY
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
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- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
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- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
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- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
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| US201662396991P | 2016-09-20 | 2016-09-20 | |
| US201762482296P | 2017-04-06 | 2017-04-06 | |
| EP17784400.8A EP3515887B1 (en) | 2016-09-20 | 2017-09-20 | Trpv4 antagonists |
| PCT/IB2017/055700 WO2018055524A1 (en) | 2016-09-20 | 2017-09-20 | Trpv4 antagonists |
Publications (1)
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| SMT202100561T1 true SMT202100561T1 (it) | 2021-11-12 |
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Family Applications (1)
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| SM20210561T SMT202100561T1 (it) | 2016-09-20 | 2017-09-20 | Antagonisti di trpv4 |
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| RU (1) | RU2019111882A (OSRAM) |
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| TW (1) | TW201825458A (OSRAM) |
| UY (1) | UY37410A (OSRAM) |
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| EP3515889A1 (en) | 2016-09-20 | 2019-07-31 | GlaxoSmithKline Intellectual Property (No. 2) Limited | Trpv4 antagonists |
| JP7106528B2 (ja) | 2016-09-20 | 2022-07-26 | グラクソスミスクライン、インテレクチュアル、プロパティー、(ナンバー2)、リミテッド | Trpv4拮抗薬 |
| TW201825458A (zh) * | 2016-09-20 | 2018-07-16 | 英商葛蘭素史克智慧財產(第二)有限公司 | Trpv4拮抗劑 |
| CN108836972A (zh) * | 2018-08-16 | 2018-11-20 | 青岛大学 | Ws6对trp通道的作用 |
| JP6994061B2 (ja) | 2019-02-15 | 2022-01-14 | ノバルティス アーゲー | 4-(7-ヒドロキシ-2-イソプロピル-4-オキソ-4h-キナゾリン-3-イル)-ベンゾニトリルの製剤 |
| TWI878266B (zh) | 2019-02-15 | 2025-04-01 | 愛爾蘭商博士倫愛爾蘭有限公司 | 治療眼表痛之方法 |
| CA3157279A1 (en) * | 2019-11-21 | 2021-05-27 | Paul Richard Sebahar | Trpv4 receptor ligands |
| US20230339934A1 (en) | 2020-04-30 | 2023-10-26 | Raqualia Pharma Inc. | Pyrimidin-4(3h)-one derivatives as trpv4 antagonists |
| WO2021233752A1 (en) | 2020-05-19 | 2021-11-25 | Bayer Aktiengesellschaft | Trpa1 antagonists for the treatment of diseases associated with pain and inflammation |
| EP4178982A1 (en) | 2020-07-13 | 2023-05-17 | Precirix N.V. | Antibody fragment against folr1 |
| TW202216143A (zh) | 2020-07-16 | 2022-05-01 | 日商拉夸里亞創藥股份有限公司 | 作為眼疾病的治療藥之trpv4抑制藥 |
| CN112574090B (zh) * | 2020-11-23 | 2022-04-29 | 浙大城市学院 | 一种含硫的多取代吡咯类化合物及其制备方法 |
| WO2023203135A1 (en) | 2022-04-22 | 2023-10-26 | Precirix N.V. | Improved radiolabelled antibody |
| AU2023264245A1 (en) | 2022-05-02 | 2024-12-19 | Precirix N.V. | Pre-targeting |
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| GB2064336B (en) | 1979-12-06 | 1984-03-14 | Glaxo Group Ltd | Device for dispensing medicaments |
| DE3274065D1 (de) | 1981-07-08 | 1986-12-11 | Draco Ab | Powder inhalator |
| IT1203660B (it) | 1982-10-08 | 1989-02-15 | Glaxo Group Ltd | Dispositivi per somministrare farmaci a pazienti e confezione di blister per essi |
| GB2169265B (en) | 1982-10-08 | 1987-08-12 | Glaxo Group Ltd | Pack for medicament |
| US4778054A (en) | 1982-10-08 | 1988-10-18 | Glaxo Group Limited | Pack for administering medicaments to patients |
| GB2178965B (en) | 1985-07-30 | 1988-08-03 | Glaxo Group Ltd | Devices for administering medicaments to patients |
| HU213221B (en) | 1990-03-02 | 1997-03-28 | Glaxo Group Ltd | Inhalation device and medicine packet for device |
| GB9004781D0 (en) | 1990-03-02 | 1990-04-25 | Glaxo Group Ltd | Device |
| US6536427B2 (en) | 1990-03-02 | 2003-03-25 | Glaxo Group Limited | Inhalation device |
| CN1232451A (zh) | 1996-08-28 | 1999-10-20 | 普罗克特和甘保尔公司 | 取代的环状胺金属蛋白酶抑制剂 |
| GB9700226D0 (en) | 1997-01-08 | 1997-02-26 | Glaxo Group Ltd | Inhalation device |
| DK1461315T3 (da) | 2001-12-06 | 2009-11-16 | Cornell Res Foundation Inc | Katalytisk carbonylering af tre- og fireleddede heterocykler |
| GB0201677D0 (en) | 2002-01-25 | 2002-03-13 | Glaxo Group Ltd | Medicament dispenser |
| JP4969238B2 (ja) | 2003-03-27 | 2012-07-04 | サイトキネティクス・インコーポレーテッド | 化合物、組成物および方法 |
| GB0317374D0 (en) | 2003-07-24 | 2003-08-27 | Glaxo Group Ltd | Medicament dispenser |
| KR101105909B1 (ko) | 2004-02-16 | 2012-01-17 | 글락소 그룹 리미티드 | 약품 분배기에 사용되는 카운터 |
| AR048523A1 (es) | 2004-04-07 | 2006-05-03 | Kalypsys Inc | Compuestos con estructura de aril sulfonamida y sulfonilo como moduladores de ppar y metodos para tratar trastornos metabolicos |
| EP1755603A4 (en) | 2004-04-28 | 2009-03-11 | Merck & Co Inc | 3,3-DISUBSTITUTED TETRAHYDROPYRANYL CYCLOPENTYL AMIDE MODULATORS OF CHEMOKIN RECEPTOR ACTIVITY |
| EP1758884A2 (en) | 2004-05-20 | 2007-03-07 | Elan Pharmaceuticals, Inc. | N-cyclic sulfonamido inhibitors of gamma secretase |
| CN1329374C (zh) | 2004-06-09 | 2007-08-01 | 上海靶点药物有限公司 | 作为ccr5拮抗剂的化合物 |
| KR20070041742A (ko) | 2004-07-12 | 2007-04-19 | 바이엘 크롭사이언스 아게 | 살진균제 및 살충제로서의 치환된 2-피롤리돈 유도체 |
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| DOP2006000010A (es) | 2005-01-10 | 2006-07-31 | Arena Pharm Inc | Procedimiento para preparar eteres aromáticos |
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| AR058289A1 (es) | 2005-12-12 | 2008-01-30 | Glaxo Group Ltd | Colector para ser usado en dispensador de medicamento |
| JP2009521451A (ja) | 2005-12-21 | 2009-06-04 | シェーリング コーポレイション | ヒスタミンh3アンタゴニストとして有用な置換アニリン誘導体 |
| US20090012011A1 (en) | 2006-01-11 | 2009-01-08 | Smithkline Beecham Corporation | Novel Compounds |
| US7884107B2 (en) | 2006-06-30 | 2011-02-08 | Merck | Substituted piperidines that increase P53 activity and the uses thereof |
| WO2008091863A1 (en) | 2007-01-23 | 2008-07-31 | Kalypsys, Inc. | Sulfonyl-substituted bicyclic compounds as ppar modulators for the treatment of non-alcoholic steatohepatitis |
| US20110046199A1 (en) | 2008-01-17 | 2011-02-24 | Purdue Research Foundation | Small molecule inhibitors of hiv proteases |
| DE102008008838A1 (de) * | 2008-02-13 | 2009-08-20 | Bayer Healthcare Ag | Cycloalkoxy-substituierte 4-Phenyl-3,5-dicyanopyridine und ihre Verwendung |
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| ES2605856T3 (es) | 2012-11-16 | 2017-03-16 | Bristol-Myers Squibb Company | Moduladores GPR40 de dihidropirazol |
| CN103896946B (zh) | 2012-12-28 | 2018-04-03 | 浙江导明医药科技有限公司 | 用于预防及治疗多种自身免疫疾病的新化合物 |
| CA2900888A1 (en) | 2013-03-15 | 2014-09-18 | AbbVie Deutschland GmbH & Co. KG | Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy |
| TW201524952A (zh) | 2013-03-15 | 2015-07-01 | Araxes Pharma Llc | Kras g12c之共價抑制劑 |
| WO2014163161A1 (ja) | 2013-04-04 | 2014-10-09 | 武田薬品工業株式会社 | 複素環化合物 |
| WO2016016370A1 (en) | 2014-07-31 | 2016-02-04 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Flt3 receptor antagonists |
| JP7106528B2 (ja) | 2016-09-20 | 2022-07-26 | グラクソスミスクライン、インテレクチュアル、プロパティー、(ナンバー2)、リミテッド | Trpv4拮抗薬 |
| EP3515889A1 (en) | 2016-09-20 | 2019-07-31 | GlaxoSmithKline Intellectual Property (No. 2) Limited | Trpv4 antagonists |
| TW201825458A (zh) * | 2016-09-20 | 2018-07-16 | 英商葛蘭素史克智慧財產(第二)有限公司 | Trpv4拮抗劑 |
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| US11229623B2 (en) | 2022-01-25 |
| CY1124682T1 (el) | 2022-07-22 |
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| CN109952289B (zh) | 2022-12-09 |
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| CA3036929A1 (en) | 2018-03-29 |
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| KR20190047724A (ko) | 2019-05-08 |
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| TW201825458A (zh) | 2018-07-16 |
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| SI3515887T1 (sl) | 2021-11-30 |
| CN109952289A (zh) | 2019-06-28 |
| EP3515887A1 (en) | 2019-07-31 |
| RS62317B1 (sr) | 2021-09-30 |
| PT3515887T (pt) | 2021-09-27 |
| BR112019005464A2 (pt) | 2019-06-04 |
| LT3515887T (lt) | 2021-12-10 |
| AU2017330618A1 (en) | 2019-03-21 |
| PL3515887T3 (pl) | 2021-12-20 |
| EP3515887B1 (en) | 2021-07-07 |
| ES2890986T3 (es) | 2022-01-25 |
| HRP20211457T1 (hr) | 2021-12-24 |
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