CN110559230A - Anti-aging and anti-wrinkle essence lotion and preparation method thereof - Google Patents
Anti-aging and anti-wrinkle essence lotion and preparation method thereof Download PDFInfo
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Abstract
The invention provides anti-aging wrinkle-removing essence lotion which is characterized by being prepared from the following raw materials in percentage by mass: cannabidiol CBD 2-20%, MCT oil 3-10%, mineral substance concentrate 2-20%, collagen 1-2%, hydrogenated castor oil polyoxyethylene ether-401-6%, ethyl glycerol 1-2%, castor oil polyoxyethylene ether-401-6%, gentian extract 0.03-0.05%, 0.1 to 0.5 percent of p-hydroxybenzoate, 0.4 to 0.8 percent of yarrow extract, 1 to 7 percent of glycerol, 0.05 to 0.1 percent of polyglutamic acid, 1 to 2 percent of PEG-400, 0.1 to 0.5 percent of citric acid, 0.5 to 2 percent of sodium phytate, 0.5 to 2 percent of magnesium aluminum silicate, 0.5 to 1 percent of okra extract, 0.01 to 0.05 percent of ormosia hainanensis extract and the balance of water, wherein the total amount of the components is 100 percent. Controlling water and oil balance, resisting oxidation, scavenging free radicals, conditioning, improving and protecting skin.
Description
Technical Field
The invention relates to the technical field of cosmetics, and in particular relates to a preparation method of anti-aging wrinkle-removing essence lotion.
Background
The skin of a human body can be subjected to irresistible aging under the influence of external and natural laws. The main manifestations are that the cell metabolism is gradually slowed down, the collagen is gradually lost, the skin tissue cells are damaged, the hormone secretion is disordered, the fat content is reduced, the skin loses moisture, elasticity and luster, and then the skin is dried up to generate wrinkles. At present, anti-wrinkle products in the market are mostly moisture-keeping products, have single functions and are difficult to achieve good anti-wrinkle effects. Therefore, the field of cosmetics urgently needs an essential aquatic product which can promote skin renewal and resist aging and integrates the functions of nature, health, safety and effectiveness.
The CBD receptor content in human skin is highest, the CBD is a powerful antioxidant, and the CBD is an effective substance extracted from flowers and leaves of industrial hemp, and the CBD is applied to the field of cosmetics, can repair damaged cells of a human body, stimulate cell regeneration, control water and oil balance, has pharmacological activities of resisting inflammation, resisting oxidation, deeply nourishing skin and the like, and can relieve the skin and repair free radical damage after being taken into the human body through the skin, so that the skin quality is improved from inside to outside, and various problems faced by the skin are solved.
However, cannabidiol is difficult to dissolve in water, so that the drug has poor dissolution rate, poor absorption effect and low bioavailability, and the effect of the drug is limited to a certain extent. Therefore, the improvement of the method is needed, so that the method can be dissolved in water, the bioavailability is increased, and the application value is improved. Especially applied to cosmetics, has the functions of moistening skin, resisting wrinkles, moisturizing and preventing allergy, and has the advantages of safety, mildness and no irritation to human bodies.
Therefore, it is important to develop a new skin care product that can self-renew and self-repair skin, control water and oil balance, reduce water loss, and effectively solve various problems of skin.
Disclosure of Invention
the first purpose of the invention is to provide the anti-aging wrinkle-removing essence lotion.
The second purpose of the invention is to provide a preparation method of the anti-aging wrinkle-removing essence lotion.
The first purpose of the invention is realized by the following technical scheme: the anti-aging and anti-wrinkle essence lotion is characterized by being prepared from the following raw materials in percentage by mass:
the sum of the above components is 100%.
The cannabidiol CBD is a commercial product, is a substance extracted from dried flowers and/or leaves of industrial cannabis sativa with the content of tetrahydrocannabinol THC lower than 0.3%, belongs to a non-addictive active substance, has the main effects of repairing damaged cells, stimulating cell regeneration, controlling water-oil balance, and has the effects of oxidation resistance, inflammation resistance, bacteria resistance, allergy resistance, ultraviolet resistance and the like.
The mineral concentrated solution is a commercial product, is an indispensable substance for human bodies, contains various natural mineral elements, is easy to be absorbed by human bodies, can keep skin moisture, helps skin metabolism, promotes the barrier function of the skin, and enhances the skin resistance.
The MCT oil is a sealing agent and is of a cosmetic grade.
The collagen is hydrophilic matrix and is of cosmetic grade.
the hydrogenated castor oil polyoxyethylene ether-40 (HEL-40) and the castor oil polyoxyethylene ether-40 (EL-40) are used as emulsifiers and are of cosmetic grade.
The polyglutamic acid and the ethyl glycerol are moisturizers and are of cosmetic grade.
The PEG-400 is a solubilizer and is of cosmetic grade.
The paraben is a preservative and is of cosmetic grade.
The magnesium aluminum silicate is a fluidizing agent and is of cosmetic grade.
the sodium phytate is antioxidant and is of cosmetic grade.
The glycerol is a lubricant and is of cosmetic grade.
The citric acid is a buffering agent and is of cosmetic grade.
The milfoil extract is commercially available product, is extracted from stem, leaf and root of milfoil, and has antiinflammatory and whitening effects.
The yarrow extract is prepared by the following method: pulverizing Achillea millefolium to 60-120 mesh, extracting with 90-95% ethanol at 50-65 deg.C for 2-3 times according to the material liquid mass ratio of 1: 4-10, mixing extractive solutions, filtering, concentrating the filtrate to obtain extract, and making into powder with pore diameter of 85-90/um and specific surface area of 480-520m2Purifying with macroporous resin per gram, eluting with 90-95% ethanol, collecting eluate, and concentrating to obtain thick paste.
The radix Gentianae extract is commercially available product, is extracted from root and stem of Gentiana striolata and Gentiana rigescens of Gentianaceae, has effects of clearing heat and eliminating dampness, can improve sensitive and uncomfortable state such as dry skin and itch, enhance natural immunity of skin, and can whiten and moisturize skin.
the gentian extract is prepared by the following method: pulverizing radix Gentianae, sieving with 40-80 mesh sieve, extracting with 4-8 times of 90-95% ethanol at 70-85 deg.C for 2-3 times, each for 1-2 hr, filtering, mixing filtrates, and concentrating to obtain extract.
The okra extract is a commercially available product, is a substance extracted from fresh okra tender pods or fresh whole plant stems and leaves, has a health-care effect on skin, and can whiten and tenderize the skin.
The okra extract is prepared by the following method: pulverizing the raw materials to 60-80 mesh, adding 3-5 times of water, heating at 60-80 deg.C for 2-5 hr, standing for 8-15 hr, filtering the raw materials and water through sieve plate with mesh width of 15mm and mesh length of 15mm, and concentrating the filtrate to obtain soft extract.
The semen Adenantherae Pavoninae extract is a commercially available product, is extracted from mature fruit pod of semen Adenantherae Pavoninae of Leguminosae, and has effects of caring skin.
The ormosia angustifolia extract is prepared by the following method: crushing ormosia into 60-80 meshes, adding 4-8 times of ethanol with the mass concentration of 75-90% by mass, heating and extracting for 1-3 times at 60-70 ℃ for 2-3 hours each time to obtain an extracting solution, filtering, combining filtrates, and concentrating at 60-65 ℃ under 0.07-0.078MPa for 1-2 hours to obtain the ormosia extract.
The second purpose of the invention is realized by the following technical scheme: the preparation method of the anti-aging and anti-wrinkle essence lotion is characterized by comprising the following steps:
(1) The preparation method comprises the following steps of weighing raw materials in percentage by mass:
The sum of the components is 100 percent;
(2) Heating MCT oil and cannabidiol CBD at 45-60 ℃ until the cannabidiol CBD is completely dissolved in the MCT oil, cooling to room temperature, adding HEL-40, EL-40 and glycerol, heating and dissolving at 35-45 ℃ for 6-10min, cooling to room temperature, adding a mineral concentrate diluted with water to 25-50% mass concentration, mixing uniformly, adding 1 drop of water at 30-60s, stirring at 400-800r/min until the solution turns turbid from clear to clear, stopping adding water, and continuing stirring for 10min to obtain cannabidiol CBD nanoemulsion base solution;
(5) mixing collagen, ethyl glycerol, milfoil extract and radix Gentianae extract, adding appropriate amount of water, dissolving completely at 45-65 deg.C, cooling to 25-30 deg.C, adding semen Adenantherae Pavoninae extract and PEG-400, dissolving completely, stirring at 1000-1500r/min for 10-15 min to obtain solution A;
(6) uniformly mixing polyglutamic acid, magnesium aluminum silicate, citric acid and appropriate amount of water, heating at 30-45 deg.C for 4-7min, cooling to room temperature after sufficient dissolution, adding okra extract and sodium phytate, dropwise adding p-hydroxybenzoate, stirring at 1500-2000r/min to obtain a dissolved substance B;
(5) Heating the cannabidiol CBD nanoemulsion base liquid obtained in the step (2) at 30-45 ℃ for 5-10min, and mixing the cannabidiol CBD nanoemulsion base liquid with the solute A obtained in the step (3) and the solute B obtained in the step (4) for 5-10min to obtain the anti-aging and wrinkle-removing essence liquid.
The invention has the following advantages and effects:
According to the invention, through the preparation of the cannabidiol CBD nanoemulsion base solution, the solubility and bioavailability of the cannabidiol CBD which is insoluble in water are effectively improved, and the mineral concentrate is added, so that the anti-aging and wrinkle-removing effects of essence water are enhanced, various mineral elements required by a human body are supplemented, the absorption of skin to CBD is enhanced, and the skin is effectively protected.
Detailed Description
The present invention will be further described with reference to the following examples.
Example 1
The preparation method of the anti-aging and anti-wrinkle essence lotion comprises the following steps:
(1) Preparing the following raw materials in percentage by mass:
(2) Heating MCT oil and CBD in a water bath kettle at 45 ℃ until CBD is completely dissolved in MCT oil, cooling to room temperature, adding HEL-40, EL-40 and glycerol, heating and dissolving in a water bath kettle at 35 ℃ for 10min, cooling to room temperature, adding a mineral concentrate diluted with water to 25% mass concentration, mixing uniformly, adding water at a speed of 60s dropwise adding 1 drop while stirring until the solution turns turbid from clear, stopping adding water when the solution turns clear, and continuing stirring for 10min to obtain a nano-emulsion base solution;
(3) Mixing collagen, ethyl glycerol, yarrow extract and radix Gentianae extract, adding water, dissolving completely at 55 deg.C, cooling to 30 deg.C, adding semen Adenantherae Pavoninae extract and PEG-400, and stirring at 1500r/min for 10min to obtain solution A;
(4) Uniformly mixing polyglutamic acid, magnesium aluminum silicate, citric acid and a proper amount of water, heating at 40 ℃ for 7min, fully dissolving, cooling to room temperature, adding okra extract and sodium phytate, dropwise adding p-hydroxybenzoate, and fully stirring at 1800r/min to obtain a dissolved substance B;
(5) And (3) heating the cannabidiol CBD nano emulsion base liquid in the step (2) at 30 ℃ for 10min, and mixing the cannabidiol CBD nano emulsion base liquid with the solute A in the step (3) and the solute B in the step (4) for 10min to obtain the anti-aging and anti-wrinkle essence water.
the yarrow extract is prepared by the following method: pulverizing Achillea millefolium to 60 mesh, extracting with 90% ethanol at 65 deg.C for 2 times according to the material liquid mass ratio of 1: 10, mixing extractive solutions, filtering, concentrating the filtrate to obtain extract, and making into powder with pore diameter of 85/um and specific surface area of 520m2Purifying with macroporous resin/g, eluting with 95% ethanol, collecting eluate, and concentrating to obtain thick paste.
The gentian extract is prepared by the following method: pulverizing radix Gentianae, sieving with 40 mesh sieve, extracting with 8 times of 90% ethanol at 70 deg.C for 3 times (2 hr each time), filtering, mixing filtrates, and concentrating to obtain extract.
The okra extract is prepared by the following method: pulverizing the raw materials to 60 mesh, adding 5 times of water, heating at 80 deg.C for 5 hr, standing for 8 hr, filtering the raw materials and water through sieve plate with mesh width of 15mm and mesh length of 15mm, and concentrating the filtrate to obtain soft extract.
The ormosia angustifolia extract is prepared by the following method: pulverizing semen Adenantherae Pavoninae to 60 mesh, adding 4 times of 90% ethanol, heating and extracting at 70 deg.C for 3 times (each time for 3 hr) to obtain extractive solution, filtering, mixing filtrates, and concentrating at 65 deg.C and 0.078MPa for 2 hr to obtain semen Adenantherae Pavoninae extract.
example 2
The preparation method of the anti-aging and anti-wrinkle essence lotion comprises the following steps:
(1) Preparing the following raw materials in percentage by mass:
(2) heating MCT oil and CBD in a water bath kettle at 60 ℃ until CBD is completely dissolved in MCT oil, cooling to room temperature, adding HEL-40, EL-40 and glycerol, heating and dissolving in a water bath kettle at 45 ℃ for 6min, cooling to room temperature, adding a mineral concentrate diluted with water to 50% mass concentration, mixing uniformly, adding water at a speed of dropping 1 drop in 30s while stirring until the solution turns turbid from clear, stopping adding water when the solution turns clear, and continuing stirring for 10min to obtain a nano-emulsion base solution;
(3) Mixing collagen, ethyl glycerol, yarrow extract and radix Gentianae extract, adding water, dissolving completely at 65 deg.C, cooling to 30 deg.C, adding semen Adenantherae Pavoninae extract and PEG-400, and stirring at 1500r/min for 10min to obtain solution A;
(4) Uniformly mixing polyglutamic acid, magnesium aluminum silicate, citric acid and a proper amount of water, heating at 35 ℃ for 6min, fully dissolving, cooling to room temperature, adding okra extract and sodium phytate, dropwise adding p-hydroxybenzoate, and fully stirring at the rotating speed of 1500r/min to obtain a dissolved substance B;
(5) and (3) heating the cannabidiol CBD nano emulsion base liquid in the step (2) at 45 ℃ for 5min, and mixing the cannabidiol CBD nano emulsion base liquid with the solute A in the step (3) and the solute B in the step (4) for 5min to obtain the anti-aging and anti-wrinkle essence water.
the yarrow extract is prepared by the following method: pulverizing Achillea millefolium to 120 mesh, extracting with 90% ethanol at 65 deg.C for 2 times according to the material liquid mass ratio of 1: 4, mixing extractive solutions, filtering, concentrating the filtrate to obtain extract, and making into powder with pore diameter of 90/um and specific surface area of 520m2Purifying with macroporous resin/g, eluting with 90% ethanol, collecting eluate, and concentrating to obtain thick paste.
The gentian extract is prepared by the following method: pulverizing radix Gentianae, sieving with 80 mesh sieve, extracting with 4 times of 90% ethanol at 85 deg.C for 2 times (each for 2 hr), filtering, mixing filtrates, and concentrating to obtain extract.
the okra extract is prepared by the following method: pulverizing the raw materials to 80 mesh, adding 5 times of water, heating at 80 deg.C for 2 hr, standing for 8 hr, filtering the raw materials and water through sieve plate with mesh width of 15mm and mesh length of 15mm, and concentrating the filtrate to obtain soft extract.
The ormosia angustifolia extract is prepared by the following method: pulverizing semen Adenantherae Pavoninae to 80 mesh, adding 8 times of 75% ethanol, heating and extracting at 60 deg.C for 2 times (each time for 2 hr) to obtain extractive solution, filtering, mixing filtrates, and concentrating at 65 deg.C and 0.07MPa for 1 hr to obtain semen Adenantherae Pavoninae extract.
Example 3
The preparation method of the anti-aging and anti-wrinkle essence lotion comprises the following steps:
(1) preparing the following raw materials in percentage by mass:
(2) Heating MCT oil and CBD in a water bath kettle at 50 ℃ until CBD is completely dissolved in MCT oil, cooling to room temperature, adding HEL-40, EL-40 and glycerol, heating in the water bath kettle at 40 ℃ for 6min to dissolve, cooling to room temperature, adding mineral concentrate diluted with water to 30% mass concentration, mixing uniformly, adding 1 drop of water at 40s while stirring until the solution turns turbid from clear, stopping adding water when the solution turns clear, and continuing stirring for 10min to obtain nano-emulsion base solution;
(3) Mixing collagen, ethyl glycerol, yarrow extract and radix Gentianae extract, adding water, dissolving completely at 55 deg.C, cooling to 30 deg.C, adding semen Adenantherae Pavoninae extract and PEG-400, and stirring at 1200r/min for 12 min to obtain solution A;
(4) Uniformly mixing polyglutamic acid, magnesium aluminum silicate, citric acid and a proper amount of water, heating at 40 ℃ for 5min, fully dissolving, cooling to room temperature, adding okra extract and sodium phytate, dropwise adding p-hydroxybenzoate, and fully stirring at 1800r/min to obtain a dissolved substance B;
(5) And (3) heating the cannabidiol CBD nano emulsion base liquid in the step (2) at 40 ℃ for 8min, and mixing the cannabidiol CBD nano emulsion base liquid with the solute A in the step (3) and the solute B in the step (4) for 8min to obtain the anti-aging and anti-wrinkle essence water.
the yarrow extract is prepared by the following method: pulverizing Achillea millefolium to 90 mesh, extracting with 92% ethanol at 58 deg.C for 2 times according to feed liquid mass ratio of 1: 8, mixing extractive solutions, filtering, concentrating the filtrate to obtain extract with pore diameter of 90/um and specific surface area of 500m2purifying with macroporous resin, eluting with 92% ethanol, and collecting eluateConcentrating the effluent to obtain thick paste.
the gentian extract is prepared by the following method: pulverizing radix Gentianae, sieving with 60 mesh sieve, extracting with 6 times of 92% ethanol at 81 deg.C for 2 times, each for 2 hr, filtering, mixing filtrates, and concentrating to obtain extract.
The okra extract is prepared by the following method: pulverizing the raw materials to 70 mesh, adding 4 times of water, heating at 70 deg.C for 3 hr, standing for 12 hr, filtering the raw materials and water through sieve plate with mesh width of 15mm and mesh length of 15mm, and concentrating the filtrate to obtain soft extract.
the ormosia angustifolia extract is prepared by the following method: pulverizing semen Adenantherae Pavoninae to 70 mesh, adding 6 times of 80% ethanol, heating and extracting at 65 deg.C for 2 times (each time for 2 hr) to obtain extractive solution, filtering, mixing filtrates, and concentrating at 62 deg.C and 0.075MPa for 2 hr to obtain semen Adenantherae Pavoninae extract.
Example 4
The preparation method of the anti-aging and anti-wrinkle essence lotion comprises the following steps:
(1) Preparing the following raw materials in percentage by mass:
(2) Heating MCT oil and CBD in a water bath kettle at 55 ℃ until CBD is completely dissolved in MCT oil, cooling to room temperature, adding HEL-40, EL-40 and glycerol, heating in the water bath kettle at 40 ℃ for 7min to dissolve, cooling to room temperature, adding a mineral concentrate diluted with water to 45 mass%, mixing uniformly, adding water at a speed of 50s dropwise adding 1 drop while stirring, stirring at a stirring speed of 500r/min until the solution turns turbid from clarification, stopping adding water when the solution becomes clear, and continuing stirring for 10min to obtain a nano-emulsion base solution;
(3) Mixing collagen, ethyl glycerol, yarrow extract and radix Gentianae extract, adding water, dissolving completely at 60 deg.C, cooling to 28 deg.C, adding semen Adenantherae Pavoninae extract and PEG-400, and stirring at rotation speed of 1400r/min for 13 min to obtain solution A;
(4) Uniformly mixing polyglutamic acid, magnesium aluminum silicate, citric acid and a proper amount of water, heating at 38 ℃ for 5min, fully dissolving, cooling to room temperature, adding okra extract and sodium phytate, dropwise adding p-hydroxybenzoate, and fully stirring at the rotating speed of 1700r/min to obtain a dissolved substance B;
(5) and (3) heating the cannabidiol CBD nano emulsion base liquid in the step (2) at 40 ℃ for 7min, and mixing the cannabidiol CBD nano emulsion base liquid with the solute A in the step (3) and the solute B in the step (4) for 7min to obtain the anti-aging and anti-wrinkle essence water.
The yarrow extract is prepared by the following method: pulverizing Achillea millefolium to 100 mesh, extracting with 95% ethanol at 60 deg.C for 2 times at a material liquid mass ratio of 1: 9, mixing extractive solutions, filtering, concentrating the filtrate to obtain extract with aperture of 85/um and specific surface area of 500m2Purifying with macroporous resin/g, eluting with 90% ethanol, collecting eluate, and concentrating to obtain thick paste.
the gentian extract is prepared by the following method: pulverizing radix Gentianae, sieving with 50 mesh sieve, extracting with 7 times of 90% ethanol at 85 deg.C for 3 times, each for 1 hr, filtering, mixing filtrates, and concentrating to obtain extract.
The okra extract is prepared by the following method: pulverizing the raw materials to 65 mesh, adding 4 times of water, heating at 70 deg.C for 4 hr, standing for 12 hr, filtering the raw materials and water through sieve plate with mesh width of 15mm and mesh length of 15mm, and concentrating the filtrate to obtain soft extract.
The ormosia angustifolia extract is prepared by the following method: pulverizing semen Adenantherae Pavoninae to 65 mesh, adding 7 times of 80% ethanol, heating and extracting at 65 deg.C for 2 times (3 hr each time) to obtain extractive solution, filtering, mixing filtrates, and concentrating at 62 deg.C and 0.076MPa for 2 hr to obtain semen Adenantherae Pavoninae extract.
Example 5
The preparation method of the anti-aging and anti-wrinkle essence lotion comprises the following steps:
(1) Preparing the following raw materials in percentage by mass:
(2) heating MCT oil and CBD in a water bath kettle at 55 ℃ until CBD is completely dissolved in MCT oil, cooling to room temperature, adding HEL-40, EL-40 and glycerol, heating in the water bath kettle at 35 ℃ for 8min to dissolve, cooling to room temperature, adding a mineral concentrate diluted with water to 45 mass%, mixing uniformly, adding water at a speed of 50s dropwise adding 1 drop while stirring, stirring at a stirring speed of 500r/min until the solution turns turbid from clarification, stopping adding water when the solution becomes clear, and continuing stirring for 10min to obtain a nano-emulsion base solution;
(3) mixing collagen, ethyl glycerol, yarrow extract and radix Gentianae extract, adding water, dissolving completely at 55 deg.C, cooling to 25 deg.C, adding semen Adenantherae Pavoninae extract and PEG-400, dissolving, and stirring at 1600r/min for 12 min to obtain solution A;
(4) uniformly mixing polyglutamic acid, magnesium aluminum silicate, citric acid and a proper amount of water, heating at 42 ℃ for 7min, fully dissolving, cooling to room temperature, adding okra extract and sodium phytate, dropwise adding p-hydroxybenzoate, and fully stirring at the rotating speed of 2000r/min to obtain a dissolved substance B;
(5) and (3) heating the cannabidiol CBD nano emulsion base liquid in the step (2) at 45 ℃ for 6min, and mixing the cannabidiol CBD nano emulsion base liquid with the solute A in the step (3) and the solute B in the step (4) for 6min to obtain the anti-aging and anti-wrinkle essence water.
the yarrow extract, the gentian extract, the okra extract and the ormosia angustifolia extract are all commercially available products.
third, Experimental example
The invention is tested by the following test examples to test the safety of the product
experimental example I, examination of microorganisms
The detection method comprises the following steps: refer to technical Specification for safety of cosmetics 2015 year edition
Evaluation indexes are as follows: microbiological examination method according to technical Specification for safety of cosmetics 2015
Detection indexes are as follows:
And (3) detection results:
Evaluation criteria
the detection result of the microorganism shows that all indexes of the microorganism accord with the technical standard for cosmetic safety, and the judgment is as follows: the results of the technical detection of the total number of bacteria and the detection of heat-resistant coliform group bacteria, staphylococcus aureus, pseudomonas aeruginosa, mold and yeast of the nanoemulsion type essence water preparations containing cannabidiol CBD active ingredients and mineral substances in examples 1-5 all meet the national standard.
Experiment example two: human body experiment
120 test volunteers of 25-50 years old are randomly selected and divided into 6 groups (half of male and half of female in each group), and the test parts have no abnormality and no obvious scars or injuries. After cleaning the skin, 3 test area marks are respectively selected on the face of the volunteer, and the area of each test area is 2 x 2cm2The test areas are spaced at least 2cm apart. And (3) uniformly applying 2-3 ml of essence water to be tested on the surface of the skin, massaging until the essence water is absorbed, and applying the essence water once a day. (comparative example a common wrinkle-removing essence on the market was used for comparison) the skin wrinkle tester was used to measure the effect test indexes before and after use: skin tenderness, wrinkle depth, statistics of test results after 1 month, as shown in the following table:
And (3) testing results:
from the table, the nanoemulsion, the CBD and the mineral concentrate are integrated, have a synergistic effect, not only solve the problem that the CBD is difficult to dissolve in water, but also improve the bioavailability of the CBD and enhance the anti-aging and anti-wrinkle effects of the CBD. And no allergy phenomenon appears in the experiment, which shows that the product is suitable for various skins and has better anti-wrinkle and anti-aging effects.
Claims (6)
1. the anti-aging and anti-wrinkle essence lotion is characterized by being prepared from the following raw materials in percentage by mass:
Cannabidiol CBD 2% -20%
MCT oil 3-10%
2 to 20 percent of mineral concentrated solution
1% -2% of collagen
hydrogenated castor oil polyoxyethylene ether-401-6%
Ethyl glycerol 1% -2%
401 to 6 percent of castor oil polyoxyethylene ether
0.03-0.05% of gentian extract
0.1 to 0.5 percent of p-hydroxybenzoate ester
Achillea millefolium extract 0.4% -0.8%
1 to 7 percent of glycerin
0.05 to 0.1 percent of polyglutamic acid
PEG-400 1%-2%
0.1 to 0.5 percent of citric acid
Sodium phytate 0.5-2%
0.5 to 2 percent of magnesium aluminum silicate
Okra extract 0.5-1%
Semen Adenantherae Pavoninae extract 0.01% -0.05%
Balance of water
the sum of the above components is 100%.
2. The preparation method of the anti-aging and anti-wrinkle essence lotion is characterized by comprising the following steps:
(1) The preparation method comprises the following steps of weighing raw materials in percentage by mass:
Cannabidiol CBD 2% -20%
MCT oil 3-10%
2 to 20 percent of mineral concentrated solution
1% -2% of collagen
Hydrogenated castor oil polyoxyethylene ether-401-6%
Ethyl glycerol 1% -2%
401 to 6 percent of castor oil polyoxyethylene ether
0.03-0.05% of gentian extract
0.1 to 0.5 percent of p-hydroxybenzoate ester
Achillea millefolium extract 0.4% -0.8%
1 to 7 percent of glycerin
0.05 to 0.1 percent of polyglutamic acid
PEG-400 1%-2%
0.1 to 0.5 percent of citric acid
Sodium phytate 0.5-2%
0.5 to 2 percent of magnesium aluminum silicate
okra extract 0.5-1%
Semen Adenantherae Pavoninae extract 0.01% -0.05%
Balance of water
The sum of the components is 100 percent;
(2) Heating MCT oil and cannabidiol CBD at 45-60 ℃ until the cannabidiol CBD is completely dissolved in the MCT oil, cooling to room temperature, adding HEL-40, EL-40 and glycerol, heating and dissolving at 35-45 ℃ for 6-10min, cooling to room temperature, adding a mineral concentrate diluted with water to 25-50% mass concentration, mixing uniformly, adding 1 drop of water at 30-60s, stirring at 400-800r/min until the solution turns turbid from clear to clear, stopping adding water, and continuing stirring for 10min to obtain cannabidiol CBD nanoemulsion base solution;
(3) Mixing collagen, ethyl glycerol, milfoil extract and radix Gentianae extract, adding appropriate amount of water, dissolving completely at 45-65 deg.C, cooling to 25-30 deg.C, adding semen Adenantherae Pavoninae extract and PEG-400, dissolving completely, stirring at 1000-1500r/min for 10-15 min to obtain solution A;
(4) uniformly mixing polyglutamic acid, magnesium aluminum silicate, citric acid and appropriate amount of water, heating at 30-45 deg.C for 4-7min, cooling to room temperature after sufficient dissolution, adding okra extract and sodium phytate, dropwise adding p-hydroxybenzoate, stirring at 1500-2000r/min to obtain a dissolved substance B;
(5) Heating the cannabidiol CBD nanoemulsion base liquid obtained in the step (2) at 30-45 ℃ for 5-10min, and mixing the cannabidiol CBD nanoemulsion base liquid with the solute A obtained in the step (3) and the solute B obtained in the step (4) for 5-10min to obtain the anti-aging and wrinkle-removing essence liquid.
3. The anti-wrinkle essence lotion according to claim 1, wherein the yarrow extract is prepared by the following method: pulverizing Achillea millefolium to 60-120 mesh, extracting with 90-95% ethanol at 50-65 deg.C for 2-3 times according to the material liquid mass ratio of 1: 4-10, mixing extractive solutions, filtering, concentrating the filtrate to obtain extract, and making into powder with pore diameter of 85-90/um and specific surface area of 480-520m2 Purifying with macroporous resin per gram, eluting with 90-95% ethanol, collecting eluate, and concentrating to obtain thick paste.
4. The anti-wrinkle essence lotion according to claim 1, wherein the gentian extract is prepared by the following method: pulverizing radix Gentianae, sieving with 40-80 mesh sieve, extracting with 4-8 times of 90-95% ethanol at 70-85 deg.C for 2-3 times, each for 1-2 hr, filtering, mixing filtrates, and concentrating to obtain extract.
5. the anti-wrinkle essence lotion according to claim 1, wherein the okra extract is prepared by the following method: pulverizing the raw materials to 60-80 mesh, adding 3-5 times of water, heating at 60-80 deg.C for 2-5 hr, standing for 8-15 hr, filtering the raw materials and water through sieve plate with mesh width of 15mm and mesh length of 15mm, and concentrating the filtrate to obtain soft extract.
6. The anti-wrinkle essence lotion according to claim 1, wherein the ormosia angustifolia extract is prepared by the following method: crushing ormosia into 60-80 meshes, adding 4-8 times of ethanol with the mass concentration of 75-90% by mass, heating and extracting for 1-3 times at 60-70 ℃ for 2-3 hours each time to obtain an extracting solution, filtering, combining filtrates, and concentrating at 60-65 ℃ under 0.07-0.078MPa for 1-2 hours to obtain the ormosia extract.
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| CN201910895713.1A CN110559230A (en) | 2019-09-21 | 2019-09-21 | Anti-aging and anti-wrinkle essence lotion and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111494466A (en) * | 2020-01-14 | 2020-08-07 | 四川大学华西医院 | A topical composition containing Cannabis sativa extract and its application |
| CN112402322A (en) * | 2020-11-30 | 2021-02-26 | 黄丹 | Facial mask liquid capable of promoting expression of aquaporins AQP3 and AQP9 |
| CN112569155A (en) * | 2020-12-30 | 2021-03-30 | 上海澄穆化妆品有限公司 | Extraction method and application of yarrow extract |
-
2019
- 2019-09-21 CN CN201910895713.1A patent/CN110559230A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111494466A (en) * | 2020-01-14 | 2020-08-07 | 四川大学华西医院 | A topical composition containing Cannabis sativa extract and its application |
| CN112402322A (en) * | 2020-11-30 | 2021-02-26 | 黄丹 | Facial mask liquid capable of promoting expression of aquaporins AQP3 and AQP9 |
| CN112569155A (en) * | 2020-12-30 | 2021-03-30 | 上海澄穆化妆品有限公司 | Extraction method and application of yarrow extract |
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