BR112019000963A2 - processo para a preparação de dinitrilas de ácido fenilmalônico - Google Patents

processo para a preparação de dinitrilas de ácido fenilmalônico

Info

Publication number
BR112019000963A2
BR112019000963A2 BR112019000963A BR112019000963A BR112019000963A2 BR 112019000963 A2 BR112019000963 A2 BR 112019000963A2 BR 112019000963 A BR112019000963 A BR 112019000963A BR 112019000963 A BR112019000963 A BR 112019000963A BR 112019000963 A2 BR112019000963 A2 BR 112019000963A2
Authority
BR
Brazil
Prior art keywords
preparation
phenylmalonic acid
dinitriles
acid dinitriles
chloro
Prior art date
Application number
BR112019000963A
Other languages
English (en)
Other versions
BR112019000963B1 (pt
Inventor
Zeller Martin
Fedou Nicolas
Original Assignee
Syngenta Participations Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syngenta Participations Ag filed Critical Syngenta Participations Ag
Publication of BR112019000963A2 publication Critical patent/BR112019000963A2/pt
Publication of BR112019000963B1 publication Critical patent/BR112019000963B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/35—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/33—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring with cyano groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/08—Preparation of carboxylic acids or their salts, halides or anhydrides from nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/132—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing rings
    • C07C53/134—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing rings monocyclic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
    • B01J2231/40—Substitution reactions at carbon centres, e.g. C-C or C-X, i.e. carbon-hetero atom, cross-coupling, C-H activation or ring-opening reactions
    • B01J2231/44—Allylic alkylation, amination, alkoxylation or analogues
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/80—Complexes comprising metals of Group VIII as the central metal
    • B01J2531/82—Metals of the platinum group
    • B01J2531/824—Palladium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/24—Phosphines, i.e. phosphorus bonded to only carbon atoms, or to both carbon and hydrogen atoms, including e.g. sp2-hybridised phosphorus compounds such as phosphabenzene, phosphole or anionic phospholide ligands

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Materials Engineering (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

“processo para a preparação de dinitrilas de ácido fenilmalônico” processo para a preparação de um composto de fórmula (i): (i) o processo compreendendo a reação de um composto de fórmula (ii) com malononitrila na presença de uma base e um catalisador de paládio, (ii) em que x, y e z, independentemente um do outro, representam fluoro, cloro ou c1-4alquila; a l é um grupo de saída; com a condição de que 1 ou 2 de x e y sejam, independentemente um do outro, fluoro ou cloro.
BR112019000963-9A 2016-07-22 2017-07-20 Processos para a preparação de dinitrilas de ácido fenilmalônico e referida dinitrila BR112019000963B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16180827.4 2016-07-22
EP16180827 2016-07-22
PCT/EP2017/068345 WO2018015489A1 (en) 2016-07-22 2017-07-20 Process for the preparation of phenylmalonic acid dinitriles

Publications (2)

Publication Number Publication Date
BR112019000963A2 true BR112019000963A2 (pt) 2019-04-30
BR112019000963B1 BR112019000963B1 (pt) 2022-07-12

Family

ID=56507536

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112019000963-9A BR112019000963B1 (pt) 2016-07-22 2017-07-20 Processos para a preparação de dinitrilas de ácido fenilmalônico e referida dinitrila

Country Status (12)

Country Link
US (3) US10759742B2 (pt)
EP (1) EP3487837B1 (pt)
JP (1) JP7046050B2 (pt)
CN (1) CN109476588A (pt)
BR (1) BR112019000963B1 (pt)
DK (1) DK3487837T3 (pt)
ES (1) ES2928635T3 (pt)
HU (1) HUE060023T2 (pt)
IL (1) IL263688B (pt)
MX (1) MX2019000753A (pt)
WO (1) WO2018015489A1 (pt)
ZA (1) ZA201900032B (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3487837T3 (da) * 2016-07-22 2022-10-31 Syngenta Participations Ag Fremgangsmåde til fremstilling af spiroheterocykliske pyrrolidindion-herbicider ved hjælp af mellemforbindelsen 2-(4-chlor-2,6-dimethylphenyl)eddikesyre
WO2018210616A1 (de) 2017-05-15 2018-11-22 Bayer Cropscience Aktiengesellschaft Verfahren zur herstellung von (4-halogen-2,6-dialkylphenyl)malononitrilen
WO2019197232A1 (de) 2018-04-10 2019-10-17 Bayer Aktiengesellschaft Verfahren zur herstellung von 2,6-dialkylphenyl-essigsäuren
CN109096146B (zh) * 2018-09-03 2020-11-10 杭州中美华东制药有限公司 阿那曲唑关键中间体的合成方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9609301A (pt) 1995-06-30 1999-05-25 Bayer Ag Cetoenois dialquil-halogenofenil-substituídos
WO1999047525A1 (en) * 1998-03-13 1999-09-23 Novartis Ag Herbicidally active 3-hydroxy-4-aryl-5-oxopyrazoline derivatives
PL352102A1 (en) 1999-06-16 2003-07-28 Syngenta Participations Ag Novel semi-finished products
JPWO2002070477A1 (ja) 2001-03-01 2004-07-02 小野薬品工業株式会社 ２−メチルインドール−４−酢酸、その製造方法およびその合成中間体の製造方法
AR042282A1 (es) * 2002-12-05 2005-06-15 Syngenta Participations Ag Proceso para la preparacion de dinitrilos de acido fenilmalonico
DE102004053191A1 (de) * 2004-11-04 2006-05-11 Bayer Cropscience Ag 2,6-Diethyl-4-methyl-phenyl substituierte Tetramsäure-Derivate
PT1848678E (pt) 2005-02-09 2015-10-12 Syngenta Participations Ag Processo de preparação de intermediários
GB0720126D0 (en) 2007-10-15 2007-11-28 Syngenta Participations Ag Chemical compounds
BRPI0922824B8 (pt) 2008-12-12 2021-10-19 Syngenta Ltd Compostos n-oxipiperidinas espiro-heterocíclicas como pesticidas, seu processo de preparação, composição pesticida que as contém e método de combater e controlar pestes
WO2010102761A1 (de) 2009-03-12 2010-09-16 Bayer Cropscience Aktiengesellschaft Verfahren zur herstellung von chlor- und bromaromaten
SI3022204T1 (sl) * 2013-07-19 2018-10-30 Syngenta Participations Ag Nov postopek za pripravo spiroheterocikličnih pirolidin dionov
DK3487837T3 (da) * 2016-07-22 2022-10-31 Syngenta Participations Ag Fremgangsmåde til fremstilling af spiroheterocykliske pyrrolidindion-herbicider ved hjælp af mellemforbindelsen 2-(4-chlor-2,6-dimethylphenyl)eddikesyre

Also Published As

Publication number Publication date
US20190263752A1 (en) 2019-08-29
US11136289B2 (en) 2021-10-05
WO2018015489A1 (en) 2018-01-25
US20200283374A1 (en) 2020-09-10
JP7046050B2 (ja) 2022-04-01
ES2928635T3 (es) 2022-11-21
US20210284602A1 (en) 2021-09-16
EP3487837A1 (en) 2019-05-29
IL263688A (en) 2019-03-31
DK3487837T3 (da) 2022-10-31
EP3487837B1 (en) 2022-08-17
US10759742B2 (en) 2020-09-01
BR112019000963B1 (pt) 2022-07-12
HUE060023T2 (hu) 2023-01-28
CN109476588A (zh) 2019-03-15
MX2019000753A (es) 2019-06-03
JP2019521165A (ja) 2019-07-25
IL263688B (en) 2022-02-01
ZA201900032B (en) 2019-09-25

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Legal Events

Date Code Title Description
B06W Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 20/07/2017, OBSERVADAS AS CONDICOES LEGAIS