CN109260123B - Anti-inflammatory skin care product with light marks and preparation method thereof - Google Patents
Anti-inflammatory skin care product with light marks and preparation method thereof Download PDFInfo
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Abstract
The invention provides an anti-inflammatory pale-printed skin care product containing inula flower, which comprises 16-23 parts of anti-inflammatory pale-printed components, 6-9 parts of emulsifying agents, 5-11 parts of skin moistening agents, 15-21 parts of moisturizing agents, 3-9 parts of thickening agents, 1-2 parts of triethanolamine, 1-4 parts of preservatives, 0.1-0.5 part of essence and 150 parts of water 125-doped materials, wherein the anti-inflammatory pale-printed components comprise inula flower extracts, green tea-sophora flower extracts, aloe extracts and oat extracts, the weight ratio of each component is 10: 5-8: 1-3: 0.5-2, and the components are cooperated, besides the respective basic effects, the anti-inflammatory skin care product can be synergistic, has the functions of resisting wrinkles, moisturizing and tendering skin while resisting inflammatory skin marks, and enhances the anti-inflammatory skin care effect from multiple aspects.
Description
Technical Field
The invention belongs to the technical field of cosmetics, and particularly relates to an anti-inflammatory pale-printed skin care product containing inula flower and a preparation method thereof.
Background
With the continuous acceleration of life rhythm, the increasing competition of work and social life, the deterioration of surrounding environmental conditions, irregular diet and abnormal work and rest, the skin problems such as darkness, color spots, dryness, redness and swelling, pruritus and the like easily occur to modern people.
Skin inflammation refers to a skin condition with subjective sensory symptoms induced by susceptibility to various factors, i.e., high skin reactivity, poor tolerance, and even susceptibility to allergy. Sensitive skin occurs primarily in the face. As for daily conditions, sensitive skin has no objective skin lesions or evidence of skin disease, and is mainly characterized by being drier, easily tense and red; the skin can be stimulated slightly to generate the feeling of pruritus, red swelling, even burning and stabbing pain.
At present, products used by people with sensitive skin are provided by all major brands in the skin care product market, but few products capable of effectively relieving the sensitive skin (resisting inflammation) and improving the skin darkness (pale marks) are provided. Even the skin care products of anti-allergic type have poor effect, or the products contain the allergen, even hormone components are added in the skin care products to enable the products to have anti-allergic effect, and the products can cause epidermal atrophy, pigmentation and the like and cause irreversible damage to the skin after long-term use.
At present, skin care products using plants as raw materials on the market are disordered in variety and have good and uneven quality. Analyzing the reason, on one hand, the individual merchants pursue the benefit maximization to be false and good; on the other hand, the formula of the skin care product is not verified further, and the components cannot well play a synergistic effect; more importantly, the plant components are not properly matched with other components in the skin care product, so that the plant components are degraded and lose effectiveness. Therefore, plant materials should be further developed and applied well to skin care products.
In the industry, no anti-inflammatory skin care product with slight mark and skin care function, which combines inula flower extract, green tea-robinia pseudoacacia flower extract, aloe extract and oat extract, and a preparation method thereof are available.
Disclosure of Invention
In order to overcome the technical defects, the invention provides a skin care product with a synergistic anti-inflammatory and pale-seal effect, and the composition not only effectively relieves the symptoms of dryness, red swelling, pruritus and the like of allergic skin, but also can improve the darkness of the skin and has a better anti-inflammatory and pale-seal function.
An anti-inflammatory skin care product comprises 16-23 parts of an anti-inflammatory skin care component, 6-9 parts of an emulsifier, 5-11 parts of an emollient, 15-21 parts of a humectant, 3-9 parts of a thickener, 1-2 parts of triethanolamine, 1-4 parts of a preservative, 0.1-0.5 part of essence and 150 parts of 125-ion water.
In the anti-inflammatory skin care product, the anti-inflammatory skin care product comprises inula flower extract, green tea-black locust flower extract, aloe extract and oat extract, and the weight ratio of each component is 10: 5-8: 1-3: 0.5-2.
Furthermore, in the anti-inflammatory skin care product, the anti-inflammatory components comprise inula flower extract, green tea-black locust flower extract, aloe extract and oat extract in a weight ratio of 10: 6-7: 1.8-2.4: 0.8-1.2.
In the anti-inflammatory pale skin care product, the green tea-robinia pseudoacacia flower extract is the extract of the green tea and the robinia pseudoacacia flower in the weight ratio of 1: 1.2-1.5; preferably the weight ratio of the extracts of the green tea and the black locust flower is 1: 1.32-1.45; more preferably the weight ratio of the extracts of green tea and acacia flower is 1: 1.4.
Two types of Inula flowers are collected in Chinese pharmacopoeia, one is an Inula japonica (Inula japonica Thunb.) inflorescence of a Compositae plant, and the other is an Inula japonica (Inula Britannica L.) inflorescence, which is bitter, pungent, salty and slightly warm in nature, enters lung, spleen, stomach and large intestine channels, and has the effects of depressing qi, eliminating phlegm, promoting urination and preventing vomiting. Can be used for treating cough due to wind-cold evil, phlegm and fluid accumulation, chest distress, cough with excessive phlegm, emesis, belching, and epigastric fullness.
In the anti-inflammatory skin care product for pale skin, the inula flower extract is an extract of inula euryale.
In the anti-inflammatory pale-printed skin care variety, the green tea is Xinjiang eiderdown tea or Reyuokui.
In some embodiments of the present invention, an anti-inflammatory skin care product comprises an anti-inflammatory component comprising an extract of Inula japonica, an extract of green tea-robinia pseudoacacia, an extract of aloe vera, and an extract of oat in a weight ratio of 10: 6.2: 2.1: 0.9.
In still other embodiments of the present invention, an anti-inflammatory skin care product comprises an anti-inflammatory component comprising an extract of Inulae flos, an extract of green tea-Black locust flower, an extract of Aloe vera, and an extract of Avena sativa in a weight ratio of 10: 6.6: 2.3: 1.1.
The inula flower extract can be prepared by a conventional alcohol extraction method, and the following preparation method is preferred:
a method for preparing Inulae flos extract comprises the following steps: (1) crushing the inula powder and sieving the crushed inula powder by a sieve of 80 meshes to obtain the inula powder; (2) mixing the inula powder with 80% ethanol by mass according to the weight ratio of 1: 10, and extracting by ultrasonic wave to obtain an extracting solution; and (3) filtering the extracting solution, and concentrating the filtrate in vacuum until the relative density is 1.20-1.25 to obtain the inula flower extract.
In the method for extracting inula flower, the ultrasonic extraction is carried out at the extraction temperature of 55-60 ℃, preferably 60 ℃; the extraction time is 1-3 hours, preferably 2 hours; the extraction power is 400-500W, preferably 500W.
The green tea-black locust flower extract can be prepared by a conventional alcohol extraction method, and the following preparation method is preferred:
a method for preparing green tea-Black locust flower extract comprises the following steps: (1) pulverizing green tea and flos Sophorae Immaturus respectively, sieving with 40 mesh sieve, and mixing to obtain green tea-flos Sophorae Immaturus powder; (2) mixing green tea-black locust flower powder with 65% by weight of ethanol according to the weight ratio of 1: 7, and performing ultrasonic extraction to obtain an extract; (3) filtering the extracting solution, and concentrating the filtrate in vacuum until the relative density is 1.15-1.20 to obtain the green tea-robinia pseudoacacia flower extract.
In the extraction method of the green tea-black locust flower extract, the ultrasonic extraction is carried out at the extraction temperature of 50-55 ℃, preferably at 54 ℃; the extraction time is 2-4 hours, preferably 3 hours; the extraction power is 500-600W, preferably 550W.
The aloe extract can be prepared by a conventional alcohol extraction method, and the following preparation methods are preferred:
a method for preparing aloe extract comprises the following steps: (1) pulverizing Aloe; (2) mixing Aloe powder and 75% by weight ethanol at a weight ratio of 1: 10, soaking for 2-4 hr, reflux extracting for 2 times, filtering, collecting filtrate, and mixing to obtain crude extractive solution; (3) filtering the crude extractive solution, and concentrating under reduced pressure to obtain aloe crude extract; (4) dissolving the crude extract with water, loading onto macroporous adsorbent resin column, washing with water, eluting with 70-80% ethanol water solution, and collecting ethanol eluate; (5) filtering the ethanol eluent, and concentrating under reduced pressure until the relative density is 1.22-1.27 to obtain the aloe extract.
The oat extract can be prepared by a conventional alcohol extraction method, and the following preparation methods are preferred:
a method for preparing oat extract comprises the following steps: (1) crushing oat and sieving the crushed oat by a 40-mesh sieve to obtain oat powder; (2) mixing oat powder with 75% ethanol at a weight ratio of 1: 10, heating in 80 deg.C water bath for 3 hr, and extracting for 2 times. Filtering, collecting, and mixing the filtrates to obtain crude extractive solution; (3) and filtering the crude extract, and concentrating under reduced pressure until the relative density is 1.15-1.25 to obtain the oat extract.
The emulsifier is selected from one or more of cetyl palmitate, glyceryl stearate, PEG-20 tribehenate, polyglycerol-3 diisostearate, cetearyl olive oleate, sorbitan palmitate and sorbitan olive oleate, preferably four combinations of glyceryl stearate, PEG-20 tribehenate, polyglyceryl-3 diisostearate and sorbitan palmitate.
The thickening agent comprises an oil phase thickening agent and a water phase thickening agent, wherein the oil phase thickening agent is selected from one or the combination of more than two of behenyl alcohol, cetearyl alcohol, ozokerite, beeswax and candelilla wax; the water phase thickener is one or more of carbomer, xanthan gum and hydroxyethyl acrylate/acryloyl dimethyl sodium taurate copolymer.
The emollient is selected from one or more of shea butter, triglyceride of C10-18 fatty acid, squalane, tocopherol acetate, octyl polymethylsiloxane, dioctyl carbonate, caprylic/capric triglyceride, polydimethylsiloxane, hydrogenated polyisobutene, ethylhexyl palmitate, pentaerythritol tetraisostearate, pentaerythritol tetra (ethylhexanoate), isostearyl alcohol isostearate, isononyl isononanoate, isopropyl palmitate, isopropyl myristate, dimethicone crosspolymer, dimethicone/vinyl dimethicone crosspolymer, and dimethicone alkanol. Preferably one or more of Butyrospermum parkii fruit oil, caprylic/capric triglyceride, polydimethylsiloxane, dioctyl carbonate and tocopherol acetate.
The humectant is selected from one or more of glycerol, butanediol, propylene glycol, glycerin acrylic acid/acrylic acid copolymer, betaine, sodium hyaluronate and trehalose; four combinations of trehalose, glycerol acrylic acid/acrylic acid copolymer, propylene glycol and sodium hyaluronate are preferred.
The antiseptic is selected from one or more of methyl hydroxybenzoate, propyl hydroxybenzoate, phenoxyethanol, benzyl alcohol, sodium benzoate, and potassium sorbate.
The preparation method of the anti-inflammatory skin care product for pale skin comprises the following steps:
1) putting oil-soluble components such as an emollient, an emulsifier and the like into a dissolving pot, heating to 70-80 ℃, uniformly melting, and then preserving heat to obtain a phase A;
2) adding water-soluble components such as a humectant, a thickener and the like into water, heating to 90-100 ℃, fully dissolving the water-soluble components, and then cooling to 70-80 ℃ to obtain a phase B;
3) slowly adding the phase A prepared in the step 1) into the phase B prepared in the step 2), controlling the temperature to be 70-80 ℃, and stirring for 5-15 minutes at the stirring speed of 30-50 rpm; homogenizing at high speed for 3-8 minutes; then stirring for 15-45 min at the stirring speed of 30-50 rpm under heat preservation;
4) cooling to 40-50 ℃, adding a pH regulator and a preservative, stirring uniformly, adding an inula flower extract, a green tea-black locust flower extract, an aloe extract, an oat extract and essence, and stirring uniformly to obtain the anti-inflammatory light-mark skin care product.
The anti-inflammatory skin care product for lightening imprints provided by the invention is prepared from inula flower extract, green tea-robinia pseudoacacia flower extract, aloe extract and oat extract as anti-inflammatory skin care components, and is supplemented with common matrix components of cosmetics, such as emulsifier, emollient, humectant, thickener, preservative, essence and water.
The anti-inflammatory skin care product with the faint marks comprises the following components: the inula flower extract has the effects of protecting skin from being invaded by free radicals, repairing damaged skin, promoting skin metabolism and increasing skin elasticity; the green tea-robinia pseudoacacia flower extract has the effects of resisting free radicals, diminishing inflammation and the like, can also increase the brightness of skin, reduce the water loss through skin, enhance the moisturizing and barrier functions of the skin, enhance the resistance of the skin of a human body through the aloe extract, deeply clean the skin, inhibit the growth of bacteria, and have good curative effects on skin inflammation, particularly acne and comedo.
Detailed Description
The invention discloses an anti-inflammatory skin care product with pale skin and a preparation process thereof, and a person skilled in the art can realize the anti-inflammatory skin care product by properly improving process parameters by referring to the content of the invention. It is expressly intended that all such similar substitutes and modifications apparent to those skilled in the art are deemed to be within the scope of the invention. While the invention has been described in terms of preferred embodiments, it will be apparent to those skilled in the art that variations may be applied, or changes and combinations may be made, in the methods and applications described herein to achieve and use the inventive techniques without departing from the spirit, scope, and content of the invention.
Preparation example 1: inula flower extract
(1) Crushing the inula powder and sieving the crushed inula powder by a sieve of 80 meshes to obtain the inula powder;
(2) mixing the inula powder and 80% ethanol by weight according to the feed liquid weight ratio of 1: 10, and extracting by ultrasonic waves at 60 ℃ for 2h with the extraction power of 500W to obtain an extracting solution;
(3) filtering the extractive solution, vacuum concentrating the filtrate to relative density of 1.23 to obtain Inulae flos extract
Preparation example 2: aloe extract
(1) Pulverizing Aloe;
(2) mixing aloe powder with 75% by weight of ethanol at a feed liquid weight ratio of 1: 10, soaking for 3 hr, reflux extracting for 2 times, filtering, collecting filtrate, and mixing to obtain crude extractive solution;
(3) filtering the crude extractive solution, and concentrating under reduced pressure to obtain aloe crude extract;
(4) dissolving the aloe crude extract with 7 times of water, loading onto macroporous adsorbent resin column, washing with water, eluting with 75% ethanol water solution, and collecting ethanol eluate;
(5) filtering the ethanol eluate, and concentrating under reduced pressure to relative density of 1.25 to obtain aloe extract.
Preparation example 3: oat extract
(1) Crushing oat and sieving the crushed oat by a 40-mesh sieve to obtain oat powder;
(2) mixing oat powder with 75% ethanol at a weight ratio of 1: 10, heating in 80 deg.C water bath for 3 hr, and extracting for 2 times. Filtering, collecting, and mixing the filtrates to obtain crude extractive solution;
(3) filtering the crude extractive solution, and concentrating under reduced pressure to relative density of 1.22 to obtain herba Avenae Fatuae extract.
Preparation example 4: green tea-Black locust flower extract
(1) Respectively pulverizing Xinjiang eiderdown tea (green tea) and acacia flower at a weight ratio of 1:1.4, sieving with a 40-mesh sieve, and mixing to obtain green tea-acacia flower powder;
(2) mixing green tea-Black locust flower powder with 65% by weight of ethanol at a feed liquid weight ratio of 1: 7, and extracting with ultrasonic wave at 54 deg.C for 3 hr with an extraction power of 550W to obtain extractive solution;
(3) filtering the extractive solution, and vacuum concentrating the filtrate to relative density of 1.18 to obtain green tea-Black locust flower extract.
Preparation example 5: green tea-Black locust flower extract
(1) Respectively pulverizing Ruicakui (green tea) and Robinia Pseudoacacia in a weight ratio of 1:1.4, sieving with 40 mesh sieve, and mixing to obtain green tea-Robinia Pseudoacacia powder;
(2) mixing green tea-Black locust flower powder with 65% by weight of ethanol at a feed liquid weight ratio of 1: 7, and extracting with ultrasonic wave at 54 deg.C for 3 hr with an extraction power of 550W to obtain extractive solution;
(3) filtering the extractive solution, and vacuum concentrating the filtrate to relative density of 1.18 to obtain green tea-Black locust flower extract.
Preparation example 6: green tea-Black locust flower extract
(1) Respectively pulverizing Xinjiang eiderdown tea (green tea) and acacia flower at a weight ratio of 1:1.45, sieving with 40 mesh sieve, and mixing to obtain green tea-acacia flower powder;
(2) mixing green tea-Black locust flower powder with 65% by weight of ethanol at a feed liquid weight ratio of 1: 7, and extracting with ultrasonic wave at 54 deg.C for 3 hr with an extraction power of 550W to obtain extractive solution;
(3) filtering the extractive solution, and vacuum concentrating the filtrate to relative density of 1.18 to obtain green tea-Black locust flower extract.
Preparation example 7: green tea-Black locust flower extract
(1) Respectively pulverizing Xinjiang eiderdown tea (green tea) and acacia flower at a weight ratio of 1:1.32, sieving with 40 mesh sieve, and mixing to obtain green tea-acacia flower powder;
(2) mixing green tea-Black locust flower powder with 65% by weight of ethanol at a feed liquid weight ratio of 1: 7, and extracting with ultrasonic wave at 54 deg.C for 3 hr with an extraction power of 550W to obtain extractive solution;
(3) filtering the extractive solution, and vacuum concentrating the filtrate to relative density of 1.18 to obtain green tea-Black locust flower extract.
Preparation example 8: green tea-Black locust flower extract
(1) Respectively pulverizing green tea and flos Sophorae Immaturus at a weight ratio of 1:1.6, sieving with 40 mesh sieve, and mixing to obtain green tea-flos Sophorae Immaturus powder;
(2) mixing green tea-Black locust flower powder with 65% by weight of ethanol at a feed liquid weight ratio of 1: 7, and extracting with ultrasonic wave at 54 deg.C for 3 hr with an extraction power of 550W to obtain extractive solution;
(3) filtering the extractive solution, and vacuum concentrating the filtrate to relative density of 1.18 to obtain green tea-Black locust flower extract.
Preparation example 9: green tea-Black locust flower extract
(1) Respectively pulverizing Biluochun tea (green tea) and robinia pseudoacacia flower at a weight ratio of 1:1.1, sieving with a 40-mesh sieve, and mixing to obtain green tea-robinia pseudoacacia flower powder;
(2) mixing green tea-Black locust flower powder with 65% by weight of ethanol at a feed liquid weight ratio of 1: 7, and extracting with ultrasonic wave at 54 deg.C for 3 hr with an extraction power of 550W to obtain extractive solution;
(3) filtering the extractive solution, and vacuum concentrating the filtrate to relative density of 1.18 to obtain green tea-Black locust flower extract.
Preparation example 10: green tea-Black locust flower extract
(1) Pulverizing Camellia japonica (green tea) and Sophora japonica flower at weight ratio of 1:1.4 respectively, sieving with 40 mesh sieve, and mixing to obtain green tea-Sophora japonica flower powder;
(2) mixing green tea-black locust flower powder with 65% by weight of ethanol according to a feed liquid weight ratio of 1: 7, and performing ultrasonic extraction at 54 deg.C for 3h with an extraction power of 550W to obtain an extract;
(3) filtering the extractive solution, and vacuum concentrating the filtrate to relative density of 1.18 to obtain green tea-Black locust flower extract.
Example 1: anti-inflammatory skin care product
The preparation method comprises the following steps:
1) putting oil-soluble components in an emollient, an emulsifier and a thickener into a dissolving pot, heating to 70-80 ℃, uniformly melting, and keeping the temperature to obtain a phase A;
2) adding water-soluble components in the humectant and the thickener into water, heating to 90-100 ℃, fully dissolving the water-soluble components, and then cooling to 70-80 ℃ to obtain a phase B;
3) slowly adding the phase A prepared in the step 1) into the phase B prepared in the step 2), controlling the temperature to be 70-80 ℃, and stirring for 5-15 minutes at the stirring speed of 30-50 rpm; homogenizing at high speed for 3-8 minutes; then stirring for 15-45 min at the stirring speed of 30-50 rpm under heat preservation;
4) cooling to 40-50 ℃, adding triethanolamine and a preservative, stirring uniformly, adding inula flower extract, green tea-robinia pseudoacacia flower extract, aloe extract, oat extract and essence, and stirring uniformly to obtain the anti-inflammatory light-seal skin care product.
Example 2: anti-inflammatory skin care product
The preparation method comprises the following steps: the same as in example 1.
Example 3: anti-inflammatory skin care product
The preparation method comprises the following steps: the same as in example 1.
Example 4: anti-inflammatory skin care product
The preparation method comprises the following steps: the same as in example 1.
Example 5: anti-inflammatory skin care product
The preparation method comprises the following steps: the same as in example 1.
Example 6: anti-inflammatory skin care product
The preparation method comprises the following steps: the same as in example 1.
Example 7: anti-inflammatory skin care product
The preparation method comprises the following steps: the same as in example 1.
Example 8: anti-inflammatory skin care product
The preparation method comprises the following steps: the same as in example 1.
Example 9: anti-inflammatory skin care product
The preparation method comprises the following steps: the same as in example 1.
Example 10: anti-inflammatory skin care product
The preparation method comprises the following steps: the same as in example 1.
Comparative example 1: anti-inflammatory skin care product
The preparation method comprises the following steps: the same as in example 1.
Comparative example 2: anti-inflammatory skin care product
The preparation method comprises the following steps: the same as in example 1.
Comparative example 3: anti-inflammatory skin care product
The preparation method comprises the following steps: the same as in example 1.
Comparative example 4: anti-inflammatory skin care product
The preparation method comprises the following steps: the same as in example 1.
Comparative example 5: anti-inflammatory skin care product
The preparation method comprises the following steps: the same as in example 1.
Example 11: evaluation of anti-inflammatory Effect
(1) Preparation of sample solution: the extracts of preparation examples 1 to 10, the anti-inflammatory pale components of examples 1 to 10, and the anti-inflammatory pale components of comparative examples 1 to 5 were prepared into 10% aqueous solutions with deionized water, respectively, as sample solutions.
(2) Selecting SD rats, unhairing 24 hours before experiment, unhairing the backs of the animals, and removing the back hair with the area of about 3cm multiplied by 3 cm; when 2, 4-Dinitrochlorobenzene (DNCB) is used for molding the skin on the back of the rat and is irradiated by ultraviolet rays for 12 hours, the skin shows symptoms of dryness, desquamation, burning, stabbing pain, swelling, erythema and the like, and the molding is successful.
(3) Grouping experiments: 260 successfully molded rats were divided into 26 groups (preparation examples 1-10, comparative examples 1-5, model), each group consisting of 10 rats; preparation examples 1-10, and comparative examples 1-5 groups were applied to the area of the dorsal dehaired cortex with 0.5 ml of sample solution; the model group was coated on the back depilatory area with 0.5 ml of deionized water.
Another 10 SD rats were depilated on the back and used as a normal group, and the depilated skin area on the back was coated with 0.5 ml of deionized water.
The administration is once daily for 14 days. On day 15, the skin condition of the backs of the rats in each group was visually observed and recorded according to the criteria of the following table, and the average score of each group was recorded.
(4) Results
And (3) data analysis:
(1) the rats in the model group have serious dry and desquamation skin, serious burning, stabbing pain, severe edema and severe erythema, the scores of all the groups are more than 3.5 points, and the differences from the normal groups are very obvious.
(2) The extracts prepared in preparation examples 1-10 can relieve dry skin, desquamation, burning, stabbing pain, edema and erythema, and the score is 2.12-3.34.
(3) The extracts of the green tea and the black locust flower (weight ratio of 1: 1.45) and the green tea and the black locust flower (weight ratio of 1: 1.32) in the preparation examples 6 and 7 can relieve dry skin, desquamation, burning, pricking pain, edema and erythema, and the score is 3.06-3.31; the green tea-acacia flower (weight ratio is 1: 1.4) extracts prepared in preparation examples 4 and 5 can remarkably relieve skin dryness, desquamation, burning, stabbing pain, edema and erythema, the score is 2.12-2.46, and compared with a model group, the green tea-acacia flower extract has remarkable difference; the effect is obviously better than that of the groups of preparation examples 6 and 7.
(4) The anti-inflammatory and pale-printed components of examples 1-10 significantly alleviated skin dryness and desquamation, burning, stinging, edema, and erythema, all with a score of less than 0.5, achieved the criteria of no dryness, desquamation, no burning, stinging sensation, no edema, no erythema, and had very significant differences compared to the model group; compared with the groups of preparation examples 1-10, the method has significant difference.
(5) The anti-inflammatory and pale-printed components of examples 3-4 significantly relieved dry and desquamation, burning, stinging, edema and erythema of the skin, all with a score of less than 0.3, achieved the standards of no dry, desquamation, no burning, stinging sensation, no edema and no erythema, and the effect was superior to the groups of examples 1-2.
(6) The anti-inflammatory and pale-printed components of examples 7-8 significantly relieved dry and desquamation, burning, stinging, edema and erythema of the skin, all with a score of less than 0.1, achieved the criteria of no dryness, desquamation, no burning, stinging sensation, no edema and no erythema, and the effect was superior to the groups of examples 1-2 and 3-4.
(7) The anti-inflammatory and pale-printed components of examples 5-6 and 9-10 significantly relieved dry and desquamation, burning, stinging, edema and erythema of the skin, and the score of 0 reaches the standard of no drying, desquamation, burning, stinging, edema and erythema, and the effect is better than that of the groups of examples 3-4 and 7-8.
(8) From comparative examples 1 to 3 and examples 5, 7 to 8, and 9, it can be seen that: the green tea is different in types (comparative examples 1-3) and different in proportion of the green tea and the robinia pseudoacacia flower (comparative examples 2-3), and the prepared green tea-robinia pseudoacacia flower extract directly influences the anti-inflammatory effect of the anti-inflammatory pale-seal component, so that the green tea is preferably Xinjiang eiderdown tea or Reykui; the green tea-black locust flower extract is preferably the extract of green tea and black locust flower in the weight ratio of 1: 1.32-1.45; more preferably the weight ratio of the extracts of green tea and acacia flower is 1: 1.4.
(9) From comparative examples 4 to 5, compared to examples 1 to 6, the weight ratio of each component (inula flower extract, green tea-acacia flower extract, aloe extract, oat extract) of the anti-inflammatory pale-printed component affects the anti-inflammatory effect of the anti-inflammatory pale-printed component, and the anti-inflammatory effect is the best when the above components are within a specific ratio range, so the weight ratio of the inula flower extract, the green tea-acacia flower extract, the aloe extract, the oat extract is: 10 to (5-8) to (1-3) to (0.5-2), preferably in the weight ratio of 10 to (6-7) to (1.8-2.4) to (0.8-1.2); more preferably in a weight ratio of 10: 6.2: 2.1: 0.9; more preferably in a weight ratio of 10: 6.6: 2.3: 1.1.
The inula flower extract, the green tea-robinia pseudoacacia flower extract, the aloe extract and the oat extract in the anti-inflammatory pale-printed skin care product have a synergistic effect, and when the inula flower extract, the green tea-robinia pseudoacacia flower extract, the aloe extract and the oat extract are mixed according to a specific proportion, the skin dryness, desquamation, burning, stabbing pain, edema and erythema can be effectively relieved, and the anti-inflammatory effect is achieved.
EXAMPLE 12 evaluation of Effect
1. Test subjects: 160 skin allergy volunteers had symptoms of red and swollen face skin, pruritus and discomfort before use; divided into 16 groups of 10.
2. The test method comprises the following steps: after face cleaning every day, the anti-inflammatory skin care products of the examples 1-10 and the comparative examples 1-5 are smeared on the skin and the hair-prone part, and the results are counted in the morning and the evening, 7 days and 14 days; the control group was coated with the formulation of example 5 after removal of the anti-inflammatory pale-printed component.
And 3, judging standard:
3.1 evaluation of anti-inflammatory Effect:
(1) the effect is shown: the phenomena of red and swollen skin, pruritus and the like disappear; 2 min;
(2) the method has the following advantages: the phenomena of red and swollen skin, pruritus and the like are reduced; 1 minute;
(3) and (4) invalidation: the phenomena of red and swollen skin, pruritus and the like do not have obvious changes; and 0 point.
Evaluation after 7 days was used and the total composition of each fraction was calculated.
3.2 evaluation of print lightening Effect
The left cheek of the volunteer was tested with a colorimeter before the test and 14 days after the smearing, evaluated in L (brightness), counted and the average value was calculated.
And experimental results
4.1 anti-inflammatory results
And (3) data analysis:
(1) after the anti-inflammatory pale-printed skin care product disclosed by the embodiments 1-10 of the invention is applied, the redness, swelling, itching and the like of the skin are remarkably relieved, the score is not lower than 15 after 7 days, the phenomena of redness, swelling, itching and the like of the skin are relieved or even disappear, and the anti-inflammatory pale-printed skin care product has a very remarkable difference compared with a control group.
(2) After the anti-inflammatory pale-printed skin care product disclosed by the embodiments 3-4 of the invention is applied, the phenomena of skin redness and swelling, pruritus and the like are remarkably relieved, the score is not lower than 17 after 7 days, the phenomena of skin redness and swelling, pruritus and the like are relieved or even disappeared, and the effect is better than that of the groups in the embodiments 1-2.
(3) After the anti-inflammatory pale-printed skin care product disclosed by the invention in the examples 7-8 is applied, the redness, swelling, itching and the like of the skin are remarkably relieved, the score is not lower than 19 after 7 days, the phenomena of redness, swelling, itching and the like of the skin are relieved or even disappear, and the effect is better than that of the groups in examples 1-2 and 3-4.
(4) After the anti-inflammatory pale-printed skin care product disclosed by the embodiments 5-6 and 9-10 of the invention is applied, the red swelling, pruritus and the like of the skin are remarkably relieved, the score is not lower than 20 after 7 days, the phenomena of the red swelling, pruritus and the like of the skin completely disappear, and the effect is better than that of the embodiments 3-4 and 7-8.
(5) After the anti-inflammatory pale-printed skin care product disclosed by comparative examples 1-3 of the invention is applied, the red and swollen skin, the pruritus and the like can be relieved, and the score is 8-9 after 7 days; the effects were significantly inferior to those of examples 5, 7 to 8 and 9, and it was found that
The green tea and the black locust flower extract directly influence the anti-inflammatory effect of the anti-inflammatory pale-printed skin care product, so that the prepared skin care product has the best effect in a specific range of the green tea and the specific proportion.
(6) After the anti-inflammatory pale-printed skin care product disclosed by comparative examples 4-5 of the invention is applied, the red and swollen skin, the itching and the like can be relieved, the score is 9 after 7 days, which is obviously inferior to that in examples 1-6, the weight ratio of each component (inula flower extract, green tea-acacia flower extract, aloe extract and oat extract) of the anti-inflammatory pale-printed component influences the anti-inflammatory effect of the anti-inflammatory pale-printed component, and when the components are in a specific ratio range, the anti-inflammatory effect is optimal.
The inula flower extract, the green tea-robinia pseudoacacia flower extract, the aloe extract and the oat extract in the composition have synergistic effect, and when the extract, the green tea-robinia pseudoacacia flower extract, the aloe extract and the oat extract are in a specific proportion range, the redness and swelling, the pruritus and the like of skin can be effectively relieved, and the anti-inflammatory effect is achieved.
Light mark results
(1) After the anti-inflammatory skin care product disclosed by the embodiments 1-10 of the invention is applied, the skin darkness and the like are obviously improved, the skin brightness is obviously improved, the difference value of L is not less than 6 minutes after 14 days, the light seal effect is achieved, and compared with a control group, the anti-inflammatory skin care product has very obvious difference.
(2) After the anti-inflammatory skin care product disclosed by the embodiment 3-4 of the invention is applied, the skin darkness and the like are obviously improved, the skin brightness is obviously improved, the difference value of L is not less than 9 minutes after 14 days, the light mark effect is achieved, and the effect is superior to that of the group in the embodiment 1-2.
(3) After the anti-inflammatory skin care product disclosed by the embodiment 7-8 of the invention is applied, the skin darkness and the like are obviously improved, the skin brightness is obviously improved, the difference value of L is not less than 10 minutes after 14 days, the light mark effect is achieved, and the effect is better than that of the embodiment 1-2 groups and the embodiment 3-4 groups.
(4) After the anti-inflammatory skin care product disclosed by the embodiments 5-6 and 9-10 of the invention is applied, the skin darkness and the like are obviously improved, the skin brightness is obviously improved, the difference value of L is not less than 12 points after 14 days, the light mark effect is achieved, and the effect is better than that of the embodiments 3-4 and 7-8.
(5) After the anti-inflammatory light-printing skin care product in comparative examples 1-3 is smeared, the skin darkness and the like are improved, the skin brightness is improved, and the difference value of L is not higher than 3 minutes after 14 days; the effect is obviously inferior to that of the examples 5, 7-8 and 9, and the different types of the green tea (comparative examples 1-3) and the different proportions of the green tea and the robinia pseudoacacia flower (comparative examples 2-3) can be seen, and the prepared green tea-robinia pseudoacacia flower extract directly influences the light mark effect of the anti-inflammatory light mark skin care product, so that the light mark effect of the skin care product prepared by the specific green tea is the best within the specific proportion range.
(6) After the anti-inflammatory light-printing skin care product of comparative examples 4-5 of the invention is smeared, the skin darkness and the like are improved, the skin brightness is improved, and the difference value of L is not higher than 3 minutes after 14 days; the anti-inflammatory pale-seal component has a significantly worse effect than examples 1 to 6, and the weight ratio of each component (inula flower extract, green tea-black locust flower extract, aloe extract, oat extract) of the anti-inflammatory pale-seal component affects the pale-seal effect of the anti-inflammatory pale-seal component, and the anti-inflammatory effect is the best when the components are within a specific ratio range.
The inula flower extract, the green tea-black locust flower extract, the aloe extract and the oat extract in the composition have a synergistic effect, and can effectively relieve and improve skin darkness in a specific proportion range to achieve the effect of pale-printed spots.
| Group of | Before the experiment | After 14 days of testing | Difference value |
| Control group | 55.15 | 55.30 | 0.15 |
| Example 1 | 55.39 | 61.58 | 6.19 |
| Example 2 | 55.21 | 61.52 | 6.31 |
| Example 3 | 55.32 | 64.72 | 9.40 |
| Example 4 | 55.91 | 64.93 | 9.02 |
| Example 5 | 55.10 | 67.46 | 12.36 |
| Example 6 | 55.19 | 67.28 | 12.09 |
| Example 7 | 56.00 | 65.81 | 10.21 |
| Example 8 | 55.76 | 65.30 | 10.54 |
| Example 9 | 55.20 | 67.28 | 12.08 |
| Example 10 | 55.07 | 67.41 | 12.34 |
| Comparative example 1 | 55.78 | 58.36 | 2.58 |
| Comparative example 2 | 55.63 | 58.41 | 2.78 |
| Comparative example 3 | 55.51 | 58.18 | 2.67 |
| Comparative example 4 | 55.41 | 58.24 | 2.83 |
| Comparative example 5 | 55.60 | 58.44 | 2.84 |
Claims (8)
1. An anti-inflammatory skin care product with light seal comprises 16-23 parts of anti-inflammatory component with light seal, 6-9 parts of emulsifier, 5-11 parts of emollient, 15-21 parts of humectant, 3-9 parts of thickener, 1-2 parts of triethanolamine, 1-4 parts of preservative, 0.1-0.5 part of essence and 150 parts of water 125-plus, wherein the anti-inflammatory component with light seal comprises inula flower extract, green tea-robinia pseudoacacia flower extract, aloe extract and oat extract, and the weight ratio of the components is 10: 5-8: 1-3: 0.5-2; the inula flower extract is an extract of inula euryale; the green tea is Xinjiang eiderdown tea or Reokui; the green tea-black locust flower extract is the green tea and black locust flower extract with the ratio of 1: 1.32-1.45.
2. The anti-inflammatory pale skin care product of claim 1, wherein the inula flower extract is prepared by the method comprising: 1) crushing the inula powder and sieving the crushed inula powder by a sieve of 80 meshes to obtain the inula powder; (2) mixing the inula powder with 80% ethanol by mass according to the weight ratio of 1: 10, and extracting by ultrasonic wave to obtain an extracting solution; (3) filtering the extracting solution, and concentrating the filtrate in vacuum until the relative density is 1.20-1.25 to obtain the inula flower extract; the ultrasonic extraction in the step (2) is carried out at the extraction temperature of 60 ℃; the extraction time is 2 h; the extraction power is 500W.
3. The anti-inflammatory skin lightening product of claim 1 wherein the aloe vera extract is prepared by: (1) pulverizing Aloe; (2) mixing Aloe powder and 75% by weight ethanol at a weight ratio of 1: 10, soaking for 2-4 hr, reflux extracting for 2 times, filtering, collecting filtrate, and mixing to obtain crude extractive solution; (3) filtering the crude extractive solution, and concentrating under reduced pressure to obtain aloe crude extract; (4) dissolving the crude extract with water, loading onto macroporous adsorbent resin column, washing with water, eluting with 70-80% ethanol water solution, and collecting ethanol eluate; (5) filtering the ethanol eluent, and concentrating under reduced pressure until the relative density is 1.22-1.27 to obtain the aloe extract.
4. The anti-inflammatory skin care product according to claim 1, wherein the anti-inflammatory skin care product comprises inula flower extract, green tea-robinia pseudoacacia flower extract, aloe extract and oat extract in a weight ratio of 10: 6-7: 1.8-2.4: 0.8-1.2.
5. The anti-inflammatory pale-print skin care product of claim 1, wherein the anti-inflammatory pale-print component comprises inula flower extract, green tea-robinia flower extract, aloe extract, oat extract in a weight ratio of 10: 6.2: 2.1: 0.9.
6. The anti-inflammatory pale-print skin care product of claim 1, wherein the anti-inflammatory pale-print component comprises inula flower extract, green tea-robinia flower extract, aloe extract, oat extract in a weight ratio of 10: 6.6: 2.3: 1.1.
7. The anti-inflammatory pale-seal skin care product of claim 5, wherein the green tea-black locust flower extract is a green tea-black locust flower extract in a weight ratio of 1: 1.4.
8. The anti-inflammatory skin lightening product of claim 1 wherein the process of preparation comprises the steps of:
1) putting oil-soluble components such as an emollient, an emulsifier and the like into a dissolving pot, heating to 70-80 ℃, uniformly melting, and then preserving heat to obtain a phase A;
2) adding water-soluble components such as a humectant, a thickener and the like into water, heating to 90-100 ℃, fully dissolving the water-soluble components, and then cooling to 70-80 ℃ to obtain a phase B;
3) slowly adding the phase A prepared in the step 1) into the phase B prepared in the step 2), controlling the temperature to be 70-80 ℃, and stirring for 5-15 minutes at the stirring speed of 30-50 rpm; homogenizing at high speed for 3-8 minutes; then stirring for 15-45 min at the stirring speed of 30-50 rpm under heat preservation;
4) cooling to 40-50 ℃, adding a pH regulator and a preservative, stirring uniformly, adding an inula flower extract, a green tea-black locust flower extract, an aloe extract, an oat extract and essence, and stirring uniformly to obtain the anti-inflammatory light-mark skin care product.
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