BR112016018581A8 - processo para a fabricação de derivados de sulfamida pirimidina - Google Patents
processo para a fabricação de derivados de sulfamida pirimidinaInfo
- Publication number
- BR112016018581A8 BR112016018581A8 BR112016018581A BR112016018581A BR112016018581A8 BR 112016018581 A8 BR112016018581 A8 BR 112016018581A8 BR 112016018581 A BR112016018581 A BR 112016018581A BR 112016018581 A BR112016018581 A BR 112016018581A BR 112016018581 A8 BR112016018581 A8 BR 112016018581A8
- Authority
- BR
- Brazil
- Prior art keywords
- manufacturing
- sulfamide
- pyrimidine derivatives
- compound
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/56—One oxygen atom and one sulfur atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Abstract
processo para a fabricação de derivados de sulfamida pirimidina a invenção refere-se a um processo para fabricar o composto da fórmula i, em que r é h, alquila (c1-c6) ou benzila, ou um sal do mesmo, o processo compreendendo a reação do composto da fórmula i-1 em que x é br, c1 ou f, ou um sal do mesmo, com o composto da fórmula i-2 em que r é h, alquila (c1-c6) ou benzila, ou um sal do mesmo, na presença de uma base, e, quando x é br ou c1, na presença de hidrato de fluoreto de amônio tetra-n-butila ou fluoreto de césio. a invenção refere-se ainda ao composto da fórmula i-1 e usos do mesmo.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BR122017005939-4A BR122017005939B1 (pt) | 2014-02-14 | 2015-02-13 | Processo para a fabricação de derivados de sulfamida pirimidina |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14155137.4A EP2907811A1 (en) | 2014-02-14 | 2014-02-14 | Process for manufacturing pyrimidine sulfamide derivatives |
| EP14155137.4 | 2014-02-14 | ||
| PCT/EP2015/053047 WO2015121397A1 (en) | 2014-02-14 | 2015-02-13 | Process for manufacturing pyrimidine sulfamide derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BR112016018581A2 BR112016018581A2 (pt) | 2017-08-08 |
| BR112016018581A8 true BR112016018581A8 (pt) | 2021-06-22 |
| BR112016018581B1 BR112016018581B1 (pt) | 2022-11-16 |
Family
ID=50073084
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR122017005939-4A BR122017005939B1 (pt) | 2014-02-14 | 2015-02-13 | Processo para a fabricação de derivados de sulfamida pirimidina |
| BR112016018581-1A BR112016018581B1 (pt) | 2014-02-14 | 2015-02-13 | Processo para a fabricação de derivados de sulfamida pirimidina |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR122017005939-4A BR122017005939B1 (pt) | 2014-02-14 | 2015-02-13 | Processo para a fabricação de derivados de sulfamida pirimidina |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US9938244B2 (pt) |
| EP (3) | EP2907811A1 (pt) |
| JP (2) | JP6431922B2 (pt) |
| KR (2) | KR102406358B1 (pt) |
| CN (2) | CN107162988B (pt) |
| AR (2) | AR099434A1 (pt) |
| AU (2) | AU2015217000B2 (pt) |
| BR (2) | BR122017005939B1 (pt) |
| CA (1) | CA2937277C (pt) |
| CL (2) | CL2016002008A1 (pt) |
| CY (1) | CY1123319T1 (pt) |
| DK (1) | DK3105220T3 (pt) |
| EA (2) | EA032460B1 (pt) |
| ES (2) | ES2819504T3 (pt) |
| HK (1) | HK1243405A1 (pt) |
| HR (1) | HRP20201450T1 (pt) |
| HU (1) | HUE050974T2 (pt) |
| IL (1) | IL251126A0 (pt) |
| LT (1) | LT3105220T (pt) |
| MX (1) | MX368014B (pt) |
| NZ (1) | NZ724273A (pt) |
| PL (1) | PL3105220T3 (pt) |
| PT (1) | PT3105220T (pt) |
| SA (1) | SA516371640B1 (pt) |
| SG (2) | SG11201606667VA (pt) |
| SI (1) | SI3105220T1 (pt) |
| TW (2) | TWI663155B (pt) |
| WO (1) | WO2015121397A1 (pt) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR095727A1 (es) | 2013-03-27 | 2015-11-04 | Actelion Pharmaceuticals Ltd | Preparación de intermediarios de pirimidina |
| EP2907811A1 (en) * | 2014-02-14 | 2015-08-19 | Actelion Pharmaceuticals Ltd. | Process for manufacturing pyrimidine sulfamide derivatives |
| CN105461639B (zh) * | 2015-12-10 | 2018-03-09 | 合肥久诺医药科技有限公司 | 一种高纯度马西替坦的精制方法 |
| CN105461638A (zh) * | 2015-12-10 | 2016-04-06 | 合肥久诺医药科技有限公司 | 一种马西替坦晶型及其制备方法 |
| KR20230074610A (ko) | 2017-02-27 | 2023-05-30 | 이도르시아 파마슈티컬스 리미티드 | 엔도텔린 관련 질환의 치료를 위한 4-피리미딘술파미드 유도체와 활성 성분의 조합물 |
| CN109232546B (zh) * | 2018-09-25 | 2020-09-04 | 中国人民解放军总医院 | 一种嘧啶磺酰胺类衍生物的医药用途 |
| EP4056182A1 (en) * | 2019-11-07 | 2022-09-14 | Crystal Pharmaceutical (Suzhou) Co., Ltd. | Crystal form of aprocitentan, preparation method therefor and use thereof |
| US20230167090A1 (en) * | 2020-05-21 | 2023-06-01 | Teva Pharmaceuticals International Gmbh | Solid state forms of aprocitentan and process for preparation thereof |
| WO2023111797A1 (en) * | 2021-12-17 | 2023-06-22 | Janssen Biotech, Inc. | Pyrimidine sulfamide derivatives and process for manufacturing them |
| WO2023227721A1 (en) | 2022-05-25 | 2023-11-30 | Idorsia Pharmaceuticals Ltd | Crystalline forms of sodium (5-(4-bromophenyl)-6-(2-((5-bromopyrimidin-2-yl)oxy)ethoxy)pyrimidin-4-yl)(sulfamoyl)amide |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3921918A1 (de) * | 1989-07-04 | 1991-01-17 | Hoechst Ag | Verfahren zur herstellung von 2,4,6-trifluor-1,3,5-triazin |
| BRPI0116237B8 (pt) | 2000-12-18 | 2021-05-25 | Actelion Pharmaceuticals Ltd | "composto de sulfamida, composição farmacêutica contendo o mesmo e seu uso como medicamento antagonista de receptor de endotelina". |
| TR200103716A2 (tr) * | 2001-12-25 | 2003-07-21 | Ba�Lama Al� | Zenginleştirilmiş dizel yakıt kompozisyonu |
| KR100940432B1 (ko) * | 2002-01-02 | 2010-02-10 | 액테리온 파마슈티칼 리미티드 | 엔도텔린 길항제로 유용한 신규한 알칸설폰아마이드 |
| MX2010001837A (es) * | 2007-08-17 | 2010-03-10 | Actelion Pharmaceuticals Ltd | Derivados de 4-pirimidinasulfamida. |
| ES2435804T3 (es) | 2009-02-13 | 2013-12-23 | Bayer Intellectual Property Gmbh | Pirimidinas condensadas como inhibidores de Akt |
| WO2010144477A2 (en) * | 2009-06-12 | 2010-12-16 | Auspex Pharmaceuticals, Inc. | Sulfonylurea modulators of endothelin receptor |
| KR101471047B1 (ko) * | 2012-11-21 | 2014-12-08 | 주식회사 메디켐코리아 | 고순도 보센탄의 개선된 제조방법 |
| CN103012279B (zh) * | 2012-11-27 | 2015-01-28 | 浙江工业大学 | 一种4,5,6-三氟嘧啶化合物的制备方法 |
| AR095727A1 (es) | 2013-03-27 | 2015-11-04 | Actelion Pharmaceuticals Ltd | Preparación de intermediarios de pirimidina |
| CN103724281A (zh) * | 2013-12-03 | 2014-04-16 | 镇江圣安医药有限公司 | N-[5-（4-溴苯基）-6-[2-[（5-溴-2-嘧啶基）氧基]乙氧基]-4-嘧啶基]-n′-丙基磺酰胺的新型衍生物及其应用 |
| EP2907811A1 (en) | 2014-02-14 | 2015-08-19 | Actelion Pharmaceuticals Ltd. | Process for manufacturing pyrimidine sulfamide derivatives |
-
2014
- 2014-02-14 EP EP14155137.4A patent/EP2907811A1/en not_active Withdrawn
-
2015
- 2015-02-13 CN CN201710130956.7A patent/CN107162988B/zh active Active
- 2015-02-13 PL PL15706185T patent/PL3105220T3/pl unknown
- 2015-02-13 SI SI201531349T patent/SI3105220T1/sl unknown
- 2015-02-13 ES ES15706185T patent/ES2819504T3/es active Active
- 2015-02-13 HU HUE15706185A patent/HUE050974T2/hu unknown
- 2015-02-13 KR KR1020177006399A patent/KR102406358B1/ko active IP Right Grant
- 2015-02-13 AU AU2015217000A patent/AU2015217000B2/en active Active
- 2015-02-13 MX MX2016010486A patent/MX368014B/es active IP Right Grant
- 2015-02-13 TW TW104105167A patent/TWI663155B/zh active
- 2015-02-13 BR BR122017005939-4A patent/BR122017005939B1/pt active IP Right Grant
- 2015-02-13 DK DK15706185.4T patent/DK3105220T3/da active
- 2015-02-13 CA CA2937277A patent/CA2937277C/en active Active
- 2015-02-13 EA EA201790343A patent/EA032460B1/ru not_active IP Right Cessation
- 2015-02-13 US US15/118,046 patent/US9938244B2/en active Active
- 2015-02-13 NZ NZ724273A patent/NZ724273A/en unknown
- 2015-02-13 EP EP17159638.0A patent/EP3214082B1/en active Active
- 2015-02-13 WO PCT/EP2015/053047 patent/WO2015121397A1/en active Application Filing
- 2015-02-13 CN CN201580008410.3A patent/CN105992762B/zh active Active
- 2015-02-13 EP EP15706185.4A patent/EP3105220B1/en active Active
- 2015-02-13 PT PT157061854T patent/PT3105220T/pt unknown
- 2015-02-13 LT LTEP15706185.4T patent/LT3105220T/lt unknown
- 2015-02-13 JP JP2016551796A patent/JP6431922B2/ja active Active
- 2015-02-13 EA EA201691618A patent/EA032933B1/ru not_active IP Right Cessation
- 2015-02-13 SG SG11201606667VA patent/SG11201606667VA/en unknown
- 2015-02-13 AR ARP150100449A patent/AR099434A1/es active IP Right Grant
- 2015-02-13 TW TW106114126A patent/TWI666203B/zh not_active IP Right Cessation
- 2015-02-13 ES ES17159638T patent/ES2906458T3/es active Active
- 2015-02-13 SG SG10201701994RA patent/SG10201701994RA/en unknown
- 2015-02-13 BR BR112016018581-1A patent/BR112016018581B1/pt active IP Right Grant
- 2015-02-13 KR KR1020167025089A patent/KR102261695B1/ko active IP Right Grant
-
2016
- 2016-08-09 SA SA516371640A patent/SA516371640B1/ar unknown
- 2016-08-10 CL CL2016002008A patent/CL2016002008A1/es unknown
-
2017
- 2017-03-03 AR ARP170100539A patent/AR107801A2/es unknown
- 2017-03-03 CL CL2017000505A patent/CL2017000505A1/es unknown
- 2017-03-09 JP JP2017044868A patent/JP6421209B2/ja active Active
- 2017-03-13 IL IL251126A patent/IL251126A0/en active IP Right Grant
- 2017-04-12 AU AU2017202446A patent/AU2017202446B2/en active Active
-
2018
- 2018-02-27 HK HK18102771.1A patent/HK1243405A1/zh unknown
-
2020
- 2020-09-04 CY CY20201100833T patent/CY1123319T1/el unknown
- 2020-09-10 HR HRP20201450TT patent/HRP20201450T1/hr unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25A | Requested transfer of rights approved |
Owner name: IDORSIA PHARMACEUTICALS LTD (CH) |
|
| B25L | Entry of change of name and/or headquarter and transfer of application, patent and certificate of addition of invention: publication cancelled |
Owner name: ACTELION PHARMACEUTICALS LTD (CH) |
|
| B25C | Requirement related to requested transfer of rights |
Owner name: ACTELION PHARMACEUTICALS LTD (CH) |
|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B25A | Requested transfer of rights approved |
Owner name: IDORSIA PHARMACEUTICALS LTD (CH) |
|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
|
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B15K | Others concerning applications: alteration of classification |
Free format text: A CLASSIFICACAO ANTERIOR ERA: C07D 401/12 Ipc: C07D 401/12 (2006.01), C07D 239/56 (2006.01), C07D |
|
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 13/02/2015, OBSERVADAS AS CONDICOES LEGAIS |