WO2021003962A1 - 一种修复肌肤用护肤组合物及其制备方法 - Google Patents

一种修复肌肤用护肤组合物及其制备方法 Download PDF

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Publication number
WO2021003962A1
WO2021003962A1 PCT/CN2019/121338 CN2019121338W WO2021003962A1 WO 2021003962 A1 WO2021003962 A1 WO 2021003962A1 CN 2019121338 W CN2019121338 W CN 2019121338W WO 2021003962 A1 WO2021003962 A1 WO 2021003962A1
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Prior art keywords
skin
skin care
care composition
essence
repairing
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PCT/CN2019/121338
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English (en)
French (fr)
Inventor
张训庭
钟卫芳
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浙江康满家日用品有限公司
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Priority to JP2020535981A priority Critical patent/JP7195324B2/ja
Publication of WO2021003962A1 publication Critical patent/WO2021003962A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/736—Chitin; Chitosan; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/88—Polyamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9728—Fungi, e.g. yeasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9794—Liliopsida [monocotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine

Definitions

  • the present invention relates to the field of skin care products, and more specifically, the present invention relates to a skin care composition for repairing skin and a preparation method thereof.
  • the present invention provides a skin care composition for repairing skin, which can be used in skin care products, has high heat resistance, cold resistance and mechanical stability, and does not cause skin irritation, and can be applied to people of various skin types. It has excellent whitening, moisturizing and wrinkle removal effects.
  • the first aspect of the present invention provides a skin care composition for repairing skin.
  • the preparation raw materials of the skin care composition include lotus seed fermentation liquid, yeast extract and turmeric gel.
  • the weight ratio of the lotus seed fermentation liquid, turmeric gel and yeast extract is 3: (1.5-2.5): (0.3-0.8).
  • the skin care composition further includes succinyl chitosan, carbohydrate derivatives and schizophyllin.
  • the carbohydrate derivatives include glycerol glucoside, xylitol-based glucoside, anhydroxylitol, fructose and xylitol.
  • the weight ratio of the succinyl chitosan and the carbohydrate derivative is (1.5-2.3):1.
  • the preparation raw material of the skin care composition further includes a composite humectant;
  • the composite humectant includes sodium hyaluronate, sodium polyglutamate and tremella polysaccharide.
  • the weight ratio of the schizophyllin, lotus seed fermentation broth and the composite humectant is 1: (1.5-2.5): (2.5-4.5).
  • the second aspect of the present invention provides an application of the skin care composition for repairing skin, which is applied to skin care products;
  • the skin care products are selected from the group consisting of aqua, lotion, cream, eye cream, facial mask, BB cream, essence, One or more of essence lotion, sunscreen lotion, sunscreen lotion, acne lotion, acne lotion, essential oil, shampoo, moisturizing lotion, toner, astringent lotion, and softening lotion.
  • the skin care product is an essence; the preparation raw materials of the essence include 6-19% of the skin repair composition for skin repair and 30-40% thickening in terms of mass percentage.
  • Agent 0 ⁇ 0.05% chelating agent, 3 ⁇ 5% skin conditioner, 4 ⁇ 7% humectant, 0 ⁇ 0.2% emollient, 0 ⁇ 0.1% solubilizer, 0 ⁇ 0.05% fragrance and the balance deionized water.
  • the third aspect of the present invention provides a preparation method of essence liquid.
  • the preparation materials of essence liquid include 6-19% of the skin repairing skin care composition, 30-40% thickener, and 0% by mass percentage. ⁇ 0.05% chelating agent, 3 ⁇ 5% skin conditioner, 4 ⁇ 7% humectant, 0 ⁇ 0.2% emollient, 0 ⁇ 0.1% solubilizer, 0 ⁇ 0.05% fragrance and the balance deionized water;
  • the preparation method of the essence includes the following steps:
  • step (2) Cooling the mixture obtained in step (1) to 45-55°C, adding a humectant, and stirring;
  • step (3) Cooling the mixture obtained in step (2) to 30-40°C, adding other components of the skin care composition and skin conditioning agent except for the compound moisturizer, and stirring;
  • step (3) After the temperature of the mixture obtained in step (3) is lowered, the mixture of solubilizer and fragrance is added and stirred, and the extract is obtained after passing the test.
  • the present invention provides a skin care composition for repairing skin, which can quickly whiten and remove wrinkles through the combination of lotus seed fermentation liquid, yeast extract and turmeric gel.
  • the moisturizing function can also be improved.
  • the stability of the composition, while further repairing skin damage, promoting whitening and anti-wrinkle performance; and by adding a composite moisturizer, while promoting the comprehensive performance of the skin care composition of the present invention, the shelf life can be further extended; in addition, the present invention
  • the skin care composition for repairing skin of the invention can be used in various skin care products.
  • compositions, step, method, product or device containing the listed elements is not necessarily limited to those elements, but may include other elements not explicitly listed or inherent in such a composition, step, method, product or device Elements.
  • the first aspect of the present invention provides a skin care composition for repairing skin.
  • the preparation raw materials of the skin care composition include lotus seed fermentation liquid, yeast extract and turmeric gel.
  • the weight ratio of lotus seed fermentation broth, turmeric gel and yeast extract of the present invention is 3: (1.5-2.5): (0.3-0.8).
  • the lotus seed fermentation broth of the present invention adopts the method of peeling and extracting live lotus and then fermenting, which maintains the activity of lotus seed to the maximum degree, which is beneficial to activate epidermal cells, accelerate keratinocyte metabolism, promote melanin discharge, improve skin texture, and repair pigmentation .
  • the lotus seed fermented liquid of the present invention can be purchased or self-made.
  • the preparation method includes the following steps: de-core the lotus seed and grind it in water, heat it to 85-90°C, and add sucrose, skimmed milk powder and carboxymethyl cellulose Sodium is homogenized, sterilized and cooled to below 45° C. for inoculation, and constant temperature fermentation is performed to obtain the lotus seed fermentation broth.
  • the lotus seed fermentation broth of the present invention is purchased from Shanghai Yanzhen Industrial Co., Ltd.
  • the yeast extract of the present invention is a natural product that contains proteins, nucleic acids, vitamins, etc., extracted from the yeast after breaking the wall, and then extracted by biological enzymatic hydrolysis and other methods, which are rich in small molecules such as amino acids, peptides, nucleotides, vitamins, etc. Active ingredient. In cosmetics, it has anti-aging, moisturizing, water-locking and skin brightening effects. Amino acids are the main components of the natural moisturizing factor (NMF) in the stratum corneum of the skin. They are easily absorbed by the skin to restore the elasticity of the aging epidermis and delay skin aging.
  • NMF natural moisturizing factor
  • Nucleic acids and nucleotides are the main genetic material of the human body, which have the functions of promoting metabolism, increasing the speed of protein synthesis, enhancing immune function, enhancing SOD activity, and improving the ability of skin to resist free radicals.
  • Polysaccharides such as glucose are natural moisturizers, and certain polysaccharides ( ⁇ -glucans) have anti-inflammatory effects.
  • Yeast extract can promote the metabolism of melanin-containing keratinocytes, accelerate the shedding of keratin, promote the synthesis of epidermal protein, improve skin texture, and brighten skin tone.
  • vitamins and minerals in the yeast extract can also provide sufficient nutrition for the skin.
  • the yeast extract of the present invention also contains soybean amino acid components.
  • the yeast extract of the present invention is purchased from Shanghai Ruimu Chemical Technology Co., Ltd. under the brand name SRC.
  • the turmeric gel of the present invention includes turmeric root extract.
  • the turmeric root extract is derived from the dried rhizome of the ginger family plant turmeric. Contains volatile oil, the main components in the oil are turmeric, aromatic turmeric and gingerene; the yellow substance is curcumin, and contains demethoxycurcumin, double demethoxycurcumin, dihydrocurcumin, etc. It has the effects of lowering blood pressure, lowering blood lipids, promoting choleretics, antibacterial, anti-inflammatory and antioxidant properties. Among them, curcumin is a very important pigment compound, which can prevent the automatic oxidation of linoleic acid in food, and has anti-cancer and anti-cancer functions.
  • turmeric gel containing turmeric root extract it not only has excellent antioxidant and emollient effects, but also promotes instant relief of itching and reduces sensitivity problems caused by compatibility of different raw materials.
  • the turmeric gel of the present invention also contains a small amount of fermentation products of lactobacillus, butanediol and 1,2-hexanediol.
  • the turmeric gel of the present invention is purchased from Shanghai Ronghai Biological Technology Co., Ltd.
  • the lotus seed fermentation broth and yeast extract contain a lot of small-molecule amino acids, broken plant cells, and fermented amino acid derivatives. Because these ingredients can participate in the metabolism of skin cells and are easily absorbed, they can be quickly absorbed by the skin. Cell tissue absorption helps to remove aging flaky skin, effectively stimulates the renewal of skin stratum corneum and cells, and delays aging.
  • the above-mentioned lotus seed fermentation broth and yeast extract have been in a dynamic reaction process, and their structure and efficacy are unstable.
  • turmeric gel contains curcumin and other components, contains a large amount of polyphenol structure, it has strong antioxidant capacity and free radical trapping ability, so that the composition has good whitening and anti-aging effects.
  • curcumin and other components contains a large amount of polyphenol structure, it has strong antioxidant capacity and free radical trapping ability, so that the composition has good whitening and anti-aging effects.
  • due to its unique structure it has greater irritation to the skin with acne, wounds, etc., it is easy to make the wound ooze blood, stimulate the wound, and it is difficult to make it heal.
  • due to the difficult contact between the gel structure and endothelial tissue the penetration and absorption into the skin is slow, and the effect is long and insignificant.
  • the lotus seed fermentation liquid, turmeric gel, and yeast extract with a weight ratio of 3: (1.5-2.5): (0.3-0.8) are used, the side effects of the composition such as skin irritation and allergies are effectively avoided. Even for people with sensitive skin, oily skin, and other special skin types, it does not have any side effects such as allergies, but it can also quickly whiten, reduce red marks and acne marks. This may be because the lotus seed fermented liquid and yeast extract can quickly contact the skin, soften the stratum corneum, reversibly change the skin structure to penetrate into the skin, reduce the resistance of the turmeric gel through the stratum corneum, and effectively improve the turmeric gel The permeability and absorption rate of the glue.
  • the complex components in the lotus seed fermentation liquid and yeast extract can be covered by the gel structure of the turmeric gel, and slowly released as the skin cells are absorbed, avoiding direct contact of the high-concentration skin care composition with the skin.
  • the skin care composition of the present invention further includes succinyl chitosan, carbohydrate derivatives and schizophyllin.
  • the succinyl chitosan of the present invention is an acylated derivative of chitosan from marine organisms, and has very good biocompatibility. It not only inherits the biodegradability and film-forming properties of chitosan Many unique physical and chemical properties, such as sex and cell affinity, and change the shortcomings of chitosan insoluble in water and insoluble in common organic solvents. It is a natural and effective moisturizer. Its molecular structure contains hydroxyl and carboxyl groups. Hydrophilic group can be combined with water molecules, thus having good moisture absorption and moisturizing properties. Succinyl chitosan also has film-forming properties.
  • the succinyl chitosan of the present invention is chitosan monosuccinamide.
  • the succinyl chitosan of the present invention is purchased from Shanghai Oulong Biotechnology Co., Ltd.
  • the carbohydrate derivative in the present invention is a composite component composed of a variety of sugar alcohols and glycosides. Due to the special structure of these components, they have good affinity for water and oil and can activate pores. Absorb and retain moisture in the endothelium.
  • the carbohydrate derivatives of the present invention include glycerol glucoside, xylitol glucoside, anhydroxylitol, fructose and xylitol.
  • the weight ratio of the succinyl chitosan and carbohydrate derivatives of the present invention is (1.5-2.3):1.
  • the weight ratio of the succinyl chitosan and the carbohydrate derivative of the present invention is 2:1.
  • the carbohydrate derivatives of the present invention are purchased from Shanghai Weight Kai Industrial Co., Ltd., and the brand is C-MOIST.
  • the schizophyllin of the present invention is an extracellular polysaccharide derived from schistophyceae. It is naturally water-soluble and presents a triple-helix rigid rod-like conformation in an aqueous solution. The triple-helix conformation enables it to be specific to skin immune cells.
  • the receptor dectin-1 recognizes and binds to induce and aggregates the dectin-1 receptor, induces the expression of downstream reactive oxygen species and pro-inflammatory factors, thereby exerting the biological effects of immune cells and making the surface receptors of immune cells connect in series to form a sudden It prompts the downstream immune signal pathway of immune cells to be rapidly transmitted through the action of SRC and SYK family kinases, which also enables the immune ability of immune cells in the skin to be fully exerted, regulates and enhances the overall immunity of skin tissues and various skin cells
  • SRC and SYK family kinases which also enables the immune ability of immune cells in the skin to be fully exerted, regulates and enhances the overall immunity of skin tissues and various skin cells
  • the level of immunity of the skin is improved, and the skin's own resistance ability is also strengthened. In fact, the repair ability and anti-inflammatory ability of the skin will also be greatly enhanced.
  • Most skin problems such as skin inflammation, allergic dermatitis, pimples, sun burns, sunburn,
  • the schizophyllin of the present invention can be purchased or self-made, and the preparation method includes the following steps: the schizophyllin is degraded by ultrasonic wave, and then obtained by solvent fractionation and precipitation.
  • the solvents can be listed as follows: ethanol, methanol, isopropanol , Isobutanol, n-hexanol, methylpentanol, 2-ethylbutanol, n-octanol and other alcohols; glycerin, ethylene glycol, ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, propylene glycol , Propylene glycol monomethyl ether, propylene glycol monoethyl ether, triethylene glycol, 1,3-butanediol, hexanediol, pentanediol and other polyols or their derivatives; acetone, methyl ethyl ketone,
  • the schizophyllin of the present invention is purchased from Shanghai Yiye Biotechnology Co., Ltd., under the brand name Yi-act-007.
  • the carbohydrate derivative when compounded with succinyl chitosan, its water-replenishing and water-retaining effect is significantly improved, and after compounding, the composition can replenish water for a long time, and is also helpful for skin repair and anti-wrinkle , Fades expression lines.
  • This may be due to the structural complementarity of carbohydrate derivatives and chitosan monosuccinamide (succinyl chitosan), which can form cavity structures of different sizes, and utilize the hydroxyl groups and amide bonds in the structure. Hydrogen bonds between the cluster and water molecules and other active ingredients, van der Waals forces and other forces, coat the water molecules in these cavities for cell tissue metabolism and ensure the normal operation of the skin's metabolic function.
  • the main chain is ⁇ -1,6-pyranose, and one sugar group in every three sugar groups is connected to one ⁇ -1,6-pyranose. Due to its structural characteristics, it is soluble in water, and has strong interaction with succinyl chitosan and carbohydrate derivatives. It easily penetrates into the inner layer of the skin together with the absorbed water and participates in the development of cells. Metabolism enhances cellular immunity and promotes wound healing.
  • the raw material for preparing the skin care composition of the present invention further includes a composite humectant; the composite humectant includes sodium hyaluronate, sodium polyglutamate and tremella polysaccharide.
  • the composite moisturizer of the present invention includes sodium hyaluronate, sodium polyglutamate, tremella polysaccharides and other ingredients, has excellent moisturizing properties, and when used with succinyl chitosan and sugar derivatives, the moisturizing effect is better.
  • the composite moisturizer of the present invention is purchased from Shanghai Yiye Biotechnology Co., Ltd., with the brand name Yi-301.
  • the weight ratio of schizophyllin, lotus seed fermentation broth and composite humectant in the present invention is 1: (1.5-2.5): (2.5-4.5).
  • the composite moisturizer can be distributed in the cavity formed by succinyl chitosan, carbohydrate derivatives and other components to improve the composition.
  • the affinity with skin tissues and the reaction with skin cells accelerate the transdermal absorption of the composition.
  • the second aspect of the present invention provides an application of the skin care composition for repairing skin, which is applied to skin care products;
  • the skin care products are selected from the group consisting of aqua, lotion, cream, eye cream, facial mask, BB cream, essence, and essence
  • the lotion and face cream of the present invention are liquid cream cosmetics.
  • the facial mask of the present invention is a carrier of beauty care products, including, but not limited to, mud type, tear-off type, gel type, and wet tissue type facial masks.
  • the BB cream of the present invention is Blemish Balm, and its functions include, but are not limited to, concealer, skin tone adjustment, sun protection, and pore refinement.
  • the essence and essence of the present invention refer to cosmetics containing concentrated high-nutrient substances.
  • the sunscreen of the present invention is a cosmetic that is added with a sunscreen agent that can block or absorb ultraviolet rays to prevent the skin from being tanned and sunburned.
  • the acne water of the present invention is a liquid substance with the effect of treating acne.
  • the acne lotion of the present invention is a liquid substance with the function of treating acne.
  • the skin care product of the present invention is an essence; the preparation raw materials of the essence include 6-19% of the skin-repairing skin-care composition and 30-40% increase in mass percentage.
  • the essence provided by the present invention is a colorless to light yellow transparent gel-like uniform liquid, conforms to the prescribed fragrance, has a pH value in the range of 5.8 to 6.8, and a relative density of 1.01 ⁇ 0.02 g/cm 3 at 20°C.
  • the pH value of the present invention is obtained through a pH meter test according to the GB T13531.1-2008 pH measurement method.
  • the relative density of the present invention is obtained by using a densitometer test according to the GB T13531.4-2013 relative density measurement method.
  • the thickener of the present invention is selected from acrylate, alkyl methacrylate copolymer or its salt, carboxyvinyl polymer or its salt, alginate, polyol ester of alginic acid, polyvinylpyrrolidone , Polyvinyl alcohol, sodium acrylate, sodium tripolyphosphate, carrageenan, carbomer, glycerol acrylate/acrylic acid copolymer, xanthan gum, and hydroxypropyl cellulose.
  • the thickener of the present invention is a glycerol acrylate/acrylic acid copolymer.
  • the thickener of the present invention is purchased from Shanghai Zhaoxin Chemical Co., Ltd., and the brand is SJgel MSF.
  • the chelating agent of the present invention is selected from one or more of ethylenediamine tetraalkyl sodium salt, citric acid and its salt, phosphate, etidronic acid and its salt.
  • the skin conditioning agent of the present invention includes peptides and an extract of Cladosium sea star.
  • the peptides of the present invention include dipeptide diaminobutyrylbenzylamide diacetate and acetylhexapeptide-8.
  • the starfish Cladosporium extract of the present invention has the effect of stimulating cell regeneration, strengthening the skin barrier, and also has a soothing effect. Combined with its antioxidant properties, it can be used for skin care; it can also effectively inhibit the decomposition of hyaluronic acid.
  • the skin acts as a moisturizer.
  • the moisturizer of the present invention is selected from one or more of polyols, natural polysaccharides, hydrophilic synthetic polymers, and betaine moisturizers.
  • polyhydric alcohol moisturizers include, but are not limited to, glycerin, 1,3-propanediol, 2-methyl-1,3-propanediol, 1,4-butanediol, 1,3-butanediol, 1 , 5-pentanediol, diglycerol, erythritol, gluconic acid, 1,2,6-hexanetriol, inositol, lactitol, maltitol, mannitol, xylitol, trehalose, etc.
  • Examples of natural polysaccharide moisturizers include, but are not limited to, hyaluronic acid, hyaluronan, heparin, polyglucuronic acid, chondroitin, chondroitin sulfate, pectin and their alkali metal salts where appropriate .
  • hydrophilic synthetic polymer humectants include, but are not limited to, poly(2-methacryloxyethylphosphocholine), poly(2-methacryloxyethylphosphoryl- CO-methacrylamide).
  • betaine moisturizers include, but are not limited to, betaine and its derivatives, and any compound contained in the zwitterionic compound of the corresponding sulfobetaine (the carboxyl group of betaine is replaced with a sulfo group).
  • decyl betaine lauryl betaine, myristyl betaine, cetyl betaine, stearoyl betaine, behenyl betaine, lauryl amidopropyl betaine, oleamidopropyl Betaine, palmamidopropyl betaine, lauryl sultaine, coco sultaine, poly(methacryloyloxyethyl betaine), poly(methacryloyloxyethyl betaine) Base-co-2-hydroxyethyl methacrylic acid).
  • the humectant of the present invention is a polyhydric alcohol humectant.
  • the humectant of the present invention is methyl propylene glycol and 1,3-propanediol.
  • the 1,3-propanediol of the present invention also contains 1,2-hexanediol and octanoyl hydroxamic acid, which can be used as a multifunctional additive and can be used in skin care products with moisturizing, emollient, anti-allergy, anti-oxidation and antiseptic effects .
  • the 1,3-propanediol of the present invention is purchased from Shanghai Haoyun Chemical Co., Ltd., and the brand is PHL.
  • the emollient of the present invention is selected from cyclopentadimethylsiloxane, polydimethylsiloxane, cyclohexasiloxane, diisopropyl sebacate, dioctyl carbonate, glycerin Tris(ethylhexanoic acid) ester, isododecane, isononyl isononanoate, cetearyl ethylhexanoate, jojoba seed oil, squalane, petrolatum, PEG-7 olive oil carboxylate One or more of sodium.
  • the emollient of the present invention is PEG-7 olive oil sodium carboxylate.
  • the solubilizer of the present invention is selected from polyethylene glycol-40 hydrogenated castor oil, polyethylene glycol-60 hydrogenated castor oil, polypropylene glycol-26, buteth-26, polyoxypropylene-26-butane One or more of ethoxylate-26, polyoxypropylene-1-polyethylene glycol-9 laureth glycol ether, cocoethoxylate-7, Tween 20, and Span 60.
  • the solubilizer of the present invention is purchased from Shanghai Miaosen Chemical Technology Co., Ltd., and the brand is LRI (polyethylene glycol-40 hydrogenated castor oil and polyoxypropylene-26-butanol polyether -26 mixture).
  • the fragrance of the present invention is a fragrance and/or essential oil.
  • the third aspect of the present invention provides a preparation method of essence liquid.
  • the preparation materials of essence liquid include 6-19% of the skin repairing skin care composition, 30-40% thickener, and 0% by mass percentage. ⁇ 0.05% chelating agent, 3 ⁇ 5% skin conditioner, 4 ⁇ 7% humectant, 0 ⁇ 0.2% emollient, 0 ⁇ 0.1% solubilizer, 0 ⁇ 0.05% fragrance and the balance deionized water;
  • the preparation method of the essence includes the following steps:
  • step (2) Cooling the mixture obtained in step (1) to 45-55°C, adding a humectant, and stirring;
  • step (3) Cooling the mixture obtained in step (2) to 30-40°C, adding other components of the skin care composition and skin conditioning agent except for the compound moisturizer, and stirring;
  • step (3) After the temperature of the mixture obtained in step (3) is lowered, the mixture of solubilizer and fragrance is added and stirred, and the extract is obtained after passing the test.
  • the deionized water, chelating agent and thickener in step (1) of the present invention are stirred at 17-22 Hz.
  • the composite humectant is added and stirred.
  • vacuum is -0.03 ⁇ -0.04MPa and the temperature is lowered to 45 ⁇ 55°C, and a humectant is added;
  • the step (2) of the present invention is to vacuum -0.03 ⁇ -0.04MPa and cool to 45 ⁇ 55°C, add humectant, under 28 ⁇ 33Hz, -0.03 ⁇ -0.04MPa vacuum Stir.
  • step (3) of the present invention other components of the composition and skin conditioning agent are added in addition to the compound moisturizer, and the mixture is stirred under a vacuum of 25 to 33 Hz and -0.03 to -0.04 MPa .
  • step (4) of the present invention the mixture of solubilizer and fragrance is added and stirred at 22-27 Hz.
  • Example 1 of the present invention provides a skin care composition for repairing skin.
  • the preparation raw materials of the skin care composition include 3 parts lotus seed fermentation liquid, 0.5 parts yeast extract, and 2 parts turmeric gel in parts by weight.
  • the lotus seed fermentation liquid was purchased from Shanghai Yanzhen Industrial Co., Ltd.
  • the yeast extract was purchased from Shanghai Ruimu Chemical Technology Co., Ltd., with the brand name SRC.
  • the turmeric gel was purchased from Shanghai Ronghai Biological Technology Co., Ltd.
  • This example provides an essence containing the skin-repairing skin care composition.
  • the preparation of the essence includes 5.5% of the skin-repairing skin care composition, 35% thickener, and 0.02% by weight percentage.
  • the thickener is a glycerol acrylate/acrylic acid copolymer, purchased from Shanghai Zhaoxin Chemical Co., Ltd., with the brand name SJgel MSF.
  • the chelating agent is disodium ethylenediaminetetraacetic acid with CAS number 139-33-3.
  • the skin conditioning agent is composed of 0.5 parts of dipeptide diaminobutyrylbenzylamide diacetate, 1 part of acetyl hexapeptide-8, and 2 parts of Cladosporium seastarii extract in parts by weight.
  • the dipeptide diaminobutyrylbenzylamide diacetate has a CAS number of 823202-99-9.
  • the CAS number of the acetyl hexapeptide-8 is 616204-22-9.
  • the Starfish Cladosporium extract was purchased from Shanghai Xi'an Biological Technology Co., Ltd., and the brand was L-50.
  • the humectant is composed of 4 parts of methyl propylene glycol and 1 part of 1,3-propanediol in parts by weight.
  • the CAS number of the methyl propylene glycol is 2163-42-0.
  • the 1,3-propanediol was purchased from Shanghai Haoyun Chemical Co., Ltd., and the brand was PHL.
  • the emollient is PEG-7 olive oil sodium carboxylate with CAS number 226416-05-3.
  • the solubilizer was purchased from Shanghai Miaosen Chemical Technology Co., Ltd., and the brand was LRI.
  • the fragrance is a fragrance, purchased from Le Erfu (Shanghai) Fragrance Co., Ltd.
  • This example also provides a preparation method of the essence, including the following steps:
  • step (2) The temperature of the first mixture in step (1) is lowered to 50° C., a humectant is added, and the mixture is stirred uniformly under a vacuum of 30 Hz and -0.04 MPa, and the temperature is lowered to obtain a second mixture;
  • step (2) the second mixture is cooled to 40° C., the skin care composition and skin conditioning agent are added, and the mixture is stirred uniformly under a vacuum of -0.04 MPa at 30 Hz, and the temperature is lowered to obtain a third mixture;
  • step (3) After the solubilizer and the fragrance are uniformly mixed, they are added to the third mixture described in step (3), stirred uniformly at 25 Hz, and the material is taken and tested, and the material is discharged after being qualified.
  • Example 2 of the present invention provides a skin care composition for repairing skin.
  • the preparation raw materials of the skin care composition include 3 parts lotus seed fermentation liquid, 0.5 parts yeast extract, 2 parts turmeric gel, 2 parts by weight. Succinyl chitosan, 1 part of carbohydrate derivatives, 1.5 parts of schizophyllin.
  • the lotus seed fermentation liquid was purchased from Shanghai Yanzhen Industrial Co., Ltd.
  • the yeast extract was purchased from Shanghai Ruimu Chemical Technology Co., Ltd., with the brand name SRC.
  • the turmeric gel was purchased from Shanghai Ronghai Biological Technology Co., Ltd.
  • the succinyl chitosan was purchased from Shanghai Oulong Biotechnology Co., Ltd.
  • the carbohydrate derivatives were purchased from Shanghai Weight Enkai Industrial Co., Ltd., with the brand name C-MOIST.
  • the schizophyllin was purchased from Shanghai Yiye Biotechnology Co., Ltd., with the brand name Yi-act-007.
  • This example provides an essence containing the skin care composition for repairing skin.
  • the preparation raw materials of the essence include 10% of the skin repairing composition for skin repairing, 35% thickener, and 0.02% by weight.
  • the thickener is a glycerol acrylate/acrylic acid copolymer, purchased from Shanghai Zhaoxin Chemical Co., Ltd., with the brand name SJgel MSF.
  • the chelating agent is disodium ethylenediaminetetraacetic acid with CAS number 139-33-3.
  • the skin conditioning agent is composed of 0.5 parts of dipeptide diaminobutyrylbenzylamide diacetate, 1 part of acetyl hexapeptide-8, and 2 parts of Cladosporium seastarii extract in parts by weight.
  • the dipeptide diaminobutyrylbenzylamide diacetate has a CAS number of 823202-99-9.
  • the CAS number of the acetyl hexapeptide-8 is 616204-22-9.
  • the Starfish Cladosporium extract was purchased from Shanghai Xi'an Biological Technology Co., Ltd., and the brand was L-50.
  • the humectant is composed of 4 parts of methyl propylene glycol and 1 part of 1,3-propanediol in parts by weight.
  • the CAS number of the methyl propylene glycol is 2163-42-0.
  • the 1,3-propanediol was purchased from Shanghai Haoyun Chemical Co., Ltd., and the brand was PHL.
  • the emollient is PEG-7 olive oil sodium carboxylate, the CAS number is 226416-05-3.
  • the solubilizer was purchased from Shanghai Miaosen Chemical Technology Co., Ltd., and the brand was LRI.
  • the fragrance is a fragrance, purchased from Le Erfu (Shanghai) Fragrance Co., Ltd.
  • This example also provides a preparation method of the essence, including the following steps:
  • step (2) The temperature of the first mixture in step (1) is lowered to 50° C., a humectant is added, and the mixture is stirred uniformly under a vacuum of 30 Hz and -0.04 MPa, and the temperature is lowered to obtain a second mixture;
  • step (2) the second mixture is cooled to 40° C., the other components of the composition and the skin conditioning agent are added, and the mixture is stirred uniformly under a vacuum of -0.04 MPa at 30 Hz, and the temperature is lowered to obtain a third mixture;
  • step (3) After the solubilizer and the fragrance are uniformly mixed, they are added to the third mixture described in step (3), stirred uniformly at 25 Hz, taken and tested, and discharged after being qualified.
  • Example 3 of the present invention provides a skin care composition for restoring skin.
  • the preparation materials of the skin care composition include 3 parts lotus seed fermentation liquid, 0.5 parts yeast extract, 2 parts turmeric gel, and 2 parts by weight.
  • the lotus seed fermentation liquid was purchased from Shanghai Yanzhen Industrial Co., Ltd.
  • the yeast extract was purchased from Shanghai Ruimu Chemical Technology Co., Ltd., with the brand name SRC.
  • the turmeric gel was purchased from Shanghai Ronghai Biological Technology Co., Ltd.
  • the succinyl chitosan was purchased from Shanghai Oulong Biotechnology Co., Ltd.
  • the carbohydrate derivatives were purchased from Shanghai Weight Enkai Industrial Co., Ltd., with the brand name C-MOIST.
  • the schizophyllin was purchased from Shanghai Yiye Biotechnology Co., Ltd., with the brand name Yi-act-007.
  • the composite humectant was purchased from Shanghai Yiye Biotechnology Co., Ltd., and the brand was Yi-301.
  • This example provides an essence containing the skin-repairing skin care composition.
  • the preparation of the essence includes 15% of the skin-repairing skin care composition, 35% thickener, and 0.02% by weight.
  • the thickener is a glycerol acrylate/acrylic acid copolymer, purchased from Shanghai Zhaoxin Chemical Co., Ltd., with the brand name SJgel MSF.
  • the chelating agent is disodium ethylenediaminetetraacetic acid with CAS number 139-33-3.
  • the skin conditioning agent is composed of 0.5 parts of dipeptide diaminobutyrylbenzylamide diacetate, 1 part of acetyl hexapeptide-8, and 2 parts of Cladosporium seastarii extract in parts by weight.
  • the dipeptide diaminobutyrylbenzylamide diacetate has a CAS number of 823202-99-9.
  • the CAS number of the acetyl hexapeptide-8 is 616204-22-9.
  • the Starfish Cladosporium extract was purchased from Shanghai Xi'an Biological Technology Co., Ltd., and the brand was L-50.
  • the humectant is composed of 4 parts of methyl propylene glycol and 1 part of 1,3-propanediol in parts by weight.
  • the CAS number of the methyl propylene glycol is 2163-42-0.
  • the 1,3-propanediol was purchased from Shanghai Haoyun Chemical Co., Ltd., and the brand was PHL.
  • the emollient is PEG-7 olive oil sodium carboxylate, the CAS number is 226416-05-3.
  • the solubilizer was purchased from Shanghai Miaosen Chemical Technology Co., Ltd., and the brand was LRI.
  • the fragrance is a fragrance, purchased from Le Erfu (Shanghai) Fragrance Co., Ltd.
  • This example also provides a preparation method of the essence, including the following steps:
  • step (2) The temperature of the first mixture in step (1) is lowered to 50° C., a humectant is added, and the mixture is stirred uniformly under a vacuum of 30 Hz and -0.04 MPa, and the temperature is lowered to obtain a second mixture;
  • step (2) the second mixture is cooled to 40° C., the other components of the composition and the skin conditioning agent are added, and the mixture is stirred uniformly under a vacuum of -0.04 MPa at 30 Hz, and the temperature is lowered to obtain a third mixture;
  • step (3) After the solubilizer and the fragrance are uniformly mixed, they are added to the third mixture described in step (3), stirred uniformly at 25 Hz, taken and tested, and discharged after being qualified.
  • Example 4 of the present invention provides a skin care composition for repairing skin.
  • the preparation raw materials of the skin care composition include 2.5 parts of lotus seed fermentation liquid, 0.6 parts of yeast extract, 1.3 parts of turmeric gel, and 1.3 parts by weight.
  • the lotus seed fermentation liquid was purchased from Shanghai Yanzhen Industrial Co., Ltd.
  • the yeast extract was purchased from Shanghai Ruimu Chemical Technology Co., Ltd., with the brand name SRC.
  • the turmeric gel was purchased from Shanghai Ronghai Biological Technology Co., Ltd.
  • the succinyl chitosan was purchased from Shanghai Oulong Biotechnology Co., Ltd.
  • the carbohydrate derivatives were purchased from Shanghai Weight Enkai Industrial Co., Ltd., with the brand name C-MOIST.
  • the schizophyllin was purchased from Shanghai Yiye Biotechnology Co., Ltd., with the brand name Yi-act-007.
  • the composite humectant was purchased from Shanghai Yiye Biotechnology Co., Ltd., and the brand was Yi-301.
  • This example provides an essence containing the skin care composition for repairing skin.
  • the preparation of the essence includes 12% of the skin repairing composition for skin repairing, 30% thickener, and 0.01% by weight.
  • the thickener is a glycerol acrylate/acrylic acid copolymer, purchased from Shanghai Zhaoxin Chemical Co., Ltd., with the brand name SJgel MSF.
  • the chelating agent is disodium ethylenediaminetetraacetic acid with CAS number 139-33-3.
  • the skin conditioning agent is composed of 0.3 parts of dipeptide diaminobutyrylbenzylamide diacetate, 0.9 parts of acetyl hexapeptide-8, and 1.8 parts of Cladosporium sea star extract in parts by weight.
  • the dipeptide diaminobutyrylbenzylamide diacetate has a CAS number of 823202-99-9.
  • the CAS number of the acetyl hexapeptide-8 is 616204-22-9.
  • the Starfish Cladosporium extract was purchased from Shanghai Xi'an Biological Technology Co., Ltd., and the brand was L-50.
  • the humectant is composed of 3.2 parts of methyl propylene glycol and 0.8 parts of 1,3-propanediol in parts by weight.
  • the CAS number of the methyl propylene glycol is 2163-42-0.
  • the 1,3-propanediol was purchased from Shanghai Haoyun Chemical Co., Ltd., and the brand was PHL.
  • the emollient is PEG-7 olive oil sodium carboxylate, the CAS number is 226416-05-3.
  • the solubilizer was purchased from Shanghai Miaosen Chemical Technology Co., Ltd., and the brand was LRI.
  • the fragrance is a fragrance, purchased from Le Erfu (Shanghai) Fragrance Co., Ltd.
  • This example also provides a preparation method of the essence, including the following steps:
  • step (2) The temperature of the first mixture in step (1) is reduced to 45° C., a humectant is added, and the mixture is stirred uniformly under a vacuum of 28 Hz and -0.03 MPa, and the temperature is lowered to obtain a second mixture;
  • step (2) the second mixture is cooled to 30°C, the other components of the composition and the skin conditioner are added, and the mixture is stirred uniformly under a vacuum of -0.03MPa at 25 Hz, and the temperature is lowered to obtain a third mixture;
  • step (3) After the solubilizer and the fragrance are uniformly mixed, they are added to the third mixture described in step (3), stirred uniformly at 22 Hz, and the material is taken and tested, and the material is discharged after being qualified.
  • Example 5 of the present invention provides a skin care composition for repairing skin.
  • the preparation raw materials of the skin care composition include 3.5 parts of lotus seed fermentation liquid, 0.35 parts of yeast extract, 2.9 parts of turmeric gel, and 2.7 parts by weight.
  • the lotus seed fermentation liquid was purchased from Shanghai Yanzhen Industrial Co., Ltd.
  • the yeast extract was purchased from Shanghai Ruimu Chemical Technology Co., Ltd., with the brand name SRC.
  • the turmeric gel was purchased from Shanghai Ronghai Biological Technology Co., Ltd.
  • the succinyl chitosan was purchased from Shanghai Oulong Biotechnology Co., Ltd.
  • the carbohydrate derivatives were purchased from Shanghai Weight Enkai Industrial Co., Ltd., with the brand name C-MOIST.
  • the schizophyllin was purchased from Shanghai Yiye Biotechnology Co., Ltd., with the brand name Yi-act-007.
  • the composite moisturizer was purchased from Shanghai Yiye Biotechnology Co., Ltd., and the brand was Yi-301.
  • This example provides an essence containing the skin care composition for repairing skin.
  • the preparation raw materials of the essence include 19% of the skin repairing composition for skin repairing, 40% thickener, and 0.05% by weight.
  • the thickener is a glycerol acrylate/acrylic acid copolymer, purchased from Shanghai Zhaoxin Chemical Co., Ltd., with the brand name SJgel MSF.
  • the chelating agent is disodium ethylenediaminetetraacetic acid with CAS number 139-33-3.
  • the skin conditioner is composed of 0.8 parts of dipeptide diaminobutyrylbenzylamide diacetate, 1.7 parts of acetyl hexapeptide-8, and 2.5 parts of Cladosporium sea star extract in parts by weight.
  • the dipeptide diaminobutyrylbenzylamide diacetate has a CAS number of 823202-99-9.
  • the CAS number of the acetyl hexapeptide-8 is 616204-22-9.
  • the starfish Cladosporium extract was purchased from Shanghai Xi'an Biological Technology Co., Ltd., and the brand was L-50.
  • the moisturizer is composed of 2 parts of methyl propylene glycol and 5 parts of 1,3-propanediol in parts by weight.
  • the CAS number of the methyl propylene glycol is 2163-42-0.
  • the 1,3-propanediol was purchased from Shanghai Haoyun Chemical Co., Ltd., and the brand was PHL.
  • the emollient is PEG-7 olive oil sodium carboxylate, the CAS number is 226416-05-3.
  • the solubilizer was purchased from Shanghai Miaosen Chemical Technology Co., Ltd., and the brand was LRI.
  • the fragrance is a fragrance, purchased from Le Erfu (Shanghai) Fragrance Co., Ltd.
  • This example also provides a preparation method of the essence, including the following steps:
  • step (2) The temperature of the first mixture in step (1) is lowered to 55° C., a humectant is added, and the mixture is stirred uniformly under a vacuum of 33 Hz and -0.04 MPa, and the temperature is lowered to obtain a second mixture;
  • step (3) The second mixture in step (2) is cooled to 40°C, the other components of the composition and the skin conditioning agent are added, and the mixture is stirred uniformly under a vacuum of 33 Hz and -0.04 MPa, and the temperature is lowered to obtain a third mixture;
  • step (3) After the solubilizer and fragrance are uniformly mixed, they are added to the third mixture described in step (3), stirred uniformly at 27 Hz, and the material is taken and tested, and the material is discharged after being qualified.
  • Example 6 of the present invention provides a skin care composition for repairing skin, and its specific implementation is the same as that of Example 3, except that the raw material for preparing the composition does not include fermented lotus seeds.
  • This example provides an essence containing the skin care composition for repairing skin.
  • the specific implementation is the same as that in Example 3, except that the weight percentage of the composition is 12%.
  • Example 7 of the present invention provides a skin care composition for repairing skin, and its specific implementation is the same as that of Example 3, except that the raw material for preparing the composition does not include yeast extract.
  • This example provides an essence containing the skin care composition for repairing skin.
  • the specific implementation is the same as that in Example 3, except that the weight percentage of the composition is 14.5%.
  • Example 8 of the present invention provides a skin care composition for repairing skin.
  • the specific implementation is the same as that of Example 3, except that the raw material of the composition does not include turmeric gel.
  • This example provides an essence containing the skin care composition for repairing skin.
  • the specific implementation is the same as in Example 3, except that the weight percentage of the composition is 13%.
  • Example 9 of the present invention provides a skin care composition for repairing skin.
  • the specific implementation is the same as that of Example 3, except that the lotus seed fermentation liquid is 6 parts by weight.
  • This example provides an essence containing the skin care composition for repairing skin.
  • the specific implementation is the same as that in Example 3, except that the weight percentage of the composition is 18%.
  • Example 10 of the present invention provides a skin care composition for repairing skin.
  • the specific implementation is the same as that of Example 3, except that the weight part of the yeast extract is 3.5 parts by weight.
  • This example provides an essence containing the skin care composition for repairing skin.
  • the specific implementation is the same as that in Example 3, except that the weight percentage of the composition is 18%.
  • Example 11 of the present invention provides a skin care composition for repairing skin, and its specific implementation is the same as that of Example 3, except that the weight of the turmeric gel is 5 parts by weight.
  • This example provides an essence containing the skin care composition for repairing skin.
  • the specific implementation is the same as that in Example 3, except that the weight percentage of the composition is 18%.
  • Example 12 of the present invention provides a skin care composition for restoring skin.
  • the specific implementation is the same as that of Example 3, except that the raw material for the composition does not include succinyl chitosan.
  • This example provides an essence containing the skin care composition for repairing skin.
  • the specific implementation is the same as in Example 3, except that the weight percentage of the composition is 13%.
  • Example 13 of the present invention provides a skin care composition for repairing skin.
  • the specific implementation is the same as that of Example 3, except that the raw materials for the composition do not include sugar derivatives.
  • This example provides an essence containing the skin care composition for repairing skin.
  • the specific implementation is the same as that of Example 3, except that the weight percentage of the composition is 14%.
  • Example 14 of the present invention provides a skin care composition for repairing skin, and its specific implementation is the same as that of Example 3, except that the weight part of the succinyl chitosan is 5 parts by weight.
  • This example provides an essence containing the skin care composition for repairing skin.
  • the specific implementation is the same as that in Example 3, except that the weight percentage of the composition is 18%.
  • Example 15 of the present invention provides a skin care composition for repairing skin.
  • the specific implementation is the same as that of Example 3, except that the raw material for the composition does not include schizophyllin.
  • This example provides an essence containing the skin care composition for repairing skin.
  • the specific implementation is the same as in Example 3, except that the weight percentage of the composition is 13.5%.
  • Example 16 of the present invention provides a skin care composition for repairing skin.
  • the specific implementation is the same as that of Example 3, except that the weight part of the composite moisturizer is 1 part by weight.
  • This example provides an essence containing the skin care composition for repairing skin.
  • the specific implementation is the same as that of Example 3, except that the weight percentage of the composition is 11%.
  • Example 17 of the present invention provides an essence.
  • the specific implementation is the same as that of Example 3.
  • the difference is that the preparation raw material of the essence does not include the skin care composition for repairing skin.
  • Sensitivity test The essences provided in Examples 1-16 are subjected to sensitivity test.
  • the specific test method is as follows: Individuals with oily skin and sensitive skin are selected for patch test. The skin of the subject should not have scars. Scars or excessive hair, a known history of severe allergies or severe allergies to cosmetics can not participate; and use the essence provided in Examples 1-16, respectively, to evaluate the sensitivity of the skin of the test site of people with oily skin and sensitive skin
  • the evaluation indicators are: itching, tightness, irritation, redness, dryness, inflammation, and are divided into 0 to 4 levels.
  • the index levels are as follows: 0 level: no sensitive reaction; level 1: dry skin, slightly itching ; Grade 2: slight redness of the skin and increased pruritus; Grade 3: weak erythema, a small amount of red blood streaks; Grade 4: massive erythema, a lot of red blood streaks, inflammation, the results are shown in Table 1.
  • Heat resistance test Put the sample in an electric heating constant temperature incubator at (50 ⁇ 1)°C for 24h, and observe whether there is any thinning, discoloration, delamination and hardness change after returning to room temperature to judge the heat resistance of the sample performance;
  • Centrifugal test Put the sample in a centrifuge and test for 30 minutes at a speed of (2000 ⁇ 4000) r/min to observe the separation and stratification of the sample to judge the mechanical stability of the sample.
  • the samples are rated according to the phenomenon of thinning, discoloration, delamination and hardness changes before and after the test, and are divided into 0 to 4 levels, of which 0 is no thinning, discoloration, delamination and hardness changes, and 1 is slight thinning , Discoloration, no delamination and hardness change, level 2 is increased discoloration and thinning, no delamination, slightly changed hardness, level 3 is slightly delamination, hardness change increased, level 4 is obvious delamination And the hardness changes, the heat resistance, cold resistance and mechanical stability of the composition are obtained. The results are shown in Table 1.
  • Example 3 The essence provided in Example 3 is a light yellow transparent gel-like uniform liquid
  • Example 3 The essence provided in Example 3 was tested according to the GB T13531.4-2013 relative density measurement method, and the relative density was 1.01g/cm 3 at 20°C using a densitometer;
  • Example 14 Level 5 Level 3 level 4 Level 5
  • Example 15 level 4 Level 3 level 4 level 4
  • Example 16 Level 5 level 4 level 4 Level 5
  • the skin care composition for repairing skin provided by the present invention has high heat resistance, cold resistance and mechanical resistance, and will not cause irritation to the skin, and is very sensitive to sensitive skin and oily skin. It is also suitable for high-quality people; it can be used in a variety of skin care products, with excellent fast whitening, long-term moisturizing, wrinkle removal, and anti-aging effects.

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Abstract

一种修复肌肤用护肤组合物及其制备方法。所述护肤组合物的制备原料包括莲子发酵液、酵母提取物和姜黄凝胶。所述修复肌肤用护肤组合物具有高的耐热、耐寒和耐机械稳定性，且不会对皮肤造成刺激，对油性和敏感肤质也同样适用；可应用于多种护肤品中，具有优异的快速美白、长期保湿、祛皱、抗衰老的效果。

Description

一种修复肌肤用护肤组合物及其制备方法 技术领域
本发明涉及护肤品领域，更具体地，本发明涉及一种修复肌肤用护肤组合物及其制备方法。
背景技术
随着经济的发展，和越来越快的工作、生活节奏，使得精神压力增加，加上不良的生活习惯、日趋严重的环境污染、紫外线、灰尘对皮肤的伤害更加重了皮肤的老化，越来越多的人都被干燥、发红、皱纹、敏感、粗糙、没弹性、肤色松弛、毛孔粗大等皮肤状况紊乱的综合问题困扰，为了保持良好的面貌，广大消费者越来越重视皮肤的保养，这也对护肤品提出了新的挑战。
市面上的护肤产品类型多种多样，如保湿水、防晒霜等。但是，很多消费者需要的是一种具有综合功能，能对皮肤作整体改善的护肤品，而目前这类护肤品的性能较差。故本发明提供一种修复肌肤用护肤组合物，可应用在护肤品中，具有高的耐热、耐寒和机械稳定性，且不会对皮肤造成刺激，可适用于各种肤质的人群，具有优异的美白、保湿、祛皱的功效。
发明内容
为了解决上述问题，本发明第一个方面提供了一种修复肌肤用护肤组合物，所述护肤组合物的制备原料包括莲子发酵液、酵母提取物和姜黄凝胶。
作为本发明一种优选的技术方案，所述莲子发酵液、姜黄凝胶和酵母提取物的重量比为3：(1.5～2.5)：(0.3～0.8)。
作为本发明一种优选的技术方案，所述护肤组合物还包括琥珀酰壳聚糖、糖类衍生物和裂裥菌素。
作为本发明一种优选的技术方案，所述糖类衍生物包括甘油葡糖苷、木糖醇基葡糖苷、脱水木糖醇、果糖和木糖醇。
作为本发明一种优选的技术方案，所述琥珀酰壳聚糖和糖类衍生物的重量比为(1.5～2.3)：1。
作为本发明一种优选的技术方案，所述护肤组合物的制备原料还包括复合保湿剂；所述复合保湿剂包括透明质酸钠、聚谷氨酸钠和银耳多糖。
作为本发明一种优选的技术方案，所述裂裥菌素、莲子发酵液和复合保湿剂 的重量比为1：(1.5～2.5)：(2.5～4.5)。
本发明第二个方面提供了一种所述修复肌肤用护肤组合物的应用，应用于护肤品中；所述护肤品选自水剂、乳液、面霜、眼霜、面膜、BB霜、精华液、精华露、防晒霜、防晒水、痤疮水、粉刺露、精油、香波，保湿水、爽肤水、收敛水、柔肤水中的一种或多种。
作为本发明一种优选的技术方案，所述护肤品为精华液；所述精华液的制备原料按质量百分数计，包括6～19％所述修复肌肤用护肤组合物、30～40％增稠剂、0～0.05％螯合剂、3～5％皮肤调理剂、4～7％保湿剂、0～0.2％润肤剂、0～0.1％增溶剂、0～0.05％芳香剂和余量去离子水。
本发明第三个方面提供了一种精华液的制备方法所述精华液的制备原料按质量百分数计，包括6～19％所述修复肌肤用护肤组合物、30～40％增稠剂、0～0.05％螯合剂、3～5％皮肤调理剂、4～7％保湿剂、0～0.2％润肤剂、0～0.1％增溶剂、0～0.05％芳香剂和余量去离子水；
所述精华液的制备方法包括如下步骤：
(1)将去离子水、螯合剂和增稠剂搅拌并加热至75～85℃；
(2)将步骤(1)得到的混合物降温至45～55℃，加入保湿剂，并搅拌；
(3)将步骤(2)得到的混合物降温至30～40℃，加入除复合保湿剂外所述护肤组合物的其他组分和皮肤调理剂，并搅拌；
(4)将步骤(3)得到的混合物降温后，加入增溶剂和芳香剂的混合物并搅拌，取料检测合格后得到所述精华液。
本发明与现有技术相比具有以下有益效果：本发明提供一种修复肌肤用护肤组合物，通过莲子发酵液、酵母提取物和姜黄凝胶的复配，可以起到快速美白、祛皱的作用，且不会对皮肤产生刺激作用；另外，通过在本发明所述护肤组合物中添加琥珀酰壳聚糖、糖类衍生物和裂裥菌素，在提高保湿功能的同时，也可提高所述组合物的稳定性，同时进一步修补皮肤损伤、促进美白抗皱的性能；且通过添加复合保湿剂，在促进本发明所述护肤组合物的综合性能的同时，可以进一步延长保质期；此外，本发明所述修复肌肤用护肤组合物可用于多种护肤品中。
具体实施方式
参选以下本发明的优选实施方法的详述以及包括的实施例可更容易地理解 本发明的内容。除非另有限定，本文使用的所有技术以及科学术语具有与本发明所属领域普通技术人员通常理解的相同的含义。当存在矛盾时，以本说明书中的定义为准。
如本文所用术语“由…制备”与“包含”同义。本文中所用的术语“包含”、“包括”、“具有”、“含有”或其任何其它变形，意在覆盖非排它性的包括。例如，包含所列要素的组合物、步骤、方法、制品或装置不必仅限于那些要素，而是可以包括未明确列出的其它要素或此种组合物、步骤、方法、制品或装置所固有的要素。
连接词“由…组成”排除任何未指出的要素、步骤或组分。如果用于权利要求中，此短语将使权利要求为封闭式，使其不包含除那些描述的材料以外的材料，但与其相关的常规杂质除外。当短语“由…组成”出现在权利要求主体的子句中而不是紧接在主题之后时，其仅限定在该子句中描述的要素；其它要素并不被排除在作为整体的所述权利要求之外。
当量、浓度、或者其它值或参数以范围、优选范围、或一系列上限优选值和下限优选值限定的范围表示时，这应当被理解为具体公开了由任何范围上限或优选值与任何范围下限或优选值的任一配对所形成的所有范围，而不论该范围是否单独公开了。例如，当公开了范围“1至5”时，所描述的范围应被解释为包括范围“1至4”、“1至3”、“1至2”、“1至2和4至5”、“1至3和5”等。当数值范围在本文中被描述时，除非另外说明，否则该范围意图包括其端值和在该范围内的所有整数和分数。
单数形式包括复数讨论对象，除非上下文中另外清楚地指明。“任选的”或者“任意一种”是指其后描述的事项或事件可以发生或不发生，而且该描述包括事件发生的情形和事件不发生的情形。
说明书和权利要求书中的近似用语用来修饰数量，表示本发明并不限定于该具体数量，还包括与该数量接近的可接受的而不会导致相关基本功能的改变的修正的部分。相应的，用“大约”、“约”等修饰一个数值，意为本发明不限于该精确数值。在某些例子中，近似用语可能对应于测量数值的仪器的精度。在本申请说明书和权利要求书中，范围限定可以组合和/或互换，如果没有另外说明这些范围包括其间所含有的所有子范围。
此外，本发明要素或组分前的不定冠词“一种”和“一个”对要素或组分的数量 要求(即出现次数)无限制性。因此“一个”或“一种”应被解读为包括一个或至少一个，并且单数形式的要素或组分也包括复数形式，除非所述数量明显旨指单数形式。
以下通过具体实施方式说明本发明，但不局限于以下给出的具体实施例。
本发明第一个方面提供了一种修复肌肤用护肤组合物，所述护肤组合物的制备原料包括莲子发酵液、酵母提取物和姜黄凝胶。
在一种实施方式中，本发明所述莲子发酵液、姜黄凝胶和酵母提取物的重量比为3：(1.5～2.5)：(0.3～0.8)。
莲子发酵液
本发明所述莲子发酵液采用活莲去皮生萃然后发酵的方法，最大层度的保持莲子的活性，有利于活化表皮细胞、加速角质细胞新陈代谢、促进黑色素排出、改善肌肤纹理、修复色素沉着。
本发明所述莲子发酵液可以购买或者自制，制备方法包括以下步骤：将莲子去芯，并在水中磨浆后，加热到85～90℃，并加入蔗糖、脱脂乳粉和羧甲基纤维素钠进行均质处理，杀菌后冷却至45℃以下进行接种，并进行恒温发酵得到所述莲子发酵液。
在一种优选的实施方式中，本发明所述莲子发酵液购自上海言臻实业有限公司。
酵母提取物
本发明所述酵母提取物是酵母经破壁后将其中蛋白质、核酸、维生素等抽提，再经生物酶解等方法提取出的富含小分子的氨基酸、肽、核苷酸、维生素等天然活性成分。在化妆品中具有抗衰老、保湿锁水和亮肤等功效。氨基酸是皮肤角质层中自然保湿因子(NMF)的主要成分，易被皮肤吸收，使老化的表皮恢复弹性，延缓皮肤衰老。核酸及核苷酸是人体的主要遗传物质，具有促进新陈代谢、提高蛋白质合成速度等作用，增强免疫机能、增强SOD活性，提高皮肤抗自由基能力。葡萄糖等多糖类物质是天然的保湿剂，某些多糖成分(β葡聚糖)还有消炎的效果。酵母提取物可以促进含黑色素角质细胞的新陈代谢，加速角质脱落，促进合成表皮层蛋白质，改善肌肤质地，提亮肤色。此外，酵母提取物中少量的维生素和矿物质等营养元素还可以为皮肤提供充足的营养。
本发明所述酵母提取物还包含大豆氨基酸类成分。
在一种优选的实施方式中，本发明所述酵母提取物购自上海瑞慕化工科技有限公司，牌号为SRC。
姜黄凝胶
本发明所述姜黄凝胶包括姜黄根提取物。姜黄根提取物来源于姜科植物姜黄的干燥根茎。含挥发油，油中主成分为姜黄酮，芳姜黄酮和姜烯等；黄色物质为姜黄素，并含脱甲氧基姜黄素，双脱甲氧基姜黄素，二氢姜黄素等。具有降血压、降血脂、利胆、抗菌、抗炎和抗氧化等作用。其中，姜黄素一种非常重要的色素化合物，可防止食品中亚油酸自动氧化，并有防癌、抗癌功能。通过使用含有姜黄根提取物的姜黄凝胶，不仅具有优异的抗氧化和润肤的功效，还可促进即时止痒舒缓，减少不同原料之间因配伍问题引起的敏感问题。
本发明所述姜黄凝胶中还含有少量乳酸杆菌发酵产物、丁二醇、1,2-己二醇。
在一种优选的实施方式中，本发明所述姜黄凝胶购自上海容海生物科技有限公司。
莲子发酵液和酵母提取物中含有大量的小分子氨基酸、破碎植物细胞和发酵所得的氨基酸衍生物等成分，由于这些成分大都能参与到肌肤细胞的新陈代谢，而且容易被吸收，因此能够快速被肌肤细胞组织吸收，协助清除老化的片状肌肤，有效刺激肌肤角质层和细胞的更新，延缓老化。但是由于上述组分中成分复杂，而且其中保留有发酵菌种、微生物等活性成分，也即上述莲子发酵液和酵母提取物等成分一直处于动态反应过程，其结构和功效均不稳定。且由于其成分复杂又容易被吸收，因此很容易使肌肤产生很强的应激反应，出现红肿、过敏等现象。姜黄凝胶由于姜黄凝胶中含有姜黄素等成分，含有大量的多酚结构，具有强烈的抗氧化能力、俘获自由基能力，使组合物具有很好的美白，抗衰老等功效。但是由于其独特的结构，其对有痘痘、伤口等的肌肤有较大的刺激，容易使伤口渗血，刺激伤口，不易使其愈合。而且，由于其胶状结构与内皮组织之间的接触不易，向皮肤内部渗透和被吸收的速度慢，功效发挥周期长且不显著。
申请人发现当采用重量比例为3：(1.5～2.5)：(0.3～0.8)的莲子发酵液、姜黄凝胶和酵母提取物时，组合物对肌肤的刺激和过敏等副作用得到有效的避免，甚至对敏感肤质、油性肤质等特殊肤质人群不产生任何过敏等副作用的同时，还 能快速美白，减退红印和暗疮印等。这可能是由于莲子发酵液和酵母提取物能够快速接触肌肤，软化角质层，可逆性改变肌肤结构来渗透进肌肤内部，降低姜黄凝胶经过角质层等过程中所受到的阻力，有效提高姜黄凝胶的渗透性和被吸收速度。与此同时莲子发酵液和酵母提取物中的复杂成分能够被姜黄凝胶的凝胶结构包覆起来，随着皮肤细胞的吸收而缓慢释放，避免高浓度的护肤组合物直接与肌肤接触，从而导致肌肤的应激反应，出现过敏、红肿等问题。
在一种优选的实施方式中，本发明所述护肤组合物还包括琥珀酰壳聚糖、糖类衍生物和裂裥菌素。
琥珀酰壳聚糖
本发明所述琥珀酰壳聚糖是一种源于海洋生物所含壳聚糖的酰化衍生物，具有非常好的生物相容性，它不仅继承了壳聚糖的生物降解性、成膜性和细胞亲和性等许多独特的物理化学性质，而且改变了壳聚糖不溶于水、不溶于普通有机溶剂的缺点，是一种天然有效的保湿剂，其分子结构中含有羟基、羧基等亲水集团，可以与水分子结合，从而具有良好的吸湿和保湿性能。琥珀酰壳聚糖还具有成膜性，加入到化妆品配方中，可对皮肤发挥保水作用，增加皮肤角质层的水分使皮肤滋润光滑、细腻柔软且富有弹性，且具有强修复作用，有利于受损细胞的修复和生长。
优选地，本发明所述琥珀酰壳聚糖为脱乙酰壳多糖单琥珀酰胺。
在一种优选的实施方式中，本发明所述琥珀酰壳聚糖购自上海欧融生物科技有限公司。
糖类衍生物
本发明中的所述糖类衍生物由多种糖醇、糖苷复配而成的复合组分，由于这些成分的特殊结构，对水和油脂均具有很好的亲附性，能够激活毛细孔吸收并保持内皮中的水分。
优选地，本发明所述糖类衍生物包括甘油葡糖苷、木糖醇基葡糖苷、脱水木糖醇、果糖和木糖醇。
更优选地，本发明所述琥珀酰壳聚糖和糖类衍生物的重量比为(1.5～2.3)：1。
进一步优选地，本发明所述琥珀酰壳聚糖和糖类衍生物的重量比为2：1。
在一种优选的实施方式中，本发明所述糖类衍生物购自上海砝恩恺实业有限公司，牌号为C-MOIST。
裂裥菌素
本发明所述裂裥菌素是一种源于裂裥菌的胞外多糖，天然水溶性，在水溶液中呈三螺旋刚性棒状构象，三螺旋的构象使其能够被皮肤免疫细胞上的特异性受体dectin-1所识别而结合诱导并使dectin-1受体聚集，诱导下游的活性氧以及促炎因子的表达，从而发挥免疫细胞的生物学效应，使免疫细胞表面受体串联起来形成突触，促使免疫细胞的下游免疫信号通路通过SRC和SYK家族激酶的作用迅速传递，也就使皮肤中的免疫细胞的免疫能力得到充分发挥，调节以及增强皮肤组织以及皮肤各种细胞的整体免疫力水平，使得皮肤的免疫力得到提高，皮肤自身抵抗能力也就得到增强，实际上皮肤的修复能力以及抗炎能力也会得到极大增强。绝大多数的皮肤问题如皮肤的炎症、过敏性皮炎、丘疹、日晒性灼伤、日晒斑、日常皮肤老化造成的色斑和皱纹、激素性皮炎、皮肤红血丝等也可得到解决或者缓解。
本发明所述裂裥菌素可购买或自制，制备方法包括如下步骤：将裂裥菌素用超声波降解后，经溶剂分级沉淀获得，所述溶剂可以列举的有：乙醇、甲醇、异丙醇、异丁醇、正己醇、甲基戊醇、2-乙基丁醇、正辛醇等醇类；甘油、乙二醇、乙二醇单甲基醚、乙二醇单乙基醚、丙二醇、丙二醇单甲基醚、丙二醇单乙基醚、三甘醇、1,3-丁二醇、己二醇、戊二醇等多元醇或其衍生物；丙酮、甲基乙基酮、甲基异丁基酮、甲基正丙基酮等酮类；乙酸乙酯、乙酸异丙酯等酯类；乙醚、异丙醚、正丁醚等醚类；或者以上极性溶剂中的1种或2种以上的混合溶剂。
在一种优选的实施方式中，本发明所述裂裥菌素购自上海一也生物科技有限公司，牌号为Yi-act-007。
申请人发现当所述糖类衍生物与琥珀酰壳聚糖复配使用时，其补水保水效果得到显著的提高，而且经过复配之后组合物能够长期补水，还有助于皮肤的修补、抗皱、淡化表情纹。这可能是由于糖类衍生物和脱乙酰壳多糖单琥珀酰胺(琥珀酰壳聚糖)在结构上的互补，能够形成不同大小的空腔结构，并且利用其结构上的羟基、酰胺键等基团与水分子、其它有效成分之间的氢键、范德华力等作用力，将水分子包覆在这些空腔中，供细胞组织新陈代谢，保证肌肤的新陈代谢功能正 常运行。此外，由于糖类衍生物中的各成分与脱乙酰壳多糖单琥珀酰胺分子结构之间的差异，导致其往皮肤内部渗透的能力不相同，因此在透过表皮的角质层之后，不同的成分渗透到皮肤不同的层中，分别在角质层、透明层、颗粒层、有棘层，甚至在真皮层上参与到各层的细胞组织反应中，促进新细胞、胶原蛋白的合成，增加真皮层、表皮层的厚度，提高肌肤的弹性，同时修补损伤的肌肤，减少皱纹和老化。
此外，本发明中的裂襉菌素中主链为β-1,6-吡喃糖，每三个糖基中的一个糖基与一个β-1,6-吡喃糖连接的结构。由于结构上的特点，其能溶于水，并且与琥珀酰壳聚糖、糖类衍生物之间发生较强的作用力，容易与所吸收的水分一起渗透进皮肤内层，参与到细胞的新陈代谢，增强细胞的免疫力，促进伤口愈合。同时由于裂襉菌素与琥珀酰壳聚糖、糖类衍生物等成分之间较强的作用力，可以很好的分散在组合物体系中，避免因环境中温度等条件的改变而出现结块、絮凝等不稳定情况。
在一种优选的实施方式中，本发明所述护肤组合物的制备原料还包括复合保湿剂；所述复合保湿剂包括透明质酸钠、聚谷氨酸钠和银耳多糖。
复合保湿剂
本发明所述复合保湿剂包括透明质酸钠、聚谷氨酸钠、银耳多糖等成分，具有优异的保湿性能，搭配琥珀酰壳聚糖和糖类衍生物使用时，保湿效果更佳。
在一种优选的实施方式中，本发明所述复合保湿剂购自上海一也生物科技有限公司，牌号为Yi-301。
优选地，本发明所述裂裥菌素、莲子发酵液和复合保湿剂的重量比为1：(1.5～2.5)：(2.5～4.5)。
申请人发现在组合物中加入含有透明质酸钠、聚谷氨酸钠、银耳多糖等成分的复合保湿剂，可以显著改善组合物的高温稳定性，使得在高温或低温等极端环境中存放长时间不变质，且依然能起到很好的美白、深层保湿作用。可能是由于上述复合保湿剂易于吸收水分，而且由于其结构容易被皮肤组织吸收，容易渗透进皮肤组织中，有助于深层补水。同时在琥珀酰壳聚糖、糖类衍生物等之间的协同作用之下，复合保湿剂可以分布在琥珀酰壳聚糖、糖类衍生物等组分形成的空腔中，提高该组分与肌肤组织之间的亲附性和与肌肤细胞之间的反应，从而加快 组合物的透皮吸收。同时，在琥珀酰壳聚糖、糖类衍生物等组分形成的空腔中，复合保湿剂与裂襉菌素、莲子发酵液等成分之间发生较强的分子间作用力，提高裂襉菌素、莲子发酵液等成分的反应活性，也为这些成分与皮肤细胞组织之间的反应提供水等条件，从而使莲子发酵液、裂襉菌素等成分能够充分发挥作用，改善肌肤状态和弹性，抑制暗沉色素的生成与向上皮表面的移动。同时在裂裥菌素、莲子发酵液和复合保湿剂等组分的协同作用之下，将组合物中游离的微生物发酵菌种、破碎细胞等高活性成分包覆并液封起来，避免组合物滋生细菌造成相应的护肤品出现变质、发霉等问题。
本发明第二个方面提供一种所述修复肌肤用护肤组合物的应用，应用于护肤品中；所述护肤品选自水剂、乳液、面霜、眼霜、面膜、BB霜、精华液、精华露、防晒霜、防晒水、痤疮水、粉刺露、精油、香波，保湿水、爽肤水、收敛水、柔肤水中的一种或多种。
本发明所述乳液、面霜为液态霜类化妆品。本发明所述面膜是美容保养品的一种载体，包括但不限于泥膏型、撕拉型、冻胶型、湿纸巾型面膜。本发明所述BB霜即Blemish Balm，作用包括但不限于遮瑕、调整肤色、防晒、细致毛孔。本发明所述精华液、精华露是指包含浓缩的高营养物质的化妆品。本发明所述防晒霜为添加了能阻隔或吸收紫外线的防晒剂来达到防止肌肤被晒黑、晒伤的化妆品。本发明所述痤疮水为具有治疗痤疮功效的液态物质。本发明所述粉刺露为具有治疗粉刺功能的液态物质。
在一种优选的实施方式中，本发明所述护肤品为精华液；所述精华液的制备原料按质量百分数计，包括6～19％所述修复肌肤用护肤组合物、30～40％增稠剂、0～0.05％螯合剂、3～5％皮肤调理剂、4～7％保湿剂、0～0.2％润肤剂、0～0.1％增溶剂、0～0.05％芳香剂和余量去离子水。
本发明提供的精华液为无色至淡黄色透明啫哩状均匀液体，符合规定香气，pH值在5.8～6.8范围内，20℃下的相对密度为1.01±0.02g/cm 3。
本发明所述pH值是根据GB T13531.1-2008pH的测定方法，通过pH计测试得到。
本发明所述相对密度根据GB T13531.4-2013相对密度的测定方法，使用密度计测试得到。
增稠剂
优选地，本发明所述增稠剂选自丙烯酸酯、烷基甲基丙烯酸酯共聚物或其盐、羧基乙烯基聚合物或其盐、藻酸盐、藻酸的多元醇酯、聚乙烯吡咯烷酮、聚乙烯醇、丙烯酸钠、三聚磷酸钠、卡拉胶、卡波姆、甘油丙烯酸酯/丙烯酸共聚物、黄原胶和羟丙基纤维素中的一种或多种。
更优选地，本发明所述增稠剂为甘油丙烯酸酯/丙烯酸共聚物。
在一种优选的实施方式中，本发明所述增稠剂购自上海钊馨化学有限公司，牌号为SJgel MSF。
螯合剂
优选地，本发明所述螯合剂选自乙二胺四烷基酸钠盐、柠檬酸及其盐、磷酸盐、羟乙二膦酸及其盐中的一种或多种。
皮肤调理剂
优选地，本发明所述皮肤调理剂包括胜肽类和海星枝管藻提取物。
更优选地，本发明所述胜肽类包括二肽二氨基丁酰苄基酰胺二乙酸盐和乙酰基六肽-8。
本发明所述海星枝管藻提取物具有刺激细胞再生，强化肌肤屏障的作用，还具有舒缓的作用，结合它的抗氧化性，可用于皮肤调养；也可有效抑制透明质酸的分解，对皮肤起到保湿作用。
保湿剂
优选地，本发明所述保湿剂选自多元醇类、天然多糖类、亲水性合成高分子类、甜菜碱类保湿剂中的一种或多种。
作为多元醇类保湿剂的实例，包括但不限于，甘油、1,3-丙二醇、2-甲基-1,3-丙二醇、1,4-丁二醇、1,3-丁二醇、1,5-戊二醇、双甘油、赤藓醇、葡糖酸、1,2,6-己三醇、肌醇、乳糖醇、麦芽糖醇、甘露糖醇、木糖醇、海藻糖等。
作为天然多糖类保湿剂的实例，包括但不限于，透明质酸、乙酰透明质酸、肝素、聚葡糖醛酸、软骨素、硫酸软骨素、果胶以及适当情形下它们的碱金属盐。
作为亲水性合成高分子类保湿剂的实例，包括但不限于，聚(2-甲基丙烯酰氧基乙基磷酸胆碱)、聚(2-甲基丙烯酰氧基乙基磷酰基-CO-甲基丙烯酰胺)。
作为甜菜碱类保湿剂的实例，包括但不限于，甜菜碱及其衍生物、以及对应 的磺基甜菜碱(甜菜碱的羧基置换为磺基)的两性离子化合物所包含的任意化合物。可以列举的有，癸基甜菜碱、月桂基甜菜碱、肉豆蔻基甜菜碱、鲸蜡基甜菜碱、硬脂酰甜菜碱、山萮基甜菜碱、月桂酰胺丙基甜菜碱、油酰胺丙基甜菜碱、棕榈酰胺丙基甜菜碱、月桂基磺基甜菜碱、椰油基磺基甜菜碱、聚(甲基丙烯酰氧基乙基甜菜碱)、聚(甲基丙烯酰氧基乙基甜菜碱-共-2-羟乙基甲基丙烯酸)。
更优选地，本发明所述保湿剂为多元醇类保湿剂。
进一步优选地，本发明所述保湿剂为甲基丙二醇和1,3-丙二醇。
本发明所述1,3-丙二醇中还含有1,2-己二醇和辛酰羟肟酸，可作为多功能添加剂可用于护肤品中，具有保湿、润肤、抗敏、抗氧化及防腐作用。在一种优选的实施方式中，本发明所述1,3-丙二醇购自上海浩云化工有限公司，牌号为PHL。
润肤剂
优选地，本发明所述润肤剂选自环五聚二甲基硅氧烷、聚二甲基硅氧烷、环己硅氧烷、癸二酸二异丙酯、碳酸二辛酯、甘油三(乙基己酸)酯、异十二烷、异壬酸异壬酯、鲸蜡硬脂醇乙基己酸酯、霍霍巴籽油、角鲨烷、矿脂、PEG-7橄榄油羧酸钠中的一种或多种。
更优选地，本发明所述润肤剂为PEG-7橄榄油羧酸钠。
增溶剂
优选地，本发明所述增溶剂选自聚乙二醇-40氢化蓖麻油、聚乙二醇-60氢化蓖麻油、聚丙二醇-26、丁醇聚醚-26、聚氧丙烯-26-丁醇聚醚-26、聚氧丙烯-1-聚乙二醇-9月桂二醇醚、椰油醇聚氧乙烯醚-7、吐温20、司盘60中的一种或多种。
在一种优选的实施方式中，本发明所述增溶剂购自上海淼森化工科技有限公司，牌号为LRI(为聚乙二醇-40氢化蓖麻油和聚氧丙烯-26-丁醇聚醚-26的混合物)。
芳香剂
优选地，本发明所述芳香剂为香精和/或精油。
本发明第三个方面提供了一种精华液的制备方法所述精华液的制备原料按质量百分数计，包括6～19％所述修复肌肤用护肤组合物、30～40％增稠剂、0～ 0.05％螯合剂、3～5％皮肤调理剂、4～7％保湿剂、0～0.2％润肤剂、0～0.1％增溶剂、0～0.05％芳香剂和余量去离子水；
所述精华液的制备方法包括如下步骤：
(1)将去离子水、螯合剂和增稠剂搅拌并加热至75～85℃；
(2)将步骤(1)得到的混合物降温至45～55℃，加入保湿剂，并搅拌；
(3)将步骤(2)得到的混合物降温至30～40℃，加入除复合保湿剂外所述护肤组合物的其他组分和皮肤调理剂，并搅拌；
(4)将步骤(3)得到的混合物降温后，加入增溶剂和芳香剂的混合物并搅拌，取料检测合格后得到所述精华液。
在一种优选的实施方式中，本发明所述步骤(1)中所述去离子水、螯合剂和增稠剂在17～22Hz下搅拌。
在一种优选的实施方式中，本发明所述步骤(1)中加热至75～85℃后，加入所述复合保湿剂并搅拌。
在一种优选的实施方式中，本发明所述步骤(2)抽真空-0.03～-0.04MPa并降温至45～55℃,加入保湿剂；
在一种优选的实施方式中，本发明所述步骤(2)抽真空-0.03～-0.04MPa并降温至45～55℃,加入保湿剂，在28～33Hz、-0.03～-0.04MPa真空下搅拌。
在一种优选的实施方式中，本发明所述步骤(3)加入除复合保湿剂外所述组合物的其他组分和皮肤调理剂，在25～33Hz、-0.03～-0.04MPa真空下搅拌。
在一种优选的实施方式中，本发明所述步骤(4)加入增溶剂和芳香剂的混合物，在22～27Hz下搅拌。
实施例
下面通过实施例对本发明进行具体描述。有必要在此指出的是，以下实施例只用于对本发明作进一步说明，不能理解为对本发明保护范围的限制，该领域的专业技术人员根据上述本发明的内容做出的一些非本质的改进和调整，仍属于本发明的保护范围。
实施例1
本发明的实施例1提供一种修复肌肤用护肤组合物，所述护肤组合物的制备原料按重量份计，包括3份莲子发酵液、0.5份酵母提取物、2份姜黄凝胶。
所述莲子发酵液购自上海言臻实业有限公司。
所述酵母提取物购自上海瑞慕化工科技有限公司，牌号为SRC。
所述姜黄凝胶购自上海容海生物科技有限公司。
本例提供一种精华液，包含所述修复肌肤用护肤组合物，所述精华液的制备原料按重量百分数计，包括5.5％所述修复肌肤用护肤组合物、35％增稠剂、0.02％螯合剂、3.5％皮肤调理剂、5％保湿剂、0.05％润肤剂、0.03％增溶剂、0.01％芳香剂和余量去离子水。
所述增稠剂为甘油丙烯酸酯/丙烯酸共聚物，购自上海钊馨化学有限公司，牌号为SJgel MSF。
所述螯合剂为乙二胺四乙酸二钠，CAS号为139-33-3。
所述皮肤调理剂按重量份计，由0.5份二肽二氨基丁酰苄基酰胺二乙酸盐、1份乙酰基六肽-8、2份海星枝管藻提取物组成。
所述二肽二氨基丁酰苄基酰胺二乙酸盐，CAS号为823202-99-9。
所述乙酰基六肽-8的CAS号为616204-22-9。
所述海星枝管藻提取物购自上海熙安生物科技有限公司，牌号为L-50。
所述保湿剂按重量份计，由4份甲基丙二醇和1份1,3-丙二醇组成。
所述甲基丙二醇的CAS号为2163-42-0。
所述1,3-丙二醇购自上海浩云化工有限公司，牌号为PHL。
所述润肤剂为PEG-7橄榄油羧酸钠，CAS号为226416-05-3。
所述增溶剂购自上海淼森化工科技有限公司，牌号为LRI。
所述芳香剂为香精，购自乐尔福(上海)香精有限公司。
本例还提供所述精华液的制备方法，包括如下步骤：
(1)将去离子水、螯合剂、增稠剂在20Hz下搅拌并加热至80℃，抽真空-0.04MPa并搅拌降温得到第一混合物；
(2)步骤(1)所述第一混合物降温至50℃，加入保湿剂，在30Hz、-0.04MPa的真空下，搅拌均匀，并降温得到第二混合物；
(3)步骤(2)所述第二混合物降温至40℃，加入所述护肤组合物和皮肤调理剂，在30Hz、-0.04MPa真空下搅拌均匀，并降温得到第三混合物；
(4)将增溶剂和芳香剂混合均匀后，加入到步骤(3)所述第三混合物中， 在25Hz下搅拌均匀，取料检测，合格后出料。
实施例2
本发明的实施例2提供一种修复肌肤用护肤组合物，所述护肤组合物的制备原料按重量份计，包括3份莲子发酵液、0.5份酵母提取物、2份姜黄凝胶、2份琥珀酰壳聚糖、1份糖类衍生物、1.5份裂裥菌素。
所述莲子发酵液购自上海言臻实业有限公司。
所述酵母提取物购自上海瑞慕化工科技有限公司，牌号为SRC。
所述姜黄凝胶购自上海容海生物科技有限公司。
所述琥珀酰壳聚糖购自上海欧融生物科技有限公司。
所述糖类衍生物购自上海砝恩恺实业有限公司，牌号为C-MOIST。
所述裂裥菌素购自上海一也生物科技有限公司，牌号为Yi-act-007。
本例提供一种精华液，包含所述修复肌肤用护肤组合物，所述精华液的制备原料按重量百分数计，包括10％所述修复肌肤用护肤组合物、35％增稠剂、0.02％螯合剂、3.5％皮肤调理剂、5％保湿剂、0.05％润肤剂、0.03％增溶剂、0.01％芳香剂和余量去离子水。
所述增稠剂为甘油丙烯酸酯/丙烯酸共聚物，购自上海钊馨化学有限公司，牌号为SJgel MSF。
所述螯合剂为乙二胺四乙酸二钠，CAS号为139-33-3。
所述皮肤调理剂按重量份计，由0.5份二肽二氨基丁酰苄基酰胺二乙酸盐、1份乙酰基六肽-8、2份海星枝管藻提取物组成。
所述二肽二氨基丁酰苄基酰胺二乙酸盐，CAS号为823202-99-9。
所述乙酰基六肽-8的CAS号为616204-22-9。
所述海星枝管藻提取物购自上海熙安生物科技有限公司，牌号为L-50。
所述保湿剂按重量份计，由4份甲基丙二醇和1份1,3-丙二醇组成。
所述甲基丙二醇的CAS号为2163-42-0。
所述1,3-丙二醇购自上海浩云化工有限公司，牌号为PHL。
所述润肤剂为PEG-7橄榄油羧酸钠的CAS号为226416-05-3。
所述增溶剂购自上海淼森化工科技有限公司，牌号为LRI。
所述芳香剂为香精，购自乐尔福(上海)香精有限公司。
本例还提供所述精华液的制备方法，包括如下步骤：
(1)将去离子水、螯合剂、增稠剂在20Hz下搅拌并加热至80℃，抽真空-0.04MPa并搅拌降温得到第一混合物；
(2)步骤(1)所述第一混合物降温至50℃，加入保湿剂，在30Hz、-0.04MPa的真空下，搅拌均匀，并降温得到第二混合物；
(3)步骤(2)所述第二混合物降温至40℃，加入所述组合物的其他组分和皮肤调理剂，在30Hz、-0.04MPa真空下搅拌均匀，并降温得到第三混合物；
(4)将增溶剂和芳香剂混合均匀后，加入到步骤(3)所述第三混合物中，在25Hz下搅拌均匀，取料检测，合格后出料。
实施例3
本发明的实施例3提供一种修复肌肤用护肤组合物，所述护肤组合物的制备原料按重量份计，包括3份莲子发酵液、0.5份酵母提取物、2份姜黄凝胶、2份琥珀酰壳聚糖、1份糖类衍生物、1.5份裂裥菌素、5份复合保湿剂。
所述莲子发酵液购自上海言臻实业有限公司。
所述酵母提取物购自上海瑞慕化工科技有限公司，牌号为SRC。
所述姜黄凝胶购自上海容海生物科技有限公司。
所述琥珀酰壳聚糖购自上海欧融生物科技有限公司。
所述糖类衍生物购自上海砝恩恺实业有限公司，牌号为C-MOIST。
所述裂裥菌素购自上海一也生物科技有限公司，牌号为Yi-act-007。
所述复合保湿剂购自购自上海一也生物科技有限公司，牌号为Yi-301。
本例提供一种精华液，包含所述修复肌肤用护肤组合物，所述精华液的制备原料按重量百分数计，包括15％所述修复肌肤用护肤组合物、35％增稠剂、0.02％螯合剂、3.5％皮肤调理剂、5％保湿剂、0.05％润肤剂、0.03％增溶剂、0.01％芳香剂和余量去离子水。
所述增稠剂为甘油丙烯酸酯/丙烯酸共聚物，购自上海钊馨化学有限公司，牌号为SJgel MSF。
所述螯合剂为乙二胺四乙酸二钠，CAS号为139-33-3。
所述皮肤调理剂按重量份计，由0.5份二肽二氨基丁酰苄基酰胺二乙酸盐、1份乙酰基六肽-8、2份海星枝管藻提取物组成。
所述二肽二氨基丁酰苄基酰胺二乙酸盐，CAS号为823202-99-9。
所述乙酰基六肽-8的CAS号为616204-22-9。
所述海星枝管藻提取物购自上海熙安生物科技有限公司，牌号为L-50。
所述保湿剂按重量份计，由4份甲基丙二醇和1份1,3-丙二醇组成。
所述甲基丙二醇的CAS号为2163-42-0。
所述1,3-丙二醇购自上海浩云化工有限公司，牌号为PHL。
所述润肤剂为PEG-7橄榄油羧酸钠的CAS号为226416-05-3。
所述增溶剂购自上海淼森化工科技有限公司，牌号为LRI。
所述芳香剂为香精，购自乐尔福(上海)香精有限公司。
本例还提供所述精华液的制备方法，包括如下步骤：
(1)将去离子水、螯合剂、增稠剂在20Hz下搅拌并加热至80℃，加入所述复合保湿剂搅拌均匀，抽真空-0.04MPa并搅拌降温得到第一混合物；
(2)步骤(1)所述第一混合物降温至50℃，加入保湿剂，在30Hz、-0.04MPa的真空下，搅拌均匀，并降温得到第二混合物；
(3)步骤(2)所述第二混合物降温至40℃，加入所述组合物的其他组分和皮肤调理剂，在30Hz、-0.04MPa真空下搅拌均匀，并降温得到第三混合物；
(4)将增溶剂和芳香剂混合均匀后，加入到步骤(3)所述第三混合物中，在25Hz下搅拌均匀，取料检测，合格后出料。
实施例4
本发明的实施例4提供一种修复肌肤用护肤组合物，所述护肤组合物的制备原料按重量份计，包括2.5份莲子发酵液、0.6份酵母提取物、1.3份姜黄凝胶、1.3份琥珀酰壳聚糖、0.85份糖类衍生物、1份裂裥菌素、4.5份复合保湿剂。
所述莲子发酵液购自上海言臻实业有限公司。
所述酵母提取物购自上海瑞慕化工科技有限公司，牌号为SRC。
所述姜黄凝胶购自上海容海生物科技有限公司。
所述琥珀酰壳聚糖购自上海欧融生物科技有限公司。
所述糖类衍生物购自上海砝恩恺实业有限公司，牌号为C-MOIST。
所述裂裥菌素购自上海一也生物科技有限公司，牌号为Yi-act-007。
所述复合保湿剂购自购自上海一也生物科技有限公司，牌号为Yi-301。
本例提供一种精华液，包含所述修复肌肤用护肤组合物，所述精华液的制备原料按重量百分数计，包括12％所述修复肌肤用护肤组合物、30％增稠剂、0.01％螯合剂、3％皮肤调理剂、4％保湿剂、0.05％润肤剂、0.01％增溶剂、0.01％芳香剂和余量去离子水。
所述增稠剂为甘油丙烯酸酯/丙烯酸共聚物，购自上海钊馨化学有限公司，牌号为SJgel MSF。
所述螯合剂为乙二胺四乙酸二钠，CAS号为139-33-3。
所述皮肤调理剂按重量份计，由0.3份二肽二氨基丁酰苄基酰胺二乙酸盐、0.9份乙酰基六肽-8、1.8份海星枝管藻提取物组成。
所述二肽二氨基丁酰苄基酰胺二乙酸盐，CAS号为823202-99-9。
所述乙酰基六肽-8的CAS号为616204-22-9。
所述海星枝管藻提取物购自上海熙安生物科技有限公司，牌号为L-50。
所述保湿剂按重量份计，由3.2份甲基丙二醇和0.8份1,3-丙二醇组成。
所述甲基丙二醇的CAS号为2163-42-0。
所述1,3-丙二醇购自上海浩云化工有限公司，牌号为PHL。
所述润肤剂为PEG-7橄榄油羧酸钠的CAS号为226416-05-3。
所述增溶剂购自上海淼森化工科技有限公司，牌号为LRI。
所述芳香剂为香精，购自乐尔福(上海)香精有限公司。
本例还提供所述精华液的制备方法，包括如下步骤：
(1)将去离子水、螯合剂、增稠剂在17Hz下搅拌并加热至75℃，加入所述复合保湿剂搅拌均匀，抽真空-0.03MPa并搅拌降温得到第一混合物；
(2)步骤(1)所述第一混合物降温至45℃，加入保湿剂，在28Hz、-0.03MPa的真空下，搅拌均匀，并降温得到第二混合物；
(3)步骤(2)所述第二混合物降温至30℃，加入所述组合物的其他组分和皮肤调理剂，在25Hz、-0.03MPa真空下搅拌均匀，并降温得到第三混合物；
(4)将增溶剂和芳香剂混合均匀后，加入到步骤(3)所述第三混合物中，在22Hz下搅拌均匀，取料检测，合格后出料。
实施例5
本发明的实施例5提供一种修复肌肤用护肤组合物，所述护肤组合物的制备 原料按重量份计，包括3.5份莲子发酵液、0.35份酵母提取物、2.9份姜黄凝胶、2.7份琥珀酰壳聚糖、1.2份糖类衍生物、2.3份裂裥菌素、5.8份复合保湿剂。
所述莲子发酵液购自上海言臻实业有限公司。
所述酵母提取物购自上海瑞慕化工科技有限公司，牌号为SRC。
所述姜黄凝胶购自上海容海生物科技有限公司。
所述琥珀酰壳聚糖购自上海欧融生物科技有限公司。
所述糖类衍生物购自上海砝恩恺实业有限公司，牌号为C-MOIST。
所述裂裥菌素购自上海一也生物科技有限公司，牌号为Yi-act-007。
所述复合保湿剂购自购自上海一也生物科技有限公司，牌号为Yi-301。
本例提供一种精华液，包含所述修复肌肤用护肤组合物，所述精华液的制备原料按重量百分数计，包括19％所述修复肌肤用护肤组合物、40％增稠剂、0.05％螯合剂、5％皮肤调理剂、7％保湿剂、0.2％润肤剂、0.1％增溶剂、0.05％芳香剂和余量去离子水。
所述增稠剂为甘油丙烯酸酯/丙烯酸共聚物，购自上海钊馨化学有限公司，牌号为SJgel MSF。
所述螯合剂为乙二胺四乙酸二钠，CAS号为139-33-3。
所述皮肤调理剂按重量份计，由0.8份二肽二氨基丁酰苄基酰胺二乙酸盐、1.7份乙酰基六肽-8、2.5份海星枝管藻提取物组成。
所述二肽二氨基丁酰苄基酰胺二乙酸盐，CAS号为823202-99-9。
所述乙酰基六肽-8的CAS号为616204-22-9。
所述海星枝管藻提取物购自上海熙安生物科技有限公司，牌号为L-50。
所述保湿剂按重量份计，由2份甲基丙二醇和5份1,3-丙二醇组成。
所述甲基丙二醇的CAS号为2163-42-0。
所述1,3-丙二醇购自上海浩云化工有限公司，牌号为PHL。
所述润肤剂为PEG-7橄榄油羧酸钠的CAS号为226416-05-3。
所述增溶剂购自上海淼森化工科技有限公司，牌号为LRI。
所述芳香剂为香精，购自乐尔福(上海)香精有限公司。
本例还提供所述精华液的制备方法，包括如下步骤：
(1)将去离子水、螯合剂、增稠剂在22Hz下搅拌并加热至85℃，加入所述复合保湿剂搅拌均匀，抽真空-0.04MPa并搅拌降温得到第一混合物；
(2)步骤(1)所述第一混合物降温至55℃，加入保湿剂，在33Hz、-0.04MPa的真空下，搅拌均匀，并降温得到第二混合物；
(3)步骤(2)所述第二混合物降温至40℃，加入所述组合物的其他组分和皮肤调理剂，在33Hz、-0.04MPa真空下搅拌均匀，并降温得到第三混合物；
(4)将增溶剂和芳香剂混合均匀后，加入到步骤(3)所述第三混合物中，在27Hz下搅拌均匀，取料检测，合格后出料。
实施例6
本发明的实施例6提供一种修复肌肤用护肤组合物，其具体实施方式同实施例3，不同之处在于，所述组合物的制备原料不包括莲子发酵物。
本例提供一种精华液，包含所述修复肌肤用护肤组合物，具体实施方式同实施例3，不同之处在于，所述组合物的重量百分数为12％。
本例还提供所述精华液的制备方法，具体实施方法同实施例3。
实施例7
本发明的实施例7提供一种修复肌肤用护肤组合物，其具体实施方式同实施例3，不同之处在于，所述组合物的制备原料不包括酵母提取物。
本例提供一种精华液，包含所述修复肌肤用护肤组合物，具体实施方式同实施例3，不同之处在于，所述组合物的重量百分数为14.5％。
本例还提供所述精华液的制备方法，具体实施方法同实施例3。
实施例8
本发明的实施例8提供一种修复肌肤用护肤组合物，其具体实施方式同实施例3，不同之处在于，所述组合物的制备原料不包括姜黄凝胶。
本例提供一种精华液，包含所述修复肌肤用护肤组合物，具体实施方式同实施例3，不同之处在于，所述组合物的重量百分数为13％。
本例还提供所述精华液的制备方法，具体实施方法同实施例3。
实施例9
本发明的实施例9提供一种修复肌肤用护肤组合物，其具体实施方式同实施例3，不同之处在于，所述莲子发酵液的重量份为6重量份。
本例提供一种精华液，包含所述修复肌肤用护肤组合物，具体实施方式同实施例3，不同之处在于，所述组合物的重量百分数为18％。
本例还提供所述精华液的制备方法，具体实施方法同实施例3。
实施例10
本发明的实施例10提供一种修复肌肤用护肤组合物，其具体实施方式同实施例3，不同之处在于，所述酵母提取物的重量份为3.5重量份。
本例提供一种精华液，包含所述修复肌肤用护肤组合物，具体实施方式同实施例3，不同之处在于，所述组合物的重量百分数为18％。
本例还提供所述精华液的制备方法，具体实施方法同实施例3。
实施例11
本发明的实施例11提供一种修复肌肤用护肤组合物，其具体实施方式同实施例3，不同之处在于，所述姜黄凝胶的重量份为5重量份。
本例提供一种精华液，包含所述修复肌肤用护肤组合物，具体实施方式同实施例3，不同之处在于，所述组合物的重量百分数为18％。
本例还提供所述精华液的制备方法，具体实施方法同实施例3。
实施例12
本发明的实施例12提供一种修复肌肤用护肤组合物，其具体实施方式同实施例3，不同之处在于，所述组合物的制备原料不包括琥珀酰壳聚糖。
本例提供一种精华液，包含所述修复肌肤用护肤组合物，具体实施方式同实施例3，不同之处在于，所述组合物的重量百分数为13％。
本例还提供所述精华液的制备方法，具体实施方法同实施例3。
实施例13
本发明的实施例13提供一种修复肌肤用护肤组合物，其具体实施方式同实施例3，不同之处在于，所述组合物的制备原料不包括糖类衍生物。
本例提供一种精华液，包含所述修复肌肤用护肤组合物，具体实施方式同实施例3，不同之处在于，所述组合物的重量百分数为14％。
本例还提供所述精华液的制备方法，具体实施方法同实施例3。
实施例14
本发明的实施例14提供一种修复肌肤用护肤组合物，其具体实施方式同实 施例3，不同之处在于，所述琥珀酰壳聚糖的重量份为5重量份。
本例提供一种精华液，包含所述修复肌肤用护肤组合物，具体实施方式同实施例3，不同之处在于，所述组合物的重量百分数为18％。
本例还提供所述精华液的制备方法，具体实施方法同实施例3。
实施例15
本发明的实施例15提供一种修复肌肤用护肤组合物，其具体实施方式同实施例3，不同之处在于，所述组合物的制备原料不包括裂裥菌素。
本例提供一种精华液，包含所述修复肌肤用护肤组合物，具体实施方式同实施例3，不同之处在于，所述组合物的重量百分数为13.5％。
本例还提供所述精华液的制备方法，具体实施方法同实施例3。
实施例16
本发明的实施例16提供一种修复肌肤用护肤组合物，其具体实施方式同实施例3，不同之处在于，所述复合保湿剂的重量份为1重量份。
本例提供一种精华液，包含所述修复肌肤用护肤组合物，具体实施方式同实施例3，不同之处在于，所述组合物的重量百分数为11％。
本例还提供所述精华液的制备方法，具体实施方法同实施例3。
实施例17
本发明的实施例17提供一种精华液，其具体实施方式同实施例3，不同之处在于，所述精华液的制备原料不包含所述修复肌肤用护肤组合物。
本例还提供所述精华液的制备方法，具体实施方法同实施例3。
性能评价
1、敏感性测试：将实施例1～16提供的精华液，进行敏感性测试，具体测试方法如下：分别甄选油性肤质、敏感肤质人群做斑贴试验，受试者皮肤不能有伤疤，伤痕或毛发过多，有已知严重过敏史或者对化妆品严重过敏不能参与；并分别使用实施例1～16提供的精华液，对油性肤质和敏感肤质人群的测试部位皮肤进行敏感性评价，评价指标为：瘙痒感、紧绷感、刺激感、发红、干燥感、发炎，并分为0～4级，指标等级如下：0级：无敏感反应；1级：皮肤干燥，略微瘙痒；2级：皮肤略微发红，瘙痒感增加；3级：微弱红斑，少量红血丝；4级：大量红斑，大量红血丝，发炎，结果见表1。
2、稳定性测试：将实施例1～16提供的组合物作为样品进行稳定性测试：
(1)耐热测试：将样品放入(50±1)℃的电热恒温培养箱中24h，恢复室温后观察是否有变稀、变色、分层及硬度变化等现象，以判断样品的耐热性能；
(2)耐寒试验：将样品放入(-5～-10)℃±1℃的电冰箱中24h，恢复室温后观察是否有变稀、变色、分层及硬度变化等现象，以判断样品的耐寒性能；
(3)离心试验：将样品置于离心机中，以(2000～4000)r/min的转速试验30min，观察样品的分离、分层状况，以判断样品的耐机械稳定性。
根据测试前后样品变稀、变色、分层及硬度变化等现象进行评级，共分为0～4级，其中0级为无变稀、变色、分层现象和硬度变化，1级为轻微变稀、变色，无分层和硬度变化，2级为变色和变稀现象增加，无分层现象，硬度略有变化，3级为略有分层现象，硬度变化增加，4级为有明显分层和硬度变化，获得组合物耐热、耐寒和耐机械稳定性，结果见表1。
3、感官测试：将实施例1～17提供的精华液，进行感官测试，具体测试方法如下：在使用样品前，使用者使用相同的温和洁面产品清洗脸部，再擦爽肤水和润肤乳，并涂抹实施例1～17提供的精华液，使用频率为早上使用一次，连续每天使用，试用期为2周，并进行感官评价，主要评价指标为快速美白、长效保湿、祛皱、抗衰老效果，并分为1～5级，其中，1级为无改善，2级为改善不明显，3级为改善一般，4级为改善良好，5级为改善显著，结果见表2。
4、理化性质测试：对实施例3提供的精华液进行理化性质测试：
(1)外观：实施例3提供的精华液为淡黄色透明啫哩状均匀液体；
(2)香气：对实施例3提供的精华液的香气进行感官评价，符合规定香气；
(3)pH测试：对实施例3提供的精华液根据GB T13531.1-2008pH的测定方法，通过pH计测试，发现pH为5.97。
(4)相对密度：对实施例3提供的精华液根据GB T13531.4-2013相对密度的测定方法，使用密度计进行测试20℃下相对密度为1.01g/cm 3；
表1 性能表征测试
Figure PCTCN2019121338-appb-000001
Figure PCTCN2019121338-appb-000002
表2 性能表征测试
  快速美白 长效保湿 祛皱 抗衰老
实施例1 4级 1级 2级 3级
实施例2 4级 3级 4级 4级
实施例3 5级 5级 5级 5级
实施例4 4级 4级 5级 4级
实施例5 5级 5级 5级 4级
实施例6 4级 4级 4级 3级
实施例7 4级 5级 3级 4级
实施例8 3级 4级 3级 3级
实施例9 4级 5级 4级 4级
实施例10 4级 5级 4级 4级
实施例11 3级 4级 4级 4级
实施例12 4级 2级 4级 4级
实施例13 5级 2级 4级 4级
实施例14 5级 3级 4级 5级
实施例15 4级 3级 4级 4级
实施例16 5级 4级 4级 5级
实施例17 2级 2级 1级 1级
由表1和表2测试结果可知，本发明提供的所述修复肌肤用护肤组合物具有高的耐热、耐寒和耐机械稳定性，且不会对皮肤造成刺激，对敏感肤质和油性肤质人群也同样适用；可应用于多种护肤品中，具有优异的快速美白、长期保湿、祛皱、抗衰老的效果。
前述的实例仅是说明性的，用于解释本发明所述方法的一些特征。所附的权利要求旨在要求可以设想的尽可能广的范围，且本文所呈现的实施例仅是根据所有可能的实施例的组合的选择的实施方式的说明。因此，申请人的用意是所附的权利要求不被说明本发明的特征的示例的选择限制。在权利要求中所用的一些数值范围也包括了在其之内的子范围，这些范围中的变化也应在可能的情况下解释为被所附的权利要求覆盖。

Claims (10)

  1. 一种修复肌肤用护肤组合物，其特征在于，所述护肤组合物的制备原料包括莲子发酵液、酵母提取物和姜黄凝胶。
  2. 根据权利要求1所述的修复肌肤用护肤组合物，其特征在于，所述莲子发酵液、姜黄凝胶和酵母提取物的重量比为3：(1.5～2.5)：(0.3～0.8)。
  3. 根据权利要求1所述的修复肌肤用护肤组合物，其特征在于，所述护肤组合物还包括琥珀酰壳聚糖、糖类衍生物和裂裥菌素。
  4. 根据权利要求3所述的修复肌肤用护肤组合物，其特征在于，所述糖类衍生物包括甘油葡糖苷、木糖醇基葡糖苷、脱水木糖醇、果糖和木糖醇。
  5. 根据权利要求3所述的修复肌肤用护肤组合物，其特征在于，所述琥珀酰壳聚糖和糖类衍生物的重量比为(1.5～2.3)：1。
  6. 根据权利要求3所述的修复肌肤用护肤组合物，其特征在于，所述护肤组合物的制备原料还包括复合保湿剂；所述复合保湿剂包括透明质酸钠、聚谷氨酸钠和银耳多糖。
  7. 根据权利要求6所述的修复肌肤用护肤组合物，其特征在于，所述裂裥菌素、莲子发酵液和复合保湿剂的重量比为1：(1.5～2.5)：(2.5～4.5)。
  8. 一种根据权利要求1～7任意一项所述修复肌肤用护肤组合物的应用，其特征在于，应用于护肤品中；所述护肤品选自水剂、乳液、面霜、眼霜、面膜、BB霜、精华液、精华露、防晒霜、防晒水、痤疮水、粉刺露、精油、香波，保湿水、爽肤水、收敛水、柔肤水中的一种或多种。
  9. 根据权利要求8所述修复肌肤用护肤组合物的应用，其特征在于，所述护肤品为精华液；所述精华液的制备原料按质量百分数计，包括6～19％所述修复肌肤用护肤组合物、30～40％增稠剂、0～0.05％螯合剂、3～5％皮肤调理剂、4～7％保湿剂、0～0.2％润肤剂、0～0.1％增溶剂、0～0.05％芳香剂和余量去离子水。
  10. 一种精华液的制备方法，其特征在于，所述精华液的制备原料按质量百分数计，包括6～19％所述修复肌肤用护肤组合物、30～40％增稠剂、0～0.05％螯合剂、3～5％皮肤调理剂、4～7％保湿剂、0～0.2％润肤剂、0～0.1％增溶剂、0～0.05％芳香剂和余量去离子水；
    所述精华液的制备方法包括如下步骤：
    (1)将去离子水、螯合剂和增稠剂搅拌并加热至75～85℃；
    (2)将步骤(1)得到的混合物降温至45～55℃，加入保湿剂，并搅拌；
    (3)将步骤(2)得到的混合物降温至30～40℃，加入除复合保湿剂外所述护肤组合物的其他组分和皮肤调理剂，并搅拌；
    (4)将步骤(3)得到的混合物降温后，加入增溶剂和芳香剂的混合物并搅拌，取料检测合格后得到所述精华液。
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