CN108685759B - 一种透明质酸类物质和四氢嘧啶类物质的组合物 - Google Patents
一种透明质酸类物质和四氢嘧啶类物质的组合物 Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/004—Aftersun preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/10—General cosmetic use
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Abstract
Description
分组 | 处理方法 |
对照组1 | 不照射,只换新鲜培养液 |
对照组2 | 在对照组1基础上,UV照射 |
实验组 | 加入样品溶液后,UV照射 |
分组 | 处理方法 |
对照组1 | 不照射,只换新鲜培养液 |
对照组2 | UV照射后,更换新鲜培养液 |
实验组 | UV照射后,加入样品溶液 |
透明质酸钠分子量(Da) | 总样品浓度(%) | UV照射损伤防护作用 | UV照射损伤 修复作用 |
1.1×10<sup>6</sup> | 0.06 | 88.94% | 78.49% |
5.5×10<sup>5</sup> | 0.06 | 76.38% | 75.55% |
1.2×10<sup>5</sup> | 0.06 | 79.97% | 73.32% |
5.1×10<sup>4</sup> | 0.06 | 82.35% | 75.85% |
0.83×10<sup>4</sup> | 0.06 | 97.19% | 88.21% |
Claims (5)
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CN201810754798.7A CN108685759B (zh) | 2018-07-11 | 2018-07-11 | 一种透明质酸类物质和四氢嘧啶类物质的组合物 |
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CN201810754798.7A CN108685759B (zh) | 2018-07-11 | 2018-07-11 | 一种透明质酸类物质和四氢嘧啶类物质的组合物 |
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CN108685759A CN108685759A (zh) | 2018-10-23 |
CN108685759B true CN108685759B (zh) | 2021-08-27 |
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Families Citing this family (19)
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CN109568190A (zh) * | 2018-12-30 | 2019-04-05 | 广州瑞誉化工科技有限公司 | 一种可修复晒伤的肤用组合物及其制备方法和应用 |
CN110151594B (zh) * | 2019-06-20 | 2022-03-29 | 华熙生物科技股份有限公司 | 一种含依克多因和透明质酸的口腔组合物及其应用 |
CN111096934B (zh) * | 2019-08-16 | 2022-02-08 | 华熙生物科技股份有限公司 | 一种抑制痤疮的凝胶 |
CN110974830A (zh) * | 2019-12-26 | 2020-04-10 | 华熙生物科技股份有限公司 | 一种用于预防、缓解或治疗皮肤过敏的外用组合物及其用途 |
CN111467349B (zh) * | 2020-05-14 | 2021-06-01 | 华熙生物科技股份有限公司 | 人工泪液及其制备方法 |
CN111407774B (zh) * | 2020-05-15 | 2022-03-22 | 华熙生物科技股份有限公司 | 一种眼科用组合物及其制备方法 |
CN111603478B (zh) * | 2020-06-29 | 2021-07-30 | 华熙生物科技股份有限公司 | 一种鼻腔用组合物 |
CN111743836B (zh) * | 2020-07-08 | 2022-10-25 | 广州暨创医美生物科技有限公司 | 一种舒缓修护面膜液、及其制备方法和包含其的冻干面膜 |
CN111643536A (zh) * | 2020-07-15 | 2020-09-11 | 华熙生物科技股份有限公司 | 一种鼻腔药盒及其制备方法 |
CN111773222A (zh) * | 2020-08-10 | 2020-10-16 | 华熙生物科技股份有限公司 | 四氢嘧啶和/或羟基四氢嘧啶在制备治疗烧烫伤药物中的应用 |
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CN112220102B (zh) * | 2020-09-25 | 2022-12-09 | 山东华熙海御生物医药有限公司 | 一种含透明质酸和依克多因的电子烟液及其制备方法 |
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CN116115518A (zh) * | 2022-12-07 | 2023-05-16 | 华熙生物科技股份有限公司 | 一种透明质酸钙及其在抗氧化方面的新用途 |
CN114569491B (zh) * | 2022-04-18 | 2023-08-18 | 华熙生物科技股份有限公司 | 一种抑制油脂生成的组合物及其用途 |
CN115252454A (zh) * | 2022-06-20 | 2022-11-01 | 青海大学 | 一种防晒霜及其制备方法 |
CN117138021B (zh) * | 2023-11-01 | 2024-01-09 | 南京斯拜科生物科技股份有限公司 | 一种基于蓝铜胜肽和四氢嘧啶的复配物、制法和应用 |
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CN104490747A (zh) * | 2015-01-05 | 2015-04-08 | 深圳市金因生物技术有限公司 | 具有防辐射、光保护全效防御功能的组合物及其制备方法 |
CN108261376A (zh) * | 2018-03-06 | 2018-07-10 | 森知(上海)国际贸易有限公司 | 一种三维保湿因子 |
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JP2002302444A (ja) * | 2001-04-02 | 2002-10-18 | Shiseido Co Ltd | 乾燥による皮膚傷害の抑制剤もしくは修復剤 |
CN103520082A (zh) * | 2013-10-10 | 2014-01-22 | 深圳市金因生物技术有限公司 | 一种含有表皮生长因子的抗衰老组合物及其制备方法 |
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