CN1093755C - 用于抑制毛发生长的局部施用组合物 - Google Patents

用于抑制毛发生长的局部施用组合物 Download PDF

Info

Publication number
CN1093755C
CN1093755C CN94106181A CN94106181A CN1093755C CN 1093755 C CN1093755 C CN 1093755C CN 94106181 A CN94106181 A CN 94106181A CN 94106181 A CN94106181 A CN 94106181A CN 1093755 C CN1093755 C CN 1093755C
Authority
CN
China
Prior art keywords
compositions
hair growth
weight
excipient
water
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CN94106181A
Other languages
English (en)
Other versions
CN1097982A (zh
Inventor
B·A·伯克希尔
G·W·埃默里
G·S·阿鲁瓦利亚
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gillette Co LLC
Original Assignee
Gillette Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US1993/005068 external-priority patent/WO1994021217A1/en
Application filed by Gillette Co LLC filed Critical Gillette Co LLC
Publication of CN1097982A publication Critical patent/CN1097982A/zh
Application granted granted Critical
Publication of CN1093755C publication Critical patent/CN1093755C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/69—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing fluorine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • A61Q7/02—Preparations for inhibiting or slowing hair growth

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Chemical & Material Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

本发明包括抑制哺乳动物毛发生长，特别是人胡须生长(包括多毛症)的一种局部施用的组合物，它包括一种水溶性的毛发生长抑制剂，分散在水包油乳液中，以形成擦液或乳膏。本发明还包括一种抑制哺乳动物毛发生长方法，它是通过将有效量的上述组合物施用皮肤上。本发明进一步包括一种用于将药物载运至皮肤上的局部施用组合物。

Description

用于抑制毛发生长的局部 施用组合物
本发明涉及抑制哺乳动物毛发生长的局部施用的一种新组合物，本发明也涉及通过将本发明的局部施用组合物施于皮肤以抑制毛发生长的方法。
在U.S.4,720,489号专利中，公开了局部施用包含鸟氨酰脱羧酶(“ODC”)抑制剂抑制包括胡须在内的毛发的生长。这种应用的特别有利的ODC抑制剂是2-(二氟甲基)-2，5-二氨基戊酸，也称为α-(二氟甲基)鸟氨酸(“DFMO”)。该专利证实，通过测量用这类化合物的乙醇溶液处理过的成年雌性仓鼠的胁腹器官毛发的变化，证明ODC抑制剂用于抑制毛发生长是有效的。该专利还一般地提出将ODC抑制剂掺入皮肤洗液和乳剂之类的化妆品配方的可能性，但是这种建议配方的效果和它们的稳定性及美学作用是未知的。用于DFMO是高度离子化的物质，因此，它将趋向于形成不稳定的乳液体系，使这种体系难以配制，尤其是在要求达到最大功效的高剂量水平时是这样。
在U.S.5,095,007、U.S.5,096,911和U.S.5,132,293中，公开了其它的毛发生长抑制剂，它们与前述的ODC抑制剂完全无关。但是，这些专利中的每一篇都公开了用于携带活性化合物的水—醇赋形剂。该赋形剂包括68％的水、16％的乙醇、5％的丙二醇、5％的二丙烯二醇、490的苄醇和2％的碳酸丙烯酯。由于这种赋形剂是流动性的物质，且有湿而粘的感觉，因此使用起来没有美学上地使人满意或易使用的效果。而且，在这种赋形剂中活性质的功效可能不是最佳的。即使该赋形剂包含两种已知的渗透增强剂，即苄醇和碳酸丙烯时也是如此。
本发明的目的是提供一种用于抑制毛发生长的局部施用的组合物，该组合物稳定、高效且在美学上使人感到满意。
本发明包括一种用于抑制哺乳动物毛发生长、特别是人体须发生长(包括多毛症)的局部施用的组合物，该组合物包含分散于水包油乳液中的一种水溶性毛发生长抑制剂，制成擦液或乳膏形态。本发明还包括通过将有效量的上述组合物施加于皮肤上来抑制哺乳动物毛发生长的方法。本发明进一步包括载运水溶性药物至皮肤上的局部施用的组合物。
在本发明的组合物和方法中所利用的毛发生长抑制剂可以是任意的水溶性毛发生长抑制剂，特别是任何高度离子化的水溶性的毛发生长抑制剂。这类活性剂可以选自在上述U.S.4,720,489、U.S.5,095,007，U.S.5,096,911和U.S.5,133,293中所描述的任何类型的活性剂，只要这类活性剂是水溶性的。在一个优选的实施方案中，毛发生长抑制剂是2-(二氟甲基)-2，5-二氨基戊酸，也称为α-(二氟甲基)乌酸，下文简写为“DFMO”。
本发明的局部施用的组合物包含约1-20份(重量)，优选5-15份的上述水溶性的毛发生长抑制剂，尤其是DFMO，分散在99-80份(重量)，优选95-85份的赋形剂中，该赋形剂包括如下配方(后两种成分是可选择的)的水包油乳液：
成分                        百分数(重量)        实验I       实验II
水                            78-87             80.84*      85.53*
硬脂酸甘油酯1                2.8-4.8           4.24        2.97
PEG-100硬脂酸酯1             2.7-4.7           4.09        2.86
十六醇十八醇混合物            1.9-3.3           3.05        2.14
Ceteareth-202                1.6-2.7           2.50        1.75
矿物油                        1.7-2.7           2.22        2.22
十八烷醇3                    1.0-2.0           1.67        1.17
聚二甲基硅氧烷4              0.3-1.0           0.56        0.56
柠檬酸5                      0-0.5             -           0.25
氢氧化钠6                    水溶液(q.s.)      水溶液      水溶液*抑制0.5％的水用于随配的pH值的调整1.作为掺和物提供，例如Groda Chemicals Ltd.(U.K.)的Cithrol GMSA/S ES0743。2.通用名，作为掺和物提供，定义：十六醇十八醇混合物的聚乙二醇醚，通式R(OCH2CH2)nOH，R＝十六烷基和十八烷基混合物，n平均值＝18，具体产品例如Groda Chemicals Ltd.(U.R.)的Cosmowax EM5483。3.Henkel Chemicals Ltd.以Lorol-18提供。4.由Dow Corning Corp作为粘度为200-100厘泊的聚硅氧烷流体提供。(例如360医用流体或Q7-9120流体)。5.可以其它的弱酸代替，例如乳酸、酒石酸或磷酸，用作pH缓冲剂。6.量足以调节pH值达3.5。其它的强碱，例如KOH可以采用，或在某些情况下，HCl之类的强酸也可以采用，这是在pH值需要调低时使用。
当配制完成时，活性剂加赋形剂的总量将是100份(重量)。需要时可将少量的其它成分，例如染料、香料、杀生物剂或防腐剂掺入赋形剂。优选将0.5-0.9份的Phenonip(一种由Nipa LaboratoriesLtd.(U.K.)提供的杀生物剂加入上述的配方中。
用于本发明的局部施用的组合物的赋形剂按下述的方法进行制备：将水和水溶性成分加入一混合容器中，调节pH值达约3.5，该溶液被加热到约70℃。除杀生物剂外，将油溶性成分在约70℃熔融在一起，然后在轻快搅拌下掺入水相。混合连续进行约20分钟，然后进行水冷却。在40-45℃时加入杀生物剂。继续搅拌，直到温度达25℃，得到粘度为约8,000-12,000厘泊的白色柔软的乳剂。如果希望提高生成的乳液的粘度，可以利用常用的匀化器施加剪切力，例如有方孔高剪切力筛板溶解的Silverson L4R匀化器。通常，在活性剂溶解期间，由于可以提高乳液的粘度，因此这个步骤不是需要的。
本发明的局部施用组合物可以如下来制备，即将约1-20份(重量)，优选5-15份的毛发生长抑制活性剂(优选DFMO)和相应的99-80份(重量)，优选95-85份的如上述制备的赋形剂掺和，用氢氧化钠水溶液(10％)或盐酸(10％)调节pH值达约3.5。当然，局部施用组合物也可以在上述赋形剂制备期间将活性剂包括在水相中来制备。
实例
按照上述的方法，制备了上表的实验I和II组成的两种赋形剂。这两种赋形剂分别包含0.83和O.55份phenonip。在每种赋形剂的四份中，分别加入足量DFMO，进行混合，以制取含2.5、5、10和15％ DFMO的局部施用组合物。这样，总共制备了8个局部施用组合物。利用前述的相同的4份美国专利中描述的仓鼠胁腹器官毛发研究的标准来测试每种组合物的毛发生长抑制效果。为比较起见，测试了只含赋形剂(I-V和II-V)以及U.S.5,096,911实验I中所示的在水—醇赋形剂中含10％的DFMO(W-F)的组合物。这些研究结果如下：
    组合物   ％抑制     组合物   ％抑制
    I-A(15％DFMO)I-B(10％DFMO)I-C(5％DFMO)I-D(2.5％DFMO)I-V(0％DFMO)W-E(10％DFMO)   84.287.684.560.0-68.3   II-A(15％DFMO)II-B(10％DFMO)II-C(5％DFMO)II-D(2.5％DFMO)II-V(0％DFMO)W-E(10％DFMO)   89.191.485.581.4-72.6
如上所示，本发明的每一种组合物，即I-A至1-D和II-A至II-D，在抑制哺乳动物的毛发生长中非常有效。同样，当这些组合物施用到人的面部时，胡须的生长抑制也得到了相似的效果。显然，上述的数据还证明，本发明的组合物在效果方面优先含渗透增强剂的水-醇组合物。这样就可以假定，本发明的组合物或增强了活性剂对皮肤的渗透，或延长了活性剂在处理部位的停留时间，但是，本发明的组合物可长期保持稳定，并具有美学上的令人满意的效果。
本发明的局部施用组合物施用于哺乳动物皮肤，特别是人的面部上的量，以每日一次或每日两次提供每平方厘米皮肤约10-2000毫克量的活性物质。显然，对每个不同的受试的人施用的剂量可以改变，以达到有效的适宜值。
十分清楚，可以用等同物代替上述表中指定的那些成分，而不脱离本发明的精神。例如，通过掺入约1-20％的水溶性药剂于上述的赋形剂中，可以使其分散于皮肤上。

Claims (8)

1.一种用于抑制哺乳动物毛发生长的局部施用的组合物，包括1-20份(重量)的活性剂2-(二氟甲基)-2，5-二氨基戊酸，将其分散在约99-80份的相应的赋形剂中，该赋形剂包括下述成分(以重量份计)的水包油乳液：
水                                 78-87
硬脂酸甘油酯                        2.8-4.8
PEG-100硬脂酸酯                     2.7-4.7
十六醇十八醇混合物                   1.9-3.3
Ceteareth-20                        1.6-2.7
矿物油                              1.7-2.7
十八烷醇                            1.0-2.0
聚二甲基硅氧烷                       0.3-1.0。
2.按权利要求1的组合物，其中将pH值调至约3.5，可选择地含pH缓冲剂。
3.按权利要求2的组合物，包括5-15份(重量)的上述活性剂，分散在95-85份(重量)相应的上述赋形剂中。
4.按权利要求3的组合物，其中上述赋形剂包括下述成份(重量)的水包油乳液：
水                                80.84
硬脂酸甘油酯                       4.24
PEG-100硬脂酸酯                    4.09
十六醇十八醇混合物                       3.05
Ceteareth-20                            2.50
矿物油                                  2.22
十八烷醇                                1.67
聚二甲基硅氧烷                          0.56
5.按权利要求3的组合物，其中上述的赋形剂包括下述成分(重量)的水包油乳液：
水                                      85.53
硬脂酸甘油酯                             2.97
PEG-100硬脂酸酯                          2.86
十六醇十八醇混合物                       2.14
Ceteareth-20                            1.75
矿物油                                  2.22
十八烷醇                                1.17
聚二甲基硅氧烷                           0.56
柠檬酸                                  0.25。
6.抑制哺乳动物毛发生长的美容方法，包括将有效量的权利要求1、2、3、4或5的局部施用组合物应用于哺乳动物的皮肤上。
7.按权利要求6的方法，其中所说的局部施用的组合物的施用量，以足以提供每平方厘米皮肤10-2000毫克2-(二氟甲基)-2，5-二氨基戊酸的量，每日施用一次或每日两次。
8.按权利要求6的方法，其中上述的局部施用的组合物是应用于人的皮肤。
CN94106181A 1993-05-27 1994-05-21 用于抑制毛发生长的局部施用组合物 Expired - Lifetime CN1093755C (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
USUS93/05068 1993-05-27
PCT/US1993/005068 WO1994021217A1 (en) 1993-03-19 1993-05-27 Topical composition for inhibiting hair growth
USPCT/US93/05068 1993-05-27

Publications (2)

Publication Number Publication Date
CN1097982A CN1097982A (zh) 1995-02-01
CN1093755C true CN1093755C (zh) 2002-11-06

Family

ID=22236634

Family Applications (1)

Application Number Title Priority Date Filing Date
CN94106181A Expired - Lifetime CN1093755C (zh) 1993-05-27 1994-05-21 用于抑制毛发生长的局部施用组合物

Country Status (4)

Country Link
US (1) US5648394A (zh)
CN (1) CN1093755C (zh)
IL (1) IL109536A (zh)
ZA (1) ZA943561B (zh)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5939458A (en) * 1997-09-22 1999-08-17 Henry; James P. Reduction of hair growth
JP3973748B2 (ja) 1998-01-14 2007-09-12 花王株式会社 発毛抑制剤
US5958946A (en) * 1998-01-20 1999-09-28 Styczynski; Peter Modulation of hair growth
US6060471A (en) * 1998-01-21 2000-05-09 Styczynski; Peter Reduction of hair growth
US7425579B2 (en) * 1998-04-21 2008-09-16 Universite Laval Methods for inhibiting activity of polyamine transporters
US6020006A (en) * 1998-10-27 2000-02-01 The Gillette Company Reduction of hair growth
US6121269A (en) * 1999-02-22 2000-09-19 Henry; James P. Reduction of hair growth
US6235737B1 (en) 2000-01-25 2001-05-22 Peter Styczynski Reduction of hair growth
US6299865B1 (en) 2000-05-02 2001-10-09 Peter Styczynski Reduction of hair growth
US20040047833A1 (en) * 2000-12-22 2004-03-11 Akihiro Ishino Hair growth inhibitors and compositions containing the same
US7432302B2 (en) * 2001-01-08 2008-10-07 Mediquest Therapeutics, Inc. Composition containing polyamine transport inhibitor and use thereof
USRE43327E1 (en) 2001-01-08 2012-04-24 Aminex Therapeutics, Inc. Hydrophobic polyamine analogs and methods for their use
US7439271B2 (en) 2001-06-27 2008-10-21 The Gillette Company Reduction of hair growth
JP4759182B2 (ja) * 2001-08-03 2011-08-31 花王株式会社 水溶性ショウキョウエキス
US6743822B2 (en) 2001-08-10 2004-06-01 The Gillette Company Reduction of hair growth
US20030036561A1 (en) * 2001-08-10 2003-02-20 Peter Styczynski Reduction of hair growth
US7261878B2 (en) * 2001-08-10 2007-08-28 The Gillette Company Reduction of hair growth
US7374770B2 (en) * 2001-08-15 2008-05-20 Skinmedica, Inc. Topical composition for follicular delivery of an ornithine decarboxylase inhibitor
US6730809B2 (en) 2001-08-29 2004-05-04 Women First Healthcare, Inc. Processes for the production of α-difluoromethyl ornithine (DFMO)
US20040198821A1 (en) * 2002-01-29 2004-10-07 Hwang Cheng Shine Reduction of hair growth
US7160921B2 (en) * 2002-01-29 2007-01-09 The Gillette Company Reduction of hair growth
US20030199584A1 (en) * 2002-04-11 2003-10-23 Ahluwalia Gurpreet S. Reduction of hair growth
US7144920B2 (en) * 2002-09-23 2006-12-05 Mediquest Therapeutics, Inc. Polyamine analogs that activate antizyme frameshifting
US20040141935A1 (en) * 2003-01-21 2004-07-22 Peter Styczynski Reduction of hair growth
US7934284B2 (en) 2003-02-11 2011-05-03 Braun Gmbh Toothbrushes
US7015349B2 (en) * 2003-03-26 2006-03-21 The Gillette Company Reduction of hair growth
US20050031699A1 (en) * 2003-06-26 2005-02-10 L'oreal Porous particles loaded with cosmetically or pharmaceutically active compounds
US20050249685A1 (en) * 2004-04-27 2005-11-10 Natalia Botchkareva Reduction of hair growth
JP2008523159A (ja) * 2004-12-22 2008-07-03 ザ ジレット コンパニー スルビビン阻害物質による発毛の低減
WO2006069048A2 (en) * 2004-12-22 2006-06-29 The Gillette Company Reduction of hair growth
US20060263438A1 (en) * 2005-05-17 2006-11-23 L'oreal Gelled oil particles for targeting sebaceous glands and/or hair follicles
US7618956B2 (en) * 2005-05-31 2009-11-17 The Gillette Company Reduction of hair growth
JP2008543945A (ja) * 2005-06-22 2008-12-04 ミリアド ジェネティクス， インコーポレイテッド 抗ウイルス化合物
US20070059264A1 (en) * 2005-09-13 2007-03-15 Ahluwalia Gurpreet S Reduction of hair growth
US7727516B2 (en) * 2006-02-28 2010-06-01 The Procter & Gamble Company Reduction of hair growth
US20070246057A1 (en) * 2006-04-20 2007-10-25 Muller Sigfrid A Ear treatment for excess hair
US20110144069A1 (en) * 2006-10-16 2011-06-16 Myriad Genetics, Incorporated Compounds for treating viral infections
FR2944443B1 (fr) 2009-04-21 2012-11-09 Arkema France Procede de fabrication de particules de poudre libre a base de polyamide impregnee, et particules de poudre libre a base de polyamide ayant une teneur d'au moins 25% en poids d'au moins un agent cosmetique ou pharmaceutique
FR2953716B1 (fr) 2009-12-16 2015-03-27 Oreal Kit de formulation d'un produit cosmetique
MX2012009637A (es) * 2010-02-17 2012-09-12 Procter & Gamble Articulo depilatorio eficaz.
WO2011119557A2 (en) * 2010-03-26 2011-09-29 The Procter & Gamble Company Kit and method for removing hair
ES2379703T3 (es) * 2010-03-26 2012-04-30 The Procter And Gamble Company Método de depilación y kit para depilación
US8557229B2 (en) * 2010-03-26 2013-10-15 The Procter & Gamble Company Hair removal method and hair removal kit
WO2017165313A1 (en) 2016-03-25 2017-09-28 Aminex Therapeutics Inc. Bioavailable polyamines
AU2021354039A1 (en) 2020-09-30 2023-05-25 Aminex Therapeutics, Inc. Combination drug substance of polyamine transport inhibitor and dfmo
CA3211417A1 (en) * 2021-02-20 2022-08-25 Navin Saxena Research And Technology Private Limited An eflornithine composition for inhibiting hair growth

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN85108498A (zh) * 1984-10-15 1986-06-10 约瑟夫·H·翰戴尔曼 毛发生长修饰剂

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3426137A (en) * 1965-12-23 1969-02-04 Olin Mathieson Hair growth inhibiting by aminobenzophenones
US4161540A (en) * 1966-08-22 1979-07-17 Schering Corporation Antiandrogenic agents and methods for the treatment of androgen dependent disease states
GB1458349A (en) * 1972-12-05 1976-12-15 Sykora F Composition for and a process therewith of treating the hair and/or scalps of animals
US4039669A (en) * 1975-08-01 1977-08-02 Sterling Drug Inc. Composition for topical application and use thereof
US4139638A (en) * 1976-09-23 1979-02-13 Schering Corporation Methods for the treatment of hirsutism
FR2380775A1 (fr) * 1977-02-22 1978-09-15 Sederma Sarl Composition " apres-epilation " favorisant un ralentissement progressif de la repousse des poils
US4191775A (en) * 1977-12-15 1980-03-04 Imperial Chemical Industries Limited Amide derivatives
US4269831A (en) * 1979-05-09 1981-05-26 Sterling Drug Inc. Topical dermatological method of use of an androstenopyrazole
DE2943776A1 (de) * 1979-10-26 1981-05-14 Schering Ag Berlin Und Bergkamen, 1000 Berlin 17 (alpha) -alkylsteroide, diese enthaltende praeparate sowie verfahren zu ihrer herstellung
US4439432A (en) * 1982-03-22 1984-03-27 Peat Raymond F Treatment of progesterone deficiency and related conditions with a stable composition of progesterone and tocopherols
JP2519024B2 (ja) * 1982-06-07 1996-07-31 花王株式会社 毛髪化粧料
US4508714A (en) * 1983-11-14 1985-04-02 Tihomir Cecic Organic scalp lotion
US4885289A (en) * 1983-12-12 1989-12-05 Breuer Miklos M Alteration of character of male beard growth
US4935231A (en) * 1985-08-28 1990-06-19 Repligen Corporation Use of thioredoxin, thioredoxin-derived, or thioredoxin-like dithiol peptides in hair care preparations
US4970216A (en) * 1986-03-17 1990-11-13 Richardson Vicks, Inc. Skin treatment composition and method
US4737361A (en) * 1986-06-06 1988-04-12 Bristol-Myers Company Alpha adrenergic amine of substantial alpha2 adrenergic amine activity as an antiperspirant
US5091171B2 (en) * 1986-12-23 1997-07-15 Tristrata Inc Amphoteric compositions and polymeric forms of alpha hydroxyacids and their therapeutic use
US5096911A (en) * 1990-06-25 1992-03-17 Ahluwalia Gurpreet S Alteration of rate and character of hair growth
ES2109949T3 (es) * 1990-08-14 1998-02-01 Joseph H Handelman Alteracion enzimatica del crecimiento del pelo.
US5189212A (en) * 1990-09-07 1993-02-23 University Of Georgia Research Foundation, Inc. Triarylethylene carboxylic acids with estrogenic activity
US5095007A (en) * 1990-10-24 1992-03-10 Ahluwalia Gurpreet S Alteration of rate and character of hair growth
DE4038693A1 (de) * 1990-12-05 1992-06-11 Heverhagen Ulrich Mittel zum reduzieren des wachstums bzw. zum entfernen der haare am menschlichen koerper
US5143925A (en) * 1990-12-20 1992-09-01 Douglas Shander Alteration of rate and character of hair growth
GB9118979D0 (en) * 1991-09-04 1991-10-23 Unilever Plc Cosmetic composition
GB9118866D0 (en) * 1991-09-04 1991-10-23 Unilever Plc Cosmetic composition
US5364885A (en) * 1992-11-13 1994-11-15 Ahluwalia Gurpreet S Reduction of hair growth
US5411991A (en) * 1992-12-22 1995-05-02 Shander; Douglas Method of reducing hair growth employing sulfhydryl active compounds
US5474763A (en) * 1994-03-11 1995-12-12 Shander; Douglas Reduction of hair growth
US5468476A (en) * 1994-03-16 1995-11-21 Ahluwalia; Gurpreet S. Reduction of hair growth
US5455234A (en) * 1994-03-16 1995-10-03 Ahluwalia; Gurpreet S. Inhibition of hair growth

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN85108498A (zh) * 1984-10-15 1986-06-10 约瑟夫·H·翰戴尔曼 毛发生长修饰剂

Also Published As

Publication number Publication date
CN1097982A (zh) 1995-02-01
IL109536A0 (en) 1994-08-26
ZA943561B (en) 1995-01-26
US5648394A (en) 1997-07-15
IL109536A (en) 1998-03-10

Similar Documents

Publication Publication Date Title
CN1093755C (zh) 用于抑制毛发生长的局部施用组合物
JP3657395B2 (ja) 外用組成物
AU684251B2 (en) Topical composition for inhibiting hair growth
PL185294B1 (pl) Przeciwświądowe kompozycje kosmetyczne i/lub farmaceutyczne, ich zastosowanie do wytwarzania leków i sposób ich wytwarzania
JP2013504552A (ja) 化粧用組成物
JP2937446B2 (ja) 白髪防止黒化剤
JP3568325B2 (ja) 抗アンドロゲン剤及び養毛剤並びに毛髪用化粧料
JPH07206645A (ja) 育毛剤及びこれを含有する頭髪用の化粧料
JPH0745387B2 (ja) 発毛、養毛促進剤
JP3568983B2 (ja) 養毛剤
JP2810040B2 (ja) 頭皮・頭髪用養毛料
CN101524344A (zh) 为皮肤提供镇痛效果的组合物
JPH11269043A (ja) 頭皮頭髪用化粧料
JP3675637B2 (ja) 外用組成物
JP2000239157A (ja) 皮膚外用剤
JP3150781B2 (ja) 皮膚外用剤
JPS62267214A (ja) 皮膚外用剤
JP3150780B2 (ja) 皮膚外用剤
JPH11263714A (ja) 頭皮頭髪用化粧料
JPH07206644A (ja) 育毛剤及びこれを含有する頭髪用の化粧料
JP4041451B2 (ja) 養毛料
JPH0352806A (ja) 養毛料
JP2504805B2 (ja) 頭髪料
JPH0656633A (ja) 養毛剤
JPH0667819B2 (ja) 頭髪化粧料

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C53 Correction of patent of invention or patent application
COR Change of bibliographic data

Free format text: CORRECT: APPLICANT; FROM: JOHN JOSEPH H DEILMANN TO: THE GILLETTE COMPANY

CP03 Change of name, title or address

Address after: Massachusetts, USA

Applicant after: Gillette Co.

Address before: American New York

Applicant before: Douglas Shander

C14 Grant of patent or utility model
GR01 Patent grant
C17 Cessation of patent right
CX01 Expiry of patent term

Expiration termination date: 20140521

Granted publication date: 20021106