CN109580806A - 一种用于水产品中利福平药物残留的测定方法 - Google Patents
一种用于水产品中利福平药物残留的测定方法 Download PDFInfo
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- CN109580806A CN109580806A CN201811333155.1A CN201811333155A CN109580806A CN 109580806 A CN109580806 A CN 109580806A CN 201811333155 A CN201811333155 A CN 201811333155A CN 109580806 A CN109580806 A CN 109580806A
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- 229960001225 rifampicin Drugs 0.000 title claims abstract description 51
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- 229940043376 ammonium acetate Drugs 0.000 claims abstract description 11
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- SQTCRTQCPJICLD-KTQDUKAHSA-N rifamycin B Chemical compound OC1=C(C(O)=C2C)C3=C(OCC(O)=O)C=C1NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@H](C)[C@@H](OC)\C=C\O[C@@]1(C)OC2=C3C1=O SQTCRTQCPJICLD-KTQDUKAHSA-N 0.000 description 1
- SQTCRTQCPJICLD-OQQFTUDCSA-N rifomycin-B Natural products COC1C=COC2(C)Oc3c(C)c(O)c4c(O)c(NC(=O)C(=C/C=C/C(C)C(O)C(C)C(O)C(C)C(OC(=O)C)C1C)C)cc(OCC(=O)O)c4c3C2=O SQTCRTQCPJICLD-OQQFTUDCSA-N 0.000 description 1
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N2030/022—Column chromatography characterised by the kind of separation mechanism
- G01N2030/027—Liquid chromatography
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- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Abstract
Description
序号 | 实测样品名称 | 利福平药物残留量(μg/kg) |
实施例1 | 罗非鱼 | ND |
实施例2 | 南美对白虾 | ND |
实施例3 | 中华鳖 | ND |
实施例4 | 濑尿虾 | ND |
实施例5 | 乌鳢 | 21.6 |
实施例6 | 草鱼 | ND |
Claims (10)
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CN201811333155.1A CN109580806B (zh) | 2018-11-09 | 2018-11-09 | 一种用于水产品中利福平药物残留的测定方法 |
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CN201811333155.1A CN109580806B (zh) | 2018-11-09 | 2018-11-09 | 一种用于水产品中利福平药物残留的测定方法 |
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CN109580806A true CN109580806A (zh) | 2019-04-05 |
CN109580806B CN109580806B (zh) | 2021-06-29 |
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110146620A (zh) * | 2019-06-11 | 2019-08-20 | 福建医科大学孟超肝胆医院(福州市传染病医院) | 一种uplc-ms/ms法同时检测血浆中五种抗结核药物的方法 |
CN110205303A (zh) * | 2019-06-27 | 2019-09-06 | 江南大学 | 一株利福平单克隆抗体杂交瘤细胞株nlc及其应用 |
CN113109468A (zh) * | 2021-03-29 | 2021-07-13 | 广州广电计量检测股份有限公司 | 一种测定动物饲料中利福平含量的方法 |
CN114994231A (zh) * | 2022-06-08 | 2022-09-02 | 中国食品药品检定研究院 | 一种离子色谱法测定利福平或利福喷丁中亚硝酸根的方法 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000070344A2 (en) * | 1999-05-13 | 2000-11-23 | Admetric Biochem Inc. | Method for increasing the efficiency of experimental fractionation in activity profiling of compound mixtures |
US6790668B1 (en) * | 1998-11-23 | 2004-09-14 | Fundacao Oswaldo Cruz - Fiocruz | Monitoring patient compliance and bioavailability of drugs by deproteinizing body fluids |
CN102384949A (zh) * | 2011-08-02 | 2012-03-21 | 蒋晖 | 一种同时测定血液及组织中三种抗结核药物含量的方法 |
CN105699537A (zh) * | 2016-04-07 | 2016-06-22 | 大连理工大学 | 一种水体中多种残留药物的同步检测方法 |
CN107315059A (zh) * | 2017-07-20 | 2017-11-03 | 沈阳红旗制药有限公司 | 一种利福平胶囊中利福平及其杂质的含量测定方法 |
CN107941980A (zh) * | 2017-11-26 | 2018-04-20 | 浙江省水产技术推广总站 | 水产品中利福平残留的超高效液相色谱串联质谱快速测定方法 |
-
2018
- 2018-11-09 CN CN201811333155.1A patent/CN109580806B/zh not_active Expired - Fee Related
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6790668B1 (en) * | 1998-11-23 | 2004-09-14 | Fundacao Oswaldo Cruz - Fiocruz | Monitoring patient compliance and bioavailability of drugs by deproteinizing body fluids |
WO2000070344A2 (en) * | 1999-05-13 | 2000-11-23 | Admetric Biochem Inc. | Method for increasing the efficiency of experimental fractionation in activity profiling of compound mixtures |
CN102384949A (zh) * | 2011-08-02 | 2012-03-21 | 蒋晖 | 一种同时测定血液及组织中三种抗结核药物含量的方法 |
CN105699537A (zh) * | 2016-04-07 | 2016-06-22 | 大连理工大学 | 一种水体中多种残留药物的同步检测方法 |
CN107315059A (zh) * | 2017-07-20 | 2017-11-03 | 沈阳红旗制药有限公司 | 一种利福平胶囊中利福平及其杂质的含量测定方法 |
CN107941980A (zh) * | 2017-11-26 | 2018-04-20 | 浙江省水产技术推广总站 | 水产品中利福平残留的超高效液相色谱串联质谱快速测定方法 |
Non-Patent Citations (4)
Title |
---|
SIMONE MORETTI 等: "Screening and confirmatory method for multiclass determination of62 antibiotics in meat", 《JOURNAL OF CHROMATOGRAPHY A》 * |
杨霄 等: "分散固相萃取-高效液相色谱-串联质谱法测定水产品中甲基睾酮的残留量", 《江苏农业科学》 * |
熊雯 等: "超高效液相色谱串联飞行时间质谱法测定水产品中18种磺胺类化合物", 《分析仪器》 * |
金钥 等: "水产品中14种抗生素药物残留检测方法的建立", 《食品研究与开发》 * |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110146620A (zh) * | 2019-06-11 | 2019-08-20 | 福建医科大学孟超肝胆医院(福州市传染病医院) | 一种uplc-ms/ms法同时检测血浆中五种抗结核药物的方法 |
CN110205303A (zh) * | 2019-06-27 | 2019-09-06 | 江南大学 | 一株利福平单克隆抗体杂交瘤细胞株nlc及其应用 |
CN113109468A (zh) * | 2021-03-29 | 2021-07-13 | 广州广电计量检测股份有限公司 | 一种测定动物饲料中利福平含量的方法 |
CN114994231A (zh) * | 2022-06-08 | 2022-09-02 | 中国食品药品检定研究院 | 一种离子色谱法测定利福平或利福喷丁中亚硝酸根的方法 |
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