CN109476588A - 制备苯基丙二酸二腈的方法 - Google Patents

制备苯基丙二酸二腈的方法 Download PDF

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Publication number
CN109476588A
CN109476588A CN201780044592.9A CN201780044592A CN109476588A CN 109476588 A CN109476588 A CN 109476588A CN 201780044592 A CN201780044592 A CN 201780044592A CN 109476588 A CN109476588 A CN 109476588A
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CN
China
Prior art keywords
compound
formula
malononitrile
chlorine
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201780044592.9A
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English (en)
Chinese (zh)
Inventor
M·泽勒
N·费杜
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syngenta Crop Protection AG Switzerland
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Syngenta Participations AG
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Filing date
Publication date
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Publication of CN109476588A publication Critical patent/CN109476588A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/33—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring with cyano groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/35—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/08—Preparation of carboxylic acids or their salts, halides or anhydrides from nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/132—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing rings
    • C07C53/134—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing rings monocyclic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
    • B01J2231/40—Substitution reactions at carbon centres, e.g. C-C or C-X, i.e. carbon-hetero atom, cross-coupling, C-H activation or ring-opening reactions
    • B01J2231/44—Allylic alkylation, amination, alkoxylation or analogues
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/80—Complexes comprising metals of Group VIII as the central metal
    • B01J2531/82—Metals of the platinum group
    • B01J2531/824—Palladium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/24—Phosphines, i.e. phosphorus bonded to only carbon atoms, or to both carbon and hydrogen atoms, including e.g. sp2-hybridised phosphorus compounds such as phosphabenzene, phosphole or anionic phospholide ligands

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Materials Engineering (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CN201780044592.9A 2016-07-22 2017-07-20 制备苯基丙二酸二腈的方法 Pending CN109476588A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16180827.4 2016-07-22
EP16180827 2016-07-22
PCT/EP2017/068345 WO2018015489A1 (en) 2016-07-22 2017-07-20 Process for the preparation of phenylmalonic acid dinitriles

Publications (1)

Publication Number Publication Date
CN109476588A true CN109476588A (zh) 2019-03-15

Family

ID=56507536

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780044592.9A Pending CN109476588A (zh) 2016-07-22 2017-07-20 制备苯基丙二酸二腈的方法

Country Status (12)

Country Link
US (3) US10759742B2 (https=)
EP (1) EP3487837B1 (https=)
JP (1) JP7046050B2 (https=)
CN (1) CN109476588A (https=)
BR (1) BR112019000963B1 (https=)
DK (1) DK3487837T3 (https=)
ES (1) ES2928635T3 (https=)
HU (1) HUE060023T2 (https=)
IL (1) IL263688B (https=)
MX (1) MX2019000753A (https=)
WO (1) WO2018015489A1 (https=)
ZA (1) ZA201900032B (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7046050B2 (ja) * 2016-07-22 2022-04-01 シンジェンタ パーティシペーションズ アーゲー フェニルマロン酸ジニトリルの調製方法
WO2018210616A1 (de) 2017-05-15 2018-11-22 Bayer Cropscience Aktiengesellschaft Verfahren zur herstellung von (4-halogen-2,6-dialkylphenyl)malononitrilen
JP7353295B2 (ja) * 2018-04-10 2023-09-29 バイエル・アクチエンゲゼルシヤフト ２，６－ジアルキルフェニル酢酸の製造方法
CN109096146B (zh) * 2018-09-03 2020-11-10 杭州中美华东制药有限公司 阿那曲唑关键中间体的合成方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1185234C (zh) * 1998-03-13 2005-01-19 辛根塔参与股份公司 具有除草活性的3－羟基－4－芳基－5－氧代吡唑啉衍生物
CN1329370C (zh) * 2002-12-05 2007-08-01 辛根塔参与股份公司 苯基丙二酸二腈的制备方法
CN101094855A (zh) * 2004-11-04 2007-12-26 拜尔农作物科学股份公司 2,6－二乙基－4－甲基苯基取代的特特拉姆酸衍生物
CN105408326A (zh) * 2013-07-19 2016-03-16 先正达参股股份有限公司 用于制备螺杂环吡咯烷二酮的新颖的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1152860C (zh) 1995-06-30 2004-06-09 拜尔公司 二烷基-卤代苯基取代的酮-烯醇
WO2000078712A1 (en) 1999-06-16 2000-12-28 Syngenta Participations Ag Substituted arylmalonic acid dinitriles as intermediates for the prepartion of herbicides
JPWO2002070477A1 (ja) 2001-03-01 2004-07-02 小野薬品工業株式会社 ２−メチルインドール−４−酢酸、その製造方法およびその合成中間体の製造方法
WO2006084663A1 (en) 2005-02-09 2006-08-17 Syngenta Participations Ag Process for the preparation of intermediates
GB0720126D0 (en) 2007-10-15 2007-11-28 Syngenta Participations Ag Chemical compounds
AU2009324389B2 (en) 2008-12-12 2016-04-28 Syngenta Crop Protection Ag Spiroheterocyclic N-oxypiperidines as pesticides
CN102395546B (zh) 2009-03-12 2014-03-12 拜耳作物科学公司 制备氯代和溴代芳烃的方法
JP7046050B2 (ja) * 2016-07-22 2022-04-01 シンジェンタ パーティシペーションズ アーゲー フェニルマロン酸ジニトリルの調製方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1185234C (zh) * 1998-03-13 2005-01-19 辛根塔参与股份公司 具有除草活性的3－羟基－4－芳基－5－氧代吡唑啉衍生物
CN1329370C (zh) * 2002-12-05 2007-08-01 辛根塔参与股份公司 苯基丙二酸二腈的制备方法
CN101094855A (zh) * 2004-11-04 2007-12-26 拜尔农作物科学股份公司 2,6－二乙基－4－甲基苯基取代的特特拉姆酸衍生物
CN105408326A (zh) * 2013-07-19 2016-03-16 先正达参股股份有限公司 用于制备螺杂环吡咯烷二酮的新颖的方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
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KOWALCZYK, BRUCE A.: "Synthesis of (dihalophenyl)acetic acids using aromatic nucleophilic substitution strategy", 《SYNTHESIS》 *
万琴: "除草剂唑啉草酯的合成研究", 《现代农药》 *

Also Published As

Publication number Publication date
US20190263752A1 (en) 2019-08-29
BR112019000963B1 (pt) 2022-07-12
US11136289B2 (en) 2021-10-05
WO2018015489A1 (en) 2018-01-25
ES2928635T3 (es) 2022-11-21
IL263688A (en) 2019-03-31
HUE060023T2 (hu) 2023-01-28
IL263688B (en) 2022-02-01
EP3487837B1 (en) 2022-08-17
US10759742B2 (en) 2020-09-01
US20200283374A1 (en) 2020-09-10
US20210284602A1 (en) 2021-09-16
JP2019521165A (ja) 2019-07-25
EP3487837A1 (en) 2019-05-29
BR112019000963A2 (pt) 2019-04-30
JP7046050B2 (ja) 2022-04-01
MX2019000753A (es) 2019-06-03
DK3487837T3 (da) 2022-10-31
ZA201900032B (en) 2019-09-25

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