CN1091764C

CN1091764C - 杀虫的硫化合物

Info

Publication number: CN1091764C
Application number: CN96195856A
Authority: CN
Inventors: 帕特里克·D·洛德; 戴维·T·曼宁; 珍妮弗·L·菲利普斯; 迈克尔·T·派拉托; 吴泰特
Original assignee: Rhone Poulenc Agrochimie SA
Current assignee: BASF open Limited by Share Ltd
Priority date: 1995-06-05
Filing date: 1996-05-31
Publication date: 2002-10-02
Anticipated expiration: 2016-05-31
Also published as: AU716967B2; EP0837852A1; HU222278B1; GR3035306T3; BR9608379A; CN1192203A; IL118481A; AR002324A1; JPH11506461A; ES2153581T3; EA199700436A1; PT837852E; JP4104163B2; KR100416288B1; ATE198886T1; CA2222936C; DE69611677T2; EA000645B1; HUP9801051A2; AU6004296A

Abstract

具有式(I)或(II)的吡唑、吡咯和咪唑衍生物，其中＝X是＝NR³、＝O或电子对且Q包含某些吡唑、吡咯和咪唑结构和在说明书中定义的余下的取代基，这些衍生物用于防治节肢动物、线虫、蠕虫或原虫害虫。

Description

杀虫的硫化合物

本发明涉及新的硫化合物[包括其硫亚胺和亚砜亚胺(sulfoximine)中间体]和这些化合物的制备方法。本发明还涉及所述化合物的组合物和使用所述的化合物防治节肢动物、线虫、蠕虫或原虫害虫的方法。具体地说，本发明涉及这些化合物或其组合物在农业使用方法中的应用，特别是作为农药的应用。

在本说明书中，“硫亚胺”一词是指包含基团的化合物。在本说明书中，“亚砜亚胺”一词是指包含

的化合物。

业已公开了各种杀虫的吡唑类、吡咯类和咪唑类：欧洲专利公开EP418016；欧洲专利公开EP403309；美国专利5,104,994；欧洲专利公开EP352944；美国专利5,079,370；美国专利5,047,550；美国专利5,232,940；美国专利4,810,720；美国专利4.804,675；美国专利5,306,694；美国专利4,614,533；WPO公开WO93/06089；和WPO公开WO94/21606描述了杀虫的(4-吡唑基)硫化物、亚砜类和砜类。美国专利5,187,185描述了4-吡咯基硫化物、亚砜类和砜类。美国专利5,223,525描述了杀虫的4-咪唑基硫化物、亚砜类和砜类。

由于存在许多的害虫和作物及其被害虫所侵害的病症，因此仍需要新颖的杀虫化合物。

一方面，本发明提供用于防治节肢动物、线虫、蠕虫和原虫害虫的化合物，所述的化合物具有下述通式：

其中

＝X是＝NR³、＝O或电子对(在这种情况下，应理解为另一种代表式I的方式是删除＝X)；

R¹是C₁-C₆烷基、C₃-C₆环烷基或C₄-C₈(环烷基)烷基，它们各任选由一或多个卤素取代；

R²和R³相互独立地选自：H；C₁-C₆烷基；C₁-C₆卤代烷基；COR⁴；S(O)_pR⁴；CN；NO₂；COOR⁴；CONR⁴R⁵；C(O)SR⁴；C(S)OR⁴；SO₂NR⁴R⁵；P(O)_q(R⁴)(R⁵)；P(O)_q(OR⁴)(R⁵)；P(O)_q(OR⁴)(OR⁵)；C＝(NR⁴)NR⁵R⁶；CH＝NR⁴；C＝(NR⁴)(OR⁵)；C(S)N(R⁴)(R⁵)；C(O)C(O)R⁴；C(O)C(O)OR⁴；C(O)C(O)NR⁴R⁵；和CONR⁴SO₂R⁵；

m是1或2；

p是0、1或2；

q是0或1；R⁴、R⁵和R⁶相互独立地选自H；NO₂；CN；CHO；R¹⁴；苯基，它任选由一或多个下列基团取代：R¹⁴、卤素、CN、NO₂、OR¹⁴、SR¹⁴、COR¹⁴、COOR¹⁴或OR¹⁴；卤素；COR¹⁴；COOR¹⁴；CHO；和OH；

Q是如下所定义的Q-1、Q-2或Q-3：

R⁷是CN、NO₂、H、C₁-C₄烷基、C₁-C₄卤代烷基、卤素、CHO或COR²⁰；

R⁸是H、卤素、CN、S(O)_pR¹⁴、OR¹⁴、NR¹⁶R¹⁷、N(R¹⁶)CON(R¹⁷)(R¹⁸)、N₃或由一或多个下列基团取代的NH(C₁-C₅烷基)：OH、OR¹⁴、S(O)_pR¹⁴、CN、NO₂、COOR¹或CON(R¹⁶)(R¹⁷)；

R⁹和R¹¹相互独立地选自：H、卤素、R¹⁴、OR¹⁴、SR¹⁴和R¹⁴；

R¹⁰是CN；

R¹²是H、卤素、R¹⁴、OR¹⁴、S(O)_pR¹⁴或

R¹³是H、卤素或R¹⁴；

Ar是苯基、任选带有一或多个选自卤素、R¹⁴、OR¹⁵、SF₅和S(O)_pR¹⁵的取代基；或Ar是2-吡啶基，任选带有一或多个选自卤素、R¹⁵、OR¹⁵、SF₅和S(O)_pR¹⁵的取代基；

R¹⁴和R¹⁹相互独立地选自：C₁-C₆烷基、C₃-C₆环烷基和C₄-C₈(环烷基)烷基，它们各任选由一或多个卤素取代；

R¹⁵是C₁-C₆烷基，任选由一或多个卤素取代；

R¹⁶、R¹⁷和R¹⁸相互独立地选自：H、NO₂、CN、CHO、R¹⁹、COR¹⁹和COOR¹⁹；

R²⁰选自C₁-C₆-烷基，任选由一或多个卤素取代；和

Z是阴离子抗衡离子，如Cl^-、Br^-、I^-、F^-、OSO₂R⁴、ClO^4-、OCOR^-、BF₄ ^-、SbF₆ ^-、SO₃ ^-或HSO₄ ^-，磷酸根阴离子(phosphate anion)或磷酸氢根阴离子(hydrogenophosphate anion)或其它农业上可接受的阴离子。

式(I)或式(II)的立体异构体，例如非对映异构体或光学异构体也包括于本发明中。

本发明优选的化合物包括一或多个下列特点：

(1)R¹是任选卤代的C₁-C₆烷基，优选是甲基或乙基；和/或

(2)R²是H、COOR⁴、S(O)_pR⁴、CONR⁴R⁵、CN、COR⁴、P(O)_q(OR⁴)(OR⁵)、P(O)_q(R⁴)(R⁵)；更优选的是，R²是H或CN或COOR⁴(其中R⁴是C₁-C₆烷基)；或R²是S(O)_pR⁴(其中p是2且R⁴是C₁-C₆烷基或任选取代的苯基)；或R²是CONR⁴R⁵(其中R⁴是H或C₁-C₆烷基且是R⁵是C₁-C₆烷基，或其中R⁴是H且R⁵是COR¹⁴(其中R¹⁴是任选卤代的C₁-C₆烷基)；或R²是COR⁴(其中R⁴是H或C₁-C₆-烷基)；或R²是P(O)_q(OR⁴)(OR⁵)或P(O)_q(R⁴)(R⁵)(其中q是1且R⁴和R⁵各是C₁-C₆烷基)；和/或

(3)Q是Q-1，优选其中R⁷是CN或H或C₁-C₄烷基和/或其中R⁸是N(R¹⁶)(R¹⁷)，最优选其中R⁸是NH₂；和/或

(4)Ar是苯基，该苯基在2位和6位由卤素取代和在4位上由卤代的C₁-C₆烷基或SF₅或OR¹⁵取代，优选的是，Ar是2，6-二氯-4-三氟甲基苯基；或Ar是2-吡啶基，该吡啶基在3位上由卤素取代或在5位上由卤代C₁-C₆-烷基或SF₅或OR¹⁵取代，优选的是Ar是3-氯-5-三氟甲基吡啶-2-基。

另一方面，本发明提供杀虫组合物(即，杀节肢动物、杀线虫、抗蠕虫或抗原虫组合物)包含杀虫有效量的(即，杀节肢动物有效量、杀线虫有效量、抗蠕虫有效量或抗原虫有效量)的式(I)或(II)化合物和其农业上可接受的盐。用于此及整个申请中的“式(I)或(II)化合物”的表述将式(I)或(II)及其盐的各种立体异构体形式包括在其范围内。

再一方面，本发明提供在一地点防治节肢动物、线虫、蠕虫或原虫的方法，所述的方法包含向所述的地点施用杀虫有效量(即，杀节肢动物有效量、杀线虫有效量、抗蠕虫有效量或抗原虫有效量)的式(I)或(II)化合物或上面定义的杀虫组合物。

式(I)(其中X是O且R²不是H)化合物由式(I)(其中X是电子对且R²不是H)化合物[所述的式(I)化合物也是本发明的一部分]通过本领域技术人员本身已知的方法，将硫原子氧化成亚砜亚胺基团而制备。这种转变可以用各种氧化剂，包括(但不限于)过锰酸钾、高碘酸钠和四氧化钌。可以在普通的溶剂如水、醚类例如二噁烷、腈类例如乙腈，或卤代烃如二氯甲烷、氯仿、四氯化碳等中，在约-100℃至约100℃间的温度下，优选在约0℃至约50℃下进行这种转变。这些化学方法可类似于见于(《四面体》[Tetrahedron]，1975，31，305)的方法。

式(I)化合物(其中X是电子对且R²不是氢)可以由式(II)化合物，在碱存在下，通过与适宜的亲电试剂R²-L反应而制备。R²具有上面给出的含意，只是它不是H，且L是离去基团。离去基团L的实例是卤离子、乙酸根、苯基磺酸根、烷基磺酸根和苯氧基基团。可以用于反应的碱的实例是氢化钠、三乙胺和叔丁醇钾。

这些反应可以在各种普通的溶剂中进行，溶剂如(但不限于)醚类如四氢呋喃或二噁烷；水；卤代烃类如二氯甲烷或氯仿；腈类如乙腈等等。这些反应可以在约-100℃至100℃间的温度下进行，但优选在约0℃至溶剂的沸点温度下。

式(I)化合物(其中X是电子对且其中R²是H)可以通过常规的水解，由相应的式(I)化合物(其中R²是成酯基团COOR¹⁴)制备。

式(II)化合物可以根据本领域技术人员已知的方法，由式(III)化合物胺化而制备。

此化学法可以通过将式(III)的硫化物与胺化试剂混合来进行。所述的胺化试剂例如(但不限于)O-苯甲酰基羟胺，例如O-(2，4，6-三甲基苯甲酰基)羟胺或O-(3-氯苯甲酰基)羟胺；O-磺酰基羟胺如(但不限于)羟胺磺酸或O-(2，4，6-三异丙基苯磺酰基)羟胺；或O-氧膦基羟胺(O-phosphinic hydroxylamine)如O-(二苯基氧膦基)羟胺。此方法可以在各种溶剂中进行，溶剂包括(但不限于)水、卤代烃如二氯甲烷、氯仿、二氯乙烷等，和芳族溶剂如苯、甲苯、二甲苯类等，且可以在约-100℃至约100℃之间的温度下进行，优选在0℃至溶剂的沸点温度之间的温度下进行。此化学法类似于见于A/drichimicaActa，1980，13(1)3)中的方法。

式(I)(其中X是NH且R²是H)化合物可以可以通过式(III)化合物与氯胺反应而制备[《四面体》[Tetrahedron]，1970，51，4449]。此反应可以在氨中，在约-100℃至-33℃之间的温度下进行。

式(I)[其中＝X是＝NR³(其中R³是如上所定义，只是它不是氢)且R²是H]化合物，可以通过在碱存在下，由式(I)(其中＝X是NH且R²是H)化合物与适宜的亲电试剂R³-L反应而获得。R³如上所定义，只是它不是氢，且L是离去基团。离去基团L的实例是卤离子、乙酸根、苯基磺酸根、烷基磺酸根和苯氧基基团。可以用于反应的碱的实例是氢化钠、三乙胺和叔丁醇钾。

这些反应可以在各种普通溶剂中进行，溶剂例如(但不限于)醚类如四氢呋喃或二噁烷；水；卤代烃如二氯甲烷或氯仿；腈类如乙腈等。这些反应可以在约-100℃至约100℃之间的温度下进行，优选在0℃至溶剂的沸点温度之间的温度下进行。相似的反应可见于《比利时化学》((Chem.Ber)，1984，117，2779)。

式(I)(其中(＝X是＝NR³其中R²和R³相同且均不是氢)化合物可以在碱存在下，由式(I)(其中R²是H且X是NH)化合物与至少二当量的适宜的亲电试剂R³-L反应而获得。R³具有上文中给定的含意，只是不是氢，且L是离去基团。离去基团L的实例是卤离子、乙酸根、苯基磺酸根、烷基磺酸根和苯氧基基团。可以用于反应的碱的实例是氢化钠、三乙胺和叔丁醇钾。

这些反应可以在各种普通溶剂中进行，溶剂例如(但不限于)醚类如四氢呋喃或二噁烷；水；卤代烃如二氯甲烷或氯仿；腈类如乙腈等。这些反应可以在约-100℃至约100℃之间的温度下进行，优选在0℃至溶剂之间的沸点温度下进行。相似的反应可见于(Lieb.Ann.Chem.，1972，759，107)。

式(III)化合物是本领域已知的。例如其中Q是Q-1的那些化合物描述于下列文献中：欧洲专利公开418016；欧洲专利公开403309；美国专利5,104,994；欧洲专利公开EP 352944；美国专利5,079,370；美国专利5,047,550；美国专利5,232,940；美国专利4,810,720；美国专利4,804,675；美国专利5,306,694；美国专利4,614,533；WPO公开WO93/06089；和WPO公开WO94/21606。其中Q是Q-2的式(III)化合物描述于美国专利5,187,185中。其中Q是Q-3的化合物描述于美国专利5,223,525中。

在上文中描述的许多转变中，选择的取代基或许会偶而干预所构思的反应，这点是显而易见的。这些负面作用可以通过使用适宜的保护基团，阻止不利的副反应来避免。也可以不影响除那些欲改变的官能团之外的官能团的反应剂。具体地选择适宜的保护基团和试剂是本领域技术人员易于理解的。《美国化学文摘》[Chemical Abstracts]被认为且建议作为本领域技术人员的知识构成。

为进一步说明本发明及其优点，给出下列具体实施例，这些实施例应理解为只用作说明的目的，而非以任何方式限制本发明的范围。

实施例1

2，4，6-三甲基苯磺酸，与S-4-[5-氨基-3-氰基-1-(2，6-二氯-4-三氟甲基)苯基]吡唑基-S-乙基硫亚胺的化合物：

O-亚基磺酰基乙酰氧肟酸乙酯(10克，0.035摩尔)溶解于二噁烷(10毫升)中，并冷却至0℃。加入70％的高氯酸(3.3毫升，0.038摩尔)，并将混合物搅拌10分钟。加入水(200毫升)，滤出余下的固体，用水洗涤，之后溶解于二氯甲烷(50毫升)中，并与水相分离。

将5-氨基-3-氰基-1-(2，6-二氯-4-三氟甲基)苯基-4-乙硫基吡唑(10.7克，0.028摩尔)溶解于二氯甲烷(50毫升)中，将所得的溶液冷却至0℃。加入上段中的溶液。在0℃且之后在室温下搅拌1小时后，去除二氯甲烷，加入乙醚(200毫升)。滤出所得的固体，给出标题化合物，为白色固体(12.45克，75％)，熔点约193℃。

以相似的方式，制备下列化合物：2，4，6-三甲基苯磺酸，与S-4-[5-氨基-3-氰基-1-(2，6-二氯-4-三氟甲基)苯基]吡唑基-S-甲基硫亚胺的化合物，熔点约180℃，下文称作实施例1a；2，4，6-三甲基苯磺酸，与S-4-[5-氨基-1-(2，6-二氯-4-三氟甲基)苯基]吡唑基-S-甲基硫亚胺的化合物，熔点约187℃，下文称作实施例1b。

下面的二个化合物也由上面的方法(但不分离)制备，用作实施例2：2，4，6-三甲基苯磺酸，与S-4-[5-氨基-1-(2，6-二氯-4-三氟甲基)苯基-3-甲基]吡唑基-S-乙基硫亚胺的化合物和2，4，6-三甲基苯磺酸，与S-4-[5-氨基-1-(2，6-二氯-4-三氟甲基)苯基-3-乙基]吡唑基-S-乙基硫亚胺的化合物。

实施例2

S-{[5-氨基-3-氰基-1-(2，6-二氯-4-三氟甲基)苯基]-4-(1H-吡唑基)}-S-乙基-N-(叔丁氧基羰基)硫亚胺：

将实施例1的产物(1.0克，1.7毫摩尔)于二氯甲烷(10毫升)中搅拌，冷却至0℃，并加入三乙胺(1.2毫升，8.5毫摩尔)。加入二叔丁基二碳酸酯(0.6毫升，2.6毫摩尔)，并将反应搅拌50分钟。混合物用乙醚稀释，用水(3×50毫升)和饱和氯化钠水溶液(75毫升)洗涤。将有机层干燥，过滤并浓缩。所得的油状物与冷戊烷混合，并滤出沉淀。将固体物与滤液合并，去除溶剂，使的油状物与冷戊烷混合，并滤出沉淀。将固体物与滤液合并，去除溶剂，使用2∶3的乙酸乙酯∶己烷作洗脱液，将油状物经硅胶过滤。去除溶剂后，由乙醚/戊烷沉淀，给出标题化合物，为白色固体(0.36克，43％)，熔点约191℃。

用相似的方式，制备下列的化合物(表1)。

表1

实施例 #R¹ R² R⁷ 熔点3 Et COMe CN 约163℃4 Et COOMe CN 约200℃5 Et SO₂Me CN 约191℃6 Et CONHMe CN 约187℃7 Et CN CN 约175℃8 Et CHO CN 约181℃9 Me COMe CN 约159℃10 Et PO(OEt)₂ CN 胶11 Et CON(Me)₂ CN 约173℃12 Et PO(Me)₂ CN 约150℃13 Et CONHCOCCl₃ CN 约116℃14 Et CONHCOCH₂Cl CN 约159℃15 Et C(S)NHMe CN 约90℃

表1(续)实施例 #R¹ R² R⁷ 熔点16 Et CONHCH₂COOEt CN 约91℃17 Me C(S)NHMe CN 约95℃18 Et CONHCOOEt CN 约167℃19 Me CHO CN 约160℃20 Me CN CN 约181℃21 Me C(O)C(O)Me CN 约204℃22 Me COOtBu CN 约196℃23 Me CHO H 约199℃24 Me COMe H 约181℃25 Me CN H 约182℃26 Et CHO Me 约159℃27 Et CN Me 约67℃28 Et CHO Et 胶29 Et CN Et 约64℃

实施例30

N-(叔丁氧基羰基)-S-4-[5-氨基-3-氰基-1-(2，6-二氯-4-三氟甲基)苯基吡唑基]-S-乙基亚砜亚胺：

将实施例2的产物(1.55克，31毫摩尔)溶解于1∶1的乙腈∶四氯化碳的混合物(19毫升)。加入偏高碘酸钠(2.7克，12.4毫摩尔)的水(19毫升)溶液。加入氯化钌(III)水合物(20毫克，用于原位产生四氧化物)和乙腈(25毫升)。2小时后，加入另一份高碘酸钠(1.8克，8.2毫摩尔)和氯化钌(III)水合物(15毫克，用于原位产生氧化物)，并将反应搅拌30分钟。之后依次加入水(100毫升)和乙醚(100毫升)和异丙醇(2毫升)，并混合。分离有机相，接着用水(100毫升)和饱和氯化钠水溶液(100毫升)洗涤。在经硫酸镁干燥后，将混合物过滤，去除溶剂，提供油状残留物，将之用冷乙醚和二氯甲烷研磨，给出标题化合物，为棕色胶状固体(0.94克，60％)。于CDCl₃中的质子核磁共振谱具有下列化学位移：7.81(m，2H)；5.57(brs，2H)；3.7-3.5(m，2H)；1.44(s，9H)；1.39(t，3H)。

用相似的方式，制备出N-乙酰基-S-4-[5-氨基-3-氰基-1-(2，6-二氯-4-三氟甲基)苯基吡唑基]-S-乙基亚砜亚胺(熔点约217℃)，下文称作实施例30a。

实施例31

S-4-[5-氨基-3-氰基-1-(2，6-二氯-4-三氟甲基)苯基吡唑基]-S-乙基亚砜亚胺：

将实施例30的产物(0.1克，0.2毫摩尔)溶解于2毫升乙腈中。将粉末状分子筛(0.1克)、碘化钠(0.07克，0.46毫摩尔)和氯三甲基硅烷(0.06毫升，0.46毫摩尔)合并于2毫升乙腈中，并将之加入至上述溶液中。25分钟后，将混合物用乙醚(7毫升)稀释，接着用水、10％盐酸水溶液和饱和氯化钠水溶液洗涤。有机相经硫酸钠干燥，过滤并减压浓缩。残留的油状物用冷戊烷和二氯甲烷研磨，留下所需的产物，为黄色固体(46毫克)，熔点约86℃。

实施例32

S-[5-氨基-3-氰基-1-(2，6-二氯-4-三氟甲基)苯基-4-(1H-吡唑基)]-S-甲基-N-[(4-甲基苯基)磺酰基]硫亚胺：

向搅拌着的5-氨基-1-(2，6-二氯-4-三氟甲基)苯基-4-甲硫基-1H-吡唑-3-腈(0.99克，2.7毫摩尔)的乙腈(25毫升)溶液，经2分钟，加入N-氯-对甲苯磺酰胺钠盐水合物(Chloramine-T水合物)(0.61克，2.7毫摩尔)于水(5毫升)中的水溶液。搅拌于室温下继续大约2小时，之后将混合物用蒸汽浴加热至沸腾1小时。在减压下去除挥发物，并将残留物于硅胶上层析，洗脱用3∶1的乙酸乙酯/己烷，给出0.81克标题化合物，为固体，熔点约197℃。

实施例33

S-4-[5-氨基-3-氰基-1-(2-(3-氯5-三氟甲基)吡啶基)吡唑基]-S-乙基亚砜

将O-亚基磺酰基乙酰氧肟酸乙酯(0.47克，1.64毫摩尔)溶解于二噁烷(1毫升)中，并冷却至0℃。加入70％的高氯酸(0.5毫升)，并将混合物搅拌10分钟。加入水中，滤出余下固体，用水洗涤，之后溶解于二氯甲烷中，并与水相分离。

将5-氨基-3-氰基-1-(2-(3-氯-5-三氟甲基)吡啶基)-4-乙基亚磺酰基吡唑(0.5克，1.37毫摩尔)溶解于二氯甲烷(25毫升)，并将所得的溶液冷却至0℃。加入上段中的溶液。一月后，将混合物浓缩至固体，且反复洗涤，直到无原料吡唑留下。由此给出标题化合物，为白色固体，熔点约193℃。

进一步的说明性本发明具体化合物给出下列表格2-5中。在整个表中，标志“¨”用于表示单独电子对。

表2R¹ R⁷ R⁸ NR² XMe CN NH₂ NCOEtMe CN NH₂ NCOPrMe CN NH₂ NCOiPrMe CN NH₂ NCOtBuMe CN NH₂ NCOPhMe CN NH₂ NSO₂EtMe CN NH₂ NSO₂PhMe CN NH₂ NSO₂PrMe CN NH₂ NSO₂iPrMe CN NH₂ NNO₂Me CN NH₂ NCOOEtMe CN NH₂ NCOOPh

表2(续)R¹ R⁷ R⁸ NR² XMe CN NH₂ NCOOPrMe CN NH₂ NCOOiPrMe CN NH₂ NCONHEtMe CN NH₂ NCONHPrMe CN NH₂ NCONHiPr ¨Me CN NH₂ NCOSMeMe CN NH₂ NCOSEtMe CN NH₂ NCSOMeMe CN NH₂ NCSOEtMe CN NH₂ NCSOPrMe CN NH₂ NSO₂NH₂Me CN NH₂ NSO₂NHMeMe CN NH₂ NSO₂NMe₂Me CN NH₂ NP(O)(OMe)₂Me CN NH₂ NP(O)(OMe)(OMe)Me CN NH₂ NP(O)(OPr)₂Me CN NH₂ NP(O)(Et)₂Me CN NH₂ NC(O)C(O)HMe CN NH₂ NC(O)C(O)MeMe CN NH₂ NC(O)C(O)OMeMe CN NH₂ NC(O)C(O)OEtMe CN NH₂ NC(O)C(O)NH₂Me CN NH₂ NC(O)C(O)OHMe CN NH₂ NC(NH)NH₂Me CN NH₂ NC(NOH)NH₂Me CN NH₂ NC(NH)NHMeMe CN NH₂ NC(NH)NMe₂Me CN NH₂ NC(NH)OMe ¨Me CN NH₂ NC(NH)OEtEt CN NH₂ NCOEtEt CN NH₂ NCOPr ¨Et CN NH₂ NCOiPr ¨Et CN NH₂ NCOtBu ¨Et CN NH₂ NCOPhEt CN NH₂ NSO₂EtEt CN NH₂ NSO₂PhEt CN NH₂ NSO₂PrEt CN NH₂ NSO₂iPrEt CN NH₂ NNO₂Et CN NH₂ NCOOEtEt CN NH₂ NCOOPhEt CN NH₂ NCOOPrEt CN NH₂ NCOOiPrEt CN NH₂ NCONHEtEt CN NH₂ NCONHPrEt CN NH₂ NCONHiPrEt CN NH₂ NCOSMeEt CN NH₂ NCOSEtEt CN NH₂ NCSOMeEt CN NH₂ NCSOEtEt CN NH₂ NCSOPrEt CN NH₂ NSO₂NH₂Et CN NH₂ NSO₂NHMeEt CN NH₂ NSO₂NMe₂Et CN NH₂ NP(O)(OMe)₂Et CN NH₂ NP(O)(OMe)(OMe)Et CN NH₂ NP(O)(OPr)₂Et CN NH₂ NP(O)(Et)₂ ¨Et CN NH₂ NC(O)C(O)H ¨Et CN NH₂ NC(O)C(O)Me ¨Et CN NH₂ NC(O)C(O)OMe ¨Et CN NH₂ NC(O)C(O)OEtEt CN NH₂ NC(O)C(O)NH₂Et CN NH₂ NC(O)C(O)OHEt CN NH₂ NC(NH)NH₂Et CN NH₂ NC(NOH)NH₂Et CN NH₂ NC(NH)NHMeEt CN NH₂ NC(NH)NMe₂Et CN NH₂ NC(NH)OMeEt CN NH₂ NC(NH)OEtMe CN NHMe NCOMeMe CN NHMe NCOEtMe CN NHMe NCOPrMe CN NHMe NCHOMe CN NHMe NCOiPrMe CN NHMe NCOtBuMe CN NHMe NCOPhMe CN NHMe NSO₂MeMe CN NHMe NSO₂EtMe CN NHMe NSO₂PrMe CN NHMe NSO₂PhMe CN NHMe NSO₂iPrMe CN NHMe NNO₂Me CN NHMe NCOOMeMe CN NHMe NCOOEt ¨Me CN NHMe NCOOPr ¨Me CN NHMe NCOOiPr ¨Me CN NHMe NCONHEt ¨Me CN NHMe NCONHPr ¨Me CN NHMe NCONH₂ ¨Me CN NHMe NCONHMeMe CN NHMe NCNMe CN NHMe NCOSMeMe CN NHMe NCOSEtMe CN NHMe NCSOMeMe CN NHMe NCSOEtMe CN NHMe NCSOPrMe CN NHMe NSO₂NH₂Me CN NHMe NSO₂NHMeMe CN NHMe NSO₂NMe₂Me CN NHMe NP(O)(OMe)₂Me CN NHMe NP(O)(OEt)₂Me CN NHMe NP(O)Me₂Me CN NHMe NP(O)Et₂Me CN NHMe NP(O)Me(OMe)Me CN NHMe NP(O)(OPr)₂Me CN NHMe NC(O)C(O)HMe CN NHMe NC(O)C(O)MeMe CN NHMe NC(O)C(O)OMeMe CN NHMe NC(O)C(O)OEtMe CN NHMe NC(O)C(O)NH₂Me CN NHMe NC(O)C(O)OHMe CN NHMe NC(NH)NH₂Me CN NHMe NC(NOH)NH₂Me CN NHMe NC(NH)NHMe ¨Me CN NHMe NC(NH)NMe₂ ¨Me CN NHMe NC(NH)OMe ¨Me CN NHMe NC(NH)OEtMe CN NHEt NCOMeMe CN NHEt NCOEtMe CN NHEt NCOPrMe CN NHEt NCHOMe CN NHEt NCOiPrMe CN NHEt NCOtBuMe CN NHEt NCOPhMe CN NHEt NSO₂MeMe CN NHEt NSO₂EtMe CN NHEt NSO₂PrMe CN NHEt NSO₂PhMe CN NHEt NSO₂iPrMe CN NHEt NNO₂Me CN NHEt NCOOMeMe CN NHEt NCOOEtMe CN NHEt NCOOPrMe CN NHEt NCOOiPrMe CN NHEt NCONHEtMe CN NHEt NCONHPrMe CN NHEt NCONH₂Me CN NHEt NCONHMeMe CN NHEt NCNMe CN NHEt NCOSMe ¨Me CN NHEt NCOSEt ¨Me CN NHEt NCSOMeMe CN NHEt NCSOEt ¨Me CN NHEt NCSOPr ¨Me CN NHEt NSO₂NH₂Me CN NHEt NSO₂NHMeMe CN NHEt NSO₂NMe₂Me CN NHEt NP(O)(OMe)₂Me CN NHEt NP(O)(OEt)₂Me CN NHEt NP(O)Me₂Me CN NHEt NP(O)Et₂Me CN NHEt NP(O)Me(OMe)Me CN NHEt NP(O)(OPr)₂Me CN NHEt NC(O)C(O)HMe CN NHEt NC(O)C(O)MeMe CN NHEt NC(O)C(O)OMeMe CN NHEt NC(O)C(O)OEtMe CN NHEt NC(O)C(O)NH₂Me CN NHEt NC(O)C(O)OHMe CN NHEt NC(NH)NH₂Me CN NHEt NC(NOH)NH₂Me CN NHEt NC(NH)NHMeMe CN NHEt NC(NH)NMe₂Me CN NHEt NC(NH)OMeMe CN NHEt NC(NH)OEtMe CN NHPr NCOMeMe CN NHPr NCOEtMe CN NHPr NCOPrMe CN NHPr NCHOMe CN NHPr NCOiPrMe CN NHPr NCOtBuMe CN NHPr NCOPhMe CN NHPr NSO₂MeMe CN NHPr NSO₂EtMe CN NHPr NSO₂PrMe CN NHPr NSO₂PhMe CN NHPr NSO₂iPrMe CN NHPr NNO₂Me CN NHPr NCOOMeMe CN NHPr NCOOEtMe CN NHPr NCOOPrMe CN NHPr NCOOiPrMe CN NHPr NCONHEtMe CN NHPr NCONHPrMe CN NHPr NCONH₂Me CN NHPr NCONHMeMe CN NHPr NCNMe CN NHPr NCOSMeMe CN NHPr NCOSEtMe CN NHPr NCSOMeMe CN NHPr NCSOEtMe CN NHPr NCSOPrMe CN NHPr NSO₂NH₂Me CN NHPr NSO₂NHMeMe CN NHPr NSO₂NMe₂Me CN NHPr NP(O)(OMe)₂Me CN NHPr NP(O)(OEt)₂Me CN NHPr NP(O)Me₂Me CN NHPr NP(O)Et₂Me CN NHPr NP(O)Me(OMe)Me CN NHPr NP(O)(OPr)₂Me CN NHPr NC(O)C(O)HMe CN NHPr NC(O)C(O)MeMe CN NHPr NC(O)C(O)OMeMe CN NHPr NC(O)C(O)OEtMe CN NHPr NC(O)C(O)NH₂Me CN NHPr NC(O)C(O)OHMe CN NHPr NC(NH)NH₂Me CN NHPr NC(NOH)NH₂Me CN NHPr NC(NH)NHMeMe CN NHPr NC(NH)NMe₂Me CN NHPr NC(NH)OMeMe CN NHPr NC(NH)OEtEt CN NHMe NCOMeEt CN NHMe NCOEtEt CN NHMe NCOPrEt CN NHMe NCHOEt CN NHMe NCOiPrEt CN NHMe NCOtBuEt CN NHMe NCOPhEt CN NHMe NSO₂MeEt CN NHMe NSO₂EtEt CN NHMe NSO₂PrEt CN NHMe NSO₂PhEt CN NHMe NSO₂iPrEt CN NHMe NNO₂ ¨Et CN NHMe NCOOMeEt CN NHMe NCOOEtEt CN NHMe NCOOPrEt CN NHMe NCOOiPrEt CN NHMe NCONHEtEt CN NHMe NCONHPrEt CN NHMe NCONH₂Et CN NHMe NCONHMeEt CN NHMe NCNEt CN NHMe NCOSMeEt CN NHMe NCOSEtEt CN NHMe NCSOMeEt CN NHMe NCSOEtEt CN NHMe NCSOPrEt CN NHMe NSO₂NH₂Et CN NHMe NSO₂NHMeEt CN NHMe NSO₂NMe₂Et CN NHMe NP(O)(OMe)₂Et CN NHMe NP(O)(OEt)₂Et CN NHMe NP(O)Me₂Et CN NHMe NP(O)Et₂Et CN NHMe NP(O)Me(OMe)Et CN NHMe NP(O)(OPr)₂Et CN NHMe NC(O)C(O)H ¨Et CN NHMe NC(O)C(O)Me ¨Et CN NHMe NC(O)C(O)OMe ¨Et CN NHMe NC(O)C(O)OEtEt CN NHMe NC(O)C(O)NH₂Et CN NHMe NC(O)C(O)OH ¨Et CN NHMe NC(NH)NH₂ ¨Et CN NHMe NC(NOH)NH₂Et CN NHMe NC(NH)NHMeEt CN NHMe NC(NH)NMe₂Et CN NHMe NC(NH)OMeEt CN NHMe NC(NH)OEtEt CN NHEt NCOMeEt CN NHEt NCOEtEt CN NHEt NCOPrEt CN NHEt NCHOEt CN NHEt NCOiPrEt CN NHEt NCOtBuEt CN NHEt NCOPhEt CN NHEt NSO₂MeEt CN NHEt NSO₂EtEt CN NHEt NSO₂PrEt CN NHEt NSO₂PhEt CN NHEt NSO₂iPrEt CN NHEt NNO₂Et CN NHEt NCOOMeEt CN NHEt NCOOEtEt CN NHEt NCOOPrEt CN NHEt NCOOiPrEt CN NHEt NCONHEtEt CN NHEt NCONHPr ¨Et CN NHEt NCONH₂Et CN NHEt NCONHMe ¨Et CN NHEt NCN ¨Et CN NHEt NCOSMe ¨Et CN NHEt NCOSEtEt CN NHEt NCSOMeEt CN NHEt NCSOEtEt CN NHEt NCSOPrEt CN NHEt NSO₂NH₂Et CN NHEt NSO₂NHMeEt CN NHEt NSO₂NMe₂Et CN NHEt NP(O)(OMe)₂Et CN NHEt NP(O)(OEt)₂Et CN NHEt NP(O)Me₂Et CN NHEt NP(O)Et₂Et CN NHEt NP(O)Me(OMe)Et CN NHEt NP(O)(OPr)₂Et CN NHEt NC(O)C(O)HEt CN NHEt NC(O)C(O)MeEt CN NHEt NC(O)C(O)OMeEt CN NHEt NC(O)C(O)OEtEt CN NHEt NC(O)C(O)NH₂Et CN NHEt NC(O)C(O)OHEt CN NHEt NC(NH)NH₂Et CN NHEt NC(NOH)NH₂Et CN NHEt NC(NH)NHMeEt CN NHEt NC(NH)NMe₂Et CN NHEt NC(NH)OMeEt CN NHEt NC(NH)OEtEt CN NHPr NCOMeEt CN NHPr NCOEtEt CN NHPr NCOPrEt CN NHPr NCHOEt CN NHPr NCOiPrEt CN NHPr NCOtBuEt CN NHPr NCOPhEt CN NHPr NSO₂MeEt CN NHPr NSO₂EtEt CN NHPr NSO₂PrEt CN NHPr NSO₂PhEt CN NHPr NSO₂iPrEt CN NHPr NNO₂Et CN NHPr NCOOMeEt CN NHPr NCOOEtEt CN NHPr NCOOPrEt CN NHPr NCOOiPrEt CN NHPr NCONHEtEt CN NHPr NCONHPrEt CN NHPr NCONH₂Et CN NHPr NCONHMeEt CN NHPr NCNEt CN NHPr NCOSMeEt CN NHPr NCOSEtEt CN NHPr NCSOMeEt CN NHPr NCSOEtEt CN NHPr NCSOPr ¨Et CN NHPr NSO₂NH₂ ¨Et CN NHPr NSO₂NHMe ¨Et CN NHPr NSO₂NMe₂ ¨Et CN NHPr NP(O)(OMe)₂ ¨Et CN NHPr NP(O)(OEt)₂Et CN NHPr NP(O)Me₂Et CN NHPr NP(O)Et₂Et CN NHPr NP(O)Me(OMe)Et CN NHPr NP(O)(OPr)₂Et CN NHPr NC(O)C(O)HEt CN NHPr NC(O)C(O)MeEt CN NHPr NC(O)C(O)OMeEt CN NHPr NC(O)C(O)OEtEt CN NHPr NC(O)C(O)NH₂Et CN NHPr NC(O)C(O)OHEt CN NHPr NC(NH)NH₂Et CN NHPr NC(NOH)NH₂Et CN NHPr NC(NH)NHMeEt CN NHPr NC(NH)NMe₂Et CN NHPr NC(NH)OMeEt CN NHPr NC(NH)OEtMe CN NH₂ NCOMe OMe CN NH₂ NCOEt OMe CN NH₂ NCOPr OMe CN NH₂ NCHO OMe CN NH₂ NCOiPr OMe CN NH₂ NCOtBu OMe CN NH₂ NCOPh OMe CN NH₂ NSO₂Me OMe CN NH₂ NSO₂Et OMe CN NH₂ NSO₂Pr OMe CN NH₂ NSO₂Ph OMe CN NH₂ NSO₂iPr OMe CN NH₂ NNO₂ OMe CN NH₂ NCOOMe OMe CN NH₂ NCOOEt OMe CN NH₂ NCOOPr OMe CN NH₂ NCOOiPr OMe CN NH₂ NCONHEt OMe CN NH₂ NCONHPr OMe CN NH₂ NCONH₂ OMe CN NH₂ NCONHMe OMe CN NH₂ NCN OMe CN NH₂ NCOSMe OMe CN NH₂ NCOSEt OMe CN NH₂ NCSOMe OMe CN NH₂ NCSOEt OMe CN NH₂ NCSOPr OMe CN NH₂ NSO₂NH₂ OMe CN NH₂ NSO₂NHMe OMe CN NH₂ NSO₂NMe₂ OMe CN NH₂ NP(O)(OMe)₂ OMe CN NH₂ NP(O)(OEt)₂ OMe CN NH₂ NP(O)Me₂ OMe CN NH₂ NP(O)Et₂ OMe CN NH₂ NP(O)Me(OMe) OMe CN NH₂ NP(O)(OPr)₂ OMe CN NH₂ NC(O)C(O)H OMe CN NH₂ NC(O)C(O)Me OMe CN NH₂ NC(O)C(O)OMe OMe CN NH₂ NC(O)C(O)OEt OMe CN NH₂ NC(O)C(O)NH₂ OMe CN NH₂ NC(O)C(O)OH OMe CN NH₂ NC(NH)NH₂ OMe CN NH₂ NC(NOH)NH₂ OMe CN NH₂ NC(NH)NHMe OMe CN NH₂ NC(NH)NMe₂ OMe CN NH₂ NC(NH)OMe OMe CN NH₂ NC(NH)OEt OMe CN NH₂ NH OMe CN NHMe NCOMe OMe CN NHMe NCOEt OMe CN NHMe NCOPr OMe CN NHMe NCHO OMe CN NHMe NCOiPr OMe CN NHMe NCOtBu OMe CN NHMe NCOPh OMe CN NHMe NSO₂Me OMe CN NHMe NSO₂Et OMe CN NHMe NSO₂Pr OMe CN NHMe NSO₂Ph OMe CN NHMe NSO₂iPr OMe CN NHMe NNO₂ OMe CN NHMe NCOOMe OMe CN NHMe NCOOEt OMe CN NHMe NCOOPr OMe CN NHMe NCOOiPr OMe CN NHMe NCONHEt OMe CN NHMe NCONHPr OMe CN NHMe NCONH₂ OMe CN NHMe NCONHMe OMe CN NHMe NCN OMe CN NHMe NCOSMe OMe CN NHMe NCOSEt OMe CN NHMe NCSOMe OMe CN NHMe NCSOEt OMe CN NHMe NCSOPr OMe CN NHMe NSO₂NH₂ OMe CN NHMe NSO₂NHMe OMe CN NHMe NSO₂NMe₂ OMe CN NHMe NP(O)(OMe)₂ OMe CN NHMe NP(O)(OEt)₂ OMe CN NHMe NP(O)Me₂ OMe CN NHMe NP(O)Et₂ OMe CN NHMe NP(O)Me(OMe) OMe CN NHMe NP(O)(OPr)₂ OMe CN NHMe NC(O)C(O)H OMe CN NHMe NC(O)C(O)Me OMe CN NHMe NC(O)C(O)OMe OMe CN NHMe NC(O)C(O)OEt OMe CN NHMe NC(O)C(O)NH₂ OMe CN NHMe NC(O)C(O)OH OMe CN NHMe NC(NH)NH₂ OMe CN NHMe NC(NOH)NH₂ OMe CN NHMe NC(NH)NHMe OMe CN NHMe NC(NH)NMe₂ OMe CN NHMe NC(NH)OMe OMe CN NHMe NC(NH)OEt OMe CN NHEt NCOMe OMe CN NHEt NCOEt OMe CN NHEt NCOPr OMe CN NHEt NCHO OMe CN NHEt NCOiPr OMe CN NHEt NCOtBu OMe CN NHEt NCOPh OMe CN NHEt NSO₂Me OMe CN NHEt NSO₂Et OMe CN NHEt NSO₂Pr OMe CN NHEt NSO₂Ph OMe CN NHEt NSO₂iPr OMe CN NHEt NNO₂ OMe CN NHEt NCOOMe OMe CN NHEt NCOOEt OMe CN NHEt NCOOPr OMe CN NHEt NCOOiPr OMe CN NHEt NCONHEt OMe CN NHEt NCONHPr OMe CN NHEt NCONH₂ OMe CN NHEt NCONHMe OMe CN NHEt NCN OMe CN NHEt NCOSMe OMe CN NHEt NCOSEt OMe CN NHEt NCSOMe OMe CN NHEt NCSOEt OMe CN NHEt NCSOPr OMe CN NHEt NSO₂NH₂ OMe CN NHEt NSO₂NHMe OMe CN NHEt NSO₂NMe₂ OMe CN NHEt NP(O)(OMe)₂ OMe CN NHEt NP(O)(OEt)₂ OMe CN NHEt NP(O)Me₂ OMe CN NHEt NP(O)Et₂ OMe CN NHEt NP(O)Me(OMe) OMe CN NHEt NP(O)(OPr)₂ OMe CN NHEt NC(O)C(O)H OMe CN NHEt NC(O)C(O)Me OMe CN NHEt NC(O)C(O)OMe OMe CN NHEt NC(O)C(O)OEt OMe CN NHEt NC(O)C(O)NH₂ OMe CN NHEt NC(O)C(O)OH OMe CN NHEt NC(NH)NH₂ OMe CN NHEt NC(NOH)NH₂ OMe CN NHEt NC(NH)NHMe OMe CN NHEt NC(NH)NMe₂ OMe CN NHEt NC(NH)OMe OMe CN NHEt NC(NH)OEt OEt CN NH₂ NCOEt OEt CN NH₂ NCOPr OEt CN NH₂ NCHO OEt CN NH₂ NCOiPr OEt CN NH₂ NCOtBu OEt CN NH₂ NCOPh OEt CN NH₂ NSO₂Me OEt CN NH₂ NSO₂Et OEt CN NH₂ NSO₂Pr OEt CN NH₂ NSO₂Ph OEt CN NH₂ NSO₂iPr OEt CN NH₂ NNO₂ OEt CN NH₂ NCOOMe OEt CN NH₂ NCOOEt OEt CN NH₂ NCOOPr OEt CN NH₂ NCOOiPr OEt CN NH₂ NCONHEt OEt CN NH₂ NCONHPr OEt CN NH₂ NCONH₂ OEt CN NH₂ NCONHMe OEt CN NH₂ NCN OEt CN NH₂ NCOSMe OEt CN NH₂ NCOSEt OEt CN NH₂ NCSOMe OEt CN NH₂ NCSOEt OEt CN NH₂ NCSOPr OEt CN NH₂ NSO₂NH₂ OEt CN NH₂ NSO₂NHMe OEt CN NH₂ NSO₂NMe₂ OEt CN NH₂ NP(O)(OMe)₂ OEt CN NH₂ NP(O)(OEt)₂ OEt CN NH₂ NP(O)Me₂ OEt CN NH₂ NP(O)Et₂ OEt CN NH₂ NP(O)Me(OMe) OEt CN NH₂ NP(O)(OPr)₂ OEt CN NH₂ NC(O)C(O)H OEt CN NH₂ NC(O)C(O)Me OEt CN NH₂ NC(O)C(O)OMe OEt CN NH₂ NC(O)C(O)OEt OEt CN NH₂ NC(O)C(O)NH₂ OEt CN NH₂ NC(O)C(O)OH OEt CN NH₂ NC(NH)NH₂ OEt CN NH₂ NC(NOH)NH₂ OEt CN NH₂ NC(NH)NHMe OEt CN NH₂ NC(NH)NMe₂ OEt CN NH₂ NC(NH)OMe OEt CN NH₂ NC(NH)OEt OEt CN NHMe NH OEt CN NHMe NCOMe OEt CN NHMe NCOEt OEt CN NHMe NCOPr OEt CN NHMe NCHO OEt CN NHMe NCOiPr OEt CN NHMe NCOtBu OEt CN NHMe NCOPh OEt CN NHMe NSO₂Me OEt CN NHMe NSO₂Et OEt CN NHMe NSO₂Pr OEt CN NHMe NSO₂Ph OEt CN NHMe NSO₂iPr OEt CN NHMe NNO₂ OEt CN NHMe NCOOMe OEt CN NHMe NCOOEt OEt CN NHMe NCOOPr OEt CN NHMe NCOOiPr OEt CN NHMe NCONHEt OEt CN NHMe NCONHPr OEt CN NHMe NCONH₂ OEt CN NHMe NCONHMe OEt CN NHMe NCN OEt CN NHMe NCOSMe OEt CN NHMe NCOSEt OEt CN NHMe NCSOMe OEt CN NHMe NCSOEt OEt CN NHMe NCSOPr OEt CN NHMe NSO₂NH₂ OEt CN NHMe NSO₂NHMe OEt CN NHMe NSO₂NMe₂ OEt CN NHMe NP(O)(OMe)₂ OEt CN NHMe NP(O)(OEt)₂ OEt CN NHMe NP(O)Me₂ OEt CN NHMe NP(O)Et₂ OEt CN NHMe NP(O)Me(OMe) OEt CN NHMe NP(O)(OPr)₂ OEt CN NHMe NC(O)C(O)H OEt CN NHMe NC(O)C(O)Me OEt CN NHMe NC(O)C(O)OMe OEt CN NHMe NC(O)C(O)OEt OEt CN NHMe NC(O)C(O)NH₂ OEt CN NHMe NC(O)C(O)OH OEt CN NHMe NC(NH)NH₂ OEt CN NHMe NC(NOH)NH₂ OEt CN NHMe NC(NH)NHMe OEt CN NHMe NC(NH)NMe₂ OEt CN NHMe NC(NH)OMe OEt CN NHMe NC(NH)OEt OEt CN NHEt NCOMe OEt CN NHEt NCOEt OEt CN NHEt NCOPr OEt CN NHEt NCHO OEt CN NHEt NCOiPr OEt CN NHEt NCOtBu OEt CN NHEt NCOPh OEt CN NHEt NSO₂Me OEt CN NHEt NSO₂Et OEt CN NHEt NSO₂Pr OEt CN NHEt NSO₂Ph OEt CN NHEt NSO₂iPr OEt CN NHEt NNO₂ OEt CN NHEt NCOOMe OEt CN NHEt NCOOEt OEt CN NHEt NCOOPr OEt CN NHEt NCOOiPr OEt CN NHEt NCONHEt OEt CN NHEt NCONHPr OEt CN NHEt NCONH₂ OEt CN NHEt NCONHMe OEt CN NHEt NCN OEt CN NHEt NCOSMe OEt CN NHEt NCOSEt OEt CN NHEt NCSOMe OEt CN NHEt NCSOEt OEt CN NHEt NCSOPr OEt CN NHEt NSO₂NH₂ OEt CN NHEt NSO₂NHMe OEt CN NHEt NSO₂NMe₂ OEt CN NHEt NP(O)(OMe)₂ OEt CN NHEt NP(O)(OEt)₂ OEt CN NHEt NP(O)Me₂ OEt CN NHEt NP(O)Et₂ OEt CN NHEt NP(O)Me(OMe) OEt CN NHEt NP(O)(OPr)₂ OEt CN NHEt NC(O)C(O)H OEt CN NHEt NC(O)C(O)Me OEt CN NHEt NC(O)C(O)OMe OEt CN NHEt NC(O)C(O)OEt OEt CN NHEt NC(O)C(O)NH₂ OEt CN NHEt NC(O)C(O)OH OEt CN NHEt NC(NH)NH₂ OEt CN NHEt NC(NOH)NH₂ OEt CN NHEt NC(NH)NHMe OEt CN NHEt NC(NH)NMe₂ OEt CN NHEt NC(NH)OMe OEt CN NHEt NC(NH)OEt OMe CN NHCOMe NCOMeMe CN NHCOMe NCOEtMe CN NHCOMe NCOPrMe CN NHCOMe NCHOMe CN NHCOMe NCOiPrMe CN NHCOMe NCOtBuMe CN NHCOMe NCOPhMe CN NHCOMe NSO₂MeMe CN NHCOMe NSO₂EtMe CN NHCOMe NSO₂PrMe CN NHCOMe NSO₂PhMe CN NHCOMe NSO₂iPrMe CN NHCOMe NNO₂Me CN NHCOMe NCOOMeMe CN NHCOMe NCOOEtMe CN NHCOMe NCOOPrMe CN NHCOMe NCOOiPrMe CN NHCOMe NCONHFMe CN NHCOMe NCONHPrMe CN NHCOMe NCONH₂Me CN NHCOMe NCONHMeMe CN NHCOMe NCNMe CN NHCOMe NCOSMeMe CN NHCOMe NCOSEtMe CN NHCOMe NCSOMe ¨Me CN NHCOMe NCSOEtMe CN NHCOMe NCSOPr ¨Me CN NHCOMe NSO₂NH₂ ¨Me CN NHCOMe NSO₂NHMe ¨Me CN NHCOMe NSO₂NMe₂ ¨Me CN NHCOMe NP(O)(OMe)₂ ¨Me CN NHCOMe NP(O)(OEt)₂ ¨Me CN NHCOMe NP(O)Me₂Me CN NHCOMe NP(O)Et₂Me CN NHCOMe NP(O)Me(OMe) ¨Me CN NHCOMe NP(O)(OPr)₂Me CN NHCOMe NC(O)C(O)H ¨Me CN NHCOMe NC(O)C(O)MeMe CN NHCOMe NC(O)C(O)OMeMe CN NHCOMe NC(O)C(O)OEtMe CN NHCOMe NC(O)C(O)NH₂Me CN NHCOMe NC(O)C(O)OHMe CN NHCOMe NC(NH)NH₂Me CN NHCOMe NC(NOH)NH₂Me CN NHCOMe NC(NH)NHMeMe CN NHCOMe NC(NH)NMe₂Me CN NHCOMe NC(NH)OMeMe CN NHCOMe NC(NH)OEtEt CN NHCOMe NCOMeEt CN NHCOMe NCOEtEt CN NHCOMe NCOPrEt CN NHCOMe NCHOEt CN NHCOMe NCOiPrEt CN NHCOMe NCOtBuEt CN NHCOMe NCOPhEt CN NHCOMe NSO₂MeEt CN NHCOMe NSO₂EtEt CN NHCOMe NSO₂PrEt CN NHCOMe NSO₂PhEt CN NHCOMe NSO₂iPrEt CN NHCOMe NNO₂Et CN NHCOMe NCOOMeEt CN NHCOMe NCOOEtEt CN NHCOMe NCOOPrEt CN NHCOMe NCOOiPrEt CN NHCOMe NCONHEtEt CN NHCOMe NCONHPrEt CN NHCOMe NCONH₂Et CN NHCOMe NCONHMeEt CN NHCOMe NCNEt CN NHCOMe NCOSMeEt CN NHCOMe NCOSEt ¨Et CN NHCOMe NCSOMeEt CN NHCOMe NCSOEt ¨Et CN NHCOMe NCSOPrEt CN NHCOMe NSO₂NH₂Et CN NHCOMe NSO₂NHMe ¨Et CN NHCOMe NSO₂NMe₂Et CN NHCOMe NP(O)(Ote)₂Et CN NHCOMe NP(O)(OEt)₂Et CN NHCOMe NP(O)Me₂ ¨Et CN NHCOMe NP(O)Et₂ ¨Et CN NHCOMe NP(O)Me(OMe) ¨Et CN NHCOMe NP(O)(OPr)₂ ¨Et CN NHCOMe NC(O)C(O)H ¨Et CN NHCOMe NC(O)C(O)Me ¨Et CN NHCOMe NC(O)C(O)OMe ¨Et CN NHCOMe NC(O)C(O)OEtEt CN NHCOMe NC(O)C(O)NH₂Et CN NHCOMe NC(O)C(O)OHEt CN NHCOMe NC(NH)NH₂Et CN NHCOMe NC(NOH)NH₂Et CN NHCOMe NC(NH)NHMeEt CN NHCOMe NC(NH)NMe₂Et CN NHCOMe NC(NH)OMeEt CN NHCOMe NC(NH)OEtMe CN NHCOOMe NCOMeMe CN NHCOOMe NCOEtMe CN NHCOOMe NCOPrMe CN NHCOOMe NCHOMe CN NHCOOMe NCOiPrMe CN NHCOOMe NCOtBuMe CN NHCOOMe NCOPhMe CN NHCOOMe NSO₂MeMe CN NHCOOMe NSO₂EtMe CN NHCOOMe NSO₂PrMe CN NHCOOMe NSO₂PhMe CN NHCOOMe NSO₂iPrMe CN NHCOOMe NNO₂ ¨Me CN NHCOOMe NCOOMe ¨Me CN NHCOOMe NCOOEt ¨Me CN NHCOOMe NCOOPr ¨Me CN NHCOOMe NCOOiPr ¨Me CN NHCOOMe NCONHEt ¨Me CN NHCOOMe NCONHPr ¨Me CN NHCOOMe NCONH₂ ¨Me CN NHCOOMe NCONHMe ¨Me CN NHCOOMe NCNMe CN NHCOOMe NCOSMeMe CN NHCOOMe NCOSEtMe CN NHCOOMe NCSOMeMe CN NHCOOMe NCSOEtMe CN NHCOOMe NCSOPrMe CN NHCOOMe NSO₂NH₂Me CN NHCOOMe NSO₂NHMeMe CN NHCOOMe NSO₂NMe₂Me CN NHCOOMe NP(O)(OMe)₂Me CN NHCOOMe NP(O)(OEt)₂Me CN NHCOOMe NP(O)Me₂Me CN NHCOOMe NP(O)Et₂Me CN NHCOOMe NP(O)Me(OMe)Me CN NHCOOMe NP(O)(OPr)₂Me CN NHCOOMe NC(O)C(O)HMe CN NHCOOMe NC(O)C(O)MeMe CN NHCOOMe NC(O)C(O)OMeMe CN NHCOOMe NC(O)C(O)OEtMe CN NHCOOMe NC(O)C(O)NH₂ ¨Me CN NHCOOMe NC(O)C(O)OH ¨Me CN NHCOOMe NC(NH)NH₂ ¨Me CN NHCOOMe NC(NOH)NH₂ ¨Me CN NHCOOMe NC(NH)NHMe ¨Me CN NHCOOMe NC(NH)NMe₂ ¨Me CN NHCOOMe NC(NH)OMe ¨Me CN NHCOOMe NC(NH)OEt ¨Et CN NHCOOMe NCOMe ¨Et CN NHCOOMe NCOEtEt CN NHCOOMe NCOPrEt CN NHCOOMe NCHOEt CN NHCOOMe NCOiPrEt CN NHCOOMe NCOtBuEt CN NHCOOMe NCOPhEt CN NHCOOMe NSO₂MeEt CN NHCOOMe NSO₂EtEt CN NHCOOMe NSO₂PrEt CN NHCOOMe NSO₂PhEt CN NHCOOMe NSO₂iPrEt CN NHCOOMe NNO₂ ¨Et CN NHCOOMe NCOOMe ¨Et CN NHCOOMe NCOOEtEt CN NHCOOMe NCOOPrEt CN NHCOOMe NCOOiPrEt CN NHCOOMe NCONHEtEt CN NHCOOMe NCONHPrEt CN NHCOOMe NCONH₂Et CN NHCOOMe NCONHMeEt CN NHCOOMe NCN ¨Et CN NHCOOMe NCOSMe ¨Et CN NHCOOMe NCOSEt ¨Et CN NHCOOMe NCSOMe ¨Et CN NHCOOMe NCSOEt ¨Et CN NHCOOMe NCSOPr ¨Et CN NHCOOMe NSO₂NH₂ ¨Et CN NHCOOMe NSO₂NHMeEt CN NHCOOMe NSO₂NMe₂Et CN NHCOOMe NP(O)(OMe)₂Et CN NHCOOMe NP(O)(OEt)₂Et CN NHCOOMe NP(O)Me₂Et CN NHCOOMe NP(O)Et₂Et CN NHCOOMe NP(O)Me(OMe)Et CN NHCOOMe NP(O)(OPr)₂Et CN NHCOOMe NC(O)C(O)HEt CN NHCOOMe NC(O)C(O)MeEt CN NHCOOMe NC(O)C(O)OMeEt CN NHCOOMe NC(O)C(O)OEtEt CN NHCOOMe NC(O)C(O)NH₂Et CN NHCOOMe NC(O)C(O)OHEt CN NHCOOMe NC(NH)NH₂Et CN NHCOOMe NC(NOH)NH₂Et CN NHCOOMe NC(NH)NHMeMe CN NHCOOEt NCSOEtMe CN NHCOOEt NCSOPrMe CN NHCOOEt NSO₂NH₂Me CN NHCOOEt NSO₂NHMeMe CN NHCOOEt NSO₂NMe₂ ¨Me CN NHCOOEt NP(O)(OMe)₂ ¨Me CN NHCOOEt NP(O)(OEt)₂ ¨Me CN NHCOOEt NP(O)Me₂ ¨Me CN NHCOOEt NP(O)Et₂ ¨Me CN NHCOOEt NP(O)Me(OMe) ¨Me CN NHCOOEt NP(O)(OPr)₂Me CN NHCOOEt NC(O)C(O)HMe CN NHCOOEt NC(O)C(O)MeMe CN NHCOOEt NC(O)C(O)OMeMe CN NHCOOEt NC(O)C(O)OEtMe CN NHCOOEt NC(O)C(O)NH₂Me CN NHCOOEt NC(O)C(O)OHMe CN NHCOOEt NC(NH)NH₂Me CN NHCOOEt NC(NOH)NH₂Me CN NHCOOEt NC(NH)NHMeMe CN NHCOOEt NC(NH)NMe₂Me CN NHCOOEt NC(NH)OMeMe CN NHCOOEt NC(NH)OEtEt CN NHCOOEt NCOMeEt CN NHCOOEt NCOEtEt CN NHCOOEt NCOPr ¨Et CN NHCOOEt NCHOEt CN NHCOOEt NCOiPrEt CN NHCOOMe NC(NH)NMe₂Et CN NHCOOMe NC(NH)OMeEt CN NHCOOMe NC(NH)OEtMe CN NHCOOEt NCOMe ¨Me CN NHCOOEt NCOEtMe CN NHCOOEt NCOPr ¨Me CN NHCOOEt NCHO ¨Me CN NHCOOEt NCOiPr ¨Me CN NHCOOEt NCOtBu ¨Me CN NHCOOEt NCOPhMe CN NHCOOEt NSO₂MeMe CN NHCOOEt NSO₂EtMe CN NHCOOEt NSO₂PrMe CN NHCOOEt NSO₂PhMe CN NHCOOEt NSO₂iPrMe CN NHCOOEt NNO₂Me CN NHCOOEt NCOOMeMe CN NHCOOEt NCOOEtMe CN NHCOOEt NCOOPrMe CN NHCOOEt NCOOiPrMe CN NHCOOEt NCONHEtMe CN NHCOOEt NCONHPrMe CN NHCOOEt NCONH₂Me CN NHCOOEt NCONHMeMe CN NHCOOEt NCNMe CN NHCOOEt NCOSMeMe CN NHCOOEt NCOSEtMe CN NHCOOEt NCSOMeEt CN NHCOOEt NCOtBuEt CN NHCOOEt NCOPhEt CN NHCOOEt NSO₂MeEt CN NHCOOEt NSO₂EtEt CN NHCOOEt NSO₂PrEt CN NHCOOEt NSO₂Ph ¨Et CN NHCOOEt NSO₂iPr ¨Et CN NHCOOEt NNO₂ ¨Et CN NHCOOEt NCOOMe ¨Et CN NHCOOEt NCOOEt ¨Et CN NHCOOEt NCOOPrEt CN NHCOOEt NCOOiPrEt CN NHCOOEt NCONHEtEt CN NHCOOEt NCONHPrEt CN NHCOOEt NCONH₂Et CN NHCOOEt NCONHMeEt CN NHCOOEt NCNEt CN NHCOOEt NCOSMeEt CN NHCOOEt NCOSEtEt CN NHCOOEt NCSOMeEt CN NHCOOEt NCSOEtEt CN NHCOOEt NCSOPrEt CN NHCOOEt NSO₂NH₂Et CN NHCOOEt NSO₂NHMeEt CN NHCOOEt NSO₂NMe₂Et CN NHCOOEt NP(O)(OMe)₂Et CN NHCOOEt NP(O)(OEt)₂Et CN NHCOOEt NP(O)Me₂ ¨Et CN NHCOOEt NP(O)Et₂Et CN NHCOOEt NP(O)Me(OMe)Et CN NHCOOEt NP(O)(OPr)₂Et CN NHCOOEt NC(O)C(O)HEt CN NHCOOEt NC(O)C(O)MeEt CN NHCOOEt NC(O)C(O)OMe ¨Et CN NHCOOEt NC(O)C(O)OEt ¨Et CN NHCOOEt NC(O)C(O)NH₂ ¨Et CN NHCOOEt NC(O)C(O)OH ¨Et CN NHCOOEt NC(NH)NH₂ ¨Et CN NHCOOEt NC(NOH)NH₂Et CN NHCOOEt NC(NH)NHMeEt CN NHCOOEt NC(NH)NMe₂Et CN NHCOOEt NC(NH)OMeEt CN NHCOOEt NC(NH)OEtMe CN NHCH₂COOMe NCOMeMe CN NHCH₂COOMe NCOEtMe CN NHCH₂COOMe NCOPrMe CN NHCH₂COOMe NCHOMe CN NHCH₂COOMe NCOiPrMe CN NHCH₂COOMe NCOtBuMe CN NHCH₂COOMe NCOPhMe CN NHCH₂COOMe NSO₂MeMe CN NHCH₂COOMe NSO₂EtMe CN NHCH₂COOMe NSO₂PrMe CN NHCH₂COOMe NSO₂PhMe CN NHCH₂COOMe NSO₂iPrMe CN NHCH₂COOMe NNO₂Me CN NHCH₂COOMe NCOOMeMe CN NHCH₂COOMe NCOOEtMe CN NHCH₂COOMe NCOOPrMe CN NHCH₂COOMe NCOOiPrMe CN NHCH₂COOMe NCONHEtMe CN NHCH₂COOMe NCONHPr ¨Me CN NHCH₂COOMe NCONH₂ ¨Me CN NHCH₂COOMe NCONHMe ¨Me CN NHCH₂COOMe NCN ¨Me CN NHCH₂COOMe NCOSMe ¨Me CN NHCH₂COOMe NCOSEtMe CN NHCH₂COOMe NCSOMeMe CN NHCH₂COOMe NCSOEtMe CN NHCH₂COOMe NCSOPrMe CN NHCH₂COOMe NSO₂NH₂Me CN NHCH₂COOMe NSO₂NHMeMe CN NHCH₂COOMe NSO₂NMe₂Me CN NHCH₂COOMe NP(O)(OMe)₂Me CN NHCH₂COOMe NP(O)(OEt)₂Me CN NHCH₂COOMe NP(O)Me₂Me CN NHCH₂COOMe NP(O)Et₂Me CN NHCH₂COOMe NP(O)Me(OMe)Me CN NHCH₂COOMe NP(O)(OPr)₂Me CN NHCH₂COOMe NC(O)C(O)HMe CN NHCH₂COOMe NC(O)C(O)MeMe CN NHCH₂COOMe NC(O)C(O)OMeMe CN NHCH₂COOMe NC(O)C(O)OEtMe CN NHCH₂COOMe NC(O)C(O)NH₂Me CN NHCH₂COOMe NC(O)C(O)OHMe CN NHCH₂COOMe NC(NH)NH₂Me CN NHCH₂COOMe NC(NOH)NH₂Me CN NHCH₂COOMe NC(NH)NHMeMe CN NHCH₂COOMe NC(NH)NMe₂ ¨Me CN NHCH₂COOMe NC(NH)OMe ¨Me CN NHCH₂COOMe NC(NH)OEt ¨Et CN NHCH₂COOMe NCOMe ¨Et CN NHCH₂COOMe NCOEtEt CN NHCH₂COOMe NCOPrEt CN NHCH₂COOMe NCHOEt CN NHCH₂COOMe NCOiPrEt CN NHCH₂COOMe NCOtBuEt CN NHCH₂COOMe NCOPhEt CN NHCH₂COOMe NSO₂MeEt CN NHCH₂COOMe NSO₂EtEt CN NHCH₂COOMe NSO₂PrEt CN NHCH₂COOMe NSO₂PhEt CN NHCH₂COOMe NSO₂iPrEt CN NHCH₂COOMe NNO₂Et CN NHCH₂COOMe NCOOMeEt CN NHCH₂COOMe NCOOEtEt CN NHCH₂COOMe NCOOPrEt CN NHCH₂COOMe NCOOiPrEt CN NHCH₂COOMe NCONHEtEt CN NHCH₂COOMe NCONHPrEt CN NHCH₂COOMe NCONH₂Et CN NHCH₂COOMe NCONHMeEt CN NHCH₂COOMe NCNEt CN NHCH₂COOMe NCOSMeEt CN NHCH₂COOMe NCOSEtEt CN NHCH₂COOMe NCSOMe ¨Et CN NHCH₂COOMe NCSOEt ¨Et CN NHCH₂COOMe NCSOPr ¨Et CN NHCH₂COOMe NSO₂NH₂ ¨Et CN NHCH₂COOMe NSO₂NHMe ¨Et CN NHCH₂COOMe NSO₂NMe₂ ¨Et CN NHCH₂COOMe NP(O)(OMe)₂Et CN NHCH₂COOMe NP(O)(OEt)₂Et CN NHCH₂COOMe NP(O)Me₂Et CN NHCH₂COOMe NP(O)Et₂Et CN NHCH₂COOMe NP(O)Me(OMe)Et CN NHCH₂COOMe NP(O)(OPr)₂Et CN NHCH₂COOMe NC(O)C(O)HEt CN NHCH₂COOMe NC(O)C(O)MeEt CN NHCH₂COOMe NC(O)C(O)OMeEt CN NHCH₂COOMe NC(O)C(O)OEtEt CN NHCH₂COOMe NC(O)C(O)NH₂Et CN NHCH₂COOMe NC(O)C(O)OHEt CN NHCH₂COOMe NC(NH)NH₂Et CN NHCH₂COOMe NC(NOH)NH₂Et CN NHCH₂COOMe NC(NH)NHMeEt CN NHCH₂COOMe NC(NH)NMe₂Et CN NHCH₂COOMe NC(NH)OMeEt CN NHCH₂COOMe NC(NH)OEtMe CN NHCH₂CN NCOMeMe CN NHCH₂CN NCOEtMe CN NHCH₂CN NCOPrMe CN NHCH₂CN NCHOMe CN NHCH₂CN NCOiPrMe CN NHCH₂CN NCOtBuMe CN NHCH₂CN NCOPhMe CN NHCH₂CN NSO₂Me ¨Me CN NHCH₂CN NSO₂Et ¨Me CN NHCH₂CN NSO₂PrMe CN NHCH₂CN NSO₂PhMe CN NHCH₂CN NSO₂iPrMe CN NHCH₂CN NNO₂Me CN NHCH₂CN NCOOMeMe CN NHCH₂CN NCOOEtMe CN NHCH₂CN NCOOPrMe CN NHCH₂CN NCOOiPrMe CN NHCH₂CN NCONHEtMe CN NHCH₂CN NCONHPrMe CN NHCH₂CN NCONH₂Me CN NHCH₂CN NCONHMeMe CN NHCH₂CN NCNMe CN NHCH₂CN NCOSMeMe CN NHCH₂CN NCOSEtMe CN NHCH₂CN NCSOMeMe CN NHCH₂CN NCSOEtMe CN NHCH₂CN NCSOPrMe CN NHCH₂CN NSO₂NH₂Me CN NHCH₂CN NSO₂NHMeMe CN NHCH₂CN NSO₂NMe₂Me CN NHCH₂CN NP(O)(OMe)₂Me CN NHCH₂CN NP(O)(OEt)₂Me CN NHCH₂CN NP(O)Me₂ ¨Me CN NHCH₂CN NP(O)Et₂Me CN NHCH₂CN NP(O)Me(OMe) ¨Me CN NHCH₂CN NP(O)(OPr)₂ ¨Me CN NHCH₂CN NC(O)C(O)H ¨Me CN NHCH₂CN NC(O)C(O)Me ¨Me CN NHCH₂CN NC(O)C(O)OMe ¨Me CN NHCH₂CN NC(O)C(O)OEtMe CN NHCH₂CN NC(O)C(O)NH₂Me CN NHCH₂CN NC(O)C(O)OHMe CN NHCH₂CN NC(NH)NH₂Me CN NHCH₂CN NC(NOH)NH₂Me CN NHCH₂CN NC(NH)NHMeMe CN NHCH₂CN NC(NH)NMe₂Me CN NHCH₂CN NC(NH)OMeMe CN NHCH₂CN NC(NH)OEtEt CN NHCH₂CN NCOMeEt CN NHCH₂CN NCOEtEt CN NHCH₂CN NCOPrEt CN NHCH₂CN NCHOEt CN NHCH₂CN NCOiPrEt CN NHCH₂CN NCOtBuEt CN NHCH₂CN NCOPhEt CN NHCH₂CN NSO₂MeEt CN NHCH₂CN NSO₂EtEt CN NHCH₂CN NSO₂PrEt CN NHCH₂CN NSO₂PhEt CN NHCH₂CN NSO₂iPr ¨Et CN NHCH₂CN NNO₂ ¨Et CN NHCH₂CN NCOOMe ¨Et CN NHCH₂CN NCOOEt ¨Et CN NHCH₂CN NCOOPr ¨Et CN NHCH₂CN NCOOiPr ¨Et CN NHCH₂CN NCONHEt ¨Et CN NHCH₂CN NCONHPr ¨Et CN NHCH₂CN NCONH₂ ¨Et CN NHCH₂CN NCONHMeEt CN NHCH₂CN NCNEt CN NHCH₂CN NCOSMeEt CN NHCH₂CN NCOSEtEt CN NHCH₂CN NCSOMeEt CN NHCH₂CN NCSOEtEt CN NHCH₂CN NCSOPrEt CN NHCH₂CN NSO₂NH₂Et CN NHCH₂CN NSO₂NHMeEt CN NHCH₂CN NSO₂NMe₂Et CN NHCH₂CN NP(O)(OMe)₂Et CN NHCH₂CN NP(O)(OEt)₂Et CN NHCH₂CN NP(O)Me₂Et CN NHCH₂CN NP(O)Et₂Et CN NHCH₂CN NP(O)Me(OMe)Et CN NHCH₂CN NP(O)(OPr)₂Et CN NHCH₂CN NC(O)C(O)HEt CN NHCH₂CN NC(O)C(O)MeEt CN NHCH₂CN NC(O)C(O)OMeEt CN NHCH₂CN NC(O)C(O)OEt ¨Et CN NHCH₂CN NC(O)C(O)NH₂ ¨Et CN NHCH₂CN NC(O)C(O)OH ¨Et CN NHCH₂CN NC(NH)NH₂ ¨Et CN NHCH₂CN NC(NOH)NH₂ ¨Et CN NHCH₂CN NC(NH)NHMe ¨Et CN NHCH₂CN NC(NH)NMe₂ ¨Et CN NHCH₂CN NC(NH)OMe ¨Et CN NHCH₂CN NC(NH)OEtMe CN NHCH₂CONH₂ NCOMeMe CN NHCH₂CONH₂ NCOEtMe CN NHCH₂CONH₂ NCOPrMe CN NHCH₂CONH₂ NCHOMe CN NHCH₂CONH₂ NCOiPrMe CN NHCH₂CONH₂ NCOtBuMe CN NHCH₂CONH₂ NCOPhMe CN NHCH₂CONH₂ NSO₂MeMe CN NHCH₂CONH₂ NSO₂EtMe CN NHCH₂CONH₂ NSO₂PrMe CN NHCH₂CONH₂ NSO₂Ph ¨Me CN NHCH₂CONH₂ NSO₂iPrMe CN NHCH₂CONH₂ NNO₂Me CN NHCH₂CONH₂ NCOOMeMe CN NHCH₂CONH₂ NCOOEtMe CN NHCH₂CONH₂ NCOOPr ¨Me CN NHCH₂CONH₂ NCOOiPr ¨Me CN NHCH₂CONH₂ NCONHEtMe CN NHCH₂CONH₂ NCONHPrMe CN NHCH₂CONH₂ NCONH₂Me CN NHCH₂CONH₂ NCONHMeMe CN NHCH₂CONH₂ NCN ¨Me CN NHCH₂CONH₂ NCOSMe ¨Me CN NHCH₂CONH₂ NCOSEt ¨Me CN NHCH₂CONH₂ NCSOMe ¨Me CN NHCH₂CONH₂ NCSOEt ¨Me CN NHCH₂CONH₂ NCSOPrMe CN NHCH₂CONH₂ NSO₂NH₂Me CN NHCH₂CONH₂ NSO₂NHMeMe CN NHCH₂CONH₂ NSO₂NMe₂Me CN NHCH₂CONH₂ NP(O)(OMe)₂Me CN NHCH₂CONH₂ NP(O)(OEt)₂Me CN NHCH₂CONH₂ NP(O)Me₂Me CN NHCH₂CONH₂ NP(O)Et₂Me CN NHCH₂CONH₂ NP(O)Me(OMe)Me CN NHCH₂CONH₂ NP(O)(OPr)₂Me CN NHCH₂CONH₂ NC(O)C(O)HMe CN NHCH₂CONH₂ NC(O)C(O)MeMe CN NHCH₂CONH₂ NC(O)C(O)OMeMe CN NHCH₂CONH₂ NC(O)C(O)OEtMe CN NHCH₂CONH₂ NC(O)C(O)NH₂ ¨Me CN NHCH₂CONH₂ NC(O)C(O)OH ¨Me CN NHCH₂CONH₂ NC(NH)NH₂Me CN NHCH₂CONH₂ NC(NOH)NH₂Me CN NHCH₂CONH₂ NC(NH)NHMeMe CN NHCH₂CONH₂ NC(NH)NMe₂Me CN NHCH₂CONH₂ NC(NH)OMeMe CN NHCH₂CONH₂ NC(NH)OEtEt CN NHCH₂CONH₂ NCOMe ¨Et CN NHCH₂CONH₂ NCOEt ¨Et CN NHCH₂CONH₂ NCOPr ¨Et CN NHCH₂CONH₂ NCHO ¨Et CN NHCH₂CONH₂ NCOiPr ¨Et CN NHCH₂CONH₂ NCOtBu ¨Et CN NHCH₂CONH₂ NCOPh ¨Et CN NHCH₂CONH₂ NSO₂Me ¨Et CN NHCH₂CONH₂ NSO₂Et ¨Et CN NHCH₂CONH₂ NSO₂PrEt CN NHCH₂CONH₂ NSO₂PhEt CN NHCH₂CONH₂ NSO₂iPrEt CN NHCH₂CONH₂ NNO₂Et CN NHCH₂CONH₂ NCOOMeEt CN NHCH₂CONH₂ NCOOEtEt CN NHCH₂CONH₂ NCOOPrEt CN NHCH₂CONH₂ NCOOiPrEt CN NHCH₂CONH₂ NCONHEtEt CN NHCH₂CONH₂ NCONHPrEt CN NHCH₂CONH₂ NCONH₂Et CN NHCH₂CONH₂ NCONHMeEt CN NHCH₂CONH₂ NCNEt CN NHCH₂CONH₂ NCOSMeEt CN NHCH₂CONH₂ NCOSEtEt CN NHCH₂CONH₂ NCSOMeEt CN NHCH₂CONH₂ NCSOEtEt CN NHCH₂CONH₂ NCSOPrEt CN NHCH₂CONH₂ NSO₂NH₂ ¨Et CN NHCH₂CONH₂ NSO₂NHMe ¨Et CN NHCH₂CONH₂ NSO₂NMe₂ ¨Et CN NHCH₂CONH₂ NP(O)(OMe)₂ ¨Et CN NHCH₂CONH₂ NP(O)(OEt)₂ ¨Et CN NHCH₂CONH₂ NP(O)Me₂ ¨Et CN NHCH₂CONH₂ NP(O)Et₂ ¨Et CN NHCH₂CONH₂ NP(O)Me(OMe) ¨Et CN NHCH₂CONH₂ NP(O)(OPr)₂Et CN NHCH₂CONH₂ NC(O)C(O)HEt CN NHCH₂CONH₂ NC(O)C(O)MeEt CN NHCH₂CONH₂ NC(O)C(O)OMeEt CN NHCH₂CONH₂ NC(O)C(O)OEtEt CN NHCH₂CONH₂ NC(O)C(O)NH₂Et CN NHCH₂CONH₂ NC(O)C(O)OHEt CN NHCH₂CONH₂ NC(NH)NH₂Et CN NHCH₂CONH₂ NC(NOH)NH₂Et CN NHCH₂CONH₂ NC(NH)NHMeEt CN NHCH₂CONH₂ NC(NH)NMe₂Et CN NHCH₂CONH₂ NC(NH)OMeEt CN NHCH₂CONH₂ NC(NH)OEtMe CN NHCH₂CH₂SMe NCOMeMe CN NHCH₂CH₂SMe NCOEtMe CN NHCH₂CH₂SMe NCOPrMe CN NHCH₂CH₂SMe NCHOMe CN NHCH₂CH₂SMe NCOiPrMe CN NHCH₂CH₂SMe NCOtBuMe CN NHCH₂CH₂SMe NCOPhMe CN NHCH₂CH₂SMe NSO₂Me ¨Me CN NHCH₂CH₂SMe NSO₂Et ¨Me CN NHCH₂CH₂SMe NSO₂Pr ¨Me CN NHCH₂CH₂SMe NSO₂Ph ¨Me CN NHCH₂CH₂SMe NSO₂iPr ¨Me CN NHCH₂CH₂SMe NNO₂ ¨Me CN NHCH₂CH₂SMe NCOOMe ¨Me CN NHCH₂CH₂SMe NCOOEt ¨Me CN NHCH₂CH₂SMe NCOOPrMe CN NHCH₂CH₂SMe NCOOiPrMe CN NHCH₂CH₂SMe NCONHEtMe CN NHCH₂CH₂SMe NCONHPrMe CN NHCH₂CH₂SMe NCONH₂Me CN NHCH₂CH₂SMe NCONHMeMe CN NHCH₂CH₂SMe NCNMe CN NHCH₂CH₂SMe NCOSMeMe CN NHCH₂CH₂SMe NCOSEtMe CN NHCH₂CH₂SMe NCSOMeMe CN NHCH₂CH₂SMe NCSOEtMe CN NHCH₂CH₂SMe NCSOPrMe CN NHCH₂CH₂SMe NSO₂NH₂Me CN NHCH₂CH₂SMe NSO₂NHMeMe CN NHCH₂CH₂SMe NSO₂NMe₂Me CN NHCH₂CH₂SMe NP(O)(OMe)₂Me CN NHCH₂CH₂SMe NP(O)(OEt)₂Me CN NHCH₂CH₂SMe NP(O)Me₂Me CN NHCH₂CH₂SMe NP(O)Et₂Me CN NHCH₂CH₂SMe NP(O)Me(OMe) ¨Me CN NHCH₂CH₂SMe NP(O)(OPr)₂ ¨Me CN NHCH₂CH₂SMe NC(O)C(O)H ¨Me CN NHCH₂CH₂SMe NC(O)C(O)Me ¨Me CN NHCH₂CH₂SMe NC(O)C(O)OMe ¨Me CN NHCH₂CH₂SMe NC(O)C(O)OEt ¨Me CN NHCH₂CH₂SMe NC(O)C(O)NH₂ ¨Me CN NHCH₂CH₂SMe NC(O)C(O)OH ¨Me CN NHCH₂CH₂SMe NC(NH)NH₂ ¨Me CN NHCH₂CH₂SMe NC(NOH)NH₂ ¨Me CN NHCH₂CH₂SMe NC(NH)NHMeMe CN NHCH₂CH₂SMe NC(NH)NMe₂Me CN NHCH₂CH₂SMe NC(NH)OMeMe CN NHCH₂CH₂SMe NC(NH)OEtMe CN NHCH₂CH₂SOMe NCOMeMe CN NHCH₂CH₂SOMe NCOEtMe CN NHCH₂CH₂SOMe NCOPrMe CN NHCH₂CH₂SOMe NCHOMe CN NHCH₂CH₂SOMe NCOiPrMe CN NHCH₂CH₂SOMe NCOtBuMe CN NHCH₂CH₂SOMe NCOPh ¨Me CN NHCH₂CH₂SOMe NSO₂MeMe CN NHCH₂CH₂SOMe NSO₂EtMe CN NHCH₂CH₂SOMe NSO₂PrMe CN NHCH₂CH₂SOMe NSO₂Ph ¨Me CN NHCH₂CH₂SOMe NSO₂iPrMe CN NHCH₂CH₂SOMe NNO₂Me CN NHCH₂CH₂SOMe NCOOMeMe CN NHCH₂CH₂SOMe NCOOEtMe CN NHCH₂CH₂SOMe NCOOPrMe CN NHCH₂CH₂SOMe NCOOiPr ¨Me CN NHCH₂CH₂SOMe NCONHEt ¨Me CN NHCH₂CH₂SOMe NCONHPr ¨Me CN NHCH₂CH₂SOMe NCONH₂ ¨Me CN NHCH₂CH₂SOMe NCONHMe ¨Me CN NHCH₂CH₂SOMe NCN ¨Me CN NHCH₂CH₂SOMe NCOSMe ¨Me CN NHCH₂CH₂SOMe NCOSEtMe CN NHCH₂CH₂SOMe NCSOMeMe CN NHCH₂CH₂SOMe NCSOEtMe CN NHCH₂CH₂SOMe NCSOPrMe CN NHCH₂CH₂SOMe NSO₂NH₂Me CN NHCH₂CH₂SOMe NSO₂NHMeMe CN NHCH₂CH₂SOMe NSO₂NMe₂Me CN NHCH₂CH₂SOMe NP(O)(OMe)₂Me CN NHCH₂CH₂SOMe NP(O)(OEt)₂Me CN NHCH₂CH₂SOMe NP(O)Me₂Me CN NHCH₂CH₂SOMe NP(O)Et₂Me CN NHCH₂CH₂SOMe NP(O)Me(OMe)Me CN NHCH₂CH₂SOMe NP(O)(OPr)₂Me CN NHCH₂CH₂SOMe NC(O)C(O)HMe CN NHCH₂CH₂SOMe NC(O)C(O)MeMe CN NHCH₂CH₂SOMe NC(O)C(O)OMeMe CN NHCH₂CH₂SOMe NC(O)C(O)OEtMe CN NHCH₂CH₂SOMe NC(O)C(O)NH₂Me CN NHCH₂CH₂SOMe NC(O)C(O)OHMe CN NHCH₂CH₂SOMe NC(NH)NH₂Me CN NHCH₂CH₂SOMe NC(NOH)NH₂Me CN NHCH₂CH₂SOMe NC(NH)NHMe ¨Me CN NHCH₂CH₂SOMe NC(NH)NMe₂ ¨Me CN NHCH₂CH₂SOMe NC(NH)OMe ¨Me CN NHCH₂CH₂SOMe NC(NH)OEt ¨Et CN NHCH₂CH₂SMe NCOMe ¨Et CN NHCH₂CH₂SMe NCOEt ¨Et CN NHCH₂CH₂SMe NCOPr ¨Et CN NHCH₂CH₂SMe NCHO ¨Et CN NHCH₂CH₂SMe NCOiPrEt CN NHCH₂CH₂SMe NCOtBuEt CN NHCH₂CH₂SMe NCOPhEt CN NHCH₂CH₂SMe NSO₂MeEt CN NHCH₂CH₂SMe NSO₂EtEt CN NHCH₂CH₂SMe NSO₂PrEt CN NHCH₂CH₂SMe NSO₂PhEt CN NHCH₂CH₂SMe NSO₂iPrEt CN NHCH₂CH₂SMe NNO₂Et CN NHCH₂CH₂SMe NCOOMeEt CN NHCH₂CH₂SMe NCOOEtEt CN NHCH₂CH₂SMe NCOOPrEt CN NHCH₂CH₂SMe NCOOiPrEt CN NHCH₂CH₂SMe NCONHEtEt CN NHCH₂CH₂SMe NCONHPrEt CN NHCH₂CH₂SMe NCONH₂Et CN NHCH₂CH₂SMe NCONHMeEt CN NHCH₂CH₂SMe NCNEt CN NHCH₂CH₂SMe NCOSMeEt CN NHCH₂CH₂SMe NCOSEtEt CN NHCH₂CH₂SMe NCSOMeEt CN NHCH₂CH₂SMe NCSOEtEt CN NHCH₂CH₂SMe NCSOPrEt CN NHCH₂CH₂SMe NSO₂NH₂Et CN NHCH₂CH₂SMe NSO₂NHMeEt CN NHCH₂CH₂SMe NSO₂NMe₂Et CN NHCH₂CH₂SMe NP(O)(OMe)₂Et CN NHCH₂CH₂SMe NP(O)(OEt)₂Et CN NHCH₂CH₂SMe NP(O)Me₂Et CN NHCH₂CH₂SMe NP(O)Et₂Et CN NHCH₂CH₂SMe NP(O)Me(OMe)Et CN NHCH₂CH₂SMe NP(O)(OPr)₂Et CN NHCH₂CH₂SMe NC(O)C(O)HEt CN NHCH₂CH₂SMe NC(O)C(O)MeEt CN NHCH₂CH₂SMe NC(O)C(O)OMeEt CN NHCH₂CH₂SMe NC(O)C(O)OEtEt CN NHCH₂CH₂SMe NC(O)C(O)NH₂Et CN NHCH₂CH₂SMe NC(O)C(O)OHEt CN NHCH₂CH₂SMe NC(NH)NH₂Et CN NHCH₂CH₂SMe NC(NOH)NH₂Et CN NHCH₂CH₂SMe NC(NH)NHMeEt CN NHCH₂CH₂SMe NC(NH)NMe₂Et CN NHCH₂CH₂SMe NC(NH)OMeEt CN NHCH₂CH₂SMe NC(NH)OEtEt CN NHCH₂CH₂SOMe NCOMeEt CN NHCH₂CH₂SOMe NCOEtEt CN NHCH₂CH₂SOMe NCOPr ¨Et CN NHCH₂CH₂SOMe NCHO ¨Et CN NHCH₂CH₂SOMe NCOiPr ¨Et CN NHCH₂CH₂SOMe NCOtBu ¨Et CN NHCH₂CH₂SOMe NCOPh ¨Et CN NHCH₂CH₂SOMe NSO₂Me ¨Et CN NHCH₂CH₂SOMe NSO₂Et ¨Et CN NHCH₂CH₂SOMe NSO₂Pr ¨Et CN NHCH₂CH₂SOMe NSO₂Ph ¨Et CN NHCH₂CH₂SOMe NSO₂iPrEt CN NHCH₂CH₂SOMe NNO₂Et CN NHCH₂CH₂SOMe NCOOMeEt CN NHCH₂CH₂SOMe NCOOEtEt CN NHCH₂CH₂SOMe NCOOPrEt CN NHCH₂CH₂SOMe NCOOiPrEt CN NHCH₂CH₂SOMe NCONHEtEt CN NHCH₂CH₂SOMe NCONHPrEt CN NHCH₂CH₂SOMe NCONH₂Et CN NHCH₂CH₂SOMe NCONHMeEt CN NHCH₂CH₂SOMe NCNEt CN NHCH₂CH₂SOMe NCOSMeEt CN NHCH₂CH₂SOMe NCOSEtEt CN NHCH₂CH₂SOMe NCSOMeEt CN NHCH₂CH₂SOMe NCSOEtEt CN NHCH₂CH₂SOMe NCSOPrEt CN NHCH₂CH₂SOMe NSO₂NH₂Et CN NHCH₂CH₂SOMe NSO₂NHMeEt CN NHCH₂CH₂SOMe NSO₂NMe₂Et CN NHCH₂CH₂SOMe NP(O)(OMe)₂Et CN NHCH₂CH₂SOMe NP(O)(OEt)₂Et CN NHCH₂CH₂SOMe NP(O)Me₂Et CN NHCH₂CH₂SOMe NP(O)Et₂Et CN NHCH₂CH₂SOMe NP(O)Me(OMe)Et CN NHCH₂CH₂SOMe NP(O)(OPr)₂Et CN NHCH₂CH₂SOMe NC(O)C(O)HEt CN NHCH₂CH₂SOMe NC(O)C(O)MeEt CN NHCH₂CH₂SOMe NC(O)C(O)OMeEt CN NHCH₂CH₂SOMe NC(O)C(O)OEtEt CN NHCH₂CH₂SOMe NC(O)C(O)NH₂Et CN NHCH₂CH₂SOMe NC(O)C(O)OHEt CN NHCH₂CH₂SOMe NC(NH)NH₂Et CN NHCH₂CH₂SOMe NC(NOH)NH₂Et CN NHCH₂CH₂SOMe NC(NH)NHMeEt CN NHCH₂CH₂SOMe NC(NH)NMe₂Et CN NHCH₂CH₂SOMe NC(NH)OMeEt CN NHCH₂CH₂SOMe NC(NH)OEtMe CN NHCOMe NCOMe OMe CN NHCOMe NCOEt OMe CN NHCOMe NCOPr OMe CN NHCOMe NCHO OMe CN NHCOMe NCOiPr OMe CN NHCOMe NCOtBu OMe CN NHCOMe NCOPh OMe CN NHCOMe NSO₂Me OMe CN NHCOMe NSO₂Et OMe CN NHCOMe NSO₂Pr OMe CN NHCOMe NSO₂Ph OMe CN NHCOMe NSO₂iPr OMe CN NHCOMe NNO₂ OMe CN NHCOMe NCOOMe OMe CN NHCOMe NCOOEt OMe CN NHCOMe NCOOPr OMe CN NHCOMe NCOOiPr OMe CN NHCOMe NCONHEt OMe CN NHCOMe NCONHPr OMe CN NHCOMe NCONH₂ OMe CN NHCOMe NCONHMe OMe CN NHCOMe NCN OMe CN NHCOMe NCOSMe OMe CN NHCOMe NCOSEt OMe CN NHCOMe NCSOMe OMe CN NHCOMe NCSOEt OMe CN NHCOMe NCSOPr OMe CN NHCOMe NSO₂NH₂ OMe CN NHCOMe NSO₂NHMe OMe CN NHCOMe NSO₂NMe₂ OMe CN NHCOMe NP(O)(OMe)₂ OMe CN NHCOMe NP(O)(OEt)₂ OMe CN NHCOMe NP(O)Me₂ OMe CN NHCOMe NP(O)Et₂ OMe CN NHCOMe NP(O)Me(OMe) OMe CN NHCOMe NP(O)(OPr)₂ OMe CN NHCOMe NC(O)C(O)H OMe CN NHCOMe NC(O)C(O)Me OMe CN NHCOMe NC(O)C(O)OMe OMe CN NHCOMe NC(O)C(O)OEt OMe CN NHCOMe NC(O)C(O)NH₂ OMe CN NHCOMe NC(O)C(O)OH OMe CN NHCOMe NC(NH)NH₂ OMe CN NHCOMe NC(NOH)NH₂ OMe CN NHCOMe NC(NH)NHMe OMe CN NHCOMe NC(NH)NMe₂ OMe CN NHCOMe NC(NH)OMe OMe CN NHCOMe NC(NH)OEt OEt CN NHCOMe NCOMe OEt CN NHCOMe NCOEt OEt CN NHCOMe NCOPr OEt CN NHCOMe NCHO OEt CN NHCOMe NCOiPr OEt CN NHCOMe NCOtBu OEt CN NHCOMe NCOPh OEt CN NHCOMe NSO₂Me OEt CN NHCOMe NSO₂Et OEt CN NHCOMe NSO₂Pr OEt CN NHCOMe NSO₂Ph OEt CN NHCOMe NSO₂iPr OEt CN NHCOMe NNO₂ OEt CN NHCOMe NCOOMe OEt CN NHCOMe NCOOEt OEt CN NHCOMe NCOOPr OEt CN NHCOMe NCOOiPr OEt CN NHCOMe NCONHEt OEt CN NHCOMe NCONHPr OEt CN NHCOMe NCONH₂ OEt CN NHCOMe NCONHMe OEt CN NHCOMe NCN OEt CN NHCOMe NCOSMe OEt CN NHCOMe NCOSEt OEt CN NHCOMe NCSOMe OEt CN NHCOMe NCSOEt OEt CN NHCOMe NCSOPr OEt CN NHCOMe NSO₂NH₂ OEt CN NHCOMe NSO₂NHMe OEt CN NHCOMe NSO₂NMe₂ OEt CN NHCOMe NP(O)(OMe)₂ OEt CN NHCOMe NP(O)(OEt)₂ OEt CN NHCOMe NP(O)Me₂ OEt CN NHCOMe NP(O)Et₂ OEt CN NHCOMe NP(O)Me(OMe) OEt CN NHCOMe NP(O)(OPr)₂ OEt CN NHCOMe NC(O)C(O)H OEt CN NHCOMe NC(O)C(O)Me OEt CN NHCOMe NC(O)C(O)OMe OEt CN NHCOMe NC(O)C(O)OEt OEt CN NHCOMe NC(O)C(O)NH₂ OEt CN NHCOMe NC(O)C(O)OH OEt CN NHCOMe NC(NH)NH₂ OEt CN NHCOMe NC(NOH)NH₂ OEt CN NHCOMe NC(NH)NHMe OEt CN NHCOMe NC(NH)NMe₂ OEt CN NHCOMe NC(NH)OMe OEt CN NHCOMe NC(NH)OEt OMe CN NHCOOMe NCOMe OMe CN NHCOOMe NCOEt OMe CN NHCOOMe NCOPr OMe CN NHCOOMe NCHO OMe CN NHCOOMe NCOiPr OMe CN NHCOOMe NCOtBu OMe CN NHCOOMe NCOPh OMe CN NHCOOMe NSO₂Me OMe CN NHCOOMe NSO₂Et OMe CN NHCOOMe NSO₂Pr OMe CN NHCOOMe NSO₂Ph OMe CN NHCOOMe NSO₂iPr OMe CN NHCOOMe NNO₂ OMe CN NHCOOMe NCOOMe OMe CN NHCOOMe NCOOEt OMe CN NHCOOMe NCOOPr OMe CN NHCOOMe NCOOiPr OMe CN NHCOOMe NCONHEt OMe CN NHCOOMe NCONHPr OMe CN NHCOOMe NCONH₂ OMe CN NHCOOMe NCONHMe OMe CN NHCOOMe NCN OMe CN NHCOOMe NCOSMe OMe CN NHCOOMe NCOSEt OMe CN NHCOOMe NCSOMe OMe CN NHCOOMe NCSOEt OMe CN NHCOOMe NCSOPr OMe CN NHCOOMe NSO₂NH₂ OMe CN NHCOOMe NSO₂NHMe OMe CN NHCOOMe NSO₂NMe₂ OMe CN NHCOOMe NP(O)(OMe)₂ OMe CN NHCOOMe NP(O)(OEt)₂ OMe CN NHCOOMe NP(O)Me₂ OMe CN NHCOOMe NP(O)Et₂ OMe CN NHCOOMe NP(O)Me(OMe) OMe CN NHCOOMe NP(O)(OPr)₂ OMe CN NHCOOMe NC(O)C(O)H OMe CN NHCOOMe NC(O)C(O)Me OMe CN NHCOOMe NC(O)C(O)OMe OMe CN NHCOOMe NC(O)C(O)OEt OMe CN NHCOOMe NC(O)C(O)NH₂ OMe CN NHCOOMe NC(O)C(O)OH OMe CN NHCOOMe NC(NH)NH₂ OMe CN NHCOOMe NC(NOH)NH₂ OMe CN NHCOOMe NC(NH)NHMe OMe CN NHCOOMe NC(NH)NMe₂ OMe CN NHCOOMe NC(NH)OMe OMe CN NHCOOMe NC(NH)OEt OEt CN NHCOOMe NCOMe OEt CN NHCOOMe NCOEt OEt CN NHCOOMe NCOPr OEt CN NHCOOMe NCHO OEt CN NHCOOMe NCOiPr OEt CN NHCOOMe NCOtBu OEt CN NHCOOMe NCOPh OEt CN NHCOOMe NSO₂Me OEt CN NHCOOMe NSO₂Et OEt CN NHCOOMe NSO₂Pr OEt CN NHCOOMe NSO₂Ph OEt CN NHCOOMe NSO₂iPr OEt CN NHCOOMe NNO₂ OEt CN NHCOOMe NCOOMe OEt CN NHCOOMe NCOOEt OEt CN NHCOOMe NCOOPr OEt CN NHCOOMe NCOOiPr OEt CN NHCOOMe NCONHEt OEt CN NHCOOMe NCONHPr OEt CN NHCOOMe NCONH₂ OEt CN NHCOOMe NCONHMe OEt CN NHCOOMe NCN OEt CN NHCOOMe NCOSMe OEt CN NHCOOMe NCOSEt OEt CN NHCOOMe NCSOMe OEt CN NHCOOMe NCSOEt OEt CN NHCOOMe NCSOPr OEt CN NHCOOMe NSO₂NH₂ OEt CN NHCOOMe NSO₂NHMe OEt CN NHCOOMe NSO₂NMe₂ OEt CN NHCOOMe NP(O)(OMe)₂ OEt CN NHCOOMe NP(O)(OEt)₂ OEt CN NHCOOMe NP(O)Me₂ OEt CN NHCOOMe NP(O)Et₂ OEt CN NHCOOMe NP(O)Me(OMe) OEt CN NHCOOMe NP(O)(OPr)₂ OEt CN NHCOOMe NC(O)C(O)H OEt CN NHCOOMe NC(O)C(O)Me OEt CN NHCOOMe NC(O)C(O)OMe OEt CN NHCOOMe NC(O)C(O)OEt OEt CN NHCOOMe NC(O)C(O)NH₂ OEt CN NHCOOMe NC(O)C(O)OH OEt CN NHCOOMe NC(NH)NH₂ OEt CN NHCOOMe NC(NOH)NH₂ OEt CN NHCOOMe NC(NH)NHMe OEt CN NHCOOMe NC(NH)NMe₂ OEt CN NHCOOMe NC(NH)OMe OEt CN NHCOOMe NC(NH)OEt OCF₃ CN NH₂ NCOMeCF₃ CN NH₂ NCOEtCF₃ CN NH₂ NCOPrCF₃ CN NH₂ NCHOCF₃ CN NH₂ NCOiPrCF₃ CN NH₂ NCOtBuCF₃ CN NH₂ NCOPhCF₃ CN NH₂ NSO₂MeCF₃ CN NH₂ NSO₂EtCF₃ CN NH₂ NSO₂PrCF₃ CN NH₂ NSO₂PhCF₃ CN NH₂ NSO₂iPrCF₃ CN NH₂ NNO₂CF₃ CN NH₂ NCOOMeCF₃ CN NH₂ NCOOEt ¨CF₃ CN NH₂ NCOOPr ¨CF₃ CN NH₂ NCOOiPr ¨CF₃ CN NH₂ NCONHEt ¨CF₃ CN NH₂ NCONHPr ¨CF₃ CN NH₂ NCONH₂ ¨CF₃ CN NH₂ NCONHMe ¨CF₃ CN NH₂ NCN ¨CF₃ CN NH₂ NCOSMe ¨CF₃ CN NH₂ NCOSEtCF₃ CN NH₂ NCSOMeCF₃ CN NH₂ NCSOEtCF₃ CN NH₂ NCSOPrCF₃ CN NH₂ NSO₂NH₂CF₃ CN NH₂ NSO₂NHMeCF₃ CN NH₂ NSO₂NMe₂CF₃ CN NH₂ NP(O)(OMe)₂CF₃ CN NH₂ NP(O)(OEt)₂CF₃ CN NH₂ NP(O)Me₂CF₃ CN NH₂ NP(O)Et₂CF₃ CN NH₂ NP(O)Me(OMe)CF₃ CN NH₂ NP(O)(OPr)₂CF₃ CN NH₂ NC(O)C(O)HCF₃ CN NH₂ NC(O)C(O)MeCF₃ CN NH₂ NC(O)C(O)OMeCF₃ CN NH₂ NC(O)C(O)OEtCF₃ CN NH₂ NC(O)C(O)NH₂CF₃ CN NH₂ NC(O)C(O)OHCF₃ CN NH₂ NC(NH)NH₂ ¨CF₃ CN NH₂ NC(NOH)NH₂ ¨CF₃ CN NH₂ NC(NH)NHMe ¨CF₃ CN NH₂ NC(NH)NMe₂ ¨CF₃ CN NH₂ NC(NH)OMe ¨CF₃ CN NH₂ NC(NH)OEt ¨CF₃ CN NHMe NCOMe ¨CF₃ CN NHMe NCOEt ¨CF₃ CN NHMe NCOPr ¨CF₃ CN NHMe NCHO ¨CF₃ CN NHMe NCOiPrCF₃ CN NHMe NCOtBuCF₃ CN NHMe NCOPhCF₃ CN NHMe NSO₂MeCF₃ CN NHMe NSO₂EtCF₃ CN NHMe NSO₂PrCF₃ CN NHMe NSO₂PhCF₃ CN NHMe NSO₂iPrCF₃ CN NHMe NNO₂CF₃ CN NHMe NCOOMe ¨CF₃ CN NHMe NCOOEt ¨CF₃ CN NHMe NCOOPrCF₃ CN NHMe NCOOiPrCF₃ CN NHMe NCONHEtCF₃ CN NHMe NCONHPrCF₃ CN NHMe NCONH₂CF₃ CN NHMe NCONHMeCF₃ CN NHMe NCNCF₃ CN NHMe NCOSMe ¨CF₃ CN NHMe NCOSEt ¨CF₃ CN NHMe NCSOMe ¨CF₃ CN NHMe NCSOEt ¨CF₃ CN NHMe NCSOPr ¨CF₃ CN NHMe NSO₂NH₂ ¨CF₃ CN NHMe NSO₂NHMe ¨CF₃ CN NHMe NSO₂NMe₂ ¨CF₃ CN NHMe NP(O)(OMe)₂ ¨CF₃ CN NHMe NP(O)(OEt)₂ ¨CF₃ CN NHMe NP(O)Me₂CF₃ CN NHMe NP(O)Et₂CF₃ CN NHMe NP(O)Me(OMe)CF₃ CN NHMe NP(O)(OPr)₂CF₃ CN NHMe NC(O)C(O)HCF₃ CN NHMe NC(O)C(O)MeCF₃ CN NHMe NC(O)C(O)OMeCF₃ CN NHMe NC(O)C(O)OEtCF₃ CN NHMe NC(O)C(O)NH₂CF₃ CN NHMe NC(O)C(O)OHCF₃ CN NHMe NC(NH)NH₂CF₃ CN NHMe NC(NOH)NH₂CF₃ CN NHMe NC(NH)NHMeCF₃ CN NHMe NC(NH)NMe₂CF₃ CN NHMe NC(NH)OMeCF₃ CN NHMe NC(NH)OEtCF₃ CN NHEt NCOMeCF₃ CN NHEt NCOEtCF₃ CN NHEt NCOPrCF₃ CN NHEt NCHOCF₃ CN NHEt NCOiPr ¨CF₃ CN NHEt NCOtBu ¨CF₃ CN NHEt NCOPh ¨CF₃ CN NHEt NSO₂Me ¨CF₃ CN NHEt NSO₂Et ¨CF₃ CN NHEt NSO₂Pr ¨CF₃ CN NHEt NSO₂Ph ¨CF₃ CN NHEt NSO₂iPrCF₃ CN NHEt NNO₂CF₃ CN NHEt NCOOMeCF₃ CN NHEt NCOOEtCF₃ CN NHEt NCOOPrCF₃ CN NHEt NCOOiPrCF₃ CN NHEt NCONHEtCF₃ CN NHEt NCONHPrCF₃ CN NHEt NCONH₂CF₃ CN NHEt NCONHMeCF₃ CN NHEt NCNCF₃ CN NHEt NCOSMeCF₃ CN NHEt NCOSEtCF₃ CN NHEt NCSOMeCF₃ CN NHEt NCSOEtCF₃ CN NHEt NCSOPrCF₃ CN NHEt NSO₂NH₂CF₃ CN NHEt NSO₂NHMeCF₃ CN NHEt NSO₂NMe₂CF₃ CN NHEt NP(O)(OMe)₂CF₃ CN NHEt NP(O)(OEt)₂CF₃ CN NHEt NP(O)Me₂CF₃ CN NHEt NP(O)Et₂CF₃ CN NHEt NP(O)Me(OMe)CF₃ CN NHEt NP(O)(OPr)₂CF₃ CN NHEt NC(O)C(O)HCF₃ CN NHEt NC(O)C(O)MeCF₃ CN NHEt NC(O)C(O)OMeCF₃ CN NHEt NC(O)C(O)OEtCF₃ CN NHEt NC(O)C(O)NH₂CF₃ CN NHEt NC(O)C(O)OHCF₃ CN NHEt NC(NH)NH₂CF₃ CN NHEt NC(NOH)NH₂CF₃ CN NHEt NC(NH)NHMeCF₃ CN NHEt NC(NH)NMe₂CF₃ CN NHEt NC(NH)OMeCF₃ CN NHEt NC(NH)OEtCF₃ CN NHCOMe NCOMeCF₃ CN NHCOMe NCOEtCF₃ CN NHCOMe NCOPrCF₃ CN NHCOMe NCHOCF₃ CN NHCOMe NCOiPrCF₃ CN NHCOMe NCOtBuCF₃ CN NHCOMe NCOPhCF₃ CN NHCOMe NSO₂MeCF₃ CN NHCOMe NSO₂EtCF₃ CN NHCOMe NSO₂PrCF₃ CN NHCOMe NSO₂PhCF₃ CN NHCOMe NSO₂iPrCF₃ CN NHCOMe NNO₂CF₃ CN NHCOMe NCOOMe ¨CF₃ CN NHCOMe NCOOEt ¨CF₃ CN NHCOMe NCOOPr ¨CF₃ CN NHCOMe NCOOiPr ¨CF₃ CN NHCOMe NCONHEt ¨CF₃ CN NHCOMe NCONHPr ¨CF₃ CN NHCOMe NCONH₂CF₃ CN NHCOMe NCONHMeCF₃ CN NHCOMe NCNCF₃ CN NHCOMe NCOSMeCF₃ CN NHCOMe NCOSEtCF₃ CN NHCOMe NCSOMeCF₃ CN NHCOMe NCSOEtCF₃ CN NHCOMe NCSOPrCF₃ CN NHCOMe NSO₂NH₂CF₃ CN NHCOMe NSO₂NHMeCF₃ CN NHCOMe NSO₂NMe₂CF₃ CN NHCOMe NP(O)(OMe)₂CF₃ CN NHCOMe NP(O)(OEt)₂CF₃ CN NHCOMe NP(O)Me₂CF₃ CN NHCOMe NP(O)Et₂CF₃ CN NHCOMe NP(O)Me(OMe)CF₃ CN NHCOMe NP(O)(OPr)₂CF₃ CN NHCOMe NC(O)C(O)HCF₃ CN NHCOMe NC(O)C(O)MeCF₃ CN NHCOMe NC(O)C(O)OMeCF₃ CN NHCOMe NC(O)C(O)OEtCF₃ CN NHCOMe NC(O)C(O)NH₂CF₃ CN NHCOMe NC(O)C(O)OHCF₃ CN NHCOMe NC(NH)NH₂CF₃ CN NHCOMe NC(NOH)NH₂CF₃ CN NHCOMe NC(NH)NHMeCF₃ CN NHCOMe NC(NH)NMe₂CF₃ CN NHCOMe NC(NH)OMeCF₃ CN NHCOMe NC(NH)OEtCF₃ CN NH₂ NCOMe OCF₃ CN NH₂ NH OCF₃ CN NH₂ NCOEt OCF₃ CN NH₂ NCOPr OCF₃ CN NH₂ NCHO OCF₃ CN NH₂ NCOiPr OCF₃ CN NH₂ NCOtBu OCF₃ CN NH₂ NCOPh OCF₃ CN NH₂ NSO₂Me OCF₃ CN NH₂ NSO₂Et OCF₃ CN NH₂ NSO₂Pr OCF₃ CN NH₂ NSO₂Ph OCF₃ CN NH₂ NSO₂iPr OCF₃ CN NH₂ NNO₂ OCF₃ CN NH₂ NCOOMe OCF₃ CN NH₂ NCOOEt OCF₃ CN NH₂ NCOOPr OCF₃ CN NH₂ NCOOiPr OCF₃ CN NH₂ NCONHEt OCF₃ CN NH₂ NCONHPr OCF₃ CN NH₂ NCONH₂ OCF₃ CN NH₂ NCONHMe OCF₃ CN NH₂ NCN OCF₃ CN NH₂ NCOSMe OCF₃ CN NH₂ NCOSEt OCF₃ CN NH₂ NCSOMe OCF₃ CN NH₂ NCSOEt OCF₃ CN NH₂ NCSOPr OCF₃ CN NH₂ NSO₂NH₂ OCF₃ CN NH₂ NSO₂NHMe OCF₃ CN NH₂ NSO₂NMe₂ OCF₃ CN NH₂ NP(O)(OMe)₂ OCF₃ CN NH₂ NP(O)(OEt)₂ OCF₃ CN NH₂ NP(O)Me₂ OCF₃ CN NH₂ NP(O)Et₂ OCF₃ CN NH₂ NP(O)Me(OMe) OCF₃ CN NH₂ NP(O)(OPr)₂ OCF₃ CN NH₂ NC(O)C(O)H OCF₃ CN NH₂ NC(O)C(O)Me OCF₃ CN NH₂ NC(O)C(O)OMe OCF₃ CN NH₂ NC(O)C(O)OEt OCF₃ CN NH₂ NC(O)C(O)NH₂ OCF₃ CN NH₂ NC(O)C(O)OH OCF₃ CN NH₂ NC(NH)NH₂ OCF₃ CN NH₂ NC(NOH)NH₂ OCF₃ CN NH₂ NC(NH)NHMe OCF₃ CN NH₂ NC(NH)NMe₂ OCF₃ CN NH₂ NC(NH)OMe OCF₃ CN NH₂ NC(NH)OEt OCF₃ CN NHMe NCOMe OCF₃ CN NHMe NCOEt OCF₃ CN NHMe NCOPr OCF₃ CN NHMe NCHO OCF₃ CN NHMe NCOiPr OCF₃ CN NHMe NCOtBu OCF₃ CN NHMe NCOPh OCF₃ CN NHMe NSO₂Me OCF₃ CN NHMe NSO₂Et OCF₃ CN NHMe NSO₂Pr OCF₃ CN NHMe NSO₂Ph OCF₃ CN NHMe NSO₂iPr OCF₃ CN NHMe NNO₂ OCF₃ CN NHMe NCOOMe OCF₃ CN NHMe NCOOEt OCF₃ CN NHMe NCOOPr OCF₃ CN NHMe NCOOiPr OCF₃ CN NHMe NCONHEt OCF₃ CN NHMe NCONHPr OCF₃ CN NHMe NCONH₂ OCF₃ CN NHMe NCONHMe OCF₃ CN NHMe NCN OCF₃ CN NHMe NCOSMe OCF₃ CN NHMe NCOSEt OCF₃ CN NHMe NCSOMe OCF₃ CN NHMe NCSOEt OCF₃ CN NHMe NCSOPr OCF₃ CN NHMe NSO₂NH₂ OCF₃ CN NHMe NSO₂NHMe OCF₃ CN NHMe NSO₂NMe₂ OCF₃ CN NHMe NP(O)(OMe)₂ OCF₃ CN NHMe NP(O)(OEt)₂ OCF₃ CN NHMe NP(O)Me₂ OCF₃ CN NHMe NP(O)Et₂ OCF₃ CN NHMe NP(O)Me(OMe) OCF₃ CN NHMe NP(O)(OPr)₂ OCF₃ CN NHMe NC(O)C(O)H OCF₃ CN NHMe NC(O)C(O)Me OCF₃ CN NHMe NC(O)C(O)OMe OCF₃ CN NHMe NC(O)C(O)OEt OCF₃ CN NHMe NC(O)C(O)NH₂ OCF₃ CN NHMe NC(O)C(O)OH OCF₃ CN NHMe NC(NH)NH₂ OCF₃ CN NHMe NC(NOH)NH₂ OCF₃ CN NHMe NC(NH)NHMe OCF₃ CN NHMe NC(NH)NMe₂ OCF₃ CN NHMe NC(NH)OMe OCF₃ CN NHMe NC(NH)OEt OCF₃ CN NHEt NCOMe OCF₃ CN NHEt NCOEt OCF₃ CN NHEt NCOPr OCF₃ CN NHEt NCHO OCF₃ CN NHEt NCOiPr OCF₃ CN NHEt NCOtBu OCF₃ CN NHEt NCOPh OCF₃ CN NHEt NSO₂Me OCF₃ CN NHEt NSO₂Et OCF₃ CN NHEt NSO₂Pr OCF₃ CN NHEt NSO₂Ph OCF₃ CN NHEt NSO₂iPr OCF₃ CN NHEt NNO₂ OCF₃ CN NHEt NCOOMe OCF₃ CN NHEt NCOOEt OCF₃ CN NHEt NCOOPr OCF₃ CN NHEt NCOOiPr OCF₃ CN NHEt NCONHEt OCF₃ CN NHEt NCONHPr OCF₃ CN NHEt NCONH₂ OCF₃ CN NHEt NCONHMe OCF₃ CN NHEt NCN OCF₃ CN NHEt NCOSMe OCF₃ CN NHEt NCOSEt OCF₃ CN NHEt NCSOMe OCF₃ CN NHEt NCSOEt OCF₃ CN NHEt NCSOPr OCF₃ CN NHEt NSO₂NH₂ OCF₃ CN NHEt NSO₂NHMe OCF₃ CN NHEt NSO₂NMe₂ OCF₃ CN NHEt NP(O)(OMe)₂ OCF₃ CN NHEt NP(O)(OEt)₂ OCF₃ CN NHEt NP(O)Me₂ OCF₃ CN NHEt NP(O)Et₂ OCF₃ CN NHEt NP(O)Me(OMe) OCF₃ CN NHEt NP(O)(OPr)₂ OCF₃ CN NHEt NC(O)C(O)H OCF₃ CN NHEt NC(O)C(O)Me OCF₃ CN NHEt NC(O)C(O)OMe OCF₃ CN NHEt NC(O)C(O)OEt OCF₃ CN NHEt NC(O)C(O)NH₂ OCF₃ CN NHEt NC(O)C(O)OH OCF₃ CN NHEt NC(NH)NH₂ OCF₃ CN NHEt NC(NOH)NH₂ OCF₃ CN NHEt NC(NH)NHMe OCF₃ CN NHEt NC(NH)NMe₂ OCF₃ CN NHEt NC(NH)OMe OCF₃ CN NHEt NC(NH)OEt OCCl₂F CN NH₂ NCOMeCCl₂F CN NH₂ NCOEtCCl₂F CN NH₂ NCOPrCCl₂F CN NH₂ NCHOCCl₂F CN NH₂ NCOiPrCCl₂F CN NH₂ NCOtBuCCl₂F CN NH₂ NCOPhCCl₂F CN NH₂ NSO₂MeCCl₂F CN NH₂ NSO₂EtCCl₂F CN NH₂ NSO₂PrCCl₂F CN NH₂ NSO₂PhCCl₂F CN NH₂ NSO₂iPrCCl₂F CN NH₂ NNO₂CCl₂F CN NH₂ NCOOMeCCl₂F CN NH₂ NCOOEtCCl₂F CN NH₂ NCOOPrCCl₂F CN NH₂ NCOOiPrCCl₂F CN NH₂ NCONHEtCCl₂F CN NH₂ NCONHPrCCl₂F CN NH₂ NCONH₂CCl₂F CN NH₂ NCONHMeCCl₂F CN NH₂ NCNCCl₂F CN NH₂ NCOSMeCCl₂F CN NH₂ NCOSEtCCl₂F CN NH₂ NCSOMeCCl₂F CN NH₂ NCSOEtCCl₂F CN NH₂ NCSOPrCCl₂F CN NH₂ NSO₂NH₂CCl₂F CN NH₂ NSO₂NHMeCCl₂F CN NH₂ NSO₂NMe₂CCl₂F CN NH₂ NP(O)(OMe)₂CCl₂F CN NH₂ NP(O)(OEt)₂CCl₂F CN NH₂ NP(O)Me₂CCl₂F CN NH₂ NP(O)Et₂CCl₂F CN NH₂ NP(O)Me(OMe)CCl₂F CN NH₂ NP(O)(OPr)₂CCl₂F CN NH₂ NC(O)C(O)HCCl₂F CN NH₂ NC(O)C(O)MeCCl₂F CN NH₂ NC(O)C(O)OMeCCl₂F CN NH₂ NC(O)C(O)OEtCCl₂F CN NH₂ NC(O)C(O)NH₂CCl₂F CN NH₂ NC(O)C(O)OHCCl₂F CN NH₂ NC(NH)NH₂ ¨CCl₂F CN NH₂ NC(NOH)NH₂ ¨CCl₂F CN NH₂ NC(NH)NHMe ¨CCl₂F CN NH₂ NC(NH)NMe₂ ¨CCl₂F CN NH₂ NC(NH)OMe ¨CCl₂F CN NH₂ NC(NH)OEt ¨CCl₂F CN NHMe NCOMe ¨CCl₂F CN NHMe NCOEt ¨CCl₂F CN NHMe NCOPr ¨CCl₂F CN NHMe NCHO ¨CCl₂F CN NHMe NCOiPr ¨CCl₂F CN NHMe NCOtBuCCl₂F CN NHMe NCOPhCCl₂F CN NHMe NSO₂MeCCl₂F CN NHMe NSO₂EtCCl₂F CN NHMe NSO₂PrCCl₂F CN NHMe NSO₂PhCCl₂F CN NHMe NSO₂iPrCCl₂F CN NHMe NNO₂CCl₂F CN NHMe NCOOMeCCl₂F CN NHMe NCOOEtCCl₂F CN NHMe NCOOPrCCl₂F CN NHMe NCOOiPrCCl₂F CN NHMe NCONHEtCCl₂F CN NHMe NCONHPrCCl₂F CN NHMe NCONH₂CCl₂F CN NHMe NCONHMe ¨CCl₂F CN NHMe NCN ¨CCl₂F CN NHMe NCOSMe ¨CCl₂F CN NHMe NCOSEt ¨CCl₂F CN NHMe NCSOMe ¨CCl₂F CN NHMe NCSOEt ¨CCl₂F CN NHMe NCSOPr ¨CCl₂F CN NHMe NSO₂NH₂ ¨CCl₂F CN NHMe NSO₂NHMe ¨CCl₂F CN NHMe NSO₂NMe₂ ¨CCl₂F CN NHMe NP(O)(OMe)₂ ¨CCl₂F CN NHMe NP(O)(OEt)₂ ¨CCl₂F CN NHMe NP(O)Me₂CCl₂F CN NHMe NP(O)Et₂CCl₂F CN NHMe NP(O)Me(OMe)CCl₂F CN NHMe NP(O)(OPr)₂CCl₂F CN NHMe NC(O)C(O)HCCl₂F CN NHMe NC(O)C(O)MeCCl₂F CN NHMe NC(O)C(O)OMeCCl₂F CN NHMe NC(O)C(O)OEtCCl₂F CN NHMe NC(O)C(O)NH₂CCl₂F CN NHMe NC(O)C(O)OH ¨CCl₂F CN NHMe NC(NH)NH₂ ¨CCl₂F CN NHMe NC(NOH)NH₂ ¨CCl₂F CN NHMe NC(NH)NHMe ¨CCl₂F CN NHMe NC(NH)NMe₂ ¨CCl₂F CN NHMe NC(NH)OMe ¨CCl₂F CN NHMe NC(NH)OEtCCl₂F CN NHEt NCOMe ¨CCl₂F CN NHEt NCOEtCCl₂F CN NHEt NCOPr ¨CCl₂F CN NHEt NCHO ¨CCl₂F CN NHEt NCOiPr ¨CCl₂F CN NHEt NCOtBu ¨CCl₂F CN NHEt NCOPh ¨CCl₂F CN NHEt NSO₂Me ¨CCl₂F CN NHEt NSO₂Et ¨CCl₂F CN NHEt NSO₂Pr ¨CCl₂F CN NHEt NSO₂Ph ¨CCl₂F CN NHEt NSO₂iPr ¨CCl₂F CN NHEt NNO₂CCl₂F CN NHEt NCOOMeCCl₂F CN NHEt NCOOEtCCl₂F CN NHEt NCOOPrCCl₂F CN NHEt NCOOiPrCCl₂F CN NHEt NCONHEtCCl₂F CN NHEt NCONHPrCCl₂F CN NHEt NCONH₂CCl₂F CN NHEt NCONHMeCCl₂F CN NHEt NCNCCl₂F CN NHEt NCOSMeCCl₂F CN NHEt NCOSEtCCl₂F CN NHEt NCSOMeCCl₂F CN NHEt NCSOEtCCl₂F CN NHEt NCSOPrCCl₂F CN NHEt NSO₂NH₂CCl₂F CN NHEt NSO₂NHMe ¨CCl₂F CN NHEt NSO₂NMe₂ ¨CCl₂F CN NHEt NP(O)(OMe)₂ ¨CCl₂F CN NHEt NP(O)(OEt)₂ ¨CCl₂F CN NHEt NP(O)Me₂ ¨CCl₂F CN NHEt NP(O)Et₂ ¨CCl₂F CN NHEt NP(O)Me(OMe ¨CCl₂F CN NHEt NP(O)(OPr)₂ ¨CCl₂F CN NHEt NC(O)C(O)H ¨CCl₂F CN NHEt NC(O)C(O)Me ¨CCl₂F CN NHEt NC(O)C(O)OMe ¨CCl₂F CN NHEt NC(O)C(O)OEtCCl₂F CN NHEt NC(O)C(O)NH₂CCl₂F CN NHEt NC(O)C(O)OHCCl₂F CN NHEt NC(NH)NH₂CCl₂F CN NHEt NC(NOH)NH₂CCl₂F CN NHEt NC(NH)NHMeCCl₂F CN NHEt NC(NH)NMe₂CCl₂F CN NHEt NC(NH)OMeCCl₂F CN NHEt NC(NH)OEtCCl₂F CN NH₂ NH OCCl₂F CN NH₂ NCOMe OCCl₂F CN NH₂ NCOEt OCCl₂F CN NH₂ NCOPr OCCl₂F CN NH₂ NCHO OCCl₂F CN NH₂ NCOiPr OCCl₂F CN NH₂ NCOtBu OCCl₂F CN NH₂ NCOPh OCCl₂F CN NH₂ NSO₂Me OCCl₂F CN NH₂ NSO₂Et OCCl₂F CN NH₂ NSO₂Pr OCCl₂F CN NH₂ NSO₂Ph OCCl₂F CN NH₂ NSO₂iPr OCCl₂F CN NH₂ NNO₂ OCCl₂F CN NH₂ NCOOMe OCCl₂F CN NH₂ NCOOEt OCCl₂F CN NH₂ NCOOPr OCCl₂F CN NH₂ NCOOiPr OCCl₂F CN NH₂ NCONHEt OCCl₂F CN NH₂ NCONHPr OCCl₂F CN NH₂ NCONH₂ OCCl₂F CN NH₂ NCONHMe OCCl₂F CN NH₂ NCN OCCl₂F CN NH₂ NCOSMe OCCl₂F CN NH₂ NCOSEt OCCl₂F CN NH₂ NCSOMe OCCl₂F CN NH₂ NCSOEt OCCl₂F CN NH₂ NCSOPr OCCl₂F CN NH₂ NSO₂NH₂ OCCl₂F CN NH₂ NSO₂NHMe OCCl₂F CN NH₂ NSO₂NMe₂ OCCl₂F CN NH₂ NP(O)(OMe)₂ OCCl₂F CN NH₂ NP(O)(OEt)₂ OCCl₂F CN NH₂ NP(O)Me₂ OCCl₂F CN NH₂ NP(O)Et₂ OCCl₂F CN NH₂ NP(O)Me(OMe) OCCl₂F CN NH₂ NP(O)(OPr)₂ OCCl₂F CN NH₂ NC(O)C(O)H OCCl₂F CN NH₂ NC(O)C(O)Me OCCl₂F CN NH₂ NC(O)C(O)OMe OCCl₂F CN NH₂ NC(O)C(O)OEt OCCl₂F CN NH₂ NC(O)C(O)NH₂ OCCl₂F CN NH₂ NC(O)C(O)OH OCCl₂F CN NH₂ NC(NH)NH₂ OCCl₂F CN NH₂ NC(NOH)NH₂ OCCl₂F CN NH₂ NC(NH)NHMe OCCl₂F CN NH₂ NC(NH)NMe₂ OCCl₂F CN NH₂ NC(NH)OMe OCCl₂F CN NH₂ NC(NH)OEt OCCl₂F CN NHMe NCOMe OCCl₂F CN NHMe NCOEt OCCl₂F CN NHMe NCOPr OCCl₂F CN NHMe NCHO OCCl₂F CN NHMe NCOiPr OCCl₂F CN NHMe NCOtBu OCCl₂F CN NHMe NCOPh OCCl₂F CN NHMe NSO₂Me OCCl₂F CN NHMe NSO₂Et OCCl₂F CN NHMe NSO₂Pr OCCl₂F CN NHMe NSO₂Ph OCCl₂F CN NHMe NSO₂iPr OCCl₂F CN NHMe NNO₂ OCCl₂F CN NHMe NCOOMe OCCl₂F CN NHMe NCOOEt OCCl₂F CN NHMe NCOOPr OCCl₂F CN NHMe NCOOiPr OCCl₂F CN NHMe NCONHEt OCCl₂F CN NHMe NCONHPr OCCl₂F CN NHMe NCONH₂ OCCl₂F CN NHMe NCONHMe OCCl₂F CN NHMe NCN OCCl₂F CN NHMe NCOSMe OCCl₂F CN NHMe NCOSEt OCCl₂F CN NHMe NCSOMe OCCl₂F CN NHMe NCSOEt OCCl₂F CN NHMe NCSOPr OCCl₂F CN NHMe NSO₂NH₂ OCCl₂F CN NHMe NSO₂NHMe OCCl₂F CN NHMe NSO₂NMe₂ OCCl₂F CN NHMe NP(O)(OMe)₂ OCCl₂F CN NHMe NP(O)(OEt)₂ OCCl₂F CN NHMe NP(O)Me₂ OCCl₂F CN NHMe NP(O)Et₂ OCCl₂F CN NHMe NP(O)Me(OMe) OCCl₂F CN NHMe NP(O)(OPr)₂ OCCl₂F CN NHMe NC(O)C(O)H OCCl₂F CN NHMe NC(O)C(O)Me OCCl₂F CN NHMe NC(O)C(O)OMe OCCl₂F CN NHMe NC(O)C(O)OEt OCCl₂F CN NHMe NC(O)C(O)NH₂ OCCl₂F CN NHMe NC(O)C(O)OH OCCl₂F CN NHMe NC(NH)NH₂ OCCl₂F CN NHMe NC(NOH)NH₂ OCCl₂F CN NHMe NC(NH)NHMe OCCl₂F CN NHMe NC(NH)NMe₂ OCCl₂F CN NHMe NC(NH)OMe OCCl₂F CN NHMe NC(NH)OEt OCCl₂F CN NHEt NCOMe OCCl₂F CN NHEt NCOEt OCCl₂F CN NHEt NCOPr OCCl₂F CN NHEt NCHO OCCl₂F CN NHEt NCOiPr OCCl₂F CN NHEt NCOtBu OCCl₂F CN NHEt NCOPh OCCl₂F CN NHEt NSO₂Me OCCl₂F CN NHEt NSO₂Et OCCl₂F CN NHEt NSO₂Pr OCCl₂F CN NHEt NSO₂Ph OCCl₂F CN NHEt NSO₂iPr OCCl₂F CN NHEt NNO₂ OCCl₂F CN NHEt NCOOMe OCCl₂F CN NHEt NCOOEt OCCl₂F CN NHEt NCOOPr OCCl₂F CN NHEt NCOOiPr OCCl₂F CN NHEt NCONHEt OCCl₂F CN NHEt NCONHPr OCCl₂F CN NHEt NCONH₂ OCCl₂F CN NHEt NCONHMe OCCl₂F CN NHEt NCN OCCl₂F CN NHEt NCOSMe OCCl₂F CN NHEt NCOSEt OCCl₂F CN NHEt NCSOMe OCCl₂F CN NHEt NCSOEt OCCl₂F CN NHEt NCSOPr OCCl₂F CN NHEt NSO₂NH₂ OCCl₂F CN NHEt NSO₂NHMe OCCl₂F CN NHEt NSO₂NMe₂ OCCl₂F CN NHEt NP(O)(OMe)₂ OCCl₂F CN NHEt NP(O)(OEt)₂ OCCl₂F CN NHEt NP(O)Me₂ OCCl₂F CN NHEt NP(O)Et₂ OCCl₂F CN NHEt NP(O)Me(OMe) OCCl₂F CN NHEt NP(O)(OPr)₂ OCCl₂F CN NHEt NC(O)C(O)H OCCl₂F CN NHEt NC(O)C(O)Me OCCl₂F CN NHEt NC(O)C(O)OMe OCCl₂F CN NHEt NC(O)C(O)OEt OCCl₂F CN NHEt NC(O)C(O)NH₂ OCCl₂F CN NHEt NC(O)C(O)OH OCCl₂F CN NHEt NC(NH)NH₂ OCCl₂F CN NHEt NC(NOH)NH₂ OCCl₂F CN NHEt NC(NH)NHMe OCCl₂F CN NHEt NC(NH)NMe₂ OCCl₂F CN NHEt NC(NH)OMe OCCl₂F CN NHEt NC(NH)OEt OCF₂Cl CN NH₂ NCOMeCF₂Cl CN NH₂ NCOEtCF₂Cl CN NH₂ NCOPrCF₂Cl CN NH₂ NCHO ¨CF₂Cl CN NH₂ NCOiPr ¨CF₂Cl CN NH₂ NCOtBu ¨CF₂Cl CN NH₂ NCOPh ¨CF₂Cl CN NH₂ NSO₂Me ¨CF₂Cl CN NH₂ NSO₂Et ¨CF₂Cl CN NH₂ NSO₂Pr ¨CF₂Cl CN NH₂ NSO₂Ph ¨CF₂Cl CN NH₂ NSO₂iPr ¨CF₂Cl CN NH₂ NNO₂ ¨CF₂Cl CN NH₂ NCOOMe ¨CF₂Cl CN NH₂ NCOOEt ¨CF₂Cl CN NH₂ NCOOPr ¨CF₂Cl CN NH₂ NCOOiPr ¨CF₂Cl CN NH₂ NCONHEt ¨CF₂Cl CN NH₂ NCONHPrCF₂Cl CN NH₂ NCONH₂CF₂Cl CN NH₂ NCONHMeCF₂Cl CN NH₂ NCN ¨CF₂Cl CN NH₂ NCOSMe ¨CF₂Cl CN NH₂ NCOSEtCF₂Cl CN NH₂ NCSOMe ¨CF₂Cl CN NH₂ NCSOEt ¨CF₂Cl CN NH₂ NCSOPrCF₂Cl CN NH₂ NSO₂NH₂ ¨CF₂Cl CN NH₂ NSO₂NHMe ¨CF₂Cl CN NH₂ NSO₂NMe₂CF₂Cl CN NH₂ NP(O)(OMe)₂CF₂Cl CN NH₂ NP(O)(OEt)₂ ¨CF₂Cl CN NH₂ NP(O)Me₂ ¨CF₂Cl CN NH₂ NP(O)Et₂ ¨CF₂Cl CN NH₂ NP(O)Me(OMe) ¨CF₂Cl CN NH₂ NP(O)(OPr)₂ ¨CF₂Cl CN NH₂ NC(O)C(O)H ¨CF₂Cl CN NH₂ NC(O)C(O)Me ¨CF₂Cl CN NH₂ NC(O)C(O)OMe ¨CF₂Cl CN NH₂ NC(O)C(O)OEt ¨CF₂Cl CN NH₂ NC(O)C(O)NH₂ ¨CF₂Cl CN NH₂ NC(O)C(O)OH ¨CF₂Cl CN NH₂ NC(NH)NH₂ ¨CF₂Cl CN NH₂ NC(NOH)NH₂CF₂Cl CN NH₂ NC(NH)NHMeCF₂Cl CN NH₂ NC(NH)NMe₂CF₂Cl CN NH₂ NC(NH)OMeCF₂Cl CN NH₂ NC(NH)OEtCF₂Cl CN NHMe NCOMeCF₂Cl CN NHMe NCOEtCF₂Cl CN NHMe NCOPrCF₂Cl CN NHMe NCHOCF₂Cl CN NHMe NCOiPrCF₂Cl CN NHMe NCOtBuCF₂Cl CN NHMe NCOPhCF₂Cl CN NHMe NSO₂MeCF₂Cl CN NHMe NSO₂EtCF₂Cl CN NHMe NSO₂PrCF₂Cl CN NHMe NSO₂PhCF₂Cl CN NHMe NSO₂iPr ¨CF₂Cl CN NHMe NNO₂ ¨CF₂Cl CN NHMe NCOOMe ¨CF₂Cl CN NHMe NCOOEt ¨CF₂Cl CN NHMe NCOOPr ¨CF₂Cl CN NHMe NCOOiPr ¨CF₂Cl CN NHMe NCONHEt ¨CF₂Cl CN NHMe NCONHPr ¨CF₂Cl CN NHMe NCONH₂ ¨CF₂Cl CN NHMe NCONHMe ¨CF₂Cl CN NHMe NCN ¨CF₂Cl CN NHMe NCOSMe ¨CF₂Cl CN NHMe NCOSEt ¨CF₂Cl CN NHMe NCSOMeCF₂Cl CN NHMe NCSOEtCF₂Cl CN NHMe NCSOPrCF₂Cl CN NHMe NSO₂NH₂CF₂Cl CN NHMe NSO₂NHMeCF₂Cl CN NHMe NSO₂NMe₂CF₂Cl CN NHMe NP(O)(OMe)₂CF₂Cl CN NHMe NP(O)(OEt)₂CF₂Cl CN NHMe NP(O)Me₂CF₂Cl CN NHMe NP(O)Et₂CF₂Cl CN NHMe NP(O)Me(OMe)CF₂Cl CN NHMe NP(O)(OPr)₂CF₂Cl CN NHMe NC(O)C(O)HCF₂Cl CN NHMe NC(O)C(O)MeCF₂Cl CN NHMe NC(O)C(O)OMeCF₂Cl CN NHMe NC(O)C(O)OEtCF₂Cl CN NHMe NC(O)C(O)NH₂CF₂Cl CN NHMe NC(O)C(O)OH ¨CF₂Cl CN NHMe NC(NH)NH₂ ¨CF₂Cl CN NHMe NC(NOH)NH₂ ¨CF₂Cl CN NHMe NC(NH)NHMe ¨CF₂Cl CN NHMe NC(NH)NMe₂ ¨CF₂Cl CN NHMe NC(NH)OMe ¨CF₂Cl CN NHMe NC(NH)OEt ¨CF₂Cl CN NHEt NCOMe ¨CF₂Cl CN NHEt NCOEt ¨CF₂Cl CN NHEt NCOPr ¨CF₂Cl CN NHEt NCHOCF₂Cl CN NHEt NCOiPrCF₂Cl CN NHEt NCOtBuCF₂Cl CN NHEt NCOPhCF₂Cl CN NHEt NSO₂MeCF₂Cl CN NHEt NSO₂EtCF₂Cl CN NHEt NSO₂PrCF₂Cl CN NHEt NSO₂PhCF₂Cl CN NHEt NSO₂iPrCF₂Cl CN NHEt NNO₂CF₂Cl CN NHEt NCOOMeCF₂Cl CN NHEt NCOOEtCF₂Cl CN NHEt NCOOPrCF₂Cl CN NHEt NCOOiPrCF₂Cl CN NHEt NCONHEtCF₂Cl CN NHEt NCONHPrCF₂Cl CN NHEt NCONH₂CF₂Cl CN NHEt NCONHMeCF₂Cl CN NHEt NCN ¨CF₂Cl CN NHEt NCOSMe ¨CF₂Cl CN NHEt NCOSEtCF₂Cl CN NHEt NCSOMe ¨CF₂Cl CN NHEt NCSOEt ¨CF₂Cl CN NHEt NCSOPr ¨CF₂Cl CN NHEt NSO₂NH₂ ¨CF₂Cl CN NHEt NSO₂NHMe ¨CF₂Cl CN NHEt NSO₂NMe₂CF₂Cl CN NHEt NP(O)(OMe)₂CF₂Cl CN NHEt NP(O)(OEt)₂CF₂Cl CN NHEt NP(O)Me₂CF₂Cl CN NHEt NP(O)Et₂CF₂Cl CN NHEt NP(O)Me(OMe)CF₂Cl CN NHEt NP(O)(OPr)₂CF₂Cl CN NHEt NC(O)C(O)HCF₂Cl CN NHEt NC(O)C(O)MeCF₂Cl CN NHEt NC(O)C(O)OMeCF₂Cl CN NHEt NC(O)C(O)OEtCF₂Cl CN NHEt NC(O)C(O)NH₂CF₂Cl CN NHEt NC(O)C(O)OHCF₂Cl CN NHEt NC(NH)NH₂CF₂Cl CN NHEt NC(NOH)NH₂CF₂Cl CN NHEt NC(NH)NHMeCF₂Cl CN NHEt NC(NH)NMe₂CF₂Cl CN NHEt NC(NH)OMeCF₂Cl CN NHEt NC(NH)OEtCF₂Cl CN NH₂ NH OCF₂Cl CN NH₂ NCOMe OCF₂Cl CN NH₂ NCOEt OCF₂Cl CN NH₂ NCOPr OCF₂Cl CN NH₂ NCHO OCF₂Cl CN NH₂ NCOiPr OCF₂Cl CN NH₂ NCOtBu OCF₂Cl CN NH₂ NCOPh OCF₂Cl CN NH₂ NSO₂Me OCF₂Cl CN NH₂ NSO₂Et OCF₂Cl CN NH₂ NSO₂Pr OCF₂Cl CN NH₂ NSO₂Ph OCF₂Cl CN NH₂ NSO₂iPr OCF₂Cl CN NH₂ NNO₂ OCF₂Cl CN NH₂ NCOOMe OCF₂Cl CN NH₂ NCOOEt OCF₂Cl CN NH₂ NCOOPr OCF₂Cl CN NH₂ NCOOiPr OCF₂Cl CN NH₂ NCONHEt OCF₂Cl CN NH₂ NCONHPr OCF₂Cl CN NH₂ NCONH₂ OCF₂Cl CN NH₂ NCONHMe OCF₂Cl CN NH₂ NCN OCF₂Cl CN NH₂ NCOSMe OCF₂Cl CN NH₂ NCOSEt OCF₂Cl CN NH₂ NCSOMe OCF₂Cl CN NH₂ NCSOEt OCF₂Cl CN NH₂ NCSOPr OCF₂Cl CN NH₂ NSO₂NH₂ OCF₂Cl CN NH₂ NSO₂NHMe OCF₂Cl CN NH₂ NSO₂NMe₂ OCF₂Cl CN NH₂ NP(O)(OMe)₂ OCF₂Cl CN NH₂ NP(O)(OEt)₂ OCF₂Cl CN NH₂ NP(O)Me₂ OCF₂Cl CN NH₂ NP(O)Et₂ OCF₂Cl CN NH₂ NP(O)Me(OMe) OCF₂Cl CN NH₂ NP(O)(OPr)₂ OCF₂Cl CN NH₂ NC(O)C(O)H OCF₂Cl CN NH₂ NC(O)C(O)Me OCF₂Cl CN NH₂ NC(O)C(O)OMe OCF₂Cl CN NH₂ NC(O)C(O)OEt OCF₂Cl CN NH₂ NC(O)C(O)NH₂ OCF₂Cl CN NH₂ NC(O)C(O)OH OCF₂Cl CN NH₂ NC(NH)NH₂ OCF₂Cl CN NH₂ NC(NOH)NH₂ OCF₂Cl CN NH₂ NC(NH)NHMe OCF₂Cl CN NH₂ NC(NH)NMe₂ OCF₂Cl CN NH₂ NC(NH)OMe OCF₂Cl CN NH₂ NC(NH)OEt OCF₂Cl CN NHMe NCOMe OCF₂Cl CN NHMe NCOEt OCF₂Cl CN NHMe NCOPr OCF₂Cl CN NHMe NCHO OCF₂Cl CN NHMe NCOiPr OCF₂Cl CN NHMe NCOtBu OCF₂Cl CN NHMe NCOPh OCF₂Cl CN NHMe NSO₂Me OCF₂Cl CN NHMe NSO₂Et OCF₂Cl CN NHMe NSO₂Pr OCF₂Cl CN NHMe NSO₂Ph OCF₂Cl CN NHMe NSO₂iPr OCF₂Cl CN NHMe NNO₂ OCF₂Cl CN NHMe NCOOMe OCF₂Cl CN NHMe NCOOEt OCF₂Cl CN NHMe NCOOPr OCF₂Cl CN NHMe NCOOiPr OCF₂Cl CN NHMe NCONHEt OCF₂Cl CN NHMe NCONHPr OCF₂Cl CN NHMe NCONH₂ OCF₂Cl CN NHMe NCONHMe OCF₂Cl CN NHMe NCN OCF₂Cl CN NHMe NCOSMe OCF₂Cl CN NHMe NCOSEt OCF₂Cl CN NHMe NCSOMe OCF₂Cl CN NHMe NCSOEt OCF₂Cl CN NHMe NCSOPr OCF₂Cl CN NHMe NSO₂NH₂ OCF₂Cl CN NHMe NSO₂NHMe OCF₂Cl CN NHMe NSO₂NMe₂ OCF₂Cl CN NHMe NP(O)(OMe)₂ OCF₂Cl CN NHMe NP(O)(OEt)₂ OCF₂Cl CN NHMe NP(O)Me₂ OCF₂Cl CN NHMe NP(O)Et₂ OCF₂Cl CN NHMe NP(O)Me(OMe) OCF₂Cl CN NHMe NP(O)(OPr)₂ OCF₂Cl CN NHMe NC(O)C(O)H OCF₂Cl CN NHMe NC(O)C(O)Me OCF₂Cl CN NHMe NC(O)C(O)OMe OCF₂Cl CN NHMe NC(O)C(O)OEt OCF₂Cl CN NHMe NC(O)C(O)NH₂ OCF₂Cl CN NHMe NC(O)C(O)OH OCF₂Cl CN NHMe NC(NH)NH₂ OCF₂Cl CN NHMe NC(NOH)NH₂ OCF₂Cl CN NHMe NC(NH)NHMe OCF₂Cl CN NHMe NC(NH)NMe₂ OCF₂Cl CN NHMe NC(NH)OMe OCF₂Cl CN NHMe NC(NH)OEt OCF₂Cl CN NHEt NCOMe OCF₂Cl CN NHEt NCOEt OCF₂Cl CN NHEt NCOPr OCF₂Cl CN NHEt NCHO OCF₂Cl CN NHEt NCOiPr OCF₂Cl CN NHEt NCOtBu OCF₂Cl CN NHEt NCOPh OCF₂Cl CN NHEt NSO₂Me OCF₂Cl CN NHEt NSO₂Et OCF₂Cl CN NHEt NSO₂Pr OCF₂Cl CN NHEt NSO₂Ph OCF₂Cl CN NHEt NSO₂iPr OCF₂Cl CN NHEt NNO₂ OCF₂Cl CN NHEt NCOOMe OCF₂Cl CN NHEt NCOOEt OCF₂Cl CN NHEt NCOOPr OCF₂Cl CN NHEt NCOOiPr OCF₂Cl CN NHEt NCONHEt OCF₂Cl CN NHEt NCONHPr OCF₂Cl CN NHEt NCONH₂ OCF₂Cl CN NHEt NCONHMe OCF₂Cl CN NHEt NCN OCF₂Cl CN NHEt NCOSMe OCF₂Cl CN NHEt NCOSEt OCF₂Cl CN NHEt NCSOMe OCF₂Cl CN NHEt NCSOEt OCF₂Cl CN NHEt NCSOPr OCF₂Cl CN NHEt NSO₂NH₂ OCF₂Cl CN NHEt NSO₂NHMe OCF₂Cl CN NHEt NSO₂NMe₂ OCF₂Cl CN NHEt NP(O)(OMe)₂ OCF₂Cl CN NHEt NP(O)(OEt)₂ OCF₂Cl CN NHEt NP(O)Me₂ OCF₂Cl CN NHEt NP(O)Et₂ OCF₂Cl CN NHEt NP(O)Me(OMe) OCF₂Cl CN NHEt NP(O)(OPr)₂ OCF₂Cl CN NHEt NC(O)C(O)H OCF₂Cl CN NHEt NC(O)C(O)Me OCF₂Cl CN NHEt NC(O)C(O)OMe OCF₂Cl CN NHEt NC(O)C(O)OEt OCF₂Cl CN NHEt NC(O)C(O)NH₂ OCF₂Cl CN NHEt NC(O)C(O)OH OCF₂Cl CN NHEt NC(NH)NH₂ OCF₂Cl CN NHEt NC(NOH)NH₂ OCF₂Cl CN NHEt NC(NH)NHMe OCF₂Cl CN NHEt NC(NH)NMe₂ OCF₂Cl CN NHEt NC(NH)OMe OCF₂Cl CN NHEt NC(NH)OEt OCF₃ CN H NCOMe ¨CF₃ CN H NCOEt ¨CF₃ CN H NCOPr ¨CF₃ CN H NCHO ¨CF₃ CN H NCOiPr ¨CF₃ CN H NCOtBu ¨CF₃ CN H NCOPhCF₃ CN H NSO₂MeCF₃ CN H NSO₂Et ¨CF₃ CN H NSO₂PrCF₃ CN H NSO₂PhCF₃ CN H NSO₂iPrCF₃ CN H NNO₂CF₃ CN H NCOOMeCF₃ CN H NCOOEtCF₃ CN H NCOOPrCF₃ CN H NCOOiPrCF₃ CN H NCONHEtCF₃ CN H NCONHPrCF₃ CN H NCONH₂CF₃ CN H NCONHMeCF₃ CN H NCNCF₃ CN H NCOSMeCF₃ CN H NCOSEt ¨CF₃ CN H NCSOMe ¨CF₃ CN H NCSOEt ¨CF₃ CN H NCSOPr ¨CF₃ CN H NSO₂NH₂ ¨CF₃ CN H NSO₂NHMe ¨CF₃ CN H NSO₂NMe₂ ¨CF₃ CN H NP(O)(OMe)₂ ¨CF₃ CN H NP(O)(OEt)₂ ¨CF₃ CN H NP(O)Me₂ ¨CF₃ CN H NP(O)Et₂ ¨CF₃ CN H NP(O)Me(OMe)CF₃ CN H NP(O)(OPr)₂CF₃ CN H NC(O)C(O)HCF₃ CN H NC(O)C(O)MeCF₃ CN H NC(O)C(O)OMeCF₃ CN H NC(O)C(O)OEtCF₃ CN H NC(O)C(O)NH₂CF₃ CN H NC(O)C(O)OHCF₃ CN H NC(NH)NH₂CF₃ CN H NC(NOH)NH₂CF₃ CN H NC(NH)NHMe ¨CF₃ CN H NC(NH)NMe₂CF₃ CN H NC(NH)OMeCF₃ CN H NC(NH)OEtCF₃ CN H NH OCF₃ CN H NCOMe OCF₃ CN H NCOEt OCF₃ CN H NCOPr OCF₃ CN H NCHO OCF₃ CN H NCOiPr OCF₃ CN H NCOtBu OCF₃ CN H NCOPh OCF₃ CN H NSO₂Me OCF₃ CN H NSO₂Et OCF₃ CN H NSO₂Pr OCF₃ CN H NSO₂Ph OCF₃ CN H NSO₂iPr OCF₃ CN H NNO₂ OCF₃ CN H NCOOMe OCF₃ CN H NCOOEt OCF₃ CN H NCOOPr OCF₃ CN H NCOOiPr OCF₃ CN H NCONHEt OCF₃ CN H NCONHPr OCF₃ CN H NCONH₂ OCF₃ CN H NCONHMe OCF₃ CN H NCN OCF₃ CN H NCOSMe OCF₃ CN H NCOSEt OCF₃ CN H NCSOMe OCF₃ CN H NCSOEt OCF₃ CN H NCSOPr OCF₃ CN H NSO₂NH₂ OCF₃ CN H NSO₂NHMe OCF₃ CN H NSO₂NMe₂ OCF₃ CN H NP(O)(OMe)₂ OCF₃ CN H NP(O)(OEt)₂ OCF₃ CN H NP(O)Me₂ OCF₃ CN H NP(O)Et₂ OCF₃ CN H NP(O)Me(OMe) OCF₃ CN H NP(O)(OPr)₂ OCF₃ CN H NC(O)C(O)H OCF₃ CN H NC(O)C(O)Me OCF₃ CN H NC(O)C(O)OMe OCF₃ CN H NC(O)C(O)OEt OCF₃ CN H NC(O)C(O)NH₂ OCF₃ CN H NC(O)C(O)OH OCF₃ CN H NC(NH)NH₂ OCF₃ CN H NC(NOH)NH₂ OCF₃ CN H NC(NH)NHMe OCF₃ CN H NC(NH)NMe₂ OCF₃ CN H NC(NH)OMe OCF₃ CN H NC(NH)OEt OCF₃ CN Me NCOMeCF₃ CN Me NCOEtCF₃ CN Me NCOPrCF₃ CN Me NCHOCF₃ CN Me NCOiPr ¨CF₃ CN Me NCOtBu ¨CF₃ CN Me NCOPh ¨CF₃ CN Me NSO₂MeCF₃ CN Me NSO₂EtCF₃ CN Me NSO₂PrCF₃ CN Me NSO₂Ph ¨CF₃ CN Me NSO₂iPr ¨CF₃ CN Me NNO₂ ¨CF₃ CN Me NCOOMe ¨CF₃ CN Me NCOOEt ¨CF₃ CN Me NCOOPr ¨CF₃ CN Me NCOOiPr ¨CF₃ CN Me NCONHEt ¨CF₃ CN Me NCONHPr ¨CF₃ CN Me NCOH ¨CF₃ CN Me NCONHMe ¨CF₃ CN Me NCN ¨CF₃ CN Me NCOSMe ¨CF₃ CN Me NCOSEt ¨CF₃ CN Me NCSOMe ¨CF₃ CN Me NCSOEt ¨CF₃ CN Me NCSOPrCF₃ CN Me NSO₂HCF₃ CN Me NSO₂NHMeCF₃ CN Me NSO₂NMe₂CF₃ CN Me NP(O)(OMe)₂CF₃ CN Me NP(O)(OEt)₂ ¨CF₃ CN Me NP(O)Me₂ ¨CF₃ CN Me NP(O)Et₂ ¨CF₃ CN Me NP(O)Me(OMe) ¨CF₃ CN Me NP(O)(OPr)₂CF₃ CN Me NC(O)C(O)H ¨CF₃ CN Me NC(O)C(O)MeCF₃ CN Me NC(O)C(O)OMeCF₃ CN Me NC(O)C(O)OEtCF₃ CN Me NC(O)C(O)NH₂ ¨CF₃ CN Me NC(O)C(O)OH ¨CF₃ CN Me NC(NH)H ¨CF₃ CN Me NC(NOH)H ¨CF₃ CN Me NC(NH)NHM ¨CF₃ CN Me NC(NH)NMe ¨CF₃ CN Me NC(NH)OMe ¨CF₃ CN Me NC(NH)OEt ¨CF₃ CN Me NH OCF₃ CN Me NCOMe OCF₃ CN Me NCOEt OCF₃ CN Me NCOPr OCF₃ CN Me NCHO OCF₃ CN Me NCOiPr OCF₃ CN Me NCOtBu OCF₃ CN Me NCOPh OCF₃ CN Me NSO₂Me OCF₃ CN Me NSO₂Et OCF₃ CN Me NSO₂Pr OCF₃ CN Me NSO₂Ph OCF₃ CN Me NSO₂iPr OCF₃ CN Me NNO₂ OCF₃ CN Me NCOOMe OCF₃ CN Me NCOOEt OCF₃ CN Me NCOOPr OCF₃ CN Me NCOOiPr OCF₃ CN Me NCONHEt OCF₃ CN Me NCONHPr OCF₃ CN Me NCONH₂ OCF₃ CN Me NCONHMe OCF₃ CN Me NCN OCF₃ CN Me NCOSMe OCF₃ CN Me NCOSEt OCF₃ CN Me NCSOMe OCF₃ CN Me NCSOEt OCF₃ CN Me NCSOPr OCF₃ CN Me NSO₂NH₂ OCF₃ CN Me NSO₂NHMe OCF₃ CN Me NSO₂NMe₂ OCF₃ CN Me NP(O)(OMe)₂ OCF₃ CN Me NP(O)(OEt)₂ OCF₃ CN Me NP(O)Me₂ OCF₃ CN Me NP(O)Et₂ OCF₃ CN Me NP(O)Me(OMe) OCF₃ CN Me NP(O)(OPr)₂ OCF₃ CN Me NC(O)C(O)H OCF₃ CN Me NC(O)C(O)Me OCF₃ CN Me NC(O)C(O)OMe OCF₃ CN Me NC(O)C(O)OEt OCF₃ CN Me NC(O)C(O)NH₂ OCF₃ CN Me NC(O)C(O)OH OCF₃ CN Me NC(NH)NH₂ OCF₃ CN Me NC(NOH)NH₂ OCF₃ CN Me NC(NH)NHMe OCF₃ CN Me NC(NH)NMe₂ OCF₃ CN Me NC(NH)OMe OCF₃ CN Me NC(NH)OEt OCF₃ CN Cl NCOMe ¨CF₃ CN Cl NCOEt ¨CF₃ CN Cl NCOPr ¨CF₃ CN Cl NCHO ¨CF₃ CN Cl NCOiPr ¨CF₃ CN Cl NCOtBu ¨CF₃ CN Cl NCOPh ¨CF₃ CN Cl NSO₂Me ¨CF₃ CN Cl NSO₂Et ¨CF₃ CN Cl NSO₂Pr ¨CF₃ CN Cl NSO₂Ph ¨CF₃ CN Cl NSO₂iPrCF₃ CN Cl NNO₂ ¨CF₃ CN Cl NCOOMeCF₃ CN Cl NCOOEtCF₃ CN Cl NCOOPrCF₃ CN Cl NCOOiPrCF₃ CN Cl NCONHEt ¨CF₃ CN Cl NCONHPr ¨CF₃ CN Cl NCOHCF₃ CN Cl NCONHMeCF₃ CN Cl NCN ¨CF₃ CN Cl NCOSMe ¨CF₃ CN Cl NCOSEt ¨CF₃ CN Cl NCSOMeCF₃ CN Cl NCSOEtCF₃ CN Cl NCSOPr ¨CF₃ CN Cl NSO₂H ¨CF₃ CN Cl NSO₂NHMe ¨CF₃ CN Cl NSO₂NMe₂ ¨CF₃ CN Cl NP(O)(OMe)₂ ¨CF₃ CN Cl NP(O)(OEt)₂ ¨CF₃ CN Cl NP(O)Me₂ ¨CF₃ CN Cl NP(O)Et₂ ¨CF₃ CN Cl NP(O)Me(OMe) ¨CF₃ CN Cl NP(O)(OPr)₂CF₃ CN Cl NC(O)C(O)HCF₃ CN Cl NC(O)C(O)MeCF₃ CN Cl NC(O)C(O)OMeCF₃ CN Cl NC(O)C(O)OEtCF₃ CN Cl NC(O)C(O)NH₂CF₃ CN Cl NC(O)C(O)OHCF₃ CN Cl NC(NH)HCF₃ CN Cl NC(NOH)HCF₃ CN Cl NC(NH)NHMeCF₃ CN Cl NC(NH)NMe₂CF₃ CN Cl NC(NH)OMeCF₃ CN Cl NC(NH)OEtCF₃ CN Cl NCOMe OCF₃ CN Cl NCOEt OCF₃ CN Cl NCOPr OCF₃ CN Cl NCHO OCF₃ CN Cl NCOiPr OCF₃ CN Cl NCOtBu OCF₃ CN Cl NCOPh OCF₃ CN Cl NSO₂Me OCF₃ CN Cl NSO₂Et OCF₃ CN Cl NSO₂Pr OCF₃ CN Cl NSO₂Ph OCF₃ CN Cl NSO₂iPr OCF₃ CN Cl NNO₂ OCF₃ CN Cl NCOOMe OCF₃ CN Cl NCOOEt OCF₃ CN Cl NCOOPr OCF₃ CN Cl NCOOiPr OCF₃ CN Cl NCONHEt OCF₃ CN Cl NCONHPr OCF₃ CN Cl NCONH₂ OCF₃ CN Cl NCONHMe OCF₃ CN Cl NCN OCF₃ CN Cl NCOSMe OCF₃ CN Cl NCOSEt OCF₃ CN Cl NCSOMe OCF₃ CN Cl NCSOEt OCF₃ CN Cl NCSOPr OCF₃ CN Cl NSO₂NH₂ OCF₃ CN Cl NSO₂NHMe OCF₃ CN Cl NSO₂NMe₂ OCF₃ CN Cl NP(O)(OMe)₂ OCF₃ CN Cl NP(O)(OEt)₂ OCF₃ CN Cl NP(O)Me₂ OCF₃ CN Cl NP(O)Et₂ OCF₃ CN Cl NP(O)Me(OMe) OCF₃ CN Cl NP(O)(OPr)₂ OCF₃ CN Cl NC(O)C(O)H OCF₃ CN Cl NC(O)C(O)Me OCF₃ CN Cl NC(O)C(O)OMe OCF₃ CN Cl NC(O)C(O)OEt OCF₃ CN Cl NC(O)C(O)NH₂ OCF₃ CN Cl NC(O)C(O)OH OCF₃ CN Cl NC(NH)NH₂ OCF₃ CN Cl NC(NOH)NH₂ OCF₃ CN Cl NC(NH)NHMe OCF₃ CN Cl NC(NH)NMe₂ OCF₃ CN Cl NC(NH)OMe OCF₃ CN Cl NC(NH)OEt OCF₃ CN SMe NCOMeCF₃ CN SMe NCOEtCF₃ CN SMe NCOPrCF₃ CN SMe NCHOCF₃ CN SMe NCOiPrCF₃ CN SMe NCOtBuCF₃ CN SMe NCOPhCF₃ CN SMe NSO₂MeCF₃ CN SMe NSO₂EtCF₃ CN SMe NSO₂PrCF₃ CN SMe NSO₂PhCF₃ CN SMe NSO₂iPrCF₃ CN SMe NNO₂ ¨CF₃ CN SMe NCOOMe ¨CF₃ CN SMe NCOOEt ¨CF₃ CN SMe NCOOPr ¨CF₃ CN SMe NCOOiPr ¨CF₃ CN SMe NCONHEt ¨CF₃ CN SMe NCONHPr ¨CF₃ CN SMe NCOH ¨CF₃ CN SMe NCONHMe ¨CF₃ CN SMe NCN ¨CF₃ CN SMe NCOSMe ¨CF₃ CN SMe NCOSEt ¨CF₃ CN SMe NCSOMeCF₃ CN SMe NCSOEtCF₃ CN SMe NCSOPrCF₃ CN SMe NSO₂HCF₃ CN SMe NSO₂NHMeCF₃ CN SMe NSO₂NMe₂CF₃ CN SMe NP(O)(OMe)₂CF₃ CN SMe NP(O)(OEt)₂CF₃ CN SMe NP(O)Me₂CF₃ CN SMe NP(O)Et₂ ¨CF₃ CN SMe NP(O)Me(OMe) ¨CF₃ CN SMe NP(O)(OPr)₂ ¨CF₃ CN SMe NC(O)C(O)H ¨CF₃ CN SMe NC(O)C(O)Me ¨CF₃ CN SMe NC(O)C(O)OMe ¨CF₃ CN SMe NC(O)C(O)OEt ¨CF₃ CN SMe NC(O)C(O)NH₂CF₃ CN SMe NC(O)C(O)OHCF₃ CN SMe NC(NH)H ¨CF₃ CN SMe NC(NOH)H ¨CF₃ CN SMe NC(NH)NHMe ¨CF₃ CN SMe NC(NH)NMe₂ ¨CF₃ CN SMe NC(NH)OMe ¨CF₃ CN SMe NC(NH)OEt ¨CF₃ H NH₂ NCOMe ¨CF₃ H NH₂ NCOEt ¨CF₃ H NH₂ NCOPr ¨CF₃ H NH₂ NCHO ¨CF₃ H NH₂ NCOiPrCF₃ H NH₂ NCOtBuCF₃ H NH₂ NCOPhCF₃ H NH₂ NSO₂MeCF₃ H NH₂ NSO₂EtCF₃ H NH₂ NSO₂PrCF₃ H NH₂ NSO₂PhCF₃ H NH₂ NSO₂iPrCF₃ H NH₂ NNO₂CF₃ H NH₂ NCOOMeCF₃ H NH₂ NCOOEt ¨CF₃ H NH₂ NCOOPrCF₃ H NH₂ NCOOiPr ¨CF₃ H NH₂ NCONHEt ¨CF₃ H NH₂ NCONHPrCF₃ H NH₂ NCOH ¨CF₃ H NH₂ NCONHMeCF₃ H NH₂ NCN ¨CF₃ H NH₂ NCOSMe ¨CF₃ H NH₂ NCOSEt ¨CF₃ H NH₂ NCSOMe ¨CF₃ H NH₂ NCSOEt ¨CF₃ H NH₂ NCSOPr ¨CF₃ H NH₂ NSO₂H ¨CF₃ H NH₂ NSO₂NHMe ¨CF₃ H NH₂ NSO₂NMe₂ ¨CF₃ H NH₂ NP(O)(OMe)₂ ¨CF₃ H NH₂ NP(O)(OEt)₂ ¨CF₃ H NH₂ NP(O)Me₂CF₃ H NH₂ NP(O)Et₂CF₃ H NH₂ NP(O)Me(OMe)CF₃ H NH₂ NP(O)(OPr)₂CF₃ H NH₂ NC(O)C(O)HCF₃ H NH₂ NC(O)C(O)MeCF₃ H NH₂ NC(O)C(O)OMeCF₃ H NH₂ NC(O)C(O)OEtCF₃ H NH₂ NC(O)C(O)NH₂CF₃ H NH₂ NC(O)C(O)OHCF₃ H NH₂ NC(NH)HCF₃ H NH₂ NC(NOH)HCF₃ H NH₂ NC(NH)NHMeCF₃ H NH₂ NC(NH)NMe₂CF₃ H NH₂ NC(NH)OMeCF₃ H NH₂ NC(NH)OEtCF₃ Me NH₂ NCOMeCF₃ Me NH₂ NCOEt ¨CF₃ Me NH₂ NCOPr ¨CF₃ Me NH₂ NCHO ¨CF₃ Me NH₂ NCOiPr ¨CF₃ Me NH₂ NCOtBu ¨CF₃ Me NH₂ NCOPh ¨CF₃ Me NH₂ NSO₂Me ¨CF₃ Me NH₂ NSO₂Et ¨CF₃ Me NH₂ NSO₂Pr ¨CF₃ Me NH₂ NSO₂PhCF₃ Me NH₂ NSO₂iPrCF₃ Me NH₂ NNO₂CF₃ Me NH₂ NCOOMeCF₃ Me NH₂ NCOOEtCF₃ Me NH₂ NCOOPrCF₃ Me NH₂ NCOOiPrCF₃ Me NH₂ NCONHEtCF₃ Me NH₂ NCONHPrCF₃ Me NH₂ NCOHCF₃ Me NH₂ NCONHMeCF₃ Me NH₂ NCN ¨CF₃ Me NH₂ NCOSMe ¨CF₃ Me NH₂ NCOSEtCF₃ Me NH₂ NCSOMeCF₃ Me NH₂ NCSOEtCF₃ Me NH₂ NCSOPrCF₃ Me NH₂ NSO₂HCF₃ Me NH₂ NSO₂NHMeCF₃ Me NH₂ NSO₂NMe₂CF₃ Me NH₂ NP(O)(OMe)₂CF₃ Me NH₂ NP(O)(OEt)₂ ¨CF₃ Me NH₂ NP(O)Me₂ ¨CF₃ Me NH₂ NP(O)Et₂ ¨CF₃ Me NH₂ NP(O)Me(OMe) ¨CF₃ Me NH₂ NP(O)(OPr)₂ ¨CF₃ Me NH₂ NC(O)C(O)H ¨CF₃ Me NH₂ NC(O)C(O)Me ¨CF₃ Me NH₂ NC(O)C(O)OMeCF₃ Me NH₂ NC(O)C(O)OEtCF₃ Me NH₂ NC(O)C(O)NH₂CF₃ Me NH₂ NC(O)C(O)OHCF₃ Me NH₂ NC(NH)HCF₃ Me NH₂ NC(NOH)HCF₃ Me NH₂ NC(NH)NHMeCF₃ Me NH₂ NC(NH)NMe₂CF₃ Me NH₂ NC(NH)OMeCF₃ Me NH₂ NC(NH)OEtCF₃ H H NCOMeCF₃ H H NCOEtCF₃ H H NCOPrCF₃ H H NCHOCF₃ H H NCOiPrCF₃ H H NCOtBuCF₃ H H NCOPhCF₃ H H NSO₂MeCF₃ H H NSO₂EtCF₃ H H NSO₂PrCF₃ H H NSO₂PhCF₃ H H NSO₂iPr ¨CF₃ H H NNO₂ ¨CF₃ H H NCOOMe ¨CF₃ H H NCOOEt ¨CF₃ H H NCOOPr ¨CF₃ H H NCOOiPr ¨CF₃ H H NCONHEt ¨CF₃ H H NCONHPrCF₃ H H NCOHCF₃ H H NCONHMeCF₃ H H NCNCF₃ H H NCOSMeCF₃ H H NCOSEtCF₃ H H NCSOMeCF₃ H H NCSOEtCF₃ H H NCSOPrCF₃ H H NSO₂HCF₃ H H NSO₂NHMeCF₃ H H NSO₂NMe₂CF₃ H H NP(O)(OMe)₂CF₃ H H NP(O)(OEt)₂CF₃ H H NP(O)Me₂CF₃ H H NP(O)Et₂CF₃ H H NP(O)Me(OMe)CF₃ H H NP(O)(OPr)₂CF₃ H H NC(O)C(O)HCF₃ H H NC(O)C(O)Me ¨CF₃ H H NC(O)C(O)OMe ¨CF₃ H H NC(O)C(O)OEt ¨CF₃ H H NC(O)C(O)NH₂ ¨CF₃ H H NC(O)C(O)OH ¨CF₃ H H NC(NH)H ¨CF₃ H H NC(NOH)H ¨CF₃ H H NC(NH)NHMe ¨CF₃ H H NC(NH)NMe₂ ¨CF₃ H H NC(NH)OMe ¨CF₃ H H NC(NH)OEtCF₃ Me H NCOMeCF₃ Me H NCOEtCF₃ Me H NCOPrCF₃ Me H NCHOCF₃ Me H NCOiPrCF₃ Me H NCOtBuCF₃ Me H NCOPhCF₃ Me H NSO₂MeCF₃ Me H NSO₂EtCF₃ Me H NSO₂PrCF₃ Me H NSO₂PhCF₃ Me H NSO₂iPrCF₃ Me H NNO₂CF₃ Me H NCOOMeCF₃ Me H NCOOEtCF₃ Me H NCOOPrCF₃ Me H NCOOiPrCF₃ Me H NCONHEt ¨CF₃ Me H NCONHPr ¨CF₃ Me H NCOH ¨CF₃ Me H NCONHMe ¨CF₃ Me H NCN ¨CF₃ Me H NCOSMe ¨CF₃ Me H NCOSEt ¨CF₃ Me H NCSOMe ¨CF₃ Me H NCSOEt ¨CF₃ Me H NCSOPrCF₃ Me H NSO₂HCF₃ Me H NSO₂NHMeCF₃ Me H NSO₂NMe₂CF₃ Me H NP(O)(OMe)₂CF₃ Me H NP(O)(OEt)₂CF₃ Me H NP(O)Me₂CF₃ Me H NP(O)Et₂CF₃ Me H NP(O)Me(OMe)CF₃ Me H NP(O)(OPr)₂CF₃ Me H NC(O)C(O)HCF₃ Me H NC(O)C(O)MeCF₃ Me H NC(O)C(O)OMeCF₃ Me H NC(O)C(O)OEtCF₃ Me H NC(O)C(O)NH₂CF₃ Me H NC(O)C(O)OHCF₃ Me H NC(NH)HCF₃ Me H NC(NOH)HCF₃ Me H NC(NH)NHMeCF₃ Me H NC(NH)NMe₂CF₃ Me H NC(NH)OMe ¨CF₃ Me H NC(NH)OEt ¨CF₃ H Cl NCOMe ¨CF₃ H Cl NCOEt ¨CF₃ H Cl NCOPr ¨CF₃ H Cl NCHO ¨CF₃ H Cl NCOiPr ¨CF₃ H Cl NCOtBu ¨CF₃ H Cl NCOPhCF₃ H Cl NSO₂MeCF₃ H Cl NSO₂EtCF₃ H Cl NSO₂PrCF₃ H Cl NSO₂PhCF₃ H Cl NSO₂iPrCF₃ H Cl NNO₂CF₃ H Cl NCOOMeCF₃ H Cl NCOOEtCF₃ H Cl NCOOPrCF₃ H Cl NCOOiPrCF₃ H Cl NCONHEtCF₃ H Cl NCONHPrCF₃ H Cl NCOHCF₃ H Cl NCONHMeCF₃ H Cl NCNCF₃ H Cl NCOSMeCF₃ H Cl NCOSEtCF₃ H Cl NCSOMeCF₃ H Cl NCSOEt ¨CF₃ H Cl NCSOPr ¨CF₃ H Cl NSO₂H ¨CF₃ H Cl NSO₂NHMe ¨CF₃ H Cl NSO₂NMe₂ ¨CF₃ H Cl NP(O)(OMe)₂ ¨CF₃ H Cl NP(O)(OEt)₂ ¨CF₃ H Cl NP(O)Me₂ ¨CF₃ H Cl NP(O)Et₂ ¨CF₃ H Cl NP(O)Me(OMe) ¨CF₃ H Cl NP(O)(OPr)₂CF₃ H Cl NC(O)C(O)HCF₃ H Cl NC(O)C(O)MeCF₃ H Cl NC(O)C(O)OMeCF₃ H Cl NC(O)C(O)OEtCF₃ H Cl NC(O)C(O)NH₂CF₃ H Cl NC(O)C(O)OHCF₃ H Cl NC(NH)HCF₃ H Cl NC(NOH)HCF₃ H Cl NC(NH)NHMeCF₃ H Cl NC(NH)NMe₂CF₃ H Cl NC(NH)OMeCF₃ H Cl NC(NH)OEtCF₃ Me Cl NCOMeCF₃ Me Cl NCOEtCF₃ Me Cl NCOPrCF₃ Me Cl NCHOCF₃ Me Cl NCOiPrCF₃ Me Cl NCOtBuCF₃ Me Cl NCOPh ¨CF₃ Me Cl NSO₂Me ¨CF₃ Me Cl NSO₂Et ¨CF₃ Me Cl NSO₂Pr ¨CF₃ Me Cl NSO₂Ph ¨CF₃ Me Cl NSO₂iPr ¨CF₃ Me Cl NNO₂ ¨CF₃ Me Cl NCOOMe ¨CF₃ Me Cl NCOOEtCF₃ Me Cl NCOOPrCF₃ Me Cl NCOOiPrCF₃ Me Cl NCONHEtCF₃ Me Cl NCONHPrCF₃ Me Cl NCOHCF₃ Me Cl NCONHMeCF₃ Me Cl NCNCF₃ Me Cl NCOSMeCF₃ Me Cl NCOSEtCF₃ Me Cl NCSOMeCF₃ Me Cl NCSOEtCF₃ Me Cl NCSOPrCF₃ Me Cl NSO₂HCF₃ Me Cl NSO₂NHMeCF₃ Me Cl NSO₂NMe₂CF₃ Me Cl NP(O)(OMe)₂CF₃ Me Cl NP(O)(OEt)₂CF₃ Me Cl NP(O)Me₂CF₃ Me Cl NP(O)Et₂ ¨CF₃ Me Cl NP(O)Me(OMe) ¨CF₃ Me Cl NP(O)(OPr)₂ ¨CF₃ Me Cl NC(O)C(O)H ¨CF₃ Me Cl NC(O)C(O)Me ¨CF₃ Me Cl NC(O)C(O)OMe ¨CF₃ Me Cl NC(O)C(O)OEt ¨CF₃ Me Cl NC(O)C(O)NH₂ ¨CF₃ Me Cl NC(O)C(O)OH ¨CF₃ Me Cl NC(NH)H ¨CF₃ Me Cl NC(NOH)H ¨CF₃ Me Cl NC(NH)NHMeCF₃ Me Cl NC(NH)NMe₂CF₃ Me Cl NC(NH)OMeCF₃ Me Cl NC(NH)OEtMe H NH₂ NCOMeMe H NH₂ NCOEtMe H NH₂ NCOPrMe H NH₂ NCHOMe H NH₂ NCOiPrMe H NH₂ NCOtBuMe H NH₂ NCOPhMe H NH₂ NSO₂MeMe H NH₂ NSO₂EtMe H NH₂ NSO₂PrMe H NH₂ NSO₂PhMe H NH₂ NSO₂iPrMe H NH₂ NNO₂ ¨Me H NH₂ NCOOMe ¨Me H NH₂ NCOOEt ¨Me H NH₂ NCOOPr ¨Me H NH₂ NCOOiPr ¨Me H NH₂ NCONHEt ¨Me H NH₂ NCONHPr ¨Me H NH₂ NCOH ¨Me H NH₂ NCONHMe ¨Me H NH₂ NCN ¨Me H NH₂ NCOSMe ¨Me H NH₂ NCOSEtMe H NH₂ NCSOMeMe H NH₂ NCSOEtMe H NH₂ NCSOPrMe H NH₂ NSO₂HMe H NH₂ NSO₂NHMeMe H NH₂ NSO₂NMe₂Me H NH₂ NP(O)(OMe)₂Me H NH₂ NP(O)(OEt)₂Me H NH₂ NP(O)Me₂Me H NH₂ NP(O)Et₂Me H NH₂ NP(O)Me(OMe)Me H NH₂ NP(O)(OPr)₂Me H NH₂ NC(O)C(O)HMe H NH₂ NC(O)C(O)MeMe H NH₂ NC(O)C(O)OMeMe H NH₂ NC(O)C(O)OEtMe H NH₂ NC(O)C(O)NH₂Me H NH₂ NC(O)C(O)OH ¨Me H NH₂ NC(NH)H ¨Me H NH₂ NC(NOH)H ¨Me H NH₂ NC(NH)NHMe ¨Me H NH₂ NC(NH)NMe₂ ¨Me H NH₂ NC(NH)OMe ¨Me H NH₂ NC(NH)OEt ¨Me H NH₂ NH OMe H NH₂ NCOMe OMe H NH₂ NCOEt OMe H NH₂ NCOPr OMe H NH₂ NCHO OMe H NH₂ NCOiPr OMe H NH₂ NCOtBu OMe H NH₂ NCOPh OMe H NH₂ NSO₂Me OMe H NH₂ NSO₂Et OMe H NH₂ NSO₂Pr OMe H NH₂ NSO₂Ph OMe H NH₂ NSO₂iPr OMe H NH₂ NNO₂ OMe H NH₂ NCOOMe OMe H NH₂ NCOOEt OMe H NH₂ NCOOPr OMe H NH₂ NCOOiPr OMe H NH₂ NCONHEt OMe H NH₂ NCONHPr OMe H NH₂ NCOH OMe H NH₂ NCONHMe OMe H NH₂ NCN OMe H NH₂ NCOSMe OMe H NH₂ NCOSEt OMe H NH₂ NCSOMe OMe H NH₂ NCSOEt OMe H NH₂ NCSOPr OMe H NH₂ NSO₂H OMe H NH₂ NSO₂NHMe OMe H NH₂ NSO₂NMe₂ OMe H NH₂ NP(O)(OMe)₂ OMe H NH₂ NP(O)(OEt)₂ OMe H NH₂ NP(O)Me₂ OMe H NH₂ NP(O)Et₂ OMe H NH₂ NP(O)Me(OMe) OMe H NH₂ NP(O)(OPr)₂ OMe H NH₂ NC(O)C(O)H OMe H NH₂ NC(O)C(O)Me OMe H NH₂ NC(O)C(O)OMe OMe H NH₂ NC(O)C(O)OEt OMe H NH₂ NC(O)C(O)NH₂ OMe H NH₂ NC(O)C(O)OH OMe H NH₂ NC(NH)H OMe H NH₂ NC(NOH)H OMe H NH₂ NC(NH)NHMe OMe H NH₂ NC(NH)NMe₂ OMe H NH₂ NC(NH)OMe OMe H NH₂ NC(NH)OEt OMe Me NH₂ NCOMeMe Me NH₂ NCOEt ¨Me Me NH₂ NCOPr ¨Me Me NH₂ NCHO ¨Me Me NH₂ NCOiPr ¨Me Me NH₂ NCOtBu ¨Me Me NH₂ NCOPh ¨Me Me NH₂ NSO₂Me ¨Me Me NH₂ NSO₂Et ¨Me Me NH₂ NSO₂PrMe Me NH₂ NSO₂PhMe Me NH₂ NSO₂iPrMe Me NH₂ NNO₂Me Me NH₂ NCOOMeMe Me NH₂ NCOOEtMe Me NH₂ NCOOPrMe Me NH₂ NCOOiPrMe Me NH₂ NCONHEtMe Me NH₂ NCONHPrMe Me NH₂ NCOHMe Me NH₂ NCONHMeMe Me NH₂ NCNMe Me NH₂ NCOSMeMe Me NH₂ NCOSEtMe Me NH₂ NCSOMeMe Me NH₂ NCSOEtMe Me NH₂ NCSOPrMe Me NH₂ NSO₂HMe Me NH₂ NSO₂NHMe ¨Me Me NH₂ NSO₂NMe₂ ¨Me Me NH₂ NP(O)(OMe)₂ ¨Me Me NH₂ NP(O)(OEt)₂ ¨Me Me NH₂ NP(O)Me₂ ¨Me Me NH₂ NP(O)Et₂ ¨Me Me NH₂ NP(O)Me(OMe) ¨Me Me NH₂ NP(O)(OPr)₂ ¨Me Me NH₂ NC(O)C(O)H ¨Me Me NH₂ NC(O)C(O)Me ¨Me Me NH₂ NC(O)C(O)OMeMe Me NH₂ NC(O)C(O)OEtMe Me NH₂ NC(O)C(O)NH₂Me Me NH₂ NC(O)C(O)OHMe Me NH₂ NC(NH)HMe Me NH₂ NC(NOH)HMe Me NH₂ NC(NH)NHMeMe Me NH₂ NC(NH)NMe₂Me Me NH₂ NC(NH)OMeMe Me NH₂ NC(NH)OEtMe Me NH₂ NH OMe Me NH₂ NCOMe OMe Me NH₂ NCOEt OMe Me NH₂ NCOPr OMe Me NH₂ NCHO OMe Me NH₂ NCOiPr OMe Me NH₂ NCOtBu OMe Me NH₂ NCOPh OMe Me NH₂ NSO₂Me OMe Me NH₂ NSO₂Et OMe Me NH₂ NSO₂Pr OMe Me NH₂ NSO₂Ph OMe Me NH₂ NSO₂iPr OMe Me NH₂ NNO₂ OMe Me NH₂ NCOOMe OMe Me NH₂ NCOOEt OMe Me NH₂ NCOOPr OMe Me NH₂ NCOOiPr OMe Me NH₂ NCONHEt OMe Me NH₂ NCONHPr OMe Me NH₂ NCOH OMe Me NH₂ NCONHMe OMe Me NH₂ NCN OMe Me NH₂ NCOSMe OMe Me NH₂ NCOSEt OMe Me NH₂ NCSOMe OMe Me NH₂ NCSOEt OMe Me NH₂ NCSOPr OMe Me NH₂ NSO₂H OMe Me NH₂ NSO₂NHMe OMe Me NH₂ NSO₂NMe₂ OMe Me NH₂ NP(O)(OMe)₂ OMe Me NH₂ NP(O)(OEt)₂ OMe Me NH₂ NP(O)Me₂ OMe Me NH₂ NP(O)Et₂ OMe Me NH₂ NP(O)Me(OMe) OMe Me NH₂ NP(O)(OPr)₂ OMe Me NH₂ NC(O)C(O)H OMe Me NH₂ NC(O)C(O)Me OMe Me NH₂ NC(O)C(O)OMe OMe Me NH₂ NC(O)C(O)OEt OMe Me NH₂ NC(O)C(O)NH₂ OMe Me NH₂ NC(O)C(O)OH OMe Me NH₂ NC(NH)H OMe Me NH₂ NC(NOH)H OMe Me NH₂ NC(NH)NHMe OMe Me NH₂ NC(NH)NMe₂ OMe Me NH₂ NC(NH)OMe OMe Me NH₂ NC(NH)OEt OMe H H NCOMeMe H H NCOEtMe H H NCOPrMe H H NCHOMe H H NCOiPrMe H H NCOtBuMe H H NCOPhMe H H NSO₂MeMe H H NSO₂EtMe H H NSO₂PrMe H H NSO₂PhMe H H NSO₂iPrMe H H NNO₂Me H H NCOOMeMe H H NCOOEtMe H H NCOOPrMe H H NCOOiPr ¨Me H H NCONHEt ¨Me H H NCONHPr ¨Me H H NCOH ¨Me H H NCONHMe ¨Me H H NCN ¨Me H H NCOSMe ¨Me H H NCOSEt ¨Me H H NCSOMeMe H H NCSOEtMe H H NCSOPrMe H H NSO₂HMe H H NSO₂NHMeMe H H NSO₂NMe₂Me H H NP(O)(OMe)₂Me H H NP(O)(OEt)₂Me H H NP(O)Me₂Me H H NP(O)Et₂Me H H NP(O)Me(OMe)Me H H NP(O)(OPr)₂Me H H NC(O)C(O)HMe H H NC(O)C(O)MeMe H H NC(O)C(O)OMeMe H H NC(O)C(O)OEtMe H H NC(O)C(O)NH₂Me H H NC(O)C(O)OHMe H H NC(NH)HMe H H NC(NOH)HMe H H NC(NH)NHMe ¨Me H H NC(NH)NMe₂ ¨Me H H NC(NH)OMe ¨Me H H NC(NH)OEt ¨Me H Me NCOMe ¨Me H Me NCOEt ¨Me H Me NCOPr ¨Me H Me NCHO ¨Me H Me NCOiPrMe H Me NCOtBuMe H Me NCOPhMe H Me NSO₂MeMe H Me NSO₂EtMe H Me NSO₂PrMe H Me NSO₂PhMe H Me NSO₂iPrMe H Me NNO₂Me H Me NCOOMeMe H Me NCOOEtMe H Me NCOOPrMe H Me NCOOiPrMe H Me NCONHEtMe H Me NCONHPrMe H Me NCOHMe H Me NCONHMeMe H Me NCNMe H Me NCOSMeMe H Me NCOSEtMe H Me NCSOMe ¨Me H Me NCSOEt ¨Me H Me NCSOPr ¨Me H Me NSO₂H ¨Me H Me NSO₂NHMe ¨Me H Me NSO₂NMe₂ ¨Me H Me NP(O)(OMe)₂ ¨Me H Me NP(O)(OEt)₂ ¨Me H Me NP(O)Me₂ ¨Me H Me NP(O)Et₂Me H Me NP(O)Me(OMe)Me H Me NP(O)(OPr)₂Me H Me NC(O)C(O)HMe H Me NC(O)C(O)MeMe H Me NC(O)C(O)OMe ¨Me H Me NC(O)C(O)OEtMe H Me NC(O)C(O)NH₂Me H Me NC(O)C(O)OHMe H Me NC(NH)HMe H Me NC(NOH)H ¨Me H Me NC(NH)NHMe ¨Me H Me NC(NH)NMe₂Me H Me NC(NH)OMe ¨Me H Me NC(NH)OEtMe Me Me NCOMeMe Me Me NCOEtMe Me Me NCOPrMe Me Me NCHOMe Me Me NCOiPr ¨Me Me Me NCOtBu ¨Me Me Me NCOPh ¨Me Me Me NSO₂Me ¨Me Me Me NSO₂Et ¨Me Me Me NSO₂Pr ¨Me Me Me NSO₂Ph ¨Me Me Me NSO₂iPr ¨Me Me Me NNO₂Me Me Me NCOOMeMe Me Me NCOOEtMe Me Me NCOOPrMe Me Me NCOOiPrMe Me Me NCONHEtMe Me Me NCONHPrMe Me Me NCOHMe Me Me NCONHMeMe Me Me NCNMe Me Me NCOSMeMe Me Me NCOSEtMe Me Me NCSOMeMe Me Me NCSOEtMe Me Me NCSOPrMe Me Me NSO₂HMe Me Me NSO₂NHMeMe Me Me NSO₂NMe₂Me Me Me NP(O)(OMe)₂ ¨Me Me Me NP(O)(OEt)₂ ¨Me Me Me NP(O)Me₂ ¨Me Me Me NP(O)Et₂ ¨Me Me Me NP(O)Me(OMe) ¨Me Me Me NP(O)(OPr)₂ ¨Me Me Me NC(O)C(O)H ¨Me Me Me NC(O)C(O)Me ¨Me Me Me NC(O)C(O)OMe ¨Me Me Me NC(O)C(O)OEt ¨Me Me Me NC(O)C(O)NH₂Me Me Me NC(O)C(O)OHMe Me Me NC(NH)HMe Me Me NC(NOH)HMe Me Me NC(NH)NHMeMe Me Me NC(NH)NMe₂Me Me Me NC(NH)OMeMe Me Me NC(NH)OEtMe Me H NCOMeMe Me H NCOEtMe Me H NCOPrMe Me H NCHOMe Me H NCOiPrMe Me H NCOtBuMe Me H NCOPhMe Me H NSO₂MeMe Me H NSO₂EtMe Me H NSO₂PrMe Me H NSO₂PhMe Me H NSO₂iPrMe Me H NNO₂ ¨Me Me H NCOOMe ¨Me Me H NCOOEt ¨Me Me H NCOOPr ¨Me Me H NCOOiPr ¨Me Me H NCONHEt ¨Me Me H NCONHPr ¨Me Me H NCOH ¨Me Me H NCONHMeMe Me H NCNMe Me H NCOSMeMe Me H NCOSEtMe Me H NCSOMeMe Me H NCSOEtMe Me H NCSOPrMe Me H NSO₂HMe Me H NSO₂NHMeMe Me H NSO₂NMe₂Me Me H NP(O)(OMe)₂Me Me H NP(O)(OEt)₂Me Me H NP(O)Me₂ ¨Me Me H NP(O)Et₂Me Me H NP(O)Me(OMe)Me Me H NP(O)(OPr)₂Me Me H NC(O)C(O)HMe Me H NC(O)C(O)MeMe Me H NC(O)C(O)OMeMe Me H NC(O)C(O)OEt ¨Me Me H NC(O)C(O)NH₂ ¨Me Me H NC(O)C(O)OH ¨Me Me H NC(NH)H ¨Me Me H NC(NOH)H ¨Me Me H NC(NH)NHMe ¨Me Me H NC(NH)NMe₂ ¨Me Me H NC(NH)OMe ¨Me Me H NC(NH)OEt ¨Me CN NH₂ NH NHMe CN NHMe NH NHMe CN NMe₂ NH NHMe CN NHEt NH NHEt CN NH₂ NH NHEt CN NHMe NH NHEt CN NMe₂ NH NHEt CN NHEt NH NHCF₃ CN NH₂ NH NHCF₃ CN NHMe NH NHCF₃ CN NMe₂ NH NHCF₃ CN NHEt NH NH

表3R¹ R⁷ R⁸ NR² XCF₃ CN NH₂ NCOMeCF₃ CN NH₂ NCOEtCF₃ CN NH₂ NCOPrCF₃ CN NH₂ NCHOCF₃ CN NH₂ NCOiPrCF₃ CN NH₂ NCOtBu ¨CF₃ CN NH₂ NCOPh ¨CF₃ CN NH₂ NSO₂MeCF₃ CN NH₂ NSO₂EtCF₃ CN NH₂ NSO₂PrCF₃ CN NH₂ NSO₂PhCF₃ CN NH₂ NSO₂iPrCF₃ CN NH₂ NNO₂CF₃ CN NH₂ NCOOMeCF₃ CN NH₂ NCOOEt

表3(续)R¹ R⁷ R⁸ NR² XCF₃ CN NH₂ NCOOPr ¨CF₃ CN NH₂ NCOOiPr ¨CF₃ CN NH₂ NCONHEt ¨CF₃ CN NH₂ NCONHPr ¨CF₃ CN NH₂ NCONH₂ ¨CF₃ CN NH₂ NCONHMe ¨CF₃ CN NH₂ NCN ¨CF₃ CN NH₂ NCOSMe ¨CF₃ CN NH₂ NCOSEtCF₃ CN NH₂ NCSOMeCF₃ CN NH₂ NCSOEtCF₃ CN NH₂ NCSOPrCF₃ CN NH₂ NSO₂NH₂CF₃ CN NH₂ NSO₂NHMeCF₃ CN NH₂ NSO₂NMe₂CF₃ CN NH₂ NP(O)(OMe)₂CF₃ CN NH₂ NP(O)(OEt)₂CF₃ CN NH₂ NP(O)Me₂CF₃ CN NH₂ NP(O)Et₂CF₃ CN NH₂ NP(O)Me(OMe)CF₃ CN NH₂ NP(O)(OPr)₂CF₃ CN NH₂ NC(O)C(O)HCF₃ CN NH₂ NC(O)C(O)MeCF₃ CN NH₂ NC(O)C(O)OMeCF₃ CN NH₂ NC(O)C(O)OEt ¨CF₃ CN NH₂ NC(O)C(O)NH₂ ¨CF₃ CN NH₂ NC(O)C(O)OH ¨CF₃ CN NH₂ NC(NH)NH₂ ¨CF₃ CN NH₂ NC(NOH)NH₂ ¨CF₃ CN NH₂ NC(NH)NHMe ¨CF₃ CN NH₂ NC(NH)NMe₂ ¨CF₃ CN NH₂ NC(NH)OMe ¨CF₃ CN NH₂ NC(NH)OEt ¨CF₃ CN NH₂ NH OCF₃ CN NH₂ NCOMe OCF₃ CN NH₂ NCOEt OCF₃ CN NH₂ NCOPr OCF₃ CN NH₂ NCHO OCF₃ CN NH₂ NCOiPr OCF₃ CN NH₂ NCOtBu OCF₃ CN NH₂ NCOPh OCF₃ CN NH₂ NSO₂Me OCF₃ CN NH₂ NSO₂Et OCF₃ CN NH₂ NSO₂Pr OCF₃ CN NH₂ NSO₂Ph OCF₃ CN NH₂ NSO₂iPr OCF₃ CN NH₂ NNO₂ OCF₃ CN NH₂ NCOOMe OCF₃ CN NH₂ NCOOEt OCF₃ CN NH₂ NCOOPr OCF₃ CN NH₂ NCOOiPr OCF₃ CN NH₂ NCONHEt OCF₃ CN NH₂ NCONHPr OCF₃ CN NH₂ NCONH₂ OCF₃ CN NH₂ NCONHMe OCF₃ CN NH₂ NCN OCF₃ CN NH₂ NCOSMe OCF₃ CN NH₂ NCOSEt OCF₃ CN NH₂ NCSOMe OCF₃ CN NH₂ NCSOEt OCF₃ CN NH₂ NCSOPr OCF₃ CN NH₂ NSO₂NH₂ OCF₃ CN NH₂ NSO₂NHMe OCF₃ CN NH₂ NSO₂NMe₂ OCF₃ CN NH₂ NP(O)(OMe)₂ OCF₃ CN NH₂ NP(O)(OEt)₂ OCF₃ CN NH₂ NP(O)Me₂ OCF₃ CN NH₂ NP(O)Et₂ OCF₃ CN NH₂ NP(O)Me(OMe) OCF₃ CN NH₂ NP(O)(OPr)₂ OCF₃ CN NH₂ NC(O)C(O)H OCF₃ CN NH₂ NC(O)C(O)Me OCF₃ CN NH₂ NC(O)C(O)OMe OCF₃ CN NH₂ NC(O)C(O)OEt OCF₃ CN NH₂ NC(O)C(O)NH₂ OCF₃ CN NH₂ NC(O)C(O)OH OCF₃ CN NH₂ NC(NH)NH₂ OCF₃ CN NH₂ NC(NOH)NH₂ OCF₃ CN NH₂ NC(NH)NHMe OCF₃ CN NH₂ NC(NH)NMe₂ OCF₃ CN NH₂ NC(NH)OMe OCF₃ CN NH₂ NC(NH)OEt OCF₃ CN H NCOMe ¨CF₃ CN H NCOEt ¨CF₃ CN H NCOPr ¨CF₃ CN H NCHO ¨CF₃ CN H NCOiPr ¨CF₃ CN H NCOtBu ¨CF₃ CN H NCOPh ¨CF₃ CN H NSO₂Me ¨CF₃ CN H NSO₂EtCF₃ CN H NSO₂PrCF₃ CN H NSO₂PhCF₃ CN H NSO₂iPrCF₃ CN H NNO₂CF₃ CN H NCOOMeCF₃ CN H NCOOEtCF₃ CN H NCOOPrCF₃ CN H NCOOiPrCF₃ CN H NCONHEtCF₃ CN H NCONHPrCF₃ CN H NCONH₂CF₃ CN H NCONHMeCF₃ CN H NCNCF₃ CN H NCOSMeCF₃ CN H NCOSEtCF₃ CN H NCSOMeCF₃ CN H NCSOEtCF₃ CN H NCSOPrCF₃ CN H NSO₂NH₂CF₃ CN H NSO₂NHMe ¨CF₃ CN H NSO₂NMe₂ ¨CF₃ CN H NP(O)(OMe)₂ ¨CF₃ CN H NP(O)(OEt)₂ ¨CF₃ CN H NP(O)Me₂ ¨CF₃ CN H NP(O)Et₂ ¨CF₃ CN H NP(O)Me(OMe) ¨CF₃ CN H NP(O)(OPr)₂ ¨CF₃ CN H NC(O)C(O)HCF₃ CN H NC(O)C(O)MeCF₃ CN H NC(O)C(O)OMeCF₃ CN H NC(O)C(O)OEtCF₃ CN H NC(O)C(O)NH₂CF₃ CN H NC(O)C(O)OHCF₃ CN H NC(NH)NH₂CF₃ CN H NC(NOH)NH₂CF₃ CN H NC(NH)NHMeCF₃ CN H NC(NH)NMe₂CF₃ CN H NC(NH)OMeCF₃ CN H NC(NH)OEtCF₃ CN H NH OCF₃ CN H NCOMe OCF₃ CN H NCOEt OCF₃ CN H NCOPr OCF₃ CN H NCHO OCF₃ CN H NCOiPr OCF₃ CN H NCOtBu OCF₃ CN H NCOPh OCF₃ CN H NSO₂Me OCF₃ CN H NSO₂Et OCF₃ CN H NSO₂Pr OCF₃ CN H NSO₂Ph OCF₃ CN H NSO₂iPr OCF₃ CN H NNO₂ OCF₃ CN H NCOOMe OCF₃ CN H NCOOEt OCF₃ CN H NCOOPr OCF₃ CN H NCOOiFr OCF₃ CN H NCONHEt OCF₃ CN H NCONHPr OCF₃ CN H NCONH₂ OCF₃ CN H NCONHMe OCF₃ CN H NCN OCF₃ CN H NCOSMe OCF₃ CN H NCOSEt OCF₃ CN H NCSOMe OCF₃ CN H NCSOEt OCF₃ CN H NCSOPr OCF₃ CN H NSO₂NH₂ OCF₃ CN H NSO₂NHMe OCF₃ CN H NSO₂NMe₂ OCF₃ CN H NP(O)(OMe)₂ OCF₃ CN H NP(O)(OEt)₂ OCF₃ CN H NP(O)Me₂ OCF₃ CN H NP(O)Et₂ OCF₃ CN H NP(O)Me(OMe) OCF₃ CN H NP(O)(OPr)₂ OCF₃ CN H NC(O)C(O)H OCF₃ CN H NC(O)C(O)Me OCF₃ CN H NC(O)C(O)OMe OCF₃ CN H NC(O)C(O)OEt OCF₃ CN H NC(O)C(O)NH₂ OCF₃ CN H NC(O)C(O)OH OCF₃ CN H NC(NH)NH₂ OCF₃ CN H NC(NOH)NH₂ OCF₃ CN H NC(NH)NHMe OCF₃ CN H NC(NH)NMe₂ OCF₃ CN H NC(NH)OMe OCF₃ CN H NC(NH)OEt OCF₃ CN SMe NCOMeCF₃ CN SMe NCOEtCF₃ CN SMe NCOPrCF₃ CN SMe NCHOCF₃ CN SMe NCOiPrCF₃ CN SMe NCOtBuCF₃ CN SMe NCOPhCF₃ CN SMe NSO₂MeCF₃ CN SMe NSO₂EtCF₃ CN SMe NSO₂PrCF₃ CN SMe NSO₂PhCF₃ CN SMe NSO₂iPrCF₃ CN SMe NNO₂CF₃ CN SMe NCOOMeCF₃ CN SMe NCOOEt ¨CF₃ CN SMe NCOOPr ¨CF₃ CN SMe NCOOiPr ¨CF₃ CN SMe NCONHEt ¨CF₃ CN SMe NCONHPr ¨CF₃ CN SMe NCONH₂ ¨CF₃ CN SMe NCONHMe ¨CF₃ CN SMe NCN ¨CF₃ CN SMe NCOSMe ¨CF₃ CN SMe NCOSEtCF₃ CN SMe NCSOMeCF₃ CN SMe NCSOEtCF₃ CN SMe NCSOPrCF₃ CN SMe NSO₂NH₂CF₃ CN SMe NSO₂NHMeCF₃ CN SMe NSO₂NMe₂CF₃ CN SMe NP(O)(OMe)₂CF₃ CN SMe NP(O)(OEt)₂CF₃ CN SMe NP(O)Me₂CF₃ CN SMe NP(O)Et₂CF₃ CN SMe NP(O)Me(OMe) ¨CF₃ CN SMe NP(O)(OPr)₂CF₃ CN SMe NC(O)C(O)HCF₃ CN SMe NC(O)C(O)Me ¨CF₃ CN SMe NC(O)C(O)OMeCF₃ CN SMe NC(O)C(O)OEtCF₃ CN SMe NC(O)C(O)NH₂ ¨CF₃ CN SMe NC(O)C(O)OHCF₃ CN SMe NC(NH)NH₂CF₃ CN SMe NC(NOH)NH₂ ¨CF₃ CN SMe NC(NH)NHMe ¨CF₃ CN SMe NC(NH)NMe₂CF₃ CN SMe NC(NH)OMe ¨CF₃ CN SMe NC(NH)OEt ¨CF₃ CN SMe NCOMe OCF₃ CN SMe NCOEt OCF₃ CN SMe NCOPr OCF₃ CN SMe NCHO OCF₃ CN SMe NCOiPr OCF₃ CN SMe NCOtBu OCF₃ CN SMe NCOPh OCF₃ CN SMe NSO₂Me OCF₃ CN SMe NSO₂Et OCF₃ CN SMe NSO₂Pr OCF₃ CN SMe NSO₂Ph OCF₃ CN SMe NSO₂iPr OCF₃ CN SMe NNO₂ OCF₃ CN SMe NCOOMe OCF₃ CN SMe NCOOEt OCF₃ CN SMe NCOOPr OCF₃ CN SMe NCOOiPr OCF₃ CN SMe NCONHEt OCF₃ CN SMe NCONHPr OCF₃ CN SMe NCONH₂ OCF₃ CN SMe NCONHMe OCF₃ CN SMe NCN OCF₃ CN SMe NCOSMe OCF₃ CN SMe NCOSEt OCF₃ CN SMe NCSOMe OCF₃ CN SMe NCSOEt OCF₃ CN SMe NCSOPr OCF₃ CN SMe NSO₂NH₂ OCF₃ CN SMe NSO₂NHMe OCF₃ CN SMe NSO₂NMe₂ OCF₃ CN SMe NP(O)(OMe)₂ OCF₃ CN SMe NP(O)(OEt)₂ OCF₃ CN SMe NP(O)Me₂ OCF₃ CN SMe NP(O)Et₂ OCF₃ CN SMe NP(O)Me(OMe) OCF₃ CN SMe NP(O)(OPr)₂ OCF₃ CN SMe NC(O)C(O)H OCF₃ CN SMe NC(O)C(O)Me OCF₃ CN SMe NC(O)C(O)OMe OCF₃ CN SMe NC(O)C(O)OEt OCF₃ CN SMe NC(O)C(O)NH₂ OCF₃ CN SMe NC(O)C(O)OH OCF₃ CN SMe NC(NH)NH₂ OCF₃ CN SMe NC(NOH)NH₂ OCF₃ CN SMe NC(NH)NHMe OCF₃ CN SMe NC(NH)NMe₂ OCF₃ CN SMe NC(NH)OMe OCF₃ CN SMe NC(NH)OEt OCF₃ CN Cl NCOMeCF₃ CN Cl NCOEtCF₃ CN Cl NCOPr ¨CF₃ CN Cl NCHO ¨CF₃ CN Cl NCOiPr ¨CF₃ CN Cl NCOtBu ¨CF₃ CN Cl NCOPh ¨CF₃ CN Cl NSO₂Me ¨CF₃ CN Cl NSO₂Et ¨CF₃ CN Cl NSO₂Pr ¨CF₃ CN Cl NSO₂Ph ¨CF₃ CN Cl NSO₂iPr ¨CF₃ CN Cl NNO₂CF₃ CN Cl NCOOMeCF₃ CN Cl NCOOEtCF₃ CN Cl NCOOPrCF₃ CN Cl NCOOiPrCF₃ CN Cl NCONHEtCF₃ CN Cl NCONHPrCF₃ CN Cl NCONH₂CF₃ CN Cl NCONHMeCF₃ CN Cl NCNCF₃ CN Cl NCOSMeCF₃ CN Cl NCOSEtCF₃ CN Cl NCSOMeCF₃ CN Cl NCSOEtCF₃ CN Cl NCSOPrCF₃ CN Cl NSO₂NH₂CF₃ CN Cl NSO₂NHMeCF₃ CN Cl NSO₂NMe₂CF₃ CN Cl NP(O)(OMe)₂CF₃ CN Cl NP(O)(OEt)₂ ¨CF₃ CN Cl NP(O)Me₂ ¨CF₃ CN Cl NP(O)Et₂ ¨CF₃ CN Cl NP(O)Me(OMe) ¨CF₃ CN Cl NP(O)(OPr)₂ ¨CF₃ CN Cl NC(O)C(O)H ¨CF₃ CN Cl NC(O)C(O)Me ¨CF₃ CN Cl NC(O)C(O)OMeCF₃ CN Cl NC(O)C(O)OEtCF₃ CN Cl NC(O)C(O)NH₂ ¨CF₃ CN Cl NC(O)C(O)OHCF₃ CN Cl NC(NH)NH₂CF₃ CN Cl NC(NOH)NH₂CF₃ CN Cl NC(NH)NHMeCF₃ CN Cl NC(NH)NMe₂CF₃ CN Cl NC(NH)OMeCF₃ CN Cl NC(NH)OEtCF₃ CN Cl NCOMe OCF₃ CN Cl NCOEt OCF₃ CN Cl NCOPr OCF₃ CN Cl NCHO OCF₃ CN Cl NCOiPr OCF₃ CN Cl NCOtBu OCF₃ CN Cl NCOPh OCF₃ CN Cl NSO₂Me OCF₃ CN Cl NSO₂Et OCF₃ CN Cl NSO₂Pr OCF₃ CN Cl NSO₂Ph OCF₃ CN Cl NSO₂iPr OCF₃ CN Cl NNO₂ OCF₃ CN Cl NCOOMe OCF₃ CN Cl NCOOEt OCF₃ CN Cl NCOOPr OCF₃ CN Cl NCOOiPr OCF₃ CN Cl NCONHEt OCF₃ CN Cl NCONHPr OCF₃ CN Cl NCONH₂ OCF₃ CN Cl NCONHMe OCF₃ CN Cl NCN OCF₃ CN Cl NCOSMe OCF₃ CN Cl NCOSEt OCF₃ CN Cl NCSOMe OCF₃ CN Cl NCSOEt OCF₃ CN Cl NCSOPr OCF₃ CN Cl NSO₂NH₂ OCF₃ CN Cl NSO₂NHMe OCF₃ CN Cl NSO₂NMe₂ OCF₃ CN Cl NP(O)(OMe)₂ OCF₃ CN Cl NP(O)(OEt)₂ OCF₃ CN Cl NP(O)Me₂ OCF₃ CN Cl NP(O)Et₂ OCF₃ CN Cl NP(O)Me(OMe) OCF₃ CN Cl NP(O)(OPr)₂ OCF₃ CN Cl NC(O)C(O)H OCF₃ CN Cl NC(O)C(O)Me OCF₃ CN Cl NC(O)C(O)OMe OCF₃ CN Cl NC(O)C(O)OEt OCF₃ CN Cl NC(O)C(O)NH₂ OCF₃ CN Cl NC(O)C(O)OH OCF₃ CN Cl NC(NH)NH₂ OCF₃ CN Cl NC(NOH)NH₂ OCF₃ CN Cl NC(NH)NHMe OCF₃ CN Cl NC(NH)NMe₂ OCF₃ CN Cl NC(NH)OMe OCF₃ CN Cl NC(NH)OEt O

表4

R¹ R⁹ R¹¹ NR² XCF₃ H H NCOMeCF₃ H H NCOEtCF₃ H H NCOPrCF₃ H H NCHOCF₃ H H NCOiPrCF₃ H H NCOtBuCF₃ H H NCOPhCF₃ H H NSO₂MeCF₃ H H NSO₂EtCF₃ H H NSO₂PrCF₃ H H NSO₂PhCF₃ H H NSO₂iPrCF₃ H H NNO₂CF₃ H H NCOOMe ¨CF₃ H H NCOOEt ¨CF₃ H H NCOOPr ¨

表5(续)R¹ R⁹ R¹¹ NR² XCF₃ H H NCOOiPr ¨CF₃ H H NCONHEt ¨CF₃ H H NCONHPr ¨CF₃ H H NCONH₂ ¨CF₃ H H NCONHMe ¨CF₃ H H NCN ¨CF₃ H H NCOSMeCF₃ H H NCOSEtCF₃ H H NCSOMeCF₃ H H NCSOEtCF₃ H H NCSOPrCF₃ H H NSO₂NH₂CF₃ H H NSO₂NHMeCF₃ H H NSO₂NMe₂CF₃ H H NP(O)(OMe)₂CF₃ H H NP(O)(OEt)₂CF₃ H H NP(O)Me₂CF₃ H H NP(O)Et₂CF₃ H H NP(O)Me(OMe)CF₃ H H NP(O)(OPr)₂CF₃ H H NC(O)C(O)HCF₃ H H NC(O)C(O)MeCF₃ H H NC(O)C(O)OMeCF₃ H H NC(O)C(O)OEtCF₃ H H NC(O)C(O)NH₂ ¨CF₃ H H NC(O)C(O)OH ¨CF₃ H H NC(NH)NH₂ ¨CF₃ H H NC(NOH)NH₂ ¨CF₃ H H NC(NH)NHMe ¨CF₃ H H NC(NH)NMe₂ ¨CF₃ H H NC(NH)OMe ¨CF₃ H H NC(NH)OEt ¨CF₃ Cl H NCOMe ¨CF₃ Cl H NCOEt ¨CF₃ Cl H NCOPr ¨CF₃ Cl H NCHOCF₃ Cl H NCOiPrCF₃ Cl H NCOtBuCF₃ Cl H NCOPh ¨CF₃ Cl H NSO₂Me ¨CF₃ Cl H NSO₂EtCF₃ Cl H NSO₂Pr ¨CF₃ Cl H NSO₂Ph ¨CF₃ Cl H NSO₂iPr ¨CF₃ Cl H NNO₂ ¨CF₃ Cl H NCOOMe ¨CF₃ Cl H NCOOEt ¨CF₃ Cl H NCOOPr ¨CF₃ Cl H NCOOiPr ¨CF₃ Cl H NCONHEt ¨CF₃ Cl H NCONHPr ¨CF₃ Cl H NCONH₂ ¨CF₃ Cl H NCONHMeCF₃ Cl H NCN ¨CF₃ Cl H NCOSMe ¨CF₃ Cl H NCOSEt ¨CF₃ Cl H NCSOMe ¨CF₃ Cl H NCSOEt ¨CF₃ Cl H NCSOPr ¨CF₃ Cl H NSO₂NH₂ ¨CF₃ Cl H NSO₂NHMe ¨CF₃ Cl H NSO₂NMe₂ ¨CF₃ Cl H NP(O)(OMe)₂ ¨CF₃ Cl H NP(O)(OEt)₂ ¨CF₃ Cl H NP(O)Me₂CF₃ Cl H NP(O)Et₂CF₃ Cl H NP(O)Me(OMe)CF₃ Cl H NP(O)(OPr)₂CF₃ Cl H NC(O)C(O)HCF₃ Cl H NC(O)C(O)MeCF₃ Cl H NC(O)C(O)OMeCF₃ Cl H NC(O)C(O)OEtCF₃ Cl H NC(O)C(O)NH₂ ¨CF₃ Cl H NC(O)C(O)OHCF₃ Cl H NC(NH)NH₂ ¨CF₃ Cl H NC(NOH)NH₂ ¨CF₃ Cl H NC(NH)NHMeCF₃ Cl H NC(NH)NMe₂CF₃ Cl H NC(NH)OMeCF₃ Cl H NC(NH)OEtCF₃ Cl Me NCOMe ¨CF₃ Cl Me NCOEt ¨CF₃ Cl Me NCOPr ¨CF₃ Cl Me NCHO ¨CF₃ Cl Me NCOiPr ¨CF₃ Cl Me NCOtBu ¨CF₃ Cl Me NCOPh ¨CF₃ Cl Me NSO₂Me ¨CF₃ Cl Me NSO₂Et ¨CF₃ Cl Me NSO₂Pr ¨CF₃ Cl Me NSO₂PhCF₃ Cl Me NSO₂iPrCF₃ Cl Me NNO₂CF₃ Cl Me NCOOMeCF₃ Cl Me NCOOEtCF₃ Cl Me NCOOPrCF₃ Cl Me NCOOiPrCF₃ Cl Me NCONHEtCF₃ Cl Me NCONHPrCF₃ Cl Me NCONH₂CF₃ Cl Me NCONHMeCF₃ Cl Me NCNCF₃ Cl Me NCOSMeCF₃ Cl Me NCOSEtCF₃ Cl Me NCSOMeCF₃ Cl Me NCSOEtCF₃ Cl Me NCSOPrCF₃ Cl Me NSO₂NH₂CF₃ Cl Me NSO₂NHMeCF₃ Cl Me NSO₂NMe₂ ¨CF₃ Cl Me NP(O)(OMe)₂ ¨CF₃ Cl Me NP(O)(OEt)₂ ¨CF₃ Cl Me NP(O)Me₂ ¨CF₃ Cl Me NP(O)Et₂ ¨CF₃ Cl Me NP(O)Me(OMe) ¨CF₃ Cl Me NP(O)(OPr)₂ ¨CF₃ Cl Me NC(O)C(O)H ¨CF₃ Cl Me NC(O)C(O)Me ¨CF₃ Cl Me NC(O)C(O)OMe ¨CF₃ Cl Me NC(O)C(O)OEtCF₃ Cl Me NC(O)C(O)NH₂CF₃ Cl Me NC(O)C(O)OHCF₃ Cl Me NC(NH)NH₂CF₃ Cl Me NC(NOH)NH₂CF₃ Cl Me NC(NH)NHMeCF₃ Cl Me NC(NH)NMe₂CF₃ Cl Me NC(NH)OMeCF₃ Cl Me NC(NH)OEtCF₃ Cl SMe NCOMeCF₃ Cl SMe NCOEtCF₃ Cl SMe NCOPrCF₃ Cl SMe NCHOCF₃ Cl SMe NCOiPrCF₃ Cl SMe NCOtBu ¨CF₃ Cl SMe NCOPhCF₃ Cl SMe NSO₂Me ¨CF₃ Cl SMe NSO₂EtCF₃ Cl SMe NSO₂Pr ¨CF₃ Cl SMe NSO₂Ph ¨CF₃ Cl SMe NSO₂iPr ¨CF₃ Cl SMe NNO₂ ¨CF₃ Cl SMe NCOOMe ¨CF₃ Cl SMe NCOOEt ¨CF₃ Cl SMe NCOOPr ¨CF₃ Cl SMe NCOOiPr ¨CF₃ Cl SMe NCONHEt ¨CF₃ Cl SMe NCONHPr ¨CF₃ Cl SMe NCONH₂CF₃ Cl SMe NCONHMeCF₃ Cl SMe NCNCF₃ Cl SMe NCOSMeCF₃ Cl SMe NCOSEtCF₃ Cl SMe NCSOMeCF₃ Cl SMe NCSOEtCF₃ Cl SMe NCSOPrCF₃ Cl SMe NSO₂NH₂CF₃ Cl SMe NSO₂NHMeCF₃ Cl SMe NSO₂NMe₂CF₃ Cl SMe NP(O)(OMe)₂CF₃ Cl SMe NP(O)(OEt)₂CF₃ Cl SMe NP(O)Me₂CF₃ Cl SMe NP(O)Et₂CF₃ Cl SMe NP(O)Me(OMe)CF₃ Cl SMe NP(O)(OPr)₂CF₃ Cl SMe NC(O)C(O)H ¨CF₃ Cl SMe NC(O)C(O)Me ¨CF₃ Cl SMe NC(O)C(O)OMe ¨CF₃ Cl SMe NC(O)C(O)OEt ¨CF₃ Cl SMe NC(O)C(O)NH₂ ¨CF₃ Cl SMe NC(O)C(O)OH ¨CF₃ Cl SMe NC(NH)NH₂ ¨CF₃ Cl SMe NC(NOH)NH₂ ¨CF₃ Cl SMe NC(NH)NHMe ¨CF₃ Cl SMe NC(NH)NMe₂ ¨CF₃ Cl SMe NC(NH)OMe ¨CF₃ Cl SMe NC(NH)OEt ¨CF₃ H Me NCOMe ¨CF₃ H Me NCOEt ¨CF₃ H Me NCOPr ¨CF₃ H Me NCHOCF₃ H Me NCOiPr ¨CF₃ H Me NCOtBu ¨CF₃ H Me NCOPh ¨CF₃ H Me NSO₂Me ¨CF₃ H Me NSO₂EtCF₃ H Me NSO₂Pr ¨CF₃ H Me NSO₂PhCF₃ H Me NSO₂iPrCF₃ H Me NNO₂CF₃ H Me NCOOMe ¨CF₃ H Me NCOOEtCF₃ H Me NCOOPrCF₃ H Me NCOOiPrCF₃ H Me NCONHEt ¨CF₃ H Me NCONHPr ¨CF₃ H Me NCONH₂ ¨CF₃ H Me NCONHMe ¨CF₃ H Me NCN ¨CF₃ H Me NCOSMe ¨CF₃ H Me NCOSEt ¨CF₃ H Me NCSOMeCF₃ H Me NCSOEtCF₃ H Me NCSOPrCF₃ H Me NSO₂NH₂CF₃ H Me NSO₂NHMeCF₃ H Me NSO₂NMe₂CF₃ H Me NP(O)(OMe)₂CF₃ H Me NP(O)(OEt)₂CF₃ H Me NP(O)Me₂CF₃ H Me NP(O)Et₂CF₃ H Me NP(O)Me(OMe)CF₃ H Me NP(O)(OPr)₂CF₃ H Me NC(O)C(O)HCF₃ H Me NC(O)C(O)MeCF₃ H Me NC(O)C(O)OMeCF₃ H Me NC(O)C(O)OEtCF₃ H Me NC(O)C(O)NH₂CF₃ H Me NC(O)C(O)OHCF₃ H Me NC(NH)NH₂CF₃ H Me NC(NOH)NH₂CF₃ H Me NC(NH)NHMeCF₃ H Me NC(NH)NMe₂ ¨CF₃ H Me NC(NH)OMe ¨CF₃ H Me NC(NH)OEt ¨CF₃ H SMe NCOMe ¨CF₃ H SMe NCOEt ¨CF₃ H SMe NCOPr ¨CF₃ H SMe NCHO ¨CF₃ H SMe NCOiPr ¨CF₃ H SMe NCOtBu ¨CF₃ H SMe NCOPh ¨CF₃ H SMe NSO₂MeCF₃ H SMe NSO₂EtCF₃ H SMe NSO₂PrCF₃ H SMe NSO₂PhCF₃ H SMe NSO₂iPrCF₃ H SMe NNO₂CF₃ H SMe NCOOMeCF₃ H SMe NCOOEtCF₃ H SMe NCOOPrCF₃ H SMe NCOOiPrCF₃ H SMe NCONHEtCF₃ H SMe NCONHPrCF₃ H SMe NCONH₂CF₃ H SMe NCONHMe ¨CF₃ H SMe NCNCF₃ H SMe NCOSMeCF₃ H SMe NCOSEtCF₃ H SMe NCSOMeCF₃ H SMe NCSOEt ¨CF₃ H SMe NCSOPr ¨CF₃ H SMe NSO₂NH₂ ¨CF₃ H SMe NSO₂NHMe ¨CF₃ H SMe NSO₂NMe₂ ¨CF₃ H SMe NP(O)(OMe)₂ ¨CF₃ H SMe NP(O)(OEt)₂ ¨CF₃ H SMe NP(O)Me₂ ¨CF₃ H SMe NP(O)Et₂ ¨CF₃ H SMe NP(O)Me(OMe)CF₃ H SMe NP(O)(OPr)₂CF₃ H SMe NC(O)C(O)HCF₃ H SMe NC(O)C(O)Me ¨CF₃ H SMe NC(O)C(O)OMeCF₃ H SMe NC(O)C(O)OEtCF₃ H SMe NC(O)C(O)NH₂CF₃ H SMe NC(O)C(O)OHCF₃ H SMe NC(NH)NH₂ ¨CF₃ H SMe NC(NOH)NH₂ ¨CF₃ H SMe NC(NH)NHMe ¨CF₃ H SMe NC(NH)NMe₂ ¨CF₃ H SMe NC(NH)OMe ¨CF₃ H SMe NC(NH)OEtCF₃ Me H NCOMeCF₃ Me H NCOEt ¨CF₃ Me H NCOPr ¨CF₃ Me H NCHO ¨CF₃ Me H NCOiPrCF₃ Me H NCOtBuCF₃ Me H NCOPhCF₃ Me H NSO₂MeCF₃ Me H NSO₂EtCF₃ Me H NSO₂PrCF₃ Me H NSO₂PhCF₃ Me H NSO₂iPrCF₃ Me H NNO₂CF₃ Me H NCOOMeCF₃ Me H NCOOEtCF₃ Me H NCOOPrCF₃ Me H NCOOiPrCF₃ Me H NCONHEtCF₃ Me H NCONHPrCF₃ Me H NCONH₂CF₃ Me H NCONHMeCF₃ Me H NCNCF₃ Me H NCOSMeCF₃ Me H NCOSEtCF₃ Me H NCSOMeCF₃ Me H NCSOEtCF₃ Me H NCSOPrCF₃ Me H NSO₂NH₂CF₃ Me H NSO₂NHMeCF₃ Me H NSO₂NMe₂CF₃ Me H NP(O)(OMe)₂CF₃ Me H NP(O)(OEt)₂CF₃ Me H NP(O)Me₂CF₃ Me H NP(O)Et₂CF₃ Me H NP(O)Me(OMe) ¨CF₃ Me H NP(O)(OPr)₂ ¨CF₃ Me H NC(O)C(O)H ¨CF₃ Me H NC(O)C(O)Me ¨CF₃ Me H NC(O)C(O)OMe ¨CF₃ Me H NC(O)C(O)OEt ¨CF₃ Me H NC(O)C(O)NH₂ ¨CF₃ Me H NC(O)C(O)OH ¨CF₃ Me H NC(NH)NH₂CF₃ Me H NC(NOH)NH₂CF₃ Me H NC(NH)NHMe ¨CF₃ Me H NC(NH)NMe₂CF₃ Me H NC(NH)OMeCF₃ Me H NC(NH)OEtCF₃ Me Me NCOMeCF₃ Me Me NCOEtCF₃ Me Me NCOPrCF₃ Me Me NCHOCF₃ Me Me NCOiPr ¨CF₃ Me Me NCOtBuCF₃ Me Me NCOPh ¨CF₃ Me Me NSO₂MeCF₃ Me Me NSO₂EtCF₃ Me Me NSO₂Pr ¨CF₃ Me Me NSO₂PhCF₃ Me Me NSO₂iPrCF₃ Me Me NNO₂CF₃ Me Me NCOOMe ¨CF₃ Me Me NCOOEt ¨CF₃ Me Me NCOOPr ¨CF₃ Me Me NCOOiPr ¨CF₃ Me Me NCONHEt ¨CF₃ Me Me NCONHPr ¨CF₃ Me Me NCONH₂ ¨CF₃ Me Me NCONHMe ¨CF₃ Me Me NCN ¨CF₃ Me Me NCOSMe ¨CF₃ Me Me NCOSEtCF₃ Me Me NCSOMeCF₃ Me Me NCSOEt ¨CF₃ Me Me NCSOPr ¨CF₃ Me Me NSO₂NH₂ ¨CF₃ Me Me NSO₂NHMe ¨CF₃ Me Me NSO₂NMe₂ ¨CF₃ Me Me NP(O)(OMe)₂ ¨CF₃ Me Me NP(O)(OEt)₂CF₃ Me Me NP(O)Me₂CF₃ Me Me NP(O)Et₂ ¨CF₃ Me Me NP(O)Me(OMe) ¨CF₃ Me Me NP(O)(OPr)₂ ¨CF₃ Me Me NC(O)C(O)HCF₃ Me Me NC(O)C(O)Me ¨CF₃ Me Me NC(O)C(O)OMe ¨CF₃ Me Me NC(O)C(O)OEt ¨CF₃ Me Me NC(O)C(O)NH₂ ¨CF₃ Me Me NC(O)C(O)OH ¨CF₃ Me Me NC(NH)NH₂ ¨CF₃ Me Me NC(NOH)NH₂ ¨CF₃ Me Me NC(NH)NHMe ¨CF₃ Me Me NC(NH)NMe₂ ¨CF₃ Me Me NC(NH)OMe ¨CF₃ Me Me NC(NH)OEt ¨Me H H NCOMe ¨Me H H NCOEt ¨Me H H NCOPrMe H H NCHOMe H H NCOiPrMe H H NCOtBuMe H H NCOPhMe H H NSO₂MeMe H H NSO₂EtMe H H NSO₂PrMe H H NSO₂PhMe H H NSO₂iPrMe H H NNO₂Me H H NCOOMeMe H H NCOOEtMe H H NCOOPrMe H H NCOOiPrMe H H NCONHEtMe H H NCONHPrMe H H NCONH₂Me H H NCONHMeMe H H NCNMe H H NCOSMe ¨Me H H NCOSEt ¨Me H H NCSOMe ¨Me H H NCSOEt ¨Me H H NCSOPr ¨Me H H NSO₂NH₂ ¨Me H H NSO₂NHMe ¨Me H H NSO₂NMe₂ ¨Me H H NP(O)(OMe)₂ ¨Me H H NP(O)(OEt)₂ ¨Me H H NP(O)Me₂Me H H NP(O)Et₂ ¨Me H H NP(O)Me(OMe)Me H H NP(O)(OPr)₂ ¨Me H H NC(O)C(O)H ¨Me H H NC(O)C(O)MeMe H H NC(O)C(O)OMeMe H H NC(O)C(O)OEtMe H H NC(O)C(O)NH₂Me H H NC(O)C(O)OHMe H H NC(NH)NH₂Me H H NC(NOH)NH₂Me H H NC(NH)NHMeMe H H NC(NH)NMe₂Me H H NC(NH)OMeMe H H NC(NH)OEt ¨Me Cl H NCOMeMe Cl H NCOEt ¨Me Cl H NCOPr ¨Me Cl H NCHO ¨Me Cl H NCOiPr ¨Me Cl H NCOtBu ¨Me Cl H NCOPh ¨Me Cl H NSO₂Me ¨Me Cl H NSO₂Et ¨Me Cl H NSO₂Pr ¨Me Cl H NSO₂Ph ¨Me Cl H NSO₂iPr ¨Me Cl H NNO₂Me Cl H NCOOMeMe Cl H NCOOEtMe Cl H NCOOPrMe Cl H NCOOiPr ¨Me Cl H NCONHEtMe Cl H NCONHPrMe Cl H NCONH₂Me Cl H NCONHMe ¨Me Cl H NCN ¨Me Cl H NCOSMe ¨Me Cl H NCOSEt ¨Me Cl H NCSOMe ¨Me Cl H NCSOEt ¨Me Cl H NCSOPrMe Cl H NSO₂NH₂ ¨Me Cl H NSO₂NHMeMe Cl H NSO₂NMe₂Me Cl H NP(O)(OMe)₂ ¨Me Cl H NP(O)(OEt)₂ ¨Me Cl H NP(O)Me₂ ¨Me Cl H NP(O)Et₂ ¨Me Cl H NP(O)Me(OMe) ¨Me Cl H NP(O)(OPr)₂ ¨Me Cl H NC(O)C(O)H ¨Me Cl H NC(O)C(O)Me ¨Me Cl H NC(O)C(O)OMe ¨Me Cl H NC(O)C(O)OEt ¨Me Cl H NC(O)C(O)NH₂Me Cl H NC(O)C(O)OH ¨Me Cl H NC(NH)NH₂Me Cl H NC(NOH)NH₂Me Cl H NC(NH)NHMeMe Cl H NC(NH)NMe₂ ¨Me Cl H NC(NH)OMeMe Cl H NC(NH)OEtMe Cl Me NCOMe ¨Me Cl Me NCOEtMe Cl Me NCOPr ¨Me Cl Me NCHO ¨Me Cl Me NCOiPr ¨Me Cl Me NCOtBuMe Cl Me NCOPhMe Cl Me NSO₂MeMe Cl Me NSO₂EtMe Cl Me NSO₂PrMe Cl Me NSO₂Ph ¨Me Cl Me NSO₂iPr ¨Me Cl Me NNO₂ ¨Me Cl Me NCOOMe ¨Me Cl Me NCOOEt ¨Me Cl Me NCOOPr ¨Me Cl Me NCOOiPr ¨Me Cl Me NCONHEt ¨Me Cl Me NCONHPr ¨Me Cl Me NCONH₂ ¨Me Cl Me NCONHMe ¨Me Cl Me NCN ¨Me Cl Me NCOSMe ¨Me Cl Me NCOSEt ¨Me Cl Me NCSOMeMe Cl Me NCSOEtMe Cl Me NCSOPr ¨Me Cl Me NSO₂NH₂ ¨Me Cl Me NSO₂NHMe ¨Me Cl Me NSO₂NMe₂ ¨Me Cl Me NP(O)(OMe)₂ ¨Me Cl Me NP(O)(OEt)₂ ¨Me Cl Me NP(O)Me₂ ¨Me Ci Me NP(O)Et₂ ¨Me Cl Me NP(O)Me(OMe) ¨Me Cl Me NP(O)(OPr)₂ ¨Me Cl Me NC(O)C(O)HMe Cl Me NC(O)C(O)Me ¨Me Cl Me NC(O)C(O)OMe ¨Me Cl Me NC(O)C(O)OEt ¨Me Cl Me NC(O)C(O)NH₂ ¨Me Cl Me NC(O)C(O)OH ¨Me Cl Me NC(NH)NH₂ ¨Me Cl Me NC(NOH)NH₂ ¨Me Cl Me NC(NH)NHMe ¨Me Cl Me NC(NH)NMe₂ ¨Me Cl Me NC(NH)OMe ¨Me Cl Me NC(NH)OEtMe Cl SMe NCOMeMe Cl SMe NCOEt ¨Me Cl SMe NCOPrMe Cl SMe NCHOMe Cl SMe NCOiPrMe Cl SMe NCOtBuMe Cl SMe NCOPhMe Cl SMe NSO₂Me ¨Me Cl SMe NSO₂EtMe Cl SMe NSO₂PrMe Cl SMe NSO₂Ph ¨Me Cl SMe NSO₂iPrMe Cl SMe NNO₂Me Cl SMe NCOOMeMe Cl SMe NCOOEtMe Cl SMe NCOOPrMe Cl SMe NCOOiPrMe Cl SMe NCONHEt ¨Me Cl SMe NCONHPr ¨Me Cl SMe NCONH₂ ¨Me Cl SMe NCONHMe ¨Me Cl SMe NCN ¨Me Cl SMe NCOSMe ¨Me Cl SMe NCOSEt ¨Me Cl SMe NCSOMe ¨Me Cl SMe NCSOEt ¨Me Cl SMe NCSOPr ¨Me Cl SMe NSO₂NH₂ ¨Me Cl SMe NSO₂NHMeMe Cl SMe NSO₂NMe₂Me Cl SMe NP(O)(OMe)₂Me Cl SMe NP(O)(OEt)₂Me Cl SMe NP(O)Me₂Me Cl SMe NP(O)Et₂Me Cl SMe NP(O)Me(OMe) ¨Me Cl SMe NP(O)(OPr)₂ ¨Me Cl SMe NC(O)C(O)H ¨Me Cl SMe NC(O)C(O)MeMe Cl SMe NC(O)C(O)OMe ¨Me Cl SMe NC(O)C(O)OEt ¨Me Cl SMe NC(O)C(O)NH₂ ¨Me Cl SMe NC(O)C(O)OH ¨Me Cl SMe NC(NH)NH₂Me Cl SMe NC(NOH)NH₂ ¨Me Cl SMe NC(NH)NHMeMe Cl SMe NC(NH)NMe₂ ¨Me Cl SMe NC(NH)OMe ¨Me Cl SMe NC(NH)OEt ¨Me H Me NCOMe ¨Me H Me NCOEt ¨Me H Me NCOPr ¨Me H Me NCHO ¨Me H Me NCOiPr ¨Me H Me NCOtBu ¨Me H Me NCOPh ¨Me H Me NSO₂MeMe H Me NSO₂Et ¨Me H Me NSO₂PrMe H Me NSO₂PhMe H Me NSO₂iPrMe H Me NNO₂Me H Me NCOOMeMe H Me NCOOEtMe H Me NCOOPrMe H Me NCOOiPr ¨Me H Me NCONHEt ¨Me H Me NCONHPrMe H Me NCONH₂Me H Me NCONHMeMe H Me NCNMe H Me NCOSMeMe H Me NCOSEtMe H Me NCSOMeMe H Me NCSOEt ¨Me H Me NCSOPr ¨Me H Me NSO₂NH₂ ¨Me H Me NSO₂NHMe ¨Me H Me NSO₂NMe₂ ¨Me H Me NP(O)(OMe)₂ ¨Me H Me NP(O)(OEt)₂ ¨Me H Me NP(O)Me₂ ¨Me H Me NP(O)Et₂ ¨Me H Me NP(O)Me(OMe)Me H Me NP(O)(OPr)₂Me H Me NC(O)C(O)HMe H Me NC(O)C(O)MeMe H Me NC(O)C(O)OMeMe H Me NC(O)C(O)OEtMe H Me NC(O)C(O)NH₂Me H Me NC(O)C(O)OHMe H Me NC(NH)NH₂Me H Me NC(NOH)NH₂Me H Me NC(NH)NHMeMe H Me NC(NH)NMe₂Me H Me NC(NH)OMeMe H Me NC(NH)OEtMe H SMe NCOMeMe H SMe NCOEtMe H SMe NCOPrMe H SMe NCHOMe H SMe NCOiPrMe H SMe NCOtBu ¨Me H SMe NCOPh ¨Me H SMe NSO₂Me ¨Me H SMe NSO₂Et ¨Me H SMe NSO₂Pr ¨Me H SMe NSO₂Ph ¨Me H SMe NSO₂iPr ¨Me H SMe NNO₂ ¨Me H SMe NCOOMe ¨Me H SMe NCOOEt ¨Me H SMe NCOOPr ¨Me H SMe NCOOiPrMe H SMe NCONHEt ¨Me H SMe NCONHPr ¨Me H SMe NCONH₂Me H SMe NCONHMeMe H SMe NCNMe H SMe NCOSMe ¨Me H SMe NCOSEtMe H SMe NCSOMe ¨Me H SMe NCSOEt ¨Me H SMe NCSOPr ¨Me H SMe NSO₂NH₂ ¨Me H SMe NSO₂NHMe ¨Me H SMe NSO₂NMe₂ ¨Me H SMe NP(O)(OMe)₂Me H SMe NP(O)(OEt)₂ ¨Me H SMe NP(O)Me₂Me H SMe NP(O)Et₂ ¨Me H SMe NP(O)Me(OMe) ¨Me H SMe NP(O)(OPr)₂ ¨Me H SMe NC(O)C(O)H ¨Me H SMe NC(O)C(O)Me ¨Me H SMe NC(O)C(O)OMe ¨Me H SMe NC(O)C(O)OEt ¨Me H SMe NC(O)C(O)NH₂ ¨Me H SMe NC(O)C(O)OH ¨Me H SMe NC(NH)NH₂ ¨Me H SMe NC(NOH)NH₂Me H SMe NC(NH)NHMeMe H SMe NC(NH)NMe₂Me H SMe NC(NH)OMeMe H SMe NC(NH)OEtMe Me H NCOMeMe Me H NCOEtMe Me H NCOPrMe Me H NCHOMe Me H NCOiPrMe Me H NCOtBuMe Me H NCOPh ¨Me Me H NSO₂MeMe Me H NSO₂EtMe Me H NSO₂PrMe Me H NSO₂PhMe Me H NSO₂iPrMe Me H NNO₂Me Me H NCOOMeMe Me H NCOOEt ¨Me Me H NCOOPr ¨Me Me H NCOOiPr ¨Me Me H NCONHEt ¨Me Me H NCONHPr ¨Me Me H NCONH₂ ¨Me Me H NCONHMe ¨Me Me H NCN ¨Me Me H NCOSMeMe Me H NCOSEtMe Me H NCSOMeMe Me H NCSOEtMe Me H NCSOPrMe Me H NSO₂NH₂Me Me H NSO₂NHMeMe Me H NSO₂NMe₂Me Me H NP(O)(OMe)₂Me Me H NP(O)(OEt)₂Me Me H NP(O)Me₂Me Me H NP(O)Et₂Me Me H NP(O)Me(OMe)Me Me H NP(O)(OPr)₂Me Me H NC(O)C(O)HMe Me H NC(O)C(O)MeMe Me H NC(O)C(O)OMeMe Me H NC(O)C(O)OEtMe Me H NC(O)C(O)NH₂Me Me H NC(O)C(O)OH ¨Me Me H NC(NH)NH₂ ¨Me Me H NC(NOH)NH₂ ¨Me Me H NC(NH)NHMe ¨Me Me H NC(NH)NMe₂ ¨Me Me H NC(NH)OMe ¨Me Me H NC(NH)OEt ¨Me Me Me NCOMe ¨Me Me Me NCOEt ¨Me Me Me NCOPr ¨Me Me Me NCHOMe Me Me NCOiPrMe Me Me NCOtBuMe Me Me NCOPhMe Me Me NSO₂MeMe Me Me NSO₂EtMe Me Me NSO₂PrMe Me Me NSO₂PhMe Me Me NSO₂iPrMe Me Me NNO₂ ¨Me Me Me NCOOMe ¨Me Me Me NCOOEt ¨Me Me Me NCOOPrMe Me Me NCOOiPr ¨Me Me Me NCONHEt ¨Me Me Me NCONHPr ¨Me Me Me NCONH₂Me Me Me NCONHMeMe Me Me NCNMe Me Me NCOSMeMe Me Me NCOSEtMe Me Me NCSOMeMe Me Me NCSOEtMe Me Me NCSOPrMe Me Me NSO₂NH₂Me Me Me NSO₂NHMeMe Me Me NSO₂NMe₂Me Me Me NP(O)(OMe)₂Me Me Me NP(O)(OEt)₂Me Me Me NP(O)Me₂Me Me Me NP(O)Et₂Me Me Me NP(O)Me(OMe)Me Me Me NP(O)(OPr)₂Me Me Me NC(O)C(O)HMe Me Me NC(O)C(O)MeMe Me Me NC(O)C(O)OMeMe Me Me NC(O)C(O)OEtMe Me Me NC(O)C(O)NH₂Me Me Me NC(O)C(O)OHMe Me Me NC(NH)NH₂Me Me Me NC(NOH)NH₂Me Me Me NC(NH)NHMeMe Me Me NC(NH)NMe₂Me Me Me NC(NH)OMeMe Me Me NC(NH)OEt

表5R¹ R¹² R¹³ NR² XCF₃ Cl Me NCOMeCF₃ Cl Me NCOEtCF₃ Cl Me NCOPrCF₃ Cl Me NCHOCF₃ Cl Me NCOiPrCF₃ Cl Me NCOtBuCF₃ Cl Me NCOPhCF₃ Cl Me NSO₂MeCF₃ Cl Me NSO₂EtCF₃ Cl Me NSO₂PrCF₃ Cl Me NSO₂PhCF₃ Cl Me NSO₂iPrCF₃ Cl Me NNO₂CF₃ Cl Me NCOOMe ¨CF₃ Cl Me NCOOEt ¨CF₃ Cl Me NCOOPr ¨CF₃ Cl Me NCOOiPr ¨

表5(续)R¹ R¹² R¹³ NR² XCF₃ Cl Me NCONHEt ¨CF₃ Cl Me NCONHPr ¨CF₃ Cl Me NCONH₂ ¨CF₃ Cl Me NCONHMe ¨CF₃ Cl Me NCN ¨CF₃ Cl Me NCOSMe ¨CF₃ Cl Me NCOSEt ¨CF₃ Cl Me NCSOMeCF₃ Cl Me NCSOEtCF₃ Cl Me NCSOPrCF₃ Cl Me NSO₂NH₂CF₃ Cl Me NSO₂NHMeCF₃ Cl Me NSO₂NMe₂ ¨CF₃ Cl Me NP(O)(OMe)₂CF₃ Cl Me NP(O)(OEt)₂CF₃ Cl Me NP(O)Me₂CF₃ Cl Me NP(O)Et₂ ¨CF₃ Ci Me NP(O)Me(OMe) ¨CF₃ Cl Me NP(O)(OPr)₂ ¨CF₃ Cl Me NC(O)C(O)H ¨CF₃ Cl Me NC(O)C(O)Me ¨CF₃ Cl Me NC(O)C(O)OMe ¨CF₃ Cl Me NC(O)C(O)OEt ¨CF₃ Cl Me NC(O)C(O)NH₂CF₃ Cl Me NC(O)C(O)OH ¨CF₃ Cl Me NC(NH)NH₂ ¨CF₃ Cl Me NC(NOH)NH₂ ¨CF₃ Cl Me NC(NH)NHMe ¨CF₃ Cl Me NC(NH)NMe₂ ¨CF₃ Cl Me NC(NH)OMe ¨CF₃ Cl Me NC(NH)OEt ¨CF₃ Cl Me NCOMe OCF₃ Cl Me NCOEt OCF₃ Cl Me NCOPr OCF₃ Cl Me NCHO OCF₃ Cl Me NCOiPr OCF₃ Cl Me NCOtBu OCF₃ Cl Me NCOPh OCF₃ Cl Me NSO₂Me OCF₃ Cl Me NSO₂Et OCF₃ Cl Me NSO₂Pr OCF₃ Cl Me NSO₂Ph OCF₃ Cl Me NSO₂iPr OCF₃ Cl Me NNO₂ OCF₃ Cl Me NCOOMe OCF₃ Cl Me NCOOEt OCF₃ Cl Me NCOOPr OCF₃ Cl Me NCOOiPr OCF₃ Cl Me NCONHEt OCF₃ Cl Me NCONHPr OCF₃ Cl Me NCONH₂ OCF₃ Cl Me NCONHMe OCF₃ Cl Me NCN OCF₃ Cl Me NCOSMe OCF₃ Cl Me NCOSEt OCF₃ Cl Me NCSOMe OCF₃ Cl Me NCSOEt OCF₃ Cl Me NCSOPr OCF₃ Cl Me NSO₂NH₂ OCF₃ Cl Me NSO₂NHMe OCF₃ Cl Me NSO₂NMe₂ OCF₃ Cl Me NP(O)(OMe)₂ OCF₃ Cl Me NP(O)(OEt)₂ OCF₃ Cl Me NP(O)Me₂ OCF₃ Cl Me NP(O)Et₂ OCF₃ Cl Me NP(O)Me(OMe) OCF₃ Cl Me NP(O)(OPr)₂ OCF₃ Cl Me NC(O)C(O)H OCF₃ Cl Me NC(O)C(O)Me OCF₃ Cl Me NC(O)C(O)OMe OCF₃ Cl Me NC(O)C(O)OEt OCF₃ Cl Me NC(O)C(O)NH₂ OCF₃ Cl Me NC(O)C(O)OH OCF₃ Cl Me NC(NH)NH₂ OCF₃ Cl Me NC(NOH)NH₂ OCF₃ Cl Me NC(NH)NHMe OCF₃ Cl Me NC(NH)NMe₂ OCF₃ Cl Me NC(NH)OMe OCF₃ Cl Me NC(NH)OEt OCF₃ H Me NCOMe ¨CF₃ H Me NCOEt ¨CF₃ H Me NCOPr ¨CF₃ H Me NCHO ¨CF₃ H Me NCOiPr ¨CF₃ H Me NCOtBu ¨CF₃ H Me NCOPh ¨CF₃ H Me NSO₂Me ¨CF₃ H Me NSO₂Et ¨CF₃ H Me NSO₂Pr ¨CF₃ H Me NSO₂Ph ¨CF₃ H Me NSO₂iPr ¨CF₃ H Me NNO₂CF₃ H Me NCOOMeCF₃ H Me NCOOEtCF₃ H Me NCOOPr ¨CF₃ H Me NCOOiPrCF₃ H Me NCONHEtCF₃ H Me NCONHPrCF₃ H Me NCONH₂ ¨CF₃ H Me NCONHMe ¨CF₃ H Me NCN ¨CF₃ H Me NCOSMe ¨CF₃ H Me NCOSEt ¨CF₃ H Me NCSOMe ¨CF₃ H Me NCSOEt ¨CF₃ H Me NCSOPr ¨CF₃ H Me NSO₂NH₂ ¨CF₃ H Me NSO₂NHMeCF₃ H Me NSO₂NMe₂CF₃ H Me NP(O)(OMe)₂ ¨CF₃ H Me NP(O)(OEt)₂ ¨CF₃ H Me NP(O)Me₂ ¨CF₃ H Me NP(O)Et₂ ¨CF₃ H Me NP(O)Me(OMe) ¨CF₃ H Me NP(O)(OPr)₂ ¨CF₃ H Me NC(O)C(O)H ¨CF₃ H Me NC(O)C(O)Me ¨CF₃ H Me NC(O)C(O)OMe ¨CF₃ H Me NC(O)C(O)OEt ¨CF₃ H Me NC(O)C(O)NH₂CF₃ H Me NC(O)C(O)OHCF₃ H Me NC(NH)NH₂ ¨CF₃ H Me NC(NOH)NH₂CF₃ H Me NC(NH)NHMeCF₃ H Me NC(NH)NMe₂CF₃ H Me NC(NH)OMeCF₃ H Me NC(NH)OEtCF₃ H Me NCOMe OCF₃ H Me NCOEt OCF₃ H Me NCOPr OCF₃ H Me NCHO OCF₃ H Me NCOiPr OCF₃ H Me NCOtBu OCF₃ H Me NCOPh OCF₃ H Me NSO₂Me OCF₃ H Me NSO₂Et OCF₃ H Me NSO₂Pr OCF₃ H Me NSO₂Ph OCF₃ H Me NSO₂iPr OCF₃ H Me NNO₂ OCF₃ H Me NCOOMe OCF₃ H Me NCOOEt OCF₃ H Me NCOOPr OCF₃ H Me NCOOiPr OCF₃ H Me NCONHEt OCF₃ H Me NCONHPr OCF₃ H Me NCONH₂ OCF₃ H Me NCONHMe OCF₃ H Me NCN OCF₃ H Me NCOSMe OCF₃ H Me NCOSEt OCF₃ H Me NCSOMe OCF₃ H Me NCSOEt OCF₃ H Me NCSOPr OCF₃ H Me NSO₂NH₂ OCF₃ H Me NSO₂NHMe OCF₃ H Me NSO₂NMe₂ OCF₃ H Me NP(O)(OMe)₂ OCF₃ H Me NP(O)(OEt)₂ OCF₃ H Me NP(O)Me₂ OCF₃ H Me NP(O)Et₂ OCF₃ H Me NP(O)Me(OMe) OCF₃ H Me NP(O)(OPr)₂ OCF₃ H Me NC(O)C(O)H OCF₃ H Me NC(O)C(O)Me OCF₃ H Me NC(O)C(O)OMe OCF₃ H Me NC(O)C(O)OEt OCF₃ H Me NC(O)C(O)NH₂ OCF₃ H Me NC(O)C(O)OH OCF₃ H Me NC(NH)NH₂ OCF₃ H Me NC(NOH)NH₂ OCF₃ H Me NC(NH)NHMe OCF₃ H Me NC(NH)NMe₂ OCF₃ H Me NC(NH)OMe OCF₃ H Me NC(NH)OEt OCF₃ Me Me NCOMe ¨CF₃ Me Me NCOEtCF₃ Me Me NCOPrCF₃ Me Me NCHOCF₃ Me Me NCOiPrCF₃ Me Me NCOtBuCF₃ Me Me NCOPhCF₃ Me Me NSO₂MeCF₃ Me Me NSO₂Et ¨CF₃ Me Me NSO₂Pr ¨CF₃ Me Me NSO₂Ph ¨CF₃ Me Me NSO₂iPr ¨CF₃ Me Me NNO₂CF₃ Me Me NCOOMeCF₃ Me Me NCOOEt ¨CF₃ Me Me NCOOPr ¨CF₃ Me Me NCOOiPrCF₃ Me Me NCONHEtCF₃ Me Me NCONHPrCF₃ Me Me NCONH₂ ¨CF₃ Me Me NCONHMe ¨CF₃ Me Me NCN ¨CF₃ Me Me NCOSMe ¨CF₃ Me Me NCOSEt ¨CF₃ Me Me NCSOMe ¨CF₃ Me Me NCSOEt ¨CF₃ Me Me NCSOPr ¨CF₃ Me Me NSO₂NH₂ ¨CF₃ Me Me NSO₂NHMeCF₃ Me Me NSO₂NMe₂CF₃ Me Me NP(O)(OMe)₂CF₃ Me Me NP(O)(OEt)₂CF₃ Me Me NP(O)Me₂CF₃ Me Me NP(O)Et₂CF₃ Me Me NP(O)Me(OMe)CF₃ Me Me NP(O)(OPr)₂CF₃ Me Me NC(O)C(O)HCF₃ Me Me NC(O)C(O)Me ¨CF₃ Me Me NC(O)C(O)OMe ¨CF₃ Me Me NC(O)C(O)OEt ¨CF₃ Me Me NC(O)C(O)NH₂CF₃ Me Me NC(O)C(O)OHCF₃ Me Me NC(NH)NH₂CF₃ Me Me NC(NOH)NH₂CF₃ Me Me NC(NH)NHMeCF₃ Me Me NC(NH)NMe₂CF₃ Me Me NC(NH)OMeCF₃ Me Me NC(NH)OEt ¨CF₃ Me Me NCOMe OCF₃ Me Me NCOEt OCF₃ Me Me NCOPr OCF₃ Me Me NCHO OCF₃ Me Me NCOiPr OCF₃ Me Me NCOtBu OCF₃ Me Me NCOPh OCF₃ Me Me NSO₂Me OCF₃ Me Me NSO₂Et OCF₃ Me Me NSO₂Pr OCF₃ Me Me NSO₂Ph OCF₃ Me Me NSO₂iPr OCF₃ Me Me NNO₂ OCF₃ Me Me NCOOMe OCF₃ Me Me NCOOEt OCF₃ Me Me NCOOPr OCF₃ Me Me NCOOiPr OCF₃ Me Me NCONHEt OCF₃ Me Me NCONHPr OCF₃ Me Me NCONH₂ OCF₃ Me Me NCONHMe OCF₃ Me Me NCN OCF₃ Me Me NCOSMe OCF₃ Me Me NCOSEt OCF₃ Me Me NCSOMe OCF₃ Me Me NCSOEt OCF₃ Me Me NCSOPr OCF₃ Me Me NSO₂NH₂ OCF₃ Me Me NSONHMe OCF₃ Me Me NSO₂NMe₂ OCF₃ Me Me NP(O)(OMe)₂ OCF₃ Me Me NP(O)(OEt)₂ OCF₃ Me Me NP(O)Me₂ OCF₃ Me Me NP(O)Et₂ OCF₃ Me Me NP(O)Me(OMe) OCF₃ Me Me NP(O)(OPr)₂ OCF₃ Me Me NC(O)C(O)H OCF₃ Me Me NC(O)C(O)Me OCF₃ Me Me NC(O)C(O)OMe OCF₃ Me Me NC(O)C(O)OEt OCF₃ Me Me NC(O)C(O)NH₂ OCF₃ Me Me NC(O)C(O)OH OCF₃ Me Me NC(NH)NH₂ OCF₃ Me Me NC(NOH)NH₂ OCF₃ Me Me NC(NH)NHMe OCF₃ Me Me NC(NH)NMe₂ OCF₃ Me Me NC(NH)OMe OCF₃ Me Me NC(NH)OEt OCF₃ Cl Cl NCOMeCF₃ Cl Cl NCOEt ¨CF₃ Cl Cl NCOPr ¨CF₃ Cl Cl NCHO ¨CF₃ Cl Cl NCOiPrCF₃ Cl Cl NCOtBuCF₃ Cl Cl NCOPh ¨CF₃ Cl Cl NSO₂Me ¨CF₃ Cl Cl NSO₂Et ¨CF₃ Cl Cl NSO₂Pr ¨CF₃ Cl Cl NSO₂Ph ¨CF₃ Cl Cl NSO₂iPr ¨CF₃ Cl Cl NNO₂ ¨CF₃ Cl Cl NCOOMe ¨CF₃ Cl Cl NCOOEt ¨CF₃ Cl Cl NCOOPr ¨CF₃ Cl Cl NCOOiPrCF₃ Cl Cl NCONHEt ¨CF₃ Cl Cl NCONHPr ¨CF₃ Cl Cl NCONH₂ ¨CF₃ Cl Cl NCONHMe ¨CF₃ Cl Cl NCN ¨CF₃ Cl Cl NCOSMeCF₃ Cl Cl NCOSEt ¨CF₃ Cl Cl NCSOMe ¨CF₃ Cl Cl NCSOEt ¨CF₃ Cl Cl NCSOPr ¨CF₃ Cl Cl NSO₂NH₂ ¨CF₃ Cl Cl NSO₂NHMe ¨CF₃ Cl Cl NSO₂NMe₂ ¨CF₃ Cl Cl NP(O)(OMe)₂ ¨CF₃ Cl Cl NP(O)(OEt)₂CF₃ Cl Cl NP(O)Me₂ ¨CF₃ Cl Cl NP(O)Et₂CF₃ Cl Cl NP(O)Me(OMe) ¨CF₃ Cl Cl NP(O)(OPr)₂ ¨CF₃ Cl Cl NC(O)C(O)H ¨CF₃ Cl Cl NC(O)C(O)Me ¨CF₃ Cl Cl NC(O)C(O)OMe ¨CF₃ Cl Cl NC(O)C(O)OEt ¨CF₃ Cl Cl NC(O)C(O)NH₂ ¨CF₃ Cl Cl NC(O)C(O)OH ¨CF₃ Cl Cl NC(NH)NH₂ ¨CF₃ Cl Cl NC(NOH)NH₂CF₃ Cl Cl NC(NH)NHMeCF₃ Cl Cl NC(NH)NMe₂CF₃ Cl Cl NC(NH)OMe ¨CF₃ Cl Cl NC(NH)OEtCF₃ Cl Cl NCOMe OCF₃ Cl Cl NCOEt OCF₃ Cl Cl NCOPr OCF₃ Cl Cl NCHO OCF₃ Cl Cl NCOiPr OCF₃ Cl Cl NCOtBu OCF₃ Cl Cl NCOPh OCF₃ Cl Cl NSO₂Me OCF₃ Cl Cl NSO₂Et OCF₃ Cl Cl NSO₂Pr OCF₃ Cl Cl NSO₂Ph OCF₃ Cl Cl NSO₂iPr OCF₃ Cl Cl NNO₂ OCF₃ Cl Cl NCOOMe OCF₃ Cl Cl NCOOEt OCF₃ Cl Cl NCOOPr OCF₃ Cl Cl NCOOiPr OCF₃ Cl Cl NCONHEt OCF₃ Cl Cl NCONHPr OCF₃ Cl Cl NCONH₂ OCF₃ Cl Cl NCONHMe OCF₃ Cl Cl NCN OCF₃ Cl Cl NCOSMe OCF₃ Cl Cl NCOSEt OCF₃ Cl Cl NCSOMe OCF₃ Cl Cl NCSOEt OCF₃ Cl Cl NCSOPr OCF₃ Cl Cl NSO₂NH₂ OCF₃ Cl Cl NSO₂NHMe OCF₃ Cl Cl NSO₂NMe₂ OCF₃ Cl Cl NP(O)(OMe)₂ OCF₃ Cl Cl NP(O)(OEt)₂ OCF₃ Cl Cl NP(O)Me₂ OCF₃ Cl Cl NP(O)Et₂ OCF₃ Cl Cl NP(O)Me(OMe) OCF₃ Cl Cl NP(O)(OPr)₂ OCF₃ Cl Cl NC(O)C(O)H OCF₃ Cl Cl NC(O)C(O)Me OCF₃ Cl Cl NC(O)C(O)OMe OCF₃ Cl Cl NC(O)C(O)OEt OCF₃ Cl Cl NC(O)C(O)NH₂ OCF₃ Cl Cl NC(O)C(O)OH OCF₃ Cl Cl NC(NH)NH₂ OCF₃ Cl Cl NC(NOH)NH₂ OCF₃ Cl Cl NC(NH)NHMe OCF₃ Cl Cl NC(NH)NMe₂ OCF₃ Cl Cl NC(NH)OMe OCF₃ Cl Cl NC(NH)OEt OCF₃ Cl H NCOMe ¨CF₃ Cl H NCOEt ¨CF₃ Cl H NCOPr ¨CF₃ Cl H NCHOCF₃ Cl H NCOiPr ¨CF₃ Cl H NCOrBuCF₃ Cl H NCOPh ¨CF₃ Cl H NSO₂Me ¨CF₃ Cl H NSO₂Et ¨CF₃ Cl H NSO₂PrCF₃ Cl H NSO₂Ph ¨CF₃ Cl H NSO₂iPr ¨CF₃ Cl H NNO₂ ¨CF₃ Cl H NCOOMe ¨CF₃ Cl H NCOOEt ¨CF₃ Cl H NCOOPr ¨CF₃ Cl H NCOOiPr ¨CF₃ Cl H NCONHEt ¨CF₃ Cl H NCONHPr ¨CF₃ Cl H NCONH₂CF₃ Cl H NCONHMe ¨CF₃ Cl H NCNCF₃ Cl H NCOSMeCF₃ Cl H NCOSEt ¨CF₃ Cl H NCSOMe ¨CF₃ Cl H NCSOEt ¨CF₃ Cl H NCSOPr ¨CF₃ Cl H NSO₂NH₂ ¨CF₃ Cl H NSO₂NHMe ¨CF₃ Cl H NSO₂NMe₂ ¨CF₃ Cl H NP(O)(OMe)₂CF₃ Cl H NP(O)(OEt)₂ ¨CF₃ Cl H NP(O)Me₂CF₃ Cl H NP(O)Et₂CF₃ Cl H NP(O)Me(OMe)CF₃ Cl H NP(O)(OPr)₂CF₃ Cl H NC(O)C(O)HCF₃ Cl H NC(O)C(O)MeCF₃ Cl H NC(O)C(O)OMeCF₃ Cl H NC(O)C(O)OEt ¨CF₃ Cl H NC(O)C(O)NH₂CF₃ Cl H NC(O)C(O)OHCF₃ Cl H NC(NH)NH₂CF₃ Cl H NC(NOH)NH₂CF₃ Cl H NC(NH)NHMeCF₃ Cl H NC(NH)NMe₂CF₃ Cl H NC(NH)OMe ¨CF₃ Cl H NC(NH)OEtCF₃ Cl H NCOMe OCF₃ Cl H NCOEt OCF₃ Cl H NCOPr OCF₃ Cl H NCHO OCF₃ Cl H NCOiPr OCF₃ Cl H NCOtBu OCF₃ Cl H NCOPh OCF₃ Cl H NSO₂Me OCF₃ Cl H NSO₂Et OCF₃ Cl H NSO₂Pr OCF₃ Cl H NSO₂Ph OCF₃ Cl H NSO₂iPr OCF₃ Cl H NNO₂ OCF₃ Cl H NCOOMe OCF₃ Cl H NCOOEt OCF₃ Cl H NCOOPr OCF₃ Cl H NCOOiPr OCF₃ Cl H NCONHEt OCF₃ Cl H NCONHPr OCF₃ Cl H NCONH₂ OCF₃ Cl H NCONHMe OCF₃ Cl H NCN OCF₃ Cl H NCOSMe OCF₃ Cl H NCOSEt OCF₃ Cl H NCSOMe OCF₃ Cl H NCSOEt OCF₃ Cl H NCSOPr OCF₃ Cl H NSO₂NH₂ OCF₃ Cl H NSO₂NHMe OCF₃ Cl H NSO₂NMe₂ OCF₃ Cl H NP(O)(OMe)₂ OCF₃ Cl H NP(O)(OEt)₂ OCF₃ Cl H NP(O)Me₂ OCF₃ Cl H NP(O)Et₂ OCF₃ Cl H NP(O)Me(OMe) OCF₃ Cl H NP(O)(OPr)₂ OCF₃ Cl H NC(O)C(O)H OCF₃ Cl H NC(O)C(O)Me OCF₃ Cl H NC(O)C(O)OMe OCF₃ Cl H NC(O)C(O)OEt OCF₃ Cl H NC(O)C(O)NH₂ OCF₃ Cl H NC(O)C(O)OH OCF₃ Cl H NC(NH)NH₂ OCF₃ Cl H NC(NOH)NH₂ OCF₃ Cl H NC(NH)NHMe OCF₃ Cl H NC(NH)NMe₂ OCF₃ Cl H NC(NH)OMe OCF₃ Cl H NC(NH)OEt O表注： Et：乙基

Me：甲基

Pr：丙基

Ph：苯基

Bu：丁基

CN：氰基

组合物及应用方法

本发明提供杀虫组合物和使用在上面的本发明概述中给出的式(I)和式(II)化合物防治节肢动物、线虫、蠕虫和原虫害虫的方法。在优选的方面，本发明提供在一地点防治节肢动物或线虫的方法，所述的方法包含，将杀节肢动物或杀线虫有效量的式(I)或式(II)化合物或包含所述化合物和农业上可接受的载体的组合物，施用于所述的地点。在更优选的实施方案中，希望防治的节肢动物是昆虫，且在这一方面，本发明提供在一地点防治昆虫的方法，所述的方法包含，向所述的地点施用杀虫有效量的式(I)或式(II)化合物，或施用杀虫有效量的包含式(I)或式(II)化合物及其农业上可接受的载体的杀虫组合物。在另一优选的实施方案中，希望防治的节肢动物是线虫，且在这一方面，本发明提供在一地点防治线虫的方法，所述的方法包含，向所述的地点施用杀线虫有效量的式(I)或式(II)化合物，或施用杀线虫有效量的包含式(I)或(II)化合物及其农业上可接受的载体的杀线虫组合物。优选的是，施用杀节肢动物(特别是杀昆虫)或杀线虫有效量施用的地点是作物栽培区，即，作物生长或作物已经栽种的区域，或是作物将要种植/生长的区域。

本发明可用于杀虫，特别是杀节肢动物(特别是杀昆虫)或杀线虫、本发明处理的组合物，可以包含约0.001至约95％的式(I)或(II)活性成分。用于本文的“式(I)或(II)活性成分”或“活性成分”一词是指式(I)或(II)化合物或其盐。“式(I)或(II)化合物”的表达也在本文中使用，意指化合物或其盐。

施用于意欲处理的地点或作物的稀释液体制剂通常包含约0.001至约3％、优选约0.1至约0.5％的式(I)或(II)活性成分。

施用于所述地点或作物的固体制剂通常包含约？至约8％，优选约0.5至约5％的式(I)或式(II)活性成分。

浓缩的组合物是商业化的或运输或贮存的组合物。施用于植物时，它们通常用水稀释，且以这种稀释形式使用。稀释形式以及浓缩形式均是本发明的一部分。

浓缩的制剂通常包含约5至约95％，优选约10至约50％的式(I)或(II)活性成分。

本发明的杀虫组合物可以在整个昆虫生长季节一次或多次施用。本发明的杀虫组合物通常以约0.04至约2千克/公顷，优选约0.1至约1千克/公顷的活性成分的用量，施用于意欲处理的地点或作物区域。

本发明的浓缩杀虫组合物可以是固体(例如粉剂或颗粒剂或可湿性粉剂)的形式，或优选以液体(如乳油或真溶液)的形式。

本发明的组合物通常包含约0.5至约95％的活性成分。组合物的余量补齐至100％，包含载体以及如下文中提到的各种添加剂。

“载体”在本文中指的是有机或无机材料。所述的有机或无机材料可是天然或合成的，且可与活性成分一起且有利于活性成分施用于意欲处理的地点或作物。因此，此载体通常是惰性的且应当是农业上，特别是打算或处理的地点或作物可以接受的。载体可以是固体(陶土、硅酸盐、二氧化硅、树脂、蜡、肥料等)或液体(水、醇类、酮类、油溶剂、饱和或不饱和烃、氯代烃、液化石油气等)。

在众多的添加剂中，本发明的组合物可以包含表面活性剂以及其它成分如分散剂、粘着剂、消泡剂、抗冻剂、染料、增稠剂、粘合剂、保护性胶体、渗透剂、稳定剂、螯合剂、防絮凝剂、腐蚀抑制剂、颜料和聚合物。

更通常的是，本发明组合物可以包含所有各种固体或液体添加剂，它们是杀虫剂或杀虫处理领域已知的。

表面活性剂可以是乳化成润湿类型的离子或非离子表面活性剂。可能的表面活性剂是聚丙烯酸或木素磺酸的盐；苯酚磺酸或萘磺酸的盐；环氧乙烷与脂肪醇或脂肪酸或脂肪胺或取代的苯酚(特别是烷基苯酚或芳基苯酚)的缩聚物；磺基琥珀酸的酯盐；牛磺酸衍生物如烷基牛磺酸酯；磷酸酯；或醇或聚氧乙基化苯酚的酯。当喷雾载体是水时，通常需要使用至少一种表面活性剂，因为活性成分不是水溶性的。

本发明组合物的施用方法通常是将已经预先通过将更浓的本发明制剂制成的混合物稀释来喷雾。

固体组合物可以是用于撒粉或用于分散的粉剂(其中活性成分的含量可以多达100％)和颗粒剂，特别是挤出或压块型颗粒剂，或可以是已经通过掺合粉末制成的颗粒剂(在这种粉末中的活性成分的含量可以在约1至约80％之间)。

液体组合物或施用时须成为液体的组合物包括溶液、水溶性浓缩物、乳油、乳剂、可湿性粉剂或膏剂或可用水分散的颗粒剂。

乳油通常包含约10至约80％的活性成分；乳剂(当施用时)通常包含约0.01至约20％的活性成分。

例如，乳油可以包含溶剂和(至所需程度的)约2至约20％的适合的添加剂如稳定剂、表面活性剂、渗透剂、腐蚀抑制剂或其它已经提到的添加剂。

这些浓缩物通常于桶中水中稀释，以获得适合于喷雾的稀释液。

浓悬浮剂可以通过喷雾施用且须得是流动的，无任何固体分离和沉于底部。通常它们含有约1至约75％的活性成分(优选约2至约50％)，约0.5至约15％的表面活性剂、约0.1至约10％的增稠剂和0至约10％的其它已经提到的适合的添加剂，余下的为水或有机液体(当活性成分是不溶或具有低溶解性时)。

可湿性粉剂通常包含活性成分(约1至约95％，优选约2至约80％)、固体载体、润湿剂(0至约5％)、分散剂(约3至约10％)和(至所需程度的)0至约10％的其它添加剂如稳定剂及已经列出的其它添加剂。

为了获得这些可湿性粉剂或喷粉剂，适合的是，将活性成分与添加剂混合如通过于磨或相似的设备中研磨。

可分散颗粒剂通常是通过将粉末附聚，接着通过适合的造粒工艺而制成。

本文中描述的乳剂可以是水包油或油包水型。乳剂的流动性可以是低粘性至接近凝胶粘性的高粘性。

在此诸多的组合物或制剂中，根据处理问题的具体条件，本领域技术人员可以选择出最适合的。

本发明的化合物或组合物也可以与其它农药例如杀虫剂、杀螨剂或除草剂混合。

本发明进一步通过下列实施例来说明，这些实施例不应被认为是限制本发明，给出之是为更好地应用本发明。

生物效力

下列代表性方法用来施用本发明化合物，并观察由之获得的生物活性：土壤浸渍蚜虫侵害的植物；对蝇施诱饵。

使用的种类如下：

属、种俗名

Aphis gossypii 棉蚜

Schizaphis graminum 麦二叉蚜

Musca domestica 家蝇

土壤浸渍试验(内吸活性：蚜虫)

棉花和高粱植株长成于盆中。在处理前一天，各盆放上约25只混合虫口的蚜虫。以棉蚜侵染棉花而用麦二叉蚜侵染高梁。将选择的式(I)或(II)以稀释液施用于土壤表面，施用量相当于10.0ppm土壤浓度(按重量计)。蚜虫的计数在5DAT(即，处理后的天数)进行。将在处理植物上的蚜虫的数量与未处理对照植物上的蚜虫数比较。下列化合物显示出大于30％的棉蚜或是麦二叉蚜死亡率：1a、1b、3-29、30a、31-32。

家蝇诱饵/接触试验

将约25只四至六天大的家蝇成虫麻醉，并置于笼中，笼中放有含本发明化合物的糖水诱饵溶液。诱饵溶液中的本发明化合物浓度为100ppm。24小时后，刺激时，家蝇不动的被认为是死亡。下列化合物显示出大于30％的家蝇死亡率：1、1a、1b、2、3-10、12-14、16、18-20、22、25、26、28-30、30a、31、32。

虽然本发明已用各种优选的实施方案作为描述，但可以做出各种改进、替代、省略和改变而不偏离本发明的精神，这点对本发明技术人员而言是显而易见的。因此，本发明的范围旨在只受权利要求，包括其等同物范围的限制。

Claims

1.式(I)或式(II)化合物其中

R¹是C₁-C₆烷基、C₁-C₆环烷基或C₄-C₈(环烷基)烷基，它们各任选由一或多个卤素取代；

R²和R³相互独立地选自：H；C₁-C₆烷基；C₁-C₆卤代烷基；COR⁴；S(O)_pR⁴；CN；NO₂；COOR⁴；CONR⁴R⁵；C(O)SR⁴；C(S)OR⁴；SO₂NR⁴R⁵；P(O)_q(R⁴)(R⁵)；P(O)_q(OR⁴)(R⁵)；P(O)_q(OR⁴)(R⁵)；C＝(NR⁴)NR⁵R⁶；CH＝NR⁴；C＝(NR⁴)(OR⁵)；C(S)N(R⁴)(R⁵)；C(O)C(O)R⁴；C(O)C(O)OR⁴；C(O)C(O)NR⁴R⁵；和CONR⁴SO₂R⁵；

m是1或2；

p是0、1或2；

q是0或1；

R⁴、R⁵和R⁶相互独立地选自H；NO₂；CN；CHO；R¹⁴；苯基，它任选由一或多个下列基团取代：R¹⁴、卤素、CN、NO₂、OR¹⁴、SR¹⁴、COR¹⁴、COOR¹⁴或OR¹⁴；卤素；COR¹⁴；COOR¹⁴；CHO；和OH；

Q是如下所定义的Q-1、Q-2或Q-3：

R⁸是H、卤素、CN、S(O)_pR¹⁴、OR¹⁴、NR¹⁶R¹⁷、N(R¹⁶)CON(R¹⁷)(R¹⁸)、N₃或由一或多个下列基团取代的NH(C₁-C₅烷基)：OH、OR¹⁴、S(O)_pR¹⁴、CN、NO₂、COOR¹⁴或CON(R¹⁶)(R¹⁷)；

R⁹和R¹¹相互独立地选自：H、卤素、OR¹⁴、SR¹⁴和R¹⁴；

R¹⁰是CN；

R¹²是H、卤素、R¹⁴、OR¹⁴、S(O)_pR¹⁴或

R¹³是H、卤素或R¹⁴；

Ar是苯基、任选带有一或多个选自卤素、R¹⁵、OR¹⁵、SF₅和S(O)_pR¹⁵的取代基；或Ar是2-吡啶基，任选带有一或多个选自卤素、OR¹⁵、SF₅和S(O)_pR¹⁵的取代基；

R¹⁵是C₁-C₆烷基，任选由一或多个卤素取代；

R¹⁶、R¹⁷和R¹⁸相互独立地选自H、NO₂、CN、CHO、R¹⁹、COR¹⁹和COOR¹⁹；

R²⁰选自C₁-C₆烷基，任选由一或多个卤素取代；和

Z是阴离子抗衡离子，如Cl^-、Br^-、I^-、F^-、OSO₂R^4-、ClO₄ ^4-、OCOR^-、BF₄ ^-、SbF₆ ^-、SO₃ ^-或HSO₄ ^-，磷酸根阴离子或磷酸氢根阴离子或其它农业上可接受的阴离子。

2.根据权利要求1的化合物，其中R¹是任选卤代的C₁-C₆烷基。

3.根据权利要求2的化合物，其中R¹是甲基或乙基。

4.根据权利要求1的化合物，其中R²是H、COOR⁴、S(O)_pR⁴、CONR⁴R⁵、CN、COR⁴、P(O)_q(OR⁴)(OR⁵)、P(O)_q(R⁴)(R⁵)；或R²是S(O)_pR⁴(其中p是2且R⁴是C₁-C₆烷基或任选取代的苯基)；或R²是CONR⁴R⁵(其中R⁴是H或C₁-C₆烷基且R⁵是C₁-C₆烷基，或其中R⁴是H且R⁵是COR¹⁴且其中R¹⁴是任选卤代的C₁-C₆烷基)；或R²是COR⁴(其中R⁴是H或C₁-C₆烷基)；或R²是P(O)_q(OR⁴)(R⁵)或P(O)_q(OR⁴)(OR⁵)(其中q是1且R⁴和R⁵各是C₁-C₆烷基)。

5.根据权利要求4的化合物，其中R²是H或CN或COOR⁴(其中R⁴是C₁-C₆烷基)。

6.根据权利要求1的化合物，其中Q是Q-1。

7.根据权利要求6的化合物，其中所述Q-1中的R⁷是CN或H或C₁-C₄烷基和/或其中R⁸是N(R¹⁶)(R¹⁷)。

8.根据权利要求7的化合物，其中R⁸是NH₂。

9.根据权利要求1的化合物，其中Ar是苯基，该苯基在2位和6位由卤素取代和在4位上由卤代的C₁-C₆烷基或SF₅或OR¹⁵取代；或Ar是2-吡啶基，该吡啶基在3位上由卤素取代或在5位上由卤代C₁-C₆烷基或SF₅或OR¹⁵取代。

10. 根据权利要求9的化合物，其中Ar是2，6-二氯-4-三氟甲基苯基或3-氯-5-三氟甲基吡啶-2-基。

11.根据权利要求1的化合物，它是

2，4，6-三甲基苯磺酸，与S-4-[5-氨基-3-氰基-1-(2，6-二氯-4-三氟甲基)苯基]吡唑基-S-乙基硫亚胺的化合物；

2，4，6-三甲基苯磺酸，与S-4-[5-氨基-3-氰基-1-(2，6-二氯-4-三氟甲基)苯基]吡唑基-S-甲基硫亚胺的化合物；

2，4，6-三甲基苯磺酸，与S-4-[5-氨基-1-(2，6-二氯-4-三氟甲基)苯基]吡唑基-S-甲基硫亚胺的化合物；

S-{[5-氨基-3-氰基-1-(2，6-二氯-4-三氟甲基)苯基]-4-(1H-吡唑基)}-S-乙基-N-(叔丁氧基羰基)硫亚胺；

S-{[5-氨基-3-氰基-1-(2，6-二氯-4-三氟甲基)苯基]-4-(1H-吡唑基)}-S-乙基-N-乙酰基硫亚胺；

S-{[5-氨基-3-氰基-1-(2，6-二氯-4-三氟甲基)苯基]-4-(1H-吡唑基)}-S-乙基-N-(甲氧基羰基)硫亚胺；

S-{[5-氨基-3-氰基-1-(2，6-二氯-4-三氟甲基)苯基]-4-(1H-吡唑基)}-S-乙基-N-(甲基磺酰基)硫亚胺；

S-{[5-氨基-3-氰基-1-(2，6-二氯-4-三氟甲基)苯基]-4-(1H-吡唑基)}-S-乙基-N-(甲基氨基甲酰基)硫亚胺；

S-{[5-氨基-3-氰基-1-(2，6-二氯-4-三氟甲基)苯基]-4-(1H-吡唑基)}-S-乙基-N-(氰基)硫亚胺；

S-{[5-氨基-3-氰基-1-(2，6-二氯-4-三氟甲基)苯基]-4-(1H-吡唑基)}-S-乙基-N-(甲酰基)硫亚胺；

S-{[5-氨基-3-氰基-1-(2，6-二氯-4-三氟甲基)苯基]-4-(1H-吡唑基)}-S-甲基-N-乙酰基硫亚胺；

S-{[5-氨基-3-氰基-1-(2，6-二氯-4-三氟甲基)苯基]-4-(1H-吡唑基)}-S-乙基-N-(二乙基磷酰基)硫亚胺；

S-{[5-氨基-3-氰基-1-(2，6-二氯-4-三氟甲基)苯基]-4-(1H-吡唑基)}-S-乙基-N-(二甲基氨基甲酰基)硫亚胺；

S-{[5-氨基-3-氰基-1-(2，6-二氯-4-三氟甲基)苯基]-4-(1H-吡唑基)}-S-乙基-N-(二甲基氧膦基)硫亚胺；

S-{[5-氨基-3-氰基-1-(2，6-二氯-4-三氟甲基)苯基]-4-(1H-吡唑基)}-S-乙基-N-((三氯乙酰基氨基)羰基)硫亚胺；

S-{[5-氨基-3-氰基-1-(2，6-二氯-4-三氟甲基)苯基]-4-(1H-吡唑基)}-S-乙基-N-((氯乙酰基氨基)羰基)硫亚胺；

S-{[5-氨基-3-氰基-1-(2，6-二氯-4-三氟甲基)苯基]-4-(1H-吡唑基)}-S-乙基-N-((乙氧基羰基甲基)氨基羰基)硫亚胺；

S-{[5-氨基-3-氰基-1-(2，6-二氯-4-三氟甲基)苯基]-4-(1H-吡唑基)}-S-乙基-N-(乙氧基羰基氨基羰基)硫亚胺；

S-{[5-氨基-3-氰基-1-(2，6-二氯-4-三氟甲基)苯基]-4-(1H-吡唑基)}-S-甲基-N-(甲酰基)硫亚胺；

S-{[5-氨基-3-氰基-1-(2，6-二氯-4-三氟甲基)苯基]-4-(1H-吡唑基)}-S-甲基-N-(氰基)硫亚胺；

S-{[5-氨基-3-氰基-1-(2，6-二氯-4-三氟甲基)苯基]-4-(1H-吡唑基)}-S-甲基-N-(1，2-二氧代丙基)硫亚胺；

S-{[5-氨基-3-氰基-1-(2，6-二氯-4-三氟甲基)苯基]-4-(1H-吡唑基)}-S-甲基-N-(叔丁氧基羰基)硫亚胺；

S-{[5-氨基-1-(2，6-二氯-4-三氟甲基)苯基]-4-(1H-吡唑基)}-S-甲基-N-(甲酰基)硫亚胺；

S-{[5-氨基-1-(2，6-二氯-4-三氟甲基)苯基]-4-(1H-吡唑基)}-S-甲基-N-(乙酰基)硫亚胺；

S-{[5-氨基-1-(2，6-二氯-4-三氟甲基)苯基]-4-(1H-吡唑基)}-S-甲基-N-(氰基)硫亚胺；

S-{[5-氨基-1-(2，6-二氯-4-三氟甲基)苯基-3-甲基]-4-(1H-吡唑基)}-S-乙基-N-(甲酰基)硫亚胺；

S-{[5-氨基-1-(2，6-二氯-4-三氟甲基)苯基-3-甲基]-4-(1H-吡唑基)}-S-乙基-N-(氰基)硫亚胺；

S-{[5-氨基-1-(2，6-二氯-4-三氟甲基)苯基-3-乙基]-4-(1H-吡唑基)}-S-乙基-N-(甲酰基)硫亚胺；

S-{[5-氨基-1-(2，6-二氯-4-三氟甲基)苯基-3-乙基]-4-(1H-吡唑基)}-S-乙基-N-(氰基)硫亚胺；

N-(叔丁氧基羰基)-S-4-[5-氨基-3-氰基-1-(2，6-二氯-4-三氟甲基)苯基-吡唑基]-S-乙基氧代硫亚胺；

N-(乙酰基)-S-4-[5-氨基-3-氰基-1-(2，6-二氯-4-三氟甲基)苯基-吡唑基]-S-乙基氧代硫亚胺；

S-4-[5-氨基-3-氰基-1-(2，6-二氯-4-三氟甲基)苯基-吡唑基]-S-乙基氧代硫亚胺；

S-4-[5-氨基-3-氰基-1-(2，6-二氯-4-三氟甲基)苯基-4-(1H-吡唑基)]-S-甲基-N-[(4-甲基苯基)磺酰基]硫亚胺；

S-4-[5-氨基-3-氰基-1-(2-(3-氯-5-三氟甲基)吡啶基)吡唑基]-S-乙基氧代硫亚胺。

12.一种杀虫组合物，包含杀虫有效量的根据前述权利要求之任一项的化合物和农业上可接受的惰性载体。

13.一种在一地点防治节肢动物、线虫、蠕虫或原虫害虫的方法，所述的方法包括，向所述的地点施用杀虫有效量的根据前述权利要求之任一项的化合物或组合物。