AU2017206041B2 - Treatments and prevention of opioid neonatal abstinence syndrome - Google Patents

Treatments and prevention of opioid neonatal abstinence syndrome Download PDF

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Publication number
AU2017206041B2
AU2017206041B2 AU2017206041A AU2017206041A AU2017206041B2 AU 2017206041 B2 AU2017206041 B2 AU 2017206041B2 AU 2017206041 A AU2017206041 A AU 2017206041A AU 2017206041 A AU2017206041 A AU 2017206041A AU 2017206041 B2 AU2017206041 B2 AU 2017206041B2
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AU
Australia
Prior art keywords
opioid
brain
naltrexol
antagonist
drug
Prior art date
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Application number
AU2017206041A
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English (en)
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AU2017206041A1 (en
Inventor
John OBERDICK
Wolfgang Sadee
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Ohio State Innovation Foundation
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Ohio State Innovation Foundation
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Publication of AU2017206041A1 publication Critical patent/AU2017206041A1/en
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Publication of AU2017206041B2 publication Critical patent/AU2017206041B2/en
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Addiction (AREA)
  • Emergency Medicine (AREA)
  • Organic Chemistry (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Saccharide Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
AU2017206041A 2016-01-08 2017-01-06 Treatments and prevention of opioid neonatal abstinence syndrome Active AU2017206041B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662276691P 2016-01-08 2016-01-08
US62/276,691 2016-01-08
PCT/US2017/012452 WO2017120417A1 (en) 2016-01-08 2017-01-06 Treatments and prevention of opioid neonatal abstinence syndrome

Publications (2)

Publication Number Publication Date
AU2017206041A1 AU2017206041A1 (en) 2018-07-26
AU2017206041B2 true AU2017206041B2 (en) 2022-07-28

Family

ID=59274434

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2017206041A Active AU2017206041B2 (en) 2016-01-08 2017-01-06 Treatments and prevention of opioid neonatal abstinence syndrome

Country Status (7)

Country Link
US (3) US10925870B2 (enExample)
EP (1) EP3400066B1 (enExample)
JP (1) JP7061568B2 (enExample)
CN (1) CN108778423A (enExample)
AU (1) AU2017206041B2 (enExample)
DK (1) DK3400066T3 (enExample)
WO (1) WO2017120417A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3066284A1 (en) * 2018-04-09 2019-10-17 Katana Pharmaceuticals, Inc. Oxytocin compositions and methods of use
EP3883571B1 (en) * 2019-01-04 2026-01-28 Aether Therapeutics Inc. 6-beta-naltrexol for use in a method of treating opioid dependency
US10653690B1 (en) * 2019-07-09 2020-05-19 Orexo Ab Pharmaceutical composition for nasal delivery
US20240325379A1 (en) * 2021-07-06 2024-10-03 Aether Therapeutics Inc. Low-dose naltrexol and uses thereof
US11977085B1 (en) 2023-09-05 2024-05-07 Elan Ehrlich Date rape drug detection device and method of using same

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030069262A1 (en) * 2000-03-15 2003-04-10 Wolfgang Sadee Neutral antagonists and use thereof in treating drug abuse
US20060240085A1 (en) * 2003-07-25 2006-10-26 Euro-Celtique S.A. Treatment of dependence withdrawal

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1817023A4 (en) * 2004-11-16 2010-08-18 Limerick Biopharma Inc METHODS AND COMPOSITIONS FOR TREATING PAIN
CA2702680A1 (en) 2007-10-18 2009-04-23 Aiko Biotechnology Combination analgesic employing opioid and neutral antagonist
US8748448B2 (en) 2007-10-18 2014-06-10 Aiko Biotechnology Combination analgesic employing opioid agonist and neutral antagonist
WO2009079489A1 (en) * 2007-12-17 2009-06-25 The Ohio State University Research Foundation Methods for screening of opioid receptor neutral antagonists and inverse agonists and uses thereof
WO2010065930A1 (en) * 2008-12-04 2010-06-10 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for treating or preventing narcotic withdrawal symptoms

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030069262A1 (en) * 2000-03-15 2003-04-10 Wolfgang Sadee Neutral antagonists and use thereof in treating drug abuse
US20060240085A1 (en) * 2003-07-25 2006-10-26 Euro-Celtique S.A. Treatment of dependence withdrawal

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Debelak, K. et al., "Buprenorphine + Naloxone in the Treatment of Opioid Dependence during Pregnancy - Initial Patient Care and Outcome Data", AM J ADDICT, 2013, vol. 22, doi:10.1111/j.1521-0391.2012.12005.x, pages 252-254 *
Farid, W. O. et al., "The Effects of Maternally Administered Methadone, Buprenorphine and Naltrexone on Offspring: Review of Human and Animal Data", CURRENT NEUROPHARMACOLOGY, 2008, vol. 6, no. 2, pages 125-150 *
NPS Medicinewise, "Buprenorphine with naloxone (Suboxone Sublingual Film) for opiate dependence", 1 September 2011, <URL: https://www.nps.org.au/radar/articles/buprenorphine-with-naloxone-suboxone-sublingual-film-for-opiate-dependence> *
Wiegand, S. L. et al., "Buprenorphine and naloxone compared with methadone treatment in pregnancy", OBSTETRICS AND GYNECOLOGY, 2015, vol. 125, no. 2, doi:10.1097/AOG.0000000000000640, pages 363-368 *

Also Published As

Publication number Publication date
EP3400066B1 (en) 2021-07-28
EP3400066A4 (en) 2019-06-26
US20250177379A1 (en) 2025-06-05
WO2017120417A1 (en) 2017-07-13
JP7061568B2 (ja) 2022-04-28
EP3400066A1 (en) 2018-11-14
JP2019501194A (ja) 2019-01-17
US10925870B2 (en) 2021-02-23
US12161641B2 (en) 2024-12-10
DK3400066T3 (da) 2021-10-18
US20210205296A1 (en) 2021-07-08
CN108778423A (zh) 2018-11-09
AU2017206041A1 (en) 2018-07-26
CA3010609A1 (en) 2017-07-13
US20190015406A1 (en) 2019-01-17
NZ744112A (en) 2025-05-30

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