CN109069580A - 稳定化的糖肽抗生素配制品 - Google Patents

稳定化的糖肽抗生素配制品 Download PDF

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Publication number
CN109069580A
CN109069580A CN201780027315.7A CN201780027315A CN109069580A CN 109069580 A CN109069580 A CN 109069580A CN 201780027315 A CN201780027315 A CN 201780027315A CN 109069580 A CN109069580 A CN 109069580A
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CN
China
Prior art keywords
glycopeptide antibiotic
sulfobutyl ether
vancomycin
alanine
pharmaceutical composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201780027315.7A
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English (en)
Chinese (zh)
Inventor
萨比娜·克泽尔
伊沃娜·雅斯普里卡
杰罗姆·莱-库夫
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Xellia Pharmaceuticals ApS
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Xellia Pharmaceuticals ApS
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Filing date
Publication date
Application filed by Xellia Pharmaceuticals ApS filed Critical Xellia Pharmaceuticals ApS
Publication of CN109069580A publication Critical patent/CN109069580A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN201780027315.7A 2016-05-09 2017-05-04 稳定化的糖肽抗生素配制品 Pending CN109069580A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662333357P 2016-05-09 2016-05-09
US62/333,357 2016-05-09
PCT/EP2017/060653 WO2017194385A1 (en) 2016-05-09 2017-05-04 Stabilized glycopeptide antibiotic formulations

Publications (1)

Publication Number Publication Date
CN109069580A true CN109069580A (zh) 2018-12-21

Family

ID=58745200

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780027315.7A Pending CN109069580A (zh) 2016-05-09 2017-05-04 稳定化的糖肽抗生素配制品

Country Status (20)

Country Link
US (1) US10729708B2 (enExample)
EP (1) EP3454883A1 (enExample)
JP (1) JP6946343B2 (enExample)
KR (1) KR20190005940A (enExample)
CN (1) CN109069580A (enExample)
AR (1) AR109454A1 (enExample)
AU (1) AU2017262943B2 (enExample)
BR (1) BR112018072948A2 (enExample)
CA (1) CA3021935A1 (enExample)
CL (1) CL2018003147A1 (enExample)
CO (1) CO2018011701A2 (enExample)
EA (1) EA201892413A1 (enExample)
IL (1) IL262796A (enExample)
JO (2) JOP20170111B1 (enExample)
MX (1) MX388732B (enExample)
SA (1) SA518400392B1 (enExample)
SG (1) SG11201809908TA (enExample)
TW (2) TWI769694B (enExample)
UY (1) UY37233A (enExample)
WO (1) WO2017194385A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115804832A (zh) * 2021-09-14 2023-03-17 海南普利制药股份有限公司 一种万古霉素水溶液组合物
WO2024037451A1 (zh) * 2022-08-16 2024-02-22 海南普利制药股份有限公司 一种稳定的奥利万星药物水溶液及其制备方法

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SI3542812T1 (sl) 2014-11-06 2021-04-30 Xellia Pharmaceuticals Aps Glikopeptidni sestavki
WO2021231361A1 (en) * 2020-05-11 2021-11-18 Anovent Pharmaceutical (U.S.), Llc Pharmaceutical formulation containing active metabolites of remdesivir for inhalation
US20230302032A1 (en) * 2020-08-04 2023-09-28 Harrow Ip Llc Antibacterial compositions and methods for fabricating thereof
EP4014965A1 (en) 2020-12-16 2022-06-22 EVER Valinject GmbH Aqueous solution
EP4014969A1 (en) 2020-12-16 2022-06-22 EVER Valinject GmbH Aqueous solution
JPWO2023171588A1 (enExample) * 2022-03-08 2023-09-14
US20250295727A1 (en) * 2022-04-26 2025-09-25 Hikma Pharmaceuticals Usa Inc. Stable, ready-to-administer aqueous formulations of dalbavancin
GB202207345D0 (en) 2022-05-19 2022-07-06 Arecor Ltd Novel composition
GB202207344D0 (en) 2022-05-19 2022-07-06 Arecor Ltd Novel composition
WO2024079224A1 (en) * 2022-10-12 2024-04-18 Xellia Pharmaceuticals Aps Liquid dalbavancin composition
EP4601615A1 (en) * 2022-10-12 2025-08-20 Hikma Pharmaceuticals USA Inc. Liquid dalbavancin composition
EP4431083A1 (en) * 2023-03-16 2024-09-18 Adalvo Limited Formulation of dalbavancin
WO2025158262A1 (en) * 2024-01-23 2025-07-31 Lupin Limited Stable pharmaceutical compositions of dalbavancin as ready-to-dilute formulation

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WO1997019690A1 (en) * 1995-12-01 1997-06-05 Eli Lilly And Company Stable vancomycin hydrochloride solutions
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CN1441680A (zh) * 2000-05-02 2003-09-10 施万制药 含有糖肽抗生素和环糊精的药物组合物
US20040229775A1 (en) * 2000-05-02 2004-11-18 Linsell Martin S. Polyacid glycopeptide derivatives
CN1857716A (zh) * 2006-03-14 2006-11-08 浙江大学 注射用盐酸万古霉素及其制备方法
CN1964736A (zh) * 2004-04-27 2007-05-16 维库罗恩医药品公司 治疗细菌感染的达巴万星组合物
CN101959508A (zh) * 2008-04-28 2011-01-26 锡德克斯药物公司 磺烷基醚环糊精组合物
CN102755629A (zh) * 2012-08-02 2012-10-31 上海瑞创医药科技有限公司 与万古霉素形成抗菌增效包合物的组分和制备方法及其应用
CN104884047A (zh) * 2012-11-29 2015-09-02 英斯梅德股份有限公司 稳定的万古霉素制剂
WO2016071495A1 (en) * 2014-11-06 2016-05-12 Xellia Pharmaceuticals Aps Glycopeptide compositions
CN108712909A (zh) * 2016-02-18 2018-10-26 梅琳塔治疗公司 奥利万星制剂

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115804832A (zh) * 2021-09-14 2023-03-17 海南普利制药股份有限公司 一种万古霉素水溶液组合物
WO2023040396A1 (zh) * 2021-09-14 2023-03-23 浙江普利药业有限公司 一种万古霉素水溶液组合物
WO2024037451A1 (zh) * 2022-08-16 2024-02-22 海南普利制药股份有限公司 一种稳定的奥利万星药物水溶液及其制备方法

Also Published As

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AU2017262943A1 (en) 2018-11-22
JP6946343B2 (ja) 2021-10-06
EP3454883A1 (en) 2019-03-20
CL2018003147A1 (es) 2018-12-28
KR20190005940A (ko) 2019-01-16
JP2019518733A (ja) 2019-07-04
JOP20170111B1 (ar) 2022-03-14
WO2017194385A1 (en) 2017-11-16
US10729708B2 (en) 2020-08-04
SG11201809908TA (en) 2018-12-28
EA201892413A1 (ru) 2019-05-31
JOP20220039A1 (ar) 2023-01-30
US20190175632A1 (en) 2019-06-13
UY37233A (es) 2018-01-02
BR112018072948A2 (pt) 2019-02-19
CO2018011701A2 (es) 2019-02-08
TWI769694B (zh) 2022-07-01
MX2018013584A (es) 2019-04-01
TW202133875A (zh) 2021-09-16
SA518400392B1 (ar) 2022-05-09
AR109454A1 (es) 2018-12-12
TWI772296B (zh) 2022-08-01
MX388732B (es) 2025-03-20
IL262796A (en) 2018-12-31
TW201740955A (zh) 2017-12-01
AU2017262943B2 (en) 2020-05-14
CA3021935A1 (en) 2017-11-16

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