CN109640644B - 表达外源末端脱氧核苷酸转移酶的非人动物 - Google Patents

表达外源末端脱氧核苷酸转移酶的非人动物 Download PDF

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CN109640644B
CN109640644B CN201780048900.5A CN201780048900A CN109640644B CN 109640644 B CN109640644 B CN 109640644B CN 201780048900 A CN201780048900 A CN 201780048900A CN 109640644 B CN109640644 B CN 109640644B
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human
immunoglobulin
nucleic acid
variable region
light chain
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CN109640644A (zh
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L·麦克唐纳
A·J·莫菲
C·郭
N·莱温科娃
N·图
J·麦克维尔特
V·沃罗宁那
F·哈里斯
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Regeneron Pharmaceuticals Inc
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CN201780048900.5A 2016-06-03 2017-06-02 表达外源末端脱氧核苷酸转移酶的非人动物 Active CN109640644B (zh)

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CN202111170801.9A CN113907043B (zh) 2016-06-03 2017-06-02 表达外源末端脱氧核苷酸转移酶的非人动物
CN202310402666.9A CN116458475A (zh) 2016-06-03 2017-06-02 表达外源末端脱氧核苷酸转移酶的非人动物

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US201662345524P 2016-06-03 2016-06-03
US62/345,524 2016-06-03
PCT/US2017/035731 WO2017210586A1 (en) 2016-06-03 2017-06-02 Non-human animals expressing exogenous terminal deoxynucleotidyltransferase

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CN202111170801.9A Division CN113907043B (zh) 2016-06-03 2017-06-02 表达外源末端脱氧核苷酸转移酶的非人动物

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EP2958937B1 (en) 2013-02-22 2018-08-15 Regeneron Pharmaceuticals, Inc. Mice expressing humanized major histocompatibility complex
EP3462853B1 (en) 2016-06-03 2023-03-01 Regeneron Pharmaceuticals, Inc. Rodents expressing exogenous terminal deoxynucleotidyltransferase
PT3720279T (pt) 2017-12-05 2022-10-06 Regeneron Pharma Ratinhos tendo uma cadeia leve lambda de imunoglobulina manipulada e seus usos
HUE070158T2 (hu) * 2018-03-24 2025-05-28 Regeneron Pharma Genetikailag módosított egerek vagy patkányok peptid-mhc komplexek elleni terápiás antitestek létrehozásra, ezek elõállítására szolgáló módszerek, valamint alkalmazásuk
CA3102795A1 (en) * 2018-06-13 2019-12-19 The Children's Medical Center Corporation Methods and compositions relating to high-throughput models for antibody discovery and/or optimization
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