CN108640920B - 一种替比培南酯的制备方法 - Google Patents
一种替比培南酯的制备方法 Download PDFInfo
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- CN108640920B CN108640920B CN201810289261.8A CN201810289261A CN108640920B CN 108640920 B CN108640920 B CN 108640920B CN 201810289261 A CN201810289261 A CN 201810289261A CN 108640920 B CN108640920 B CN 108640920B
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/02—Preparation
- C07D477/06—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Catalysts (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Description
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Priority Applications (1)
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CN201810289261.8A CN108640920B (zh) | 2018-04-03 | 2018-04-03 | 一种替比培南酯的制备方法 |
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CN201810289261.8A CN108640920B (zh) | 2018-04-03 | 2018-04-03 | 一种替比培南酯的制备方法 |
Publications (2)
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CN108640920A CN108640920A (zh) | 2018-10-12 |
CN108640920B true CN108640920B (zh) | 2020-03-27 |
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CN201810289261.8A Active CN108640920B (zh) | 2018-04-03 | 2018-04-03 | 一种替比培南酯的制备方法 |
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Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ753781A (en) | 2017-02-06 | 2022-10-28 | Spero Therapeutics Inc | Tebipenem pivoxil crystalline forms, compositions including the same, methods of manufacture, and methods of use |
CN112110926B (zh) * | 2020-09-29 | 2022-05-17 | 北京阳光诺和药物研究股份有限公司 | 一种制备替比培南酯的方法 |
CN112812116A (zh) * | 2020-12-31 | 2021-05-18 | 山东华鲁制药有限公司 | 一种药用替比培南匹伏酯的制备方法 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103059028A (zh) * | 2013-01-30 | 2013-04-24 | 山东罗欣药业股份有限公司 | 一种替比培南匹伏酯的制备方法 |
CN103209765A (zh) * | 2010-09-15 | 2013-07-17 | 巴斯夫欧洲公司 | 烧结稳定的多相催化剂 |
CN106083858A (zh) * | 2016-07-08 | 2016-11-09 | 河南全宇制药股份有限公司 | 替比培南酯的制备方法 |
CN107501268A (zh) * | 2017-08-30 | 2017-12-22 | 浙江海翔川南药业有限公司 | 一种替比培南酯及其中间体的制备方法 |
WO2018010974A1 (en) * | 2016-07-12 | 2018-01-18 | Evonik Degussa Gmbh | Process for the deprotection of a carbapenem by heterogeneous catalytic hydrogenation with hydrogen in the presence of an organic amine |
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2018
- 2018-04-03 CN CN201810289261.8A patent/CN108640920B/zh active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103209765A (zh) * | 2010-09-15 | 2013-07-17 | 巴斯夫欧洲公司 | 烧结稳定的多相催化剂 |
CN103059028A (zh) * | 2013-01-30 | 2013-04-24 | 山东罗欣药业股份有限公司 | 一种替比培南匹伏酯的制备方法 |
CN106083858A (zh) * | 2016-07-08 | 2016-11-09 | 河南全宇制药股份有限公司 | 替比培南酯的制备方法 |
WO2018010974A1 (en) * | 2016-07-12 | 2018-01-18 | Evonik Degussa Gmbh | Process for the deprotection of a carbapenem by heterogeneous catalytic hydrogenation with hydrogen in the presence of an organic amine |
CN107501268A (zh) * | 2017-08-30 | 2017-12-22 | 浙江海翔川南药业有限公司 | 一种替比培南酯及其中间体的制备方法 |
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Address after: 2666 Chuangye Road, Mingshui Development Zone, Zhangqiu District, Jinan City, Shandong Province Applicant after: Kexing biopharmaceutical Co., Ltd. Address before: 250200 2666 Chuang Road, Ming Shui development area, Zhangqiu District, Ji'nan, Shandong. Applicant before: Shandong Kexing Biological Product Co., Ltd. |
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Inventor after: Zhang Yun Inventor after: Cui Ning Inventor before: Chou Duxian Inventor before: Hao Zhihai Inventor before: Zhang Yun Inventor before: Wang Cuicui Inventor before: Cui Ning |
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