CN109071549B - Pde1抑制剂 - Google Patents

Pde1抑制剂 Download PDF

Info

Publication number
CN109071549B
CN109071549B CN201780022870.0A CN201780022870A CN109071549B CN 109071549 B CN109071549 B CN 109071549B CN 201780022870 A CN201780022870 A CN 201780022870A CN 109071549 B CN109071549 B CN 109071549B
Authority
CN
China
Prior art keywords
methyl
pyrazolo
pyridin
compound
tetrahydropyran
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201780022870.0A
Other languages
English (en)
Chinese (zh)
Other versions
CN109071549A (zh
Inventor
K·朱尔
M·杰辛
M·朗格路
P·J·V·维塔尔
M·马里戈
J·凯勒
L·K·拉斯穆森
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
H Lundbeck AS
Original Assignee
H Lundbeck AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Lundbeck AS filed Critical H Lundbeck AS
Publication of CN109071549A publication Critical patent/CN109071549A/zh
Application granted granted Critical
Publication of CN109071549B publication Critical patent/CN109071549B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201780022870.0A 2016-04-12 2017-04-07 Pde1抑制剂 Active CN109071549B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA201600221 2016-04-12
DKPA201600221 2016-04-12
PCT/EP2017/058332 WO2017178350A1 (en) 2016-04-12 2017-04-07 1,5-dihydro-4h-pyrazolo[3,4-d]pyrimidin-4-ones and 1,5-dihydro-4h-pyrazolo[4,3-c]pyridin-4-ones as pde1 inhibitors

Publications (2)

Publication Number Publication Date
CN109071549A CN109071549A (zh) 2018-12-21
CN109071549B true CN109071549B (zh) 2021-11-30

Family

ID=58489694

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780022870.0A Active CN109071549B (zh) 2016-04-12 2017-04-07 Pde1抑制剂

Country Status (42)

Country Link
US (3) US20170291901A1 (ru)
EP (1) EP3442975B1 (ru)
JP (1) JP7093306B2 (ru)
KR (1) KR20180133413A (ru)
CN (1) CN109071549B (ru)
AR (1) AR108109A1 (ru)
AU (1) AU2017250431B2 (ru)
BR (1) BR112017026278A2 (ru)
CA (1) CA3020053A1 (ru)
CL (1) CL2018002881A1 (ru)
CO (1) CO2018010323A2 (ru)
CR (1) CR20180470A (ru)
CY (1) CY1123269T1 (ru)
DK (1) DK3442975T3 (ru)
DO (1) DOP2018000201A (ru)
EA (1) EA035197B1 (ru)
EC (1) ECSP18074641A (ru)
ES (1) ES2814289T3 (ru)
GE (1) GEP20207057B (ru)
HR (1) HRP20201331T1 (ru)
HU (1) HUE050320T2 (ru)
IL (1) IL262257B (ru)
LT (1) LT3442975T (ru)
MA (1) MA44656B1 (ru)
ME (1) ME03820B (ru)
MX (1) MX2018012496A (ru)
MY (1) MY194722A (ru)
NI (1) NI201800092A (ru)
PE (1) PE20181853A1 (ru)
PH (1) PH12018502168A1 (ru)
PL (1) PL3442975T3 (ru)
PT (1) PT3442975T (ru)
RS (1) RS60714B1 (ru)
RU (1) RU2018133391A (ru)
SG (1) SG11201808221QA (ru)
SI (1) SI3442975T1 (ru)
SV (1) SV2018005753A (ru)
TN (1) TN2018000321A1 (ru)
TW (1) TWI729109B (ru)
UA (1) UA121925C2 (ru)
WO (1) WO2017178350A1 (ru)
ZA (1) ZA201806407B (ru)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201629064A (zh) 2014-10-10 2016-08-16 Ｈ 朗德貝克公司 作爲ｐｄｅ１抑制劑之三唑並吡酮
JO3627B1 (ar) 2015-04-30 2020-08-27 H Lundbeck As إيميدازو بيرازينونات على هيئة مثبطات pde1
TWI729109B (zh) 2016-04-12 2021-06-01 丹麥商Ｈ 朗德貝克公司 作爲PDE1抑制劑的1,5-二氫-4H-吡唑并[3,4-d]嘧啶-4-酮和1,5-二氫-4H-吡唑并[4,3-c]吡啶-4-酮
WO2018073251A1 (en) 2016-10-18 2018-04-26 H. Lundbeck A/S Imidazopyrazinones, pyrazolopyrimidinones and pyrazolopyridinones as pde1 inhibitors
CN109803653A (zh) 2016-10-28 2019-05-24 H.隆德贝克有限公司 包括给予咪唑并吡嗪酮的组合治疗
MX2019004763A (es) 2016-10-28 2019-07-01 H Lundbeck As Tratamientos de combinacion que comprenden imidazopirazinonas para el tratamiento de trastornos psiquiatricos y/o cognitivos.
EP3562828A1 (en) 2016-12-28 2019-11-06 Dart NeuroScience LLC Substituted pyrazolopyrimidinone compounds as pde2 inhibitors
US11434247B1 (en) 2017-11-27 2022-09-06 Dart Neuroscience Llc Substituted furanopyrimidine compounds as PDE1 inhibitors
CN115304607B (zh) * 2022-07-06 2023-06-27 华南农业大学 吡唑并嘧啶衍生物的制备方法

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004018474A1 (de) * 2002-08-23 2004-03-04 Bayer Healthcare Ag Phenyl-substituierte pyrazolopyrimidine
WO2004026876A1 (de) * 2002-08-23 2004-04-01 Bayer Healthcare Ag Alkyl-substituierte pyrazolopyrimidine
EP2305262A1 (de) * 2002-08-23 2011-04-06 Boehringer Ingelheim International GmbH Selektive Phosphodiesterase 9A-Inhibitoren als Arzneimittel zur Verbesserung kognitiver Prozesse
EP1626971B1 (de) * 2003-05-09 2011-08-10 Boehringer Ingelheim International Gmbh 6-cyclylmethyl- und 6-alkylmethyl-substituierte pyrazolopyrimidine
WO2011153136A1 (en) * 2010-05-31 2011-12-08 Intra-Cellular Therapies, Inc. Organic compounds
CN101687876B (zh) * 2007-05-11 2012-12-12 辉瑞有限公司 氨基杂环化合物
WO2015091805A1 (en) * 2013-12-19 2015-06-25 H. Lundbeck A/S Quinazolin-thf-amines as pde1 inhibitors

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB973361A (en) * 1960-05-11 1964-10-28 Ciba Ltd Pyrazolo-pyrimidines and process for their manufacture
DE19709877A1 (de) 1997-03-11 1998-09-17 Bayer Ag 1,5-Dihydro-pyrazolo[3,4-d]-pyrimidinon-derivate
WO2006068978A2 (en) 2004-12-21 2006-06-29 Takeda Pharmaceutial Company Limited Dipeptidyl peptidase inhibitors
EP1919287A4 (en) 2005-08-23 2010-04-28 Intra Cellular Therapies Inc ORGANIC COMPOUNDS FOR TREATING A REDUCED DOPAMINE RECEPTOR SIGNALING ACTIVITY
US8012936B2 (en) 2006-03-29 2011-09-06 New York University Tau fragments for immunotherapy
US9006258B2 (en) 2006-12-05 2015-04-14 Intra-Cellular Therapies, Inc. Method of treating female sexual dysfunction with a PDE1 inhibitor
WO2009068320A1 (en) 2007-11-30 2009-06-04 Elbion Gmbh Aryl and heteroaryl fused imidazo (1,5-a) pyrazines as inhibitors of phosphodiesterase 10
UA105362C2 (en) 2008-04-02 2014-05-12 Бьорингер Ингельхайм Интернациональ Гмбх 1-heterocyclyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their use as pde9a modulators
EA201100446A1 (ru) 2008-09-08 2011-10-31 Бёрингер Ингельхайм Интернациональ Гмбх Пиразолопиримидины и их применение для лечения нарушений цнс
GEP20146046B (en) 2008-12-06 2014-02-25 Intracellular Therapies Inc Organic compounds
TWI404721B (zh) 2009-01-26 2013-08-11 Pfizer 胺基－雜環化合物
AR083058A1 (es) 2010-09-20 2013-01-30 Envivo Pharmaceuticals Inc Compuestos de estructura de imidazotriazinona
EP2619204A4 (en) 2010-09-21 2014-08-27 Merck Sharp & Dohme TRIAZOLOPYRAZINONES AS ANTAGONISTS OF P2X7 RECEPTORS
JO3089B1 (ar) 2010-11-19 2017-03-15 H Lundbeck As مشتقات ايميدازول كمثبطات لانزيمات pde10a
US9499610B2 (en) 2011-04-08 2016-11-22 H. Lundbeck A/S Antibodies specific to pyroglutamated Aβ
JP6051210B2 (ja) 2011-06-10 2016-12-27 イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｉｅｓ， Ｉｎｃ． 有機化合物
CA2886885C (en) 2011-10-10 2019-07-16 H. Lundbeck A/S Pde9i with imidazo pyrazinone backbone
EP2807163B1 (en) 2012-01-26 2017-03-22 H. Lundbeck A/S Pde9 inhibitors with imidazo triazinone backbone
WO2013192229A1 (en) 2012-06-18 2013-12-27 Dart Neuroscience (Cayman) Ltd Substituted pyridine azolopyrimidine - 5 - (6h) - one compounds
AU2014234990B2 (en) 2013-03-15 2017-11-16 Intra-Cellular Therapies, Inc. Organic compounds
JP5783297B2 (ja) 2013-08-06 2015-09-24 株式会社デンソー 力学量センサ
JP5797815B1 (ja) 2014-06-27 2015-10-21 細田建設株式会社 後施工アンカー及びその施工方法
US20160083400A1 (en) 2014-09-18 2016-03-24 Sunovion Pharmaceuticals Inc. Tricyclic guanidine derivative
WO2016042775A1 (en) 2014-09-18 2016-03-24 Sunovion Pharmaceuticals Inc. Tricyclic derivative
US20160083391A1 (en) 2014-09-18 2016-03-24 Sunovion Pharmaceuticals Inc. Tricyclic piperazine derivative
TW201629064A (zh) * 2014-10-10 2016-08-16 Ｈ 朗德貝克公司 作爲ｐｄｅ１抑制劑之三唑並吡酮
WO2016147659A1 (en) 2015-03-16 2016-09-22 Sumitomo Dainippon Pharma Co., Ltd. Bicyclic imidazolo derivative
TW201643167A (zh) 2015-04-22 2016-12-16 Ｈ 朗德貝克公司 作爲ｐｄｅ１抑制劑之咪唑並三酮
JO3627B1 (ar) 2015-04-30 2020-08-27 H Lundbeck As إيميدازو بيرازينونات على هيئة مثبطات pde1
AR107456A1 (es) 2016-02-12 2018-05-02 Lilly Co Eli Inhibidor de pde1
TWI729109B (zh) 2016-04-12 2021-06-01 丹麥商Ｈ 朗德貝克公司 作爲PDE1抑制劑的1,5-二氫-4H-吡唑并[3,4-d]嘧啶-4-酮和1,5-二氫-4H-吡唑并[4,3-c]吡啶-4-酮
JP2018076285A (ja) 2016-09-14 2018-05-17 大日本住友製薬株式会社 二環性イミダゾロ誘導体を含む医薬
WO2018073251A1 (en) 2016-10-18 2018-04-26 H. Lundbeck A/S Imidazopyrazinones, pyrazolopyrimidinones and pyrazolopyridinones as pde1 inhibitors
CN109803653A (zh) 2016-10-28 2019-05-24 H.隆德贝克有限公司 包括给予咪唑并吡嗪酮的组合治疗
MX2019004763A (es) 2016-10-28 2019-07-01 H Lundbeck As Tratamientos de combinacion que comprenden imidazopirazinonas para el tratamiento de trastornos psiquiatricos y/o cognitivos.

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004018474A1 (de) * 2002-08-23 2004-03-04 Bayer Healthcare Ag Phenyl-substituierte pyrazolopyrimidine
WO2004026876A1 (de) * 2002-08-23 2004-04-01 Bayer Healthcare Ag Alkyl-substituierte pyrazolopyrimidine
EP2305262A1 (de) * 2002-08-23 2011-04-06 Boehringer Ingelheim International GmbH Selektive Phosphodiesterase 9A-Inhibitoren als Arzneimittel zur Verbesserung kognitiver Prozesse
EP1626971B1 (de) * 2003-05-09 2011-08-10 Boehringer Ingelheim International Gmbh 6-cyclylmethyl- und 6-alkylmethyl-substituierte pyrazolopyrimidine
CN101687876B (zh) * 2007-05-11 2012-12-12 辉瑞有限公司 氨基杂环化合物
WO2011153136A1 (en) * 2010-05-31 2011-12-08 Intra-Cellular Therapies, Inc. Organic compounds
WO2015091805A1 (en) * 2013-12-19 2015-06-25 H. Lundbeck A/S Quinazolin-thf-amines as pde1 inhibitors

Also Published As

Publication number Publication date
PL3442975T3 (pl) 2020-11-16
MA44656A (fr) 2019-02-20
SG11201808221QA (en) 2018-10-30
EA035197B1 (ru) 2020-05-14
KR20180133413A (ko) 2018-12-14
ZA201806407B (en) 2019-12-18
EP3442975B1 (en) 2020-07-29
AU2017250431A1 (en) 2018-10-11
RU2018133391A (ru) 2020-05-12
US20170291901A1 (en) 2017-10-12
HUE050320T2 (hu) 2020-11-30
AR108109A1 (es) 2018-07-18
US20200102316A1 (en) 2020-04-02
WO2017178350A1 (en) 2017-10-19
TWI729109B (zh) 2021-06-01
JP7093306B2 (ja) 2022-06-29
GEP20207057B (en) 2020-01-27
MX2018012496A (es) 2019-02-21
SV2018005753A (es) 2018-11-27
CN109071549A (zh) 2018-12-21
LT3442975T (lt) 2020-09-25
MA44656B1 (fr) 2020-10-28
CY1123269T1 (el) 2021-12-31
ES2814289T3 (es) 2021-03-26
TW201738242A (zh) 2017-11-01
CR20180470A (es) 2018-12-21
HRP20201331T1 (hr) 2020-11-27
SI3442975T1 (sl) 2020-10-30
PH12018502168A1 (en) 2019-08-19
PT3442975T (pt) 2020-09-03
US11104680B2 (en) 2021-08-31
US10538525B2 (en) 2020-01-21
NI201800092A (es) 2019-03-14
RS60714B1 (sr) 2020-09-30
IL262257A (en) 2018-11-29
DOP2018000201A (es) 2018-11-15
IL262257B (en) 2020-11-30
AU2017250431B2 (en) 2020-07-16
PE20181853A1 (es) 2018-12-03
US20190194204A1 (en) 2019-06-27
UA121925C2 (uk) 2020-08-10
MY194722A (en) 2022-12-15
TN2018000321A1 (en) 2020-01-16
ME03820B (me) 2021-04-20
ECSP18074641A (es) 2018-10-31
CO2018010323A2 (es) 2018-12-14
EA201891897A1 (ru) 2019-03-29
CA3020053A1 (en) 2017-10-19
CL2018002881A1 (es) 2018-12-14
BR112017026278A2 (pt) 2018-09-11
JP2019517996A (ja) 2019-06-27
EP3442975A1 (en) 2019-02-20
DK3442975T3 (da) 2020-08-24
RU2018133391A3 (ru) 2020-06-23

Similar Documents

Publication Publication Date Title
CN109071549B (zh) Pde1抑制剂
JP2022133462A (ja) タンパク質キナーゼのモジュレータとしてのジアリール大環状化合物
JP6663930B2 (ja) Ｐｄｅ１阻害剤としてのイミダゾピラジノン
CN109843884B (zh) 作为pde1抑制剂的咪唑并吡嗪酮、吡唑并嘧啶酮和吡唑并吡啶酮
CN106928219B (zh) 含氮稠杂环化合物、制备方法、中间体、组合物和应用
EP2945623A1 (en) Hedgehog pathway signaling inhibitors and therapeutic applications thereof
JP2017530173A (ja) Ｐｄｅ１阻害剤としてのトリアゾロピラジノン
KR20120120252A (ko) 폴로-유사 키나제의 억제제로서의 프테리디논
CN101917995A (zh) Polo样激酶抑制剂
CN110099901B (zh) 作为PDE1抑制剂的吡唑并[3,4-b]吡啶和咪唑并[1,5-b]哒嗪
JP2022541127A (ja) キナーゼ阻害剤としての置換された縮合複素芳香族二環式化合物およびその使用
JP2019536762A (ja) 精神疾患及び／又は認知障害の治療のためのイミダゾピラジノンを含む併用療法
CN111511742A (zh) 作为PDE1抑制剂的吡唑并[3,4-b]吡啶和咪唑并[1,5-b]哒嗪
CN111072676B (zh) 含氮稠合三环衍生物及其用途
CN111072675A (zh) 含氮稠合三环衍生物及其用途
CN111018856A (zh) 8-取代的苯乙烯基黄嘌呤衍生物及其用途
CN111072663B (zh) 8-取代的苯乙烯基黄嘌呤衍生物及其用途
CN110922408B (zh) 3H-[1,2,3]三唑并[4,5-d]嘧啶-5-胺衍生物及其用途
CN116472042A (zh) 作为gaba a型受体调节剂的2-氧代-二氢喹啉-3-甲酰胺衍生物

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant