JP7061568B2 - オピオイド新生児薬物離脱症候群の処置及び予防 - Google Patents

オピオイド新生児薬物離脱症候群の処置及び予防 Download PDF

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JP7061568B2
JP7061568B2 JP2018535324A JP2018535324A JP7061568B2 JP 7061568 B2 JP7061568 B2 JP 7061568B2 JP 2018535324 A JP2018535324 A JP 2018535324A JP 2018535324 A JP2018535324 A JP 2018535324A JP 7061568 B2 JP7061568 B2 JP 7061568B2
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pharmaceutical composition
opioid
drug
naltrexol
antagonist
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JP2019501194A (ja
JP2019501194A5 (enExample
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ウォルフガング・サディー
ジョン・オーバーディック
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オハイオ・ステイト・イノベーション・ファウンデーション
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Addiction (AREA)
  • Emergency Medicine (AREA)
  • Organic Chemistry (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Saccharide Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
JP2018535324A 2016-01-08 2017-01-06 オピオイド新生児薬物離脱症候群の処置及び予防 Active JP7061568B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662276691P 2016-01-08 2016-01-08
US62/276,691 2016-01-08
PCT/US2017/012452 WO2017120417A1 (en) 2016-01-08 2017-01-06 Treatments and prevention of opioid neonatal abstinence syndrome

Publications (3)

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JP2019501194A JP2019501194A (ja) 2019-01-17
JP2019501194A5 JP2019501194A5 (enExample) 2020-01-23
JP7061568B2 true JP7061568B2 (ja) 2022-04-28

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JP2018535324A Active JP7061568B2 (ja) 2016-01-08 2017-01-06 オピオイド新生児薬物離脱症候群の処置及び予防

Country Status (7)

Country Link
US (3) US10925870B2 (enExample)
EP (1) EP3400066B1 (enExample)
JP (1) JP7061568B2 (enExample)
CN (1) CN108778423A (enExample)
AU (1) AU2017206041B2 (enExample)
DK (1) DK3400066T3 (enExample)
WO (1) WO2017120417A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3066284A1 (en) * 2018-04-09 2019-10-17 Katana Pharmaceuticals, Inc. Oxytocin compositions and methods of use
EP3883571B1 (en) * 2019-01-04 2026-01-28 Aether Therapeutics Inc. 6-beta-naltrexol for use in a method of treating opioid dependency
US10653690B1 (en) * 2019-07-09 2020-05-19 Orexo Ab Pharmaceutical composition for nasal delivery
US20240325379A1 (en) * 2021-07-06 2024-10-03 Aether Therapeutics Inc. Low-dose naltrexol and uses thereof
US11977085B1 (en) 2023-09-05 2024-05-07 Elan Ehrlich Date rape drug detection device and method of using same

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030069262A1 (en) 2000-03-15 2003-04-10 Wolfgang Sadee Neutral antagonists and use thereof in treating drug abuse
US20060111308A1 (en) 2004-11-16 2006-05-25 Wendye Robbins Methods and compositions for therapeutic treatment
US20060240085A1 (en) 2003-07-25 2006-10-26 Euro-Celtique S.A. Treatment of dependence withdrawal

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2702680A1 (en) 2007-10-18 2009-04-23 Aiko Biotechnology Combination analgesic employing opioid and neutral antagonist
US8748448B2 (en) 2007-10-18 2014-06-10 Aiko Biotechnology Combination analgesic employing opioid agonist and neutral antagonist
WO2009079489A1 (en) * 2007-12-17 2009-06-25 The Ohio State University Research Foundation Methods for screening of opioid receptor neutral antagonists and inverse agonists and uses thereof
WO2010065930A1 (en) * 2008-12-04 2010-06-10 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for treating or preventing narcotic withdrawal symptoms

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030069262A1 (en) 2000-03-15 2003-04-10 Wolfgang Sadee Neutral antagonists and use thereof in treating drug abuse
US20060240085A1 (en) 2003-07-25 2006-10-26 Euro-Celtique S.A. Treatment of dependence withdrawal
US20060111308A1 (en) 2004-11-16 2006-05-25 Wendye Robbins Methods and compositions for therapeutic treatment

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ClinicalTrials.gov，2014年06月26日，NCT01965704
DEBELAK, Kimber et al.，The American Journal of Addictions，2013年，Vol. 22, Issue 3，pp. 252-254，https://doi.org/10.1111/j.1521-0391.2012.12005.x
ELKOMY, MH. et al.，CLINICAL PHARMACOLOGY & THERAPEUTICS，2015年02月，Vol. 97, No. 2，pp. 167-176，https://doi.org/10.1002/cpt.5
WIEGAND, Samantha L. et al.，OBSTETRICS & GYNECOLOGY，2015年02月，Vol. 125, Issue 2，pp. 363-368，https://doi.org/10.1097/AOG.0000000000000640

Also Published As

Publication number Publication date
EP3400066B1 (en) 2021-07-28
EP3400066A4 (en) 2019-06-26
US20250177379A1 (en) 2025-06-05
WO2017120417A1 (en) 2017-07-13
EP3400066A1 (en) 2018-11-14
AU2017206041B2 (en) 2022-07-28
JP2019501194A (ja) 2019-01-17
US10925870B2 (en) 2021-02-23
US12161641B2 (en) 2024-12-10
DK3400066T3 (da) 2021-10-18
US20210205296A1 (en) 2021-07-08
CN108778423A (zh) 2018-11-09
AU2017206041A1 (en) 2018-07-26
CA3010609A1 (en) 2017-07-13
US20190015406A1 (en) 2019-01-17
NZ744112A (en) 2025-05-30

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