CN108778423A - 阿片类新生儿脱瘾综合征的治疗和预防 - Google Patents

阿片类新生儿脱瘾综合征的治疗和预防 Download PDF

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Publication number
CN108778423A
CN108778423A CN201780015234.5A CN201780015234A CN108778423A CN 108778423 A CN108778423 A CN 108778423A CN 201780015234 A CN201780015234 A CN 201780015234A CN 108778423 A CN108778423 A CN 108778423A
Authority
CN
China
Prior art keywords
opioid
antagonist
brain
opioid antagonist
individual
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201780015234.5A
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English (en)
Chinese (zh)
Inventor
沃尔夫冈·萨迪
约翰·奥伯迪克
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ohio State Innovation Foundation
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Ohio State Innovation Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ohio State Innovation Foundation filed Critical Ohio State Innovation Foundation
Publication of CN108778423A publication Critical patent/CN108778423A/zh
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/485Morphinan derivatives, e.g. morphine, codeine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41781,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36Opioid-abuse

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Addiction (AREA)
  • Emergency Medicine (AREA)
  • Organic Chemistry (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
CN201780015234.5A 2016-01-08 2017-01-06 阿片类新生儿脱瘾综合征的治疗和预防 Pending CN108778423A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662276691P 2016-01-08 2016-01-08
US62/276,691 2016-01-08
PCT/US2017/012452 WO2017120417A1 (en) 2016-01-08 2017-01-06 Treatments and prevention of opioid neonatal abstinence syndrome

Publications (1)

Publication Number Publication Date
CN108778423A true CN108778423A (zh) 2018-11-09

Family

ID=59274434

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780015234.5A Pending CN108778423A (zh) 2016-01-08 2017-01-06 阿片类新生儿脱瘾综合征的治疗和预防

Country Status (8)

Country Link
US (3) US10925870B2 (enExample)
EP (1) EP3400066B1 (enExample)
JP (1) JP7061568B2 (enExample)
CN (1) CN108778423A (enExample)
AU (1) AU2017206041B2 (enExample)
CA (1) CA3010609A1 (enExample)
DK (1) DK3400066T3 (enExample)
WO (1) WO2017120417A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113573711A (zh) * 2019-01-04 2021-10-29 伊瑟治疗公司 治疗药物或酒精依赖性的方法
CN114096249A (zh) * 2019-07-09 2022-02-25 奥瑞克索股份公司 用于鼻腔递送的药物组合物

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3066284A1 (en) * 2018-04-09 2019-10-17 Katana Pharmaceuticals, Inc. Oxytocin compositions and methods of use
EP4366736A4 (en) * 2021-07-06 2025-05-14 Aether Therapeutics Inc. LOW-DOSE NALTREXOL AND USES THEREOF
US11977085B1 (en) 2023-09-05 2024-05-07 Elan Ehrlich Date rape drug detection device and method of using same

Family Cites Families (7)

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Publication number Priority date Publication date Assignee Title
ATE326222T1 (de) 2000-03-15 2006-06-15 Wolfgang Sadee Naloxon- und naltrexon-analoga in der behandlung bei drogenmissbrauch
EA009921B1 (ru) * 2003-07-25 2008-04-28 Еуро-Селтик С.А. Способ лечения синдрома отвыкания от зависимости у беременных женщин
MX2007005790A (es) 2004-11-16 2007-09-11 Limerick Neurosciences Inc Metodos y composiciones para tratar el dolor.
US8748448B2 (en) 2007-10-18 2014-06-10 Aiko Biotechnology Combination analgesic employing opioid agonist and neutral antagonist
CA2702680A1 (en) 2007-10-18 2009-04-23 Aiko Biotechnology Combination analgesic employing opioid and neutral antagonist
WO2009079489A1 (en) * 2007-12-17 2009-06-25 The Ohio State University Research Foundation Methods for screening of opioid receptor neutral antagonists and inverse agonists and uses thereof
US9226918B2 (en) * 2008-12-04 2016-01-05 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for treating or preventing narcotic withdrawal symptoms

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DEBELAK ET AL: "Buprenorphine+naloxone", 《THE AMERICAN JOURNAL ON ADDICTIONS》 *
S.L. WIEGAND, ET AL.: "Buprenorphine and Naloxone Compared With Methadone Treatment in Pregnancy", 《OBSTET GYNECOL.》 *
国家食品药品监督管理总局执业药师资格认证中心: "《药学专业知识(1)第七版2015》", 28 February 2015 *
钱之玉: "《药理学4版》", 31 August 2015, 中国医药科技出版社 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113573711A (zh) * 2019-01-04 2021-10-29 伊瑟治疗公司 治疗药物或酒精依赖性的方法
CN114096249A (zh) * 2019-07-09 2022-02-25 奥瑞克索股份公司 用于鼻腔递送的药物组合物

Also Published As

Publication number Publication date
US20210205296A1 (en) 2021-07-08
AU2017206041A1 (en) 2018-07-26
US12161641B2 (en) 2024-12-10
US20250177379A1 (en) 2025-06-05
EP3400066A1 (en) 2018-11-14
JP7061568B2 (ja) 2022-04-28
CA3010609A1 (en) 2017-07-13
EP3400066A4 (en) 2019-06-26
JP2019501194A (ja) 2019-01-17
AU2017206041B2 (en) 2022-07-28
US10925870B2 (en) 2021-02-23
US20190015406A1 (en) 2019-01-17
NZ744112A (en) 2025-05-30
EP3400066B1 (en) 2021-07-28
DK3400066T3 (da) 2021-10-18
WO2017120417A1 (en) 2017-07-13

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