CN109414455B - Bcma结合分子及其使用方法 - Google Patents
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- CN109414455B CN109414455B CN201780030900.2A CN201780030900A CN109414455B CN 109414455 B CN109414455 B CN 109414455B CN 201780030900 A CN201780030900 A CN 201780030900A CN 109414455 B CN109414455 B CN 109414455B
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- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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- C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- C12N5/0634—Cells from the blood or the immune system
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/565—Complementarity determining region [CDR]
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- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
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- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310108490.6A CN116425876A (zh) | 2016-04-01 | 2017-03-31 | Bcma结合分子及其使用方法 |
| CN202310115780.3A CN117903307A (zh) | 2016-04-01 | 2017-03-31 | Bcma结合分子及其使用方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662317334P | 2016-04-01 | 2016-04-01 | |
| US62/317,334 | 2016-04-01 | ||
| PCT/US2017/025516 WO2017173349A1 (en) | 2016-04-01 | 2017-03-31 | Bcma binding molecules and methods of use thereof |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202310108490.6A Division CN116425876A (zh) | 2016-04-01 | 2017-03-31 | Bcma结合分子及其使用方法 |
| CN202310115780.3A Division CN117903307A (zh) | 2016-04-01 | 2017-03-31 | Bcma结合分子及其使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109414455A CN109414455A (zh) | 2019-03-01 |
| CN109414455B true CN109414455B (zh) | 2023-01-20 |
Family
ID=59959188
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201780030900.2A Active CN109414455B (zh) | 2016-04-01 | 2017-03-31 | Bcma结合分子及其使用方法 |
| CN202310108490.6A Pending CN116425876A (zh) | 2016-04-01 | 2017-03-31 | Bcma结合分子及其使用方法 |
| CN202310115780.3A Pending CN117903307A (zh) | 2016-04-01 | 2017-03-31 | Bcma结合分子及其使用方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202310108490.6A Pending CN116425876A (zh) | 2016-04-01 | 2017-03-31 | Bcma结合分子及其使用方法 |
| CN202310115780.3A Pending CN117903307A (zh) | 2016-04-01 | 2017-03-31 | Bcma结合分子及其使用方法 |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US10689450B2 (https=) |
| EP (1) | EP3436036A4 (https=) |
| JP (2) | JP7366543B2 (https=) |
| KR (3) | KR102397674B1 (https=) |
| CN (3) | CN109414455B (https=) |
| AR (1) | AR108067A1 (https=) |
| AU (2) | AU2017240150C1 (https=) |
| BR (1) | BR112018070159A2 (https=) |
| CA (1) | CA3019135A1 (https=) |
| CL (1) | CL2018002763A1 (https=) |
| CO (1) | CO2018010475A2 (https=) |
| CR (1) | CR20180462A (https=) |
| CU (1) | CU20180120A7 (https=) |
| DO (1) | DOP2018000212A (https=) |
| EA (1) | EA201891966A1 (https=) |
| EC (1) | ECSP18073836A (https=) |
| IL (1) | IL261942A (https=) |
| MX (1) | MX2023007400A (https=) |
| NZ (1) | NZ746700A (https=) |
| PE (1) | PE20190120A1 (https=) |
| PH (1) | PH12018550164A1 (https=) |
| SG (2) | SG10201912515XA (https=) |
| TW (4) | TWI795133B (https=) |
| WO (1) | WO2017173349A1 (https=) |
| ZA (1) | ZA201806962B (https=) |
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| CA3019650C (en) | 2016-04-01 | 2023-07-25 | Kite Pharma, Inc. | Chimeric receptors and methods of use thereof |
| ES2891578T3 (es) | 2016-04-01 | 2022-01-28 | Kite Pharma Inc | Antígeno quimérico y receptores de células T y métodos de uso |
| TWI795133B (zh) | 2016-04-01 | 2023-03-01 | 美商凱特製藥公司 | Bcma結合分子類及彼等之用途 |
| EP3548055A4 (en) | 2016-12-02 | 2020-08-19 | University of Southern California | SYNTHETIC IMMUNE RECEPTORS AND THEIR PROCESSES FOR USE |
| WO2018175476A1 (en) * | 2017-03-20 | 2018-09-27 | Baylor College Of Medicine | Transgenic c-mpl provides ligand-dependent co-stimulation and cytokine signals to tcr-engineered cells |
| EP3622092A4 (en) | 2017-05-11 | 2021-06-23 | The Broad Institute, Inc. | METHODS AND COMPOSITIONS OF USE OF CD8 + TUMOR-INFILTRATING LYMPHOCYTE SUBTYPES AND GENE SIGNATURES THEREOF |
| WO2018232195A1 (en) | 2017-06-14 | 2018-12-20 | The Broad Institute, Inc. | Compositions and methods targeting complement component 3 for inhibiting tumor growth |
| US12049643B2 (en) | 2017-07-14 | 2024-07-30 | The Broad Institute, Inc. | Methods and compositions for modulating cytotoxic lymphocyte activity |
| JP7385556B2 (ja) | 2017-09-01 | 2023-11-22 | デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド | Bcma抗原に特異的な免疫原性ペプチドおよびその使用 |
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| WO2019094955A1 (en) | 2017-11-13 | 2019-05-16 | The Broad Institute, Inc. | Methods and compositions for targeting developmental and oncogenic programs in h3k27m gliomas |
| EP3710039A4 (en) | 2017-11-13 | 2021-08-04 | The Broad Institute, Inc. | METHODS AND COMPOSITIONS FOR TREATMENT OF CANCER BY TARGETING THE CLEC2D-KLRB1 PATH |
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