IL267686A - Integrin antagonists - Google Patents
Integrin antagonistsInfo
- Publication number
- IL267686A IL267686A IL267686A IL26768619A IL267686A IL 267686 A IL267686 A IL 267686A IL 267686 A IL267686 A IL 267686A IL 26768619 A IL26768619 A IL 26768619A IL 267686 A IL267686 A IL 267686A
- Authority
- IL
- Israel
- Prior art keywords
- integrin antagonists
- integrin
- antagonists
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title 1
- 102000006495 integrins Human genes 0.000 title 1
- 108010044426 integrins Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Ophthalmology & Optometry (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662440253P | 2016-12-29 | 2016-12-29 | |
| US201762471882P | 2017-03-15 | 2017-03-15 | |
| PCT/US2017/068801 WO2018132268A1 (en) | 2016-12-29 | 2017-12-28 | Integrin antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL267686A true IL267686A (en) | 2019-08-29 |
Family
ID=62840040
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL267686A IL267686A (en) | 2016-12-29 | 2019-06-26 | Integrin antagonists |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US11306084B2 (en) |
| EP (1) | EP3562826A4 (en) |
| JP (1) | JP2020504120A (en) |
| KR (1) | KR20190100232A (en) |
| CN (1) | CN110177787A (en) |
| AU (1) | AU2017393297A1 (en) |
| BR (1) | BR112019012515A2 (en) |
| CA (1) | CA3045491A1 (en) |
| CO (1) | CO2019007023A2 (en) |
| IL (1) | IL267686A (en) |
| MX (1) | MX2019007797A (en) |
| PH (1) | PH12019501514A1 (en) |
| RU (1) | RU2019116820A (en) |
| WO (1) | WO2018132268A1 (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2019116820A (en) | 2016-12-29 | 2021-01-29 | Сент-Луис Юниверсити | INTEGRIN'S ANTAGONISTS |
| BR112019017929A2 (en) | 2017-02-28 | 2020-05-19 | Morphic Therapeutic Inc | integrin (alpha-v) (beta-6) inhibitors |
| EP4147698A1 (en) | 2017-02-28 | 2023-03-15 | Morphic Therapeutic, Inc. | Inhibitors of (alpha-v)(beta-6) integrin |
| ES3019404T3 (en) | 2018-08-29 | 2025-05-20 | Morphic Therapeutic Inc | Integrin inhibitors |
| IL321740A (en) * | 2022-12-27 | 2025-08-01 | Pliant Therapeutics Inc | Alpha-v-beta-8 integrin inhibitors and uses thereof |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004511434A (en) * | 2000-06-15 | 2004-04-15 | ファルマシア・コーポレーション | Heteroarylalkanoic acids as integrin receptor antagonists |
| JP2006513218A (en) * | 2002-12-20 | 2006-04-20 | ファルマシア・コーポレーション | Pyrazole compounds as integrin receptor antagonist derivatives |
| EP1592421A1 (en) | 2002-12-20 | 2005-11-09 | Pharmacia Corporation | Heteroarylalkanoic acids as integrin receptor antagonists |
| US7115596B2 (en) | 2002-12-20 | 2006-10-03 | Pharmacia Corporation | Thiazole compounds as integrin receptor antagonists derivatives |
| CN104640857B (en) | 2012-07-18 | 2017-07-04 | 圣路易斯大学 | As the beta amino acids derivative of integrin antagonists |
| US8716226B2 (en) * | 2012-07-18 | 2014-05-06 | Saint Louis University | 3,5 phenyl-substituted beta amino acid derivatives as integrin antagonists |
| WO2015048819A1 (en) | 2013-09-30 | 2015-04-02 | The Regents Of The University Of California | Anti-alphavbeta1 integrin compounds and methods |
| ES2925173T3 (en) | 2016-11-08 | 2022-10-14 | Bristol Myers Squibb Co | Propionic acids substituted in position 3 as inhibitors of integrin alpha V |
| CA3042714A1 (en) | 2016-11-08 | 2018-05-17 | Bristol-Myers Squibb Company | Indazole derivatives as a .alpha.v integrin antagonists |
| BR112019009245A2 (en) | 2016-11-08 | 2019-07-16 | Bristol-Myers Squibb Company | azol amides and amines as alfav integrin inhibitors |
| WO2018089360A1 (en) | 2016-11-08 | 2018-05-17 | Bristol-Myers Squibb Company | Pyrrole amides as alpha v integrin inhibitors |
| EP3538526B1 (en) | 2016-11-08 | 2024-04-10 | Bristol-Myers Squibb Company | Cyclobutane- and azetidine-containing mono and spirocyclic compounds as alpha v integrin inhibitors |
| RU2019116820A (en) | 2016-12-29 | 2021-01-29 | Сент-Луис Юниверсити | INTEGRIN'S ANTAGONISTS |
| EP4147698A1 (en) | 2017-02-28 | 2023-03-15 | Morphic Therapeutic, Inc. | Inhibitors of (alpha-v)(beta-6) integrin |
| TWI841573B (en) | 2018-06-27 | 2024-05-11 | 美商普萊恩醫療公司 | Amino acid compounds with unbranched linkers and methods of use |
| WO2020009889A1 (en) | 2018-07-03 | 2020-01-09 | Saint Louis University | ALPHAvBETA1 INTEGRIN ANTAGONISTS |
-
2017
- 2017-12-28 RU RU2019116820A patent/RU2019116820A/en not_active Application Discontinuation
- 2017-12-28 KR KR1020197019720A patent/KR20190100232A/en not_active Withdrawn
- 2017-12-28 EP EP17891632.6A patent/EP3562826A4/en not_active Withdrawn
- 2017-12-28 BR BR112019012515-9A patent/BR112019012515A2/en not_active Application Discontinuation
- 2017-12-28 CA CA3045491A patent/CA3045491A1/en not_active Abandoned
- 2017-12-28 WO PCT/US2017/068801 patent/WO2018132268A1/en not_active Ceased
- 2017-12-28 AU AU2017393297A patent/AU2017393297A1/en not_active Abandoned
- 2017-12-28 CN CN201780080614.7A patent/CN110177787A/en active Pending
- 2017-12-28 US US16/474,505 patent/US11306084B2/en active Active
- 2017-12-28 JP JP2019534956A patent/JP2020504120A/en active Pending
- 2017-12-28 MX MX2019007797A patent/MX2019007797A/en unknown
-
2019
- 2019-06-26 IL IL267686A patent/IL267686A/en unknown
- 2019-06-27 PH PH12019501514A patent/PH12019501514A1/en unknown
- 2019-06-28 CO CONC2019/0007023A patent/CO2019007023A2/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2018132268A8 (en) | 2019-06-20 |
| WO2018132268A1 (en) | 2018-07-19 |
| RU2019116820A (en) | 2021-01-29 |
| MX2019007797A (en) | 2019-10-21 |
| EP3562826A4 (en) | 2020-08-26 |
| AU2017393297A1 (en) | 2019-06-13 |
| KR20190100232A (en) | 2019-08-28 |
| JP2020504120A (en) | 2020-02-06 |
| CN110177787A (en) | 2019-08-27 |
| CO2019007023A2 (en) | 2019-07-31 |
| PH12019501514A1 (en) | 2020-09-14 |
| CA3045491A1 (en) | 2018-07-19 |
| US20190345155A1 (en) | 2019-11-14 |
| US11306084B2 (en) | 2022-04-19 |
| EP3562826A1 (en) | 2019-11-06 |
| BR112019012515A2 (en) | 2019-11-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ZA201806632B (en) | Soluble c5ar antagonists | |
| IL266472A (en) | Indazole derivatives as v integrin antagonists | |
| SG11201609614QA (en) | α4β7 INTEGRIN THIOETHER PEPTIDE ANTAGONISTS | |
| GB201305668D0 (en) | Avs6 Integrin Antagonists | |
| SI3515887T1 (en) | Trpv4 antagonists | |
| ZA202101406B (en) | Integrin antagonists | |
| IL258737A (en) | Ep4 antagonists | |
| GB201519196D0 (en) | CGRP Receptor Antagonists | |
| IL267686A (en) | Integrin antagonists | |
| IL274751A (en) | Ildr2 antagonists and combinations thereof | |
| IL256496B (en) | Novel 5-ht2 antagonists | |
| SG11202002207QA (en) | Trpv2 antagonists | |
| IL256572A (en) | Cgrp receptor antagonists | |
| GB201519195D0 (en) | CGRP Receptor Antagonists | |
| IL259482A (en) | Anti-integrin antibody | |
| GB201519194D0 (en) | CGRP receptor antagonists | |
| PL3225606T3 (en) | Construction materials | |
| GB201718256D0 (en) | Ox1 antagonists | |
| ZA201807767B (en) | Angiotensin-1-receptor antagonists | |
| PT3613739T (en) | Integrin antagonists | |
| HK40015892A (en) | Integrin antagonists | |
| HK40007545A (en) | Tetrahydronaphthyridinepentanamide integrin antagonists | |
| PT3464324T (en) | Angiotensin-1-receptor antagonists | |
| GB201604814D0 (en) | Materials |