CN1086705C - 制备二氢－2,3－苯并二氮杂䓬衍生物立体有择方法和中间体 - Google Patents

制备二氢－2,3－苯并二氮杂䓬衍生物立体有择方法和中间体 Download PDF

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Publication number
CN1086705C
CN1086705C CN95116311A CN95116311A CN1086705C CN 1086705 C CN1086705 C CN 1086705C CN 95116311 A CN95116311 A CN 95116311A CN 95116311 A CN95116311 A CN 95116311A CN 1086705 C CN1086705 C CN 1086705C
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CN
China
Prior art keywords
compound
formula
aryl
aminophenyl
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN95116311A
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English (en)
Chinese (zh)
Other versions
CN1123282A (zh
Inventor
B·A·安德逊
M·M·汉森
J·T·文森齐
D·L·瓦里
小·M·J·兹米祖斯基
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
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Eli Lilly and Co
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Filing date
Publication date
Priority claimed from US08/413,036 external-priority patent/US5665878A/en
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of CN1123282A publication Critical patent/CN1123282A/zh
Application granted granted Critical
Publication of CN1086705C publication Critical patent/CN1086705C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN95116311A 1994-08-31 1995-08-30 制备二氢－2,3－苯并二氮杂䓬衍生物立体有择方法和中间体 Expired - Fee Related CN1086705C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US413036 1982-09-02
US29864594A 1994-08-31 1994-08-31
US298645 1994-08-31
US08/413,036 US5665878A (en) 1994-08-31 1995-03-28 Stereoselective process for producing dihydro-2,3-benzodiazepine derivatives

Publications (2)

Publication Number Publication Date
CN1123282A CN1123282A (zh) 1996-05-29
CN1086705C true CN1086705C (zh) 2002-06-26

Family

ID=26970799

Family Applications (1)

Application Number Title Priority Date Filing Date
CN95116311A Expired - Fee Related CN1086705C (zh) 1994-08-31 1995-08-30 制备二氢－2,3－苯并二氮杂䓬衍生物立体有择方法和中间体

Country Status (21)

Country Link
US (3) US5919954A (enExample)
EP (1) EP0699677B1 (enExample)
JP (1) JP3481019B2 (enExample)
KR (1) KR100399518B1 (enExample)
CN (1) CN1086705C (enExample)
AT (1) ATE231867T1 (enExample)
AU (1) AU702658B2 (enExample)
BR (1) BR9503845A (enExample)
CA (1) CA2157234C (enExample)
CZ (1) CZ295675B6 (enExample)
DE (1) DE69529499T2 (enExample)
DK (1) DK0699677T3 (enExample)
ES (1) ES2189819T3 (enExample)
FI (1) FI113269B (enExample)
HU (1) HU223776B1 (enExample)
IL (1) IL115100A (enExample)
IN (1) IN190402B (enExample)
NO (1) NO312838B1 (enExample)
PL (3) PL188796B1 (enExample)
RU (1) RU2151149C1 (enExample)
TR (1) TR199501071A2 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20010022856A (ko) * 1997-08-12 2001-03-26 사바 키스 ; 아틸라 만디 야노스 템페 ; 기울라 시미그 Ａｍｐａ/카이네이트 수용체 억제제로서의 1,3-디옥솔로/4,5-ｈ//2,3/벤조디아제핀 유도체
UA67749C2 (uk) * 1997-08-12 2004-07-15 Егіш Дьйодьсердьяр Рт. Похідна 8-заміщеного-9н-1,3-діоксол/4,5-h//2,3/бензодіазепіну з властивостями амра/каїнатного антагоніста, спосіб одержання похідних, фармацевтична композиція (варіанти), спосіб її одержання та спосіб лікування
EP0918090A3 (en) * 1997-11-04 2002-08-28 Eli Lilly And Company Ketoreductase gene and protein from yeast
US20030219456A1 (en) * 2002-05-21 2003-11-27 Taing Ok Method of utilization of zygosaccharomyces rouxii
US6858605B2 (en) 2003-02-04 2005-02-22 Ivax Drug Research Institute, Ltd. Substituted 2,3-benzodiazepine derivatives
DE502005006892D1 (de) * 2005-12-05 2009-04-30 Deutsche Post Ag Verfahren zum Sortieren von Postsendungen und Vorrichtung mit einer Datenstruktur für einen Sortierplan
AU2006334172A1 (en) * 2005-12-30 2007-07-12 Egis Gyogyszergyar Nyilvanosan Mukodo Reszvenytarsasag Optical isomers of dihydro-2,3-benzodiazepines and their stereoselective synthesis
KR100841592B1 (ko) 2007-04-16 2008-06-26 한양대학교 산학협력단 벤조디옥솔 유도체와 이의 제조방법

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0492485A1 (en) * 1990-12-21 1992-07-01 Gyogyszerkutato Intezet N-Acyl-2,3-benzodiazepine derivatives, pharmaceutical compositions containing them and process for preparing same
WO1995001357A1 (en) * 1993-07-02 1995-01-12 Gyógyszerkutató Intézet Kft. Optically active 1-(4-nitrophenyl)-4-methyl-7,8-methylenedioxy-3,4-dihydro-5h-2,3-benzodiazepine and process for preparing same

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3748342A (en) * 1971-05-06 1973-07-24 Sandoz Ag Intermediates for preparing quinazolinones
US3794642A (en) * 1973-01-15 1974-02-26 Lilly Co Eli Oxidation of substituted methanes to the corresponding substituted methanols
DE2816475A1 (de) * 1978-04-15 1979-10-25 Bayer Ag Isochroman-derivate, verfahren zu ihrer herstellung und ihre verwendung als synergisten in insektiziden und akariziden mitteln
US4358041A (en) 1980-06-12 1982-11-09 Olin Corporation Powder-actuated tool with power adjustment and angle-fire control
HU191702B (en) * 1984-06-27 1987-03-30 Gyogyszerkutato Intezet New process for preparing 1-aryl-5 h-2,3-benzodiazepines
HU191698B (en) * 1984-07-27 1987-03-30 Gyogyszerkutato Intezet Process for producing new 1-aryl-5h-2beta-benzodiazepines
HU198494B (en) 1986-08-15 1989-10-30 Gyogyszerkutato Intezet Process for producing new 3,4-dihydro-5h-2,3-benzodiazepine derivative and acid addition salts thereof, as well as pharmaceutical compositions comprising same
DE68926417T2 (de) * 1988-02-12 1996-09-12 Daicel Chem Verfahren zur herstellung von optisch aktiven 2-hydroxysäureabkömmlingen
JP2679145B2 (ja) * 1988-09-02 1997-11-19 ダイセル化学工業株式会社 オキシケトンの製造法
HU206719B (en) 1990-12-21 1992-12-28 Gyogyszerkutato Intezet Process for producing 1-/4-acylamino-phenyl/-7,8-methylenedioxy-5h-2,3-benzodiazepine derivatives, acid addicional salts and pharmaceutical compositions containing them
JP3061422B2 (ja) * 1990-12-27 2000-07-10 ダイセル化学工業株式会社 光学活性（ｓ）−２−クロロ−１−フェニルプロパノールの製造法
JPH04271789A (ja) * 1991-01-10 1992-09-28 Takeda Chem Ind Ltd Ｄ−パントラクトンの製造方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0492485A1 (en) * 1990-12-21 1992-07-01 Gyogyszerkutato Intezet N-Acyl-2,3-benzodiazepine derivatives, pharmaceutical compositions containing them and process for preparing same
WO1995001357A1 (en) * 1993-07-02 1995-01-12 Gyógyszerkutató Intézet Kft. Optically active 1-(4-nitrophenyl)-4-methyl-7,8-methylenedioxy-3,4-dihydro-5h-2,3-benzodiazepine and process for preparing same

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
C.A VOL 105 NO25 226357V 1986.12.22 T.LANG.ET.AL *

Also Published As

Publication number Publication date
US6160133A (en) 2000-12-12
US5919954A (en) 1999-07-06
US5986114A (en) 1999-11-16
DE69529499D1 (de) 2003-03-06
IN190402B (enExample) 2003-07-26
JP3481019B2 (ja) 2003-12-22
HK1013818A1 (en) 1999-09-10
IL115100A0 (en) 1995-12-08
CA2157234A1 (en) 1996-03-01
AU3035595A (en) 1996-03-14
PL188796B1 (pl) 2005-04-29
TR199501071A2 (tr) 1996-06-21
PL310226A1 (en) 1996-03-04
FI954064A0 (fi) 1995-08-30
NO312838B1 (no) 2002-07-08
DK0699677T3 (da) 2003-04-22
ES2189819T3 (es) 2003-07-16
HU9502545D0 (en) 1995-10-30
FI113269B (fi) 2004-03-31
CZ295675B6 (cs) 2005-09-14
NO953396D0 (no) 1995-08-30
KR100399518B1 (ko) 2004-04-30
RU2151149C1 (ru) 2000-06-20
HUT72644A (en) 1996-05-28
KR960007595A (ko) 1996-03-22
PL190318B1 (pl) 2005-11-30
EP0699677A1 (en) 1996-03-06
ATE231867T1 (de) 2003-02-15
CN1123282A (zh) 1996-05-29
NO953396L (no) 1996-03-01
HU223776B1 (hu) 2005-01-28
CA2157234C (en) 2005-05-03
JPH0881468A (ja) 1996-03-26
BR9503845A (pt) 1996-04-16
DE69529499T2 (de) 2003-12-04
FI954064L (fi) 1996-03-01
EP0699677B1 (en) 2003-01-29
IL115100A (en) 2000-07-26
PL190640B1 (pl) 2005-12-30
AU702658B2 (en) 1999-02-25
CZ221995A3 (en) 1996-03-13

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C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20020626

Termination date: 20100830