CN1095845C - 制取冻干的1β,10β－环氧－13－二甲基氨基－愈创－3(4)－烯－6,12－内酯盐酸盐的方法和装置 - Google Patents

制取冻干的1β,10β－环氧－13－二甲基氨基－愈创－3(4)－烯－6,12－内酯盐酸盐的方法和装置 Download PDF

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Publication number
CN1095845C
CN1095845C CN97181524A CN97181524A CN1095845C CN 1095845 C CN1095845 C CN 1095845C CN 97181524 A CN97181524 A CN 97181524A CN 97181524 A CN97181524 A CN 97181524A CN 1095845 C CN1095845 C CN 1095845C
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CN
China
Prior art keywords
extractor
agrabine
extractant
solution
hydrochloride
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Expired - Lifetime
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CN97181524A
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English (en)
Chinese (zh)
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CN1245501A (zh
Inventor
S·M·阿德克诺夫
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Sm Ade Knopf
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TABIFARM CO Ltd
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Publication of CN1245501A publication Critical patent/CN1245501A/zh
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/02—Solvent extraction of solids
    • B01D11/0215—Solid material in other stationary receptacles
    • B01D11/0223—Moving bed of solid material
    • B01D11/0226—Moving bed of solid material with the general transport direction of the solids parallel to the rotation axis of the conveyor, e.g. worm
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Extraction Or Liquid Replacement (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN97181524A 1996-12-20 1997-12-19 制取冻干的1β,10β－环氧－13－二甲基氨基－愈创－3(4)－烯－6,12－内酯盐酸盐的方法和装置 Expired - Lifetime CN1095845C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KZ960995 1996-12-20
KZ9609951 1996-12-20
KZ970397 1997-04-26
KZ9703971 1997-04-26

Publications (2)

Publication Number Publication Date
CN1245501A CN1245501A (zh) 2000-02-23
CN1095845C true CN1095845C (zh) 2002-12-11

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN97181524A Expired - Lifetime CN1095845C (zh) 1996-12-20 1997-12-19 制取冻干的1β,10β－环氧－13－二甲基氨基－愈创－3(4)－烯－6,12－内酯盐酸盐的方法和装置

Country Status (6)

Country Link
EP (1) EP0946565B1 (https=)
JP (2) JP2001505548A (https=)
CN (1) CN1095845C (https=)
AT (1) ATE252104T1 (https=)
DE (1) DE69725604T2 (https=)
WO (1) WO1998028303A1 (https=)

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WO2003078016A1 (en) * 2002-03-20 2003-09-25 Matsushita Electric Industrial Co., Ltd. Extractor
DE10326152A1 (de) * 2003-06-06 2005-01-05 Aventis Pharma Deutschland Gmbh Verfahren und Vorrichtung zur quantitativen Analyse von Lösungen und Dispersionen mittels Nahinfrarot-Spektroskopie
US20050003422A1 (en) 2003-07-01 2005-01-06 Mitch Reponi Methods for assessing and treating cancer
DE102004037002B4 (de) * 2004-07-30 2006-06-14 Chemieanlagenbau Chemnitz Gmbh Verfahren zur Herstellung von Dimethylaminoarglabin-Hydrochlorid
HRP20130399T1 (hr) 2004-11-05 2013-06-30 Janssen Pharmaceutica Nv Terapeutska upotreba inhibitora farenziltransferaze i postupci praä†enja njihove efikasnosti
US20060281788A1 (en) 2005-06-10 2006-12-14 Baumann Christian A Synergistic modulation of flt3 kinase using a flt3 inhibitor and a farnesyl transferase inhibitor
WO2007124319A1 (en) 2006-04-20 2007-11-01 Janssen Pharmaceutica N.V. Inhibitors of c-fms kinase
PL2021335T3 (pl) 2006-04-20 2011-10-31 Janssen Pharmaceutica Nv Związki heterocykliczne jako inhibitory kinazy C-FMS
US8697716B2 (en) 2006-04-20 2014-04-15 Janssen Pharmaceutica Nv Method of inhibiting C-KIT kinase
EA015557B1 (ru) * 2006-09-19 2011-08-30 Сергазы Мынжасарович Адекенов СПОСОБ ПОЛУЧЕНИЯ ГИДРОХЛОРИДА 1(10)β-ЭПОКСИ-13-ДИМЕТИЛАМИНО- 5,7α,6,11β(Н)-ГВАЙ-3(4)-ЕН-6,12-ОЛИДА, ЛИОФИЛИЗИРОВАННОГО ПРОТИВООПУХОЛЕВОГО СРЕДСТВА "АРГЛАБИН"
JO3240B1 (ar) 2007-10-17 2018-03-08 Janssen Pharmaceutica Nv c-fms مثبطات كيناز
CN102190663B (zh) * 2010-03-02 2013-11-13 石药集团中奇制药技术（石家庄）有限公司 一种二甲氨基阿格拉宾盐酸盐晶型
CN102190662B (zh) * 2010-03-02 2014-06-25 石药集团中奇制药技术（石家庄）有限公司 一种二甲氨基阿格拉宾盐酸盐的制备方法
CN102372723B (zh) * 2010-08-19 2014-03-26 石药集团中奇制药技术（石家庄）有限公司 一种从多花蒿中提取阿格拉宾的方法
CN104870454B (zh) 2012-08-07 2020-03-03 詹森药业有限公司 用于制备杂环酯衍生物的方法
ES2658773T3 (es) 2012-08-07 2018-03-12 Janssen Pharmaceutica N.V. Procedimiento de sulfonilación usando fluoruro de nonafluorobutanosulfonilo
CN102850372A (zh) * 2012-10-15 2013-01-02 河北医科大学 一种蓍草倍半萜内酯化合物及其提取方法和应用
CN103833766B (zh) * 2012-11-23 2016-12-21 天津尚德药缘科技股份有限公司 阿格拉滨二甲胺富马酸盐及其在药物制备中的用途
SMT202100712T1 (it) 2015-08-17 2022-01-10 Kura Oncology Inc Metodi di trattamento di pazienti di cancro con inibitori di farnesil trasferasi
CN105251236B (zh) * 2015-11-02 2018-01-16 济宁金百特生物机械有限公司 逆流提取装置
US20190119758A1 (en) 2016-04-22 2019-04-25 Kura Oncology, Inc. Methods of selecting cancer patients for treatment with farnesyltransferase inhibitors
TW201818965A (zh) 2016-11-03 2018-06-01 美商庫拉腫瘤技術股份有限公司 以法呢基轉移酶（ｆａｒｎｅｓｙｌ ｔｒａｎｓｆｅｒａｓｅ）抑制劑治療癌症病患之方法
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TWI738314B (zh) 2017-02-21 2021-09-01 美商庫拉腫瘤技術股份有限公司 以法呢基轉移酶(farnesyltransferase)抑制劑治療癌症之方法
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MX2020001207A (es) 2017-08-07 2020-03-20 Kura Oncology Inc Metodos de tratamiento del cancer con inhibidores de farnesiltransferasa.
WO2019113269A1 (en) 2017-12-08 2019-06-13 Kura Oncology, Inc. Methods of treating cancer patients with farnesyltransferase inhibitors
EP3873469A2 (en) 2018-11-01 2021-09-08 Kura Oncology, Inc. Methods of treating cancer with farnesyltransferase inhibitors
TW202038953A (zh) 2018-12-21 2020-11-01 美商庫拉腫瘤技術股份有限公司 鱗狀細胞癌之治療
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US20220143006A1 (en) 2019-03-15 2022-05-12 Kura Oncology, Inc. Methods of treating cancer with farnesyltransferase inhibitors
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US20220305001A1 (en) 2019-05-02 2022-09-29 Kura Oncology, Inc. Methods of treating acute myeloid leukemia with farnesyltransferase inhibitors

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Also Published As

Publication number Publication date
JP2001505548A (ja) 2001-04-24
ATE252104T1 (de) 2003-11-15
WO1998028303A1 (en) 1998-07-02
EP0946565B1 (en) 2003-10-15
CN1245501A (zh) 2000-02-23
EP0946565A1 (en) 1999-10-06
DE69725604D1 (de) 2003-11-20
DE69725604T2 (de) 2005-03-03
JP2007137890A (ja) 2007-06-07

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Owner name: S.M. ADRIANO KNOPF

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Effective date: 20040209

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Patentee after: S.M. Ade Knopf

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CX01 Expiry of patent term