CN108977446A - 修饰的RNAi试剂 - Google Patents

修饰的RNAi试剂 Download PDF

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Publication number
CN108977446A
CN108977446A CN201810824847.XA CN201810824847A CN108977446A CN 108977446 A CN108977446 A CN 108977446A CN 201810824847 A CN201810824847 A CN 201810824847A CN 108977446 A CN108977446 A CN 108977446A
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Prior art keywords
nucleotide
reagent
double
modification
stranded rna
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CN201810824847.XA
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Chinese (zh)
Inventor
K·G·拉杰夫
T·齐默尔曼
M·马诺哈伦
M·梅尔
S·库奇曼奇
K·查里斯
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Alnylam Pharmaceuticals Inc
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Alnylam Pharmaceuticals Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47295193&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN108977446(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Alnylam Pharmaceuticals Inc filed Critical Alnylam Pharmaceuticals Inc
Publication of CN108977446A publication Critical patent/CN108977446A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
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    • A61P31/12—Antivirals
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
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    • C12N2310/30—Chemical structure
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    • C12N2320/00—Applications; Uses
    • C12N2320/50—Methods for regulating/modulating their activity
    • C12N2320/51—Methods for regulating/modulating their activity modulating the chemical stability, e.g. nuclease-resistance

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
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CN201810824847.XA 2011-11-18 2012-11-16 修饰的RNAi试剂 Pending CN108977446A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161561710P 2011-11-18 2011-11-18
US61/561,710 2011-11-18
CN201280067436.1A CN104105790A (zh) 2011-11-18 2012-11-16 修饰的RNAi试剂

Related Parent Applications (1)

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CN201280067436.1A Division CN104105790A (zh) 2011-11-18 2012-11-16 修饰的RNAi试剂

Publications (1)

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CN108977446A true CN108977446A (zh) 2018-12-11

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ID=47295193

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CN201610306307.3A Pending CN105861503A (zh) 2011-11-18 2012-11-16 修饰的RNAi试剂
CN201280067436.1A Pending CN104105790A (zh) 2011-11-18 2012-11-16 修饰的RNAi试剂
CN201810824847.XA Pending CN108977446A (zh) 2011-11-18 2012-11-16 修饰的RNAi试剂

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CN201610306307.3A Pending CN105861503A (zh) 2011-11-18 2012-11-16 修饰的RNAi试剂
CN201280067436.1A Pending CN104105790A (zh) 2011-11-18 2012-11-16 修饰的RNAi试剂

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US (6) US9796974B2 (enExample)
EP (3) EP3366775B2 (enExample)
JP (5) JP2015502931A (enExample)
KR (5) KR102534909B1 (enExample)
CN (3) CN105861503A (enExample)
AR (1) AR121312A2 (enExample)
CA (1) CA2856289A1 (enExample)
DK (1) DK3366775T4 (enExample)
EA (1) EA201490993A1 (enExample)
ES (1) ES2923787T5 (enExample)
FI (1) FI3366775T4 (enExample)
HK (1) HK1200191A1 (enExample)
HR (1) HRP20220908T4 (enExample)
IL (2) IL303831A (enExample)
IN (1) IN2014CN03465A (enExample)
LT (1) LT3366775T (enExample)
MX (2) MX385869B (enExample)
SG (1) SG11201402382XA (enExample)
SI (1) SI3366775T1 (enExample)
WO (1) WO2013074974A2 (enExample)

Cited By (1)

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Application publication date: 20181211