CN108348777B - 半氟化化合物和其组合物 - Google Patents

半氟化化合物和其组合物 Download PDF

Info

Publication number
CN108348777B
CN108348777B CN201680056188.9A CN201680056188A CN108348777B CN 108348777 B CN108348777 B CN 108348777B CN 201680056188 A CN201680056188 A CN 201680056188A CN 108348777 B CN108348777 B CN 108348777B
Authority
CN
China
Prior art keywords
composition
eye
weight
compositions
medicament
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201680056188.9A
Other languages
English (en)
Chinese (zh)
Other versions
CN108348777A (zh
Inventor
拉尔夫·格里伦恩伯杰
弗兰克·洛施尔
迪特尔·谢勒
哈特穆特·沃斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novaliq GmbH
Original Assignee
Novaliq GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novaliq GmbH filed Critical Novaliq GmbH
Priority to CN202010471109.9A priority Critical patent/CN111743882A/zh
Priority to CN202510904346.2A priority patent/CN120754071A/zh
Priority to CN201910679312.2A priority patent/CN110403923B/zh
Priority to CN202511027432.6A priority patent/CN120884568A/zh
Publication of CN108348777A publication Critical patent/CN108348777A/zh
Application granted granted Critical
Publication of CN108348777B publication Critical patent/CN108348777B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/02—Halogenated hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201680056188.9A 2015-09-30 2016-09-29 半氟化化合物和其组合物 Active CN108348777B (zh)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CN202010471109.9A CN111743882A (zh) 2015-09-30 2016-09-29 半氟化化合物和其组合物
CN202510904346.2A CN120754071A (zh) 2015-09-30 2016-09-29 半氟化化合物和其组合物
CN201910679312.2A CN110403923B (zh) 2015-09-30 2016-09-29 半氟化化合物和其组合物
CN202511027432.6A CN120884568A (zh) 2015-09-30 2016-09-29 半氟化化合物和其组合物

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP15187767 2015-09-30
EP15187767.7 2015-09-30
EP15192441.2 2015-10-30
EP15192441 2015-10-30
PCT/EP2016/073263 WO2017055454A1 (en) 2015-09-30 2016-09-29 Semifluorinated compounds and their compositions

Related Child Applications (4)

Application Number Title Priority Date Filing Date
CN202510904346.2A Division CN120754071A (zh) 2015-09-30 2016-09-29 半氟化化合物和其组合物
CN201910679312.2A Division CN110403923B (zh) 2015-09-30 2016-09-29 半氟化化合物和其组合物
CN202511027432.6A Division CN120884568A (zh) 2015-09-30 2016-09-29 半氟化化合物和其组合物
CN202010471109.9A Division CN111743882A (zh) 2015-09-30 2016-09-29 半氟化化合物和其组合物

Publications (2)

Publication Number Publication Date
CN108348777A CN108348777A (zh) 2018-07-31
CN108348777B true CN108348777B (zh) 2020-04-28

Family

ID=57047224

Family Applications (5)

Application Number Title Priority Date Filing Date
CN201680056188.9A Active CN108348777B (zh) 2015-09-30 2016-09-29 半氟化化合物和其组合物
CN202511027432.6A Pending CN120884568A (zh) 2015-09-30 2016-09-29 半氟化化合物和其组合物
CN202010471109.9A Pending CN111743882A (zh) 2015-09-30 2016-09-29 半氟化化合物和其组合物
CN202510904346.2A Pending CN120754071A (zh) 2015-09-30 2016-09-29 半氟化化合物和其组合物
CN201910679312.2A Active CN110403923B (zh) 2015-09-30 2016-09-29 半氟化化合物和其组合物

Family Applications After (4)

Application Number Title Priority Date Filing Date
CN202511027432.6A Pending CN120884568A (zh) 2015-09-30 2016-09-29 半氟化化合物和其组合物
CN202010471109.9A Pending CN111743882A (zh) 2015-09-30 2016-09-29 半氟化化合物和其组合物
CN202510904346.2A Pending CN120754071A (zh) 2015-09-30 2016-09-29 半氟化化合物和其组合物
CN201910679312.2A Active CN110403923B (zh) 2015-09-30 2016-09-29 半氟化化合物和其组合物

Country Status (11)

Country Link
US (5) US20170087100A1 (enExample)
EP (2) EP3495023B1 (enExample)
JP (2) JP6602964B2 (enExample)
CN (5) CN108348777B (enExample)
DE (1) DE202016008738U1 (enExample)
DK (2) DK3355990T3 (enExample)
ES (1) ES2743502T3 (enExample)
HK (1) HK1257183B (enExample)
PL (1) PL3355990T3 (enExample)
PT (1) PT3355990T (enExample)
WO (1) WO2017055454A1 (enExample)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101656121B1 (ko) 2010-03-17 2016-09-08 노바리크 게엠베하 안압 증가를 치료하기 위한 약학 조성물
EP2444063A1 (en) 2010-10-20 2012-04-25 Novaliq GmbH Liquid pharmaceutical compositions for the delivery of active ingredients
EP3311802B1 (en) 2011-05-25 2023-11-01 Dermaliq Therapeutics, Inc. Topical pharmaceutical composition based on semifluorinated alkanes
MX361681B (es) 2012-01-23 2018-12-13 Novaliq Gmbh Composiciones de proteína estabilizadas basadas en alcanos semifluorados.
DK2895144T3 (en) 2012-09-12 2017-03-06 Novaliq Gmbh SEMIFLUORED ALKAN COMPOSITIONS
EP3100722B1 (en) 2012-09-12 2024-03-20 Novaliq GmbH Semifluorinated alkanes for use in solubilizing meibum
US10273298B2 (en) 2013-07-23 2019-04-30 Novaliq Gmbh Stabilized antibody compositions
US11154513B2 (en) * 2015-09-30 2021-10-26 Novaliq Gmbh Semifluorinated compounds
US20170087100A1 (en) 2015-09-30 2017-03-30 Novaliq Gmbh Semifluorinated compounds and their compositions
JP2019520357A (ja) 2016-06-23 2019-07-18 ノバリック ゲーエムベーハー 局所投与方法
JP7012075B2 (ja) 2016-09-22 2022-01-27 ノバリック ゲーエムベーハー 眼瞼炎の治療に使用するための医薬組成物
JP6869336B2 (ja) 2016-09-23 2021-05-12 ノバリック ゲーエムベーハー シクロスポリンを含む眼科用組成物
PT3399962T (pt) 2016-12-23 2020-09-03 Novaliq Gmbh Composição oftálmica para o tratamento da doença do olho seco
ES2957559T3 (es) 2017-04-21 2024-01-22 Dermaliq Therapeutics Inc Composiciones de yodo
EP3619186B1 (en) 2017-05-05 2021-02-17 Novaliq GmbH Process for the production of semifluorinated alkanes
US20210069014A1 (en) * 2017-05-06 2021-03-11 Novaliq Gmbh Drop dispenser
WO2018206656A1 (en) 2017-05-12 2018-11-15 Novaliq Gmbh Pharmaceutical compositions comprosing semifluorinated alkanes for the treatment of contact lense-related conditions
KR20200059272A (ko) 2017-09-27 2020-05-28 노바리크 게엠베하 안구 질환의 치료에서의 사용을 위한 라타노프로스트를 포함하는 안과적 조성물
US11896559B2 (en) 2017-10-04 2024-02-13 Novaliq Gmbh Opthalmic compositions comprising F6H8
JP7353292B2 (ja) 2018-03-02 2023-09-29 ノバリック ゲーエムベーハー ネビボロールを含む医薬組成物
US12226422B2 (en) 2018-04-27 2025-02-18 Novaliq Gmbh Ophthalmic compositions comprising tafluprost for the treatment of glaucoma
JP2022500461A (ja) * 2018-09-22 2022-01-04 ノバリック ゲーエムベーハー 眼表面の損傷および乾燥の症状の治療のための眼科用組成物
US11510855B2 (en) 2018-09-27 2022-11-29 Dermaliq Therapeutics, Inc. Topical sunscreen formulation
CA3112504A1 (en) 2018-09-27 2020-04-02 Novaliq Gmbh Lipid barrier repair
CA3112031A1 (en) 2018-10-12 2020-04-16 Novaliq Gmbh Ophthalmic composition for treatment of dry eye disease
US12397039B2 (en) 2019-02-13 2025-08-26 Novaliq Gmbh Compositions and methods for the treatment of ocular neovascularization
US12419933B2 (en) 2019-09-06 2025-09-23 Novaliq Gmbh Ophthalmic composition for the treatment of uveitis
EP3861857A1 (en) * 2020-02-07 2021-08-11 Novaliq GmbH Antiparasitic compositions
BR112022024461A2 (pt) * 2020-06-01 2023-01-31 Ads Therapeutics Llc Composição oftálmica tópica e método para o tratamento de um distúrbio oftálmico

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005112667A1 (ja) * 2004-05-20 2005-12-01 Takashi Omori 健康食品
WO2012055769A1 (en) * 2010-10-25 2012-05-03 Alcatel Lucent CONTROL OF ACCESS NETWORK/ACCESS TECHNOLOGY SELECTION FOR THE ROUTING OF IP TRAFFIC BY A USER EQUIPMENT, AND QoS SUPPORT, IN A MULTI-ACCESS COMMUNICATION SYSTEM
US10349069B2 (en) * 2012-12-11 2019-07-09 Sony Interactive Entertainment Inc. Software hardware hybrid video encoder

Family Cites Families (193)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2616927A (en) 1950-05-12 1952-11-04 Minnesota Mining & Mfg Fluorocarbon tertiary amines
JPS5721312A (en) 1980-07-12 1982-02-04 Green Cross Corp:The Breathable ointment
US4452818A (en) 1982-03-19 1984-06-05 Haidt Sterling J Extraocular method of treating the eye with liquid perfluorocarbons
US4649047A (en) 1985-03-19 1987-03-10 University Of Georgia Research Foundation, Inc. Ophthalmic treatment by topical administration of cyclosporin
US5077036A (en) 1986-01-14 1991-12-31 Alliance Pharmaceutical Corp. Biocompatible stable fluorocarbon emulsions for contrast enhancement and oxygen transport comprising 40-125% wt./volume fluorocarbon combined with a phospholipid
JPH0764702B2 (ja) 1986-04-23 1995-07-12 鐘紡株式会社 多相乳化型化粧料
JPS6452722A (en) 1987-05-01 1989-02-28 Anjierini Pharmaceut Inc Ophthalmic composition
JPH03279323A (ja) 1989-12-15 1991-12-10 Johnson & Johnson Consumer Prod Inc 日焼け止め組成物
JP3046346B2 (ja) 1990-03-12 2000-05-29 昭和電工株式会社 外用剤基剤又は補助剤とそれを含有する人又は動物の外用剤
US6458376B1 (en) 1990-09-27 2002-10-01 Allergan, Inc. Nonaqueous fluorinated drug delivery suspensions
US5518731A (en) 1990-09-27 1996-05-21 Allergan, Inc. Nonaqueous fluorinated drug delivery vehicle suspensions
US5152997A (en) 1990-12-11 1992-10-06 Theratech, Inc. Method and device for transdermally administering testosterone across nonscrotal skin at therapeutically effective levels
US5326566A (en) 1991-05-17 1994-07-05 Bristol-Myers Squibb Company Use of dibutyl adipate and isopropyl myristate in topical and transdermal products
GB9114374D0 (en) 1991-07-03 1991-08-21 Smithkline Beecham Plc Novel process
US5126127A (en) 1991-07-16 1992-06-30 Euroceltique, S.A. Stabilized PVP-I solutions
FR2679150A1 (fr) 1991-07-17 1993-01-22 Atta Preparations comprenant un fluorocarbure ou compose hautement fluore et un compose organique lipophile-fluorophile, et leurs utilisations.
US6602900B2 (en) 1992-09-21 2003-08-05 Allergan, Inc. Cyclopentane heptan(ENE)oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents
US5336175A (en) 1992-10-29 1994-08-09 Mames Robert N Method for the treatment of retinal detachments
US5370313A (en) 1994-01-10 1994-12-06 Beard; Walter C. Sterile liquid dispenser
DE4405627A1 (de) 1994-02-22 1995-08-24 Hoechst Ag Fluorkohlenwasserstoffe enthaltende Ölemulsionen
FR2720943B1 (fr) 1994-06-09 1996-08-23 Applic Transferts Technolo Emulsions inverses stables à forte concentration en composé(s) fluoré(s) et leur utilisation pour l'administration pulmonaire de médicaments et pour la fabrication d'émulsions multiples.
US5849291A (en) 1994-10-17 1998-12-15 Symbollon Corporation Opthalmic non-irritating iodine medicament
US6294563B1 (en) 1994-10-27 2001-09-25 Allergan Sales, Inc. Combinations of prostaglandins and brimonidine or derivatives thereof
US5696164A (en) 1994-12-22 1997-12-09 Johnson & Johnson Consumer Products, Inc. Antifungal treatment of nails
US5874481A (en) 1995-06-07 1999-02-23 Alliance Pharmaceutical Corp. Fluorochemical solutions for the delivery of lipophilic pharmaceutical agents
US5667809A (en) 1995-06-07 1997-09-16 Alliance Pharmaceutical Corp. Continuous fluorochemical microdispersions for the delivery of lipophilic pharmaceutical agents
US5578020A (en) 1995-09-01 1996-11-26 Mosley; Manuel L. Drop dispensing apparatus
DE19536504C2 (de) 1995-09-29 1999-09-23 H Meinert Verwendung fluorierter Alkane
US5874469A (en) 1996-01-05 1999-02-23 Alcon Laboratories, Inc. Fluoroalkyl hydrocarbons for administering water insoluble or unstable drugs
RU2111738C1 (ru) 1996-06-24 1998-05-27 Акционерное общество "НИЗАР" Средство для усиления солнцезащитной активности фотозащитных агентов
FR2752161B1 (fr) 1996-08-07 1998-09-25 Atta Emulsions multiples de type hydrocarbure-dans-eau-dans- fluorocarbone pour le transport de substances medicamenteuses hydrophiles et/ou lipophiles
US5863560A (en) 1996-09-11 1999-01-26 Virotex Corporation Compositions and methods for topical application of therapeutic agents
IN184589B (enExample) 1996-10-16 2000-09-09 Alza Corp
JP4397973B2 (ja) 1997-02-04 2010-01-13 ジョンストン， マーレイ エイ． 瞼の毛髪の成長を刺激するための局所的組成物
DE19709704C2 (de) 1997-03-10 1999-11-04 Michael Georgieff Verwendung einer flüssigen Präparation von Xenon zur intravenösen Verabreichung bei Einleitung und/oder Aufrechterhaltung der Anaesthesie
US5980936A (en) 1997-08-07 1999-11-09 Alliance Pharmaceutical Corp. Multiple emulsions comprising a hydrophobic continuous phase
US6335335B2 (en) 1997-11-05 2002-01-01 Senju Pharmaceutical Co., Ltd. Prolonged-action eye drop
US5851544A (en) 1997-12-18 1998-12-22 Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. Cosmetic skin or hair care compositions containing fluorocarbons infused with carbon dioxide
US5981607A (en) 1998-01-20 1999-11-09 Allergan Emulsion eye drop for alleviation of dry eye related symptoms in dry eye patients and/or contact lens wearers
DK0983037T3 (da) 1998-02-09 2003-09-01 Macrochem Corp Fungicid neglelak
DE19861012A1 (de) 1998-03-18 1999-09-30 Pharm Pur Gmbh Behandlungsmittel für die Ophthalmologie
AU759641B2 (en) 1998-08-19 2003-04-17 Skyepharma Canada Inc. Injectable aqueous dispersions of propofol
US6140374A (en) 1998-10-23 2000-10-31 Abbott Laboratories Propofol composition
US6159977A (en) 1998-11-16 2000-12-12 Astan, Inc. Therapeutic anti-fungal nail preparation
ES2261190T3 (es) 1999-02-08 2006-11-16 Alza Corporation Vehiculos viscosos no acuosos estables de fase unica y formulaciones que utilizan dichos vehiculos.
US7258869B1 (en) 1999-02-08 2007-08-21 Alza Corporation Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicle
WO2000054588A1 (en) 1999-03-15 2000-09-21 John Claude Krusz Treatment of acute headaches and chronic pain using rapidly-cleared anesthetic drug at sub-anesthetic dosages
US6177477B1 (en) 1999-03-24 2001-01-23 American Home Products Corporation Propofol formulation containing TRIS
US6239113B1 (en) 1999-03-31 2001-05-29 Insite Vision, Incorporated Topical treatment or prevention of ocular infections
DE19926890C1 (de) 1999-06-12 2000-07-27 Pharm Pur Gmbh Verwendung eines hochfluorierten oligomeren Alkans in der Ophthalmologie
DE19938668B4 (de) 1999-08-14 2006-01-26 Bausch & Lomb Inc. Tränenersatzmittel
US6528086B2 (en) 1999-09-28 2003-03-04 Zars, Inc. Methods and apparatus for drug delivery involving phase changing formulations
JP2001158734A (ja) 1999-12-02 2001-06-12 Lion Corp 眼科用組成物及びソフトコンタクトレンズに対する吸着抑制方法
WO2001046134A1 (en) 1999-12-22 2001-06-28 Alcon Universal Ltd. 6-KETO PROSTAGLANDIN F1α AND ANALOGS FOR TREATING DRY EYE
US20030018044A1 (en) 2000-02-18 2003-01-23 Peyman Gholam A. Treatment of ocular disease
DE10024413A1 (de) 2000-05-19 2001-12-06 Mika Pharma Gmbh Pharmazeutische und/oder kosmetische Zubereitung
DE10042412B4 (de) 2000-08-30 2005-12-22 Lts Lohmann Therapie-Systeme Ag Transdermales therapeutisches System zur Abgabe von Venlafaxin, und seine Verwendung
US6399087B1 (en) 2000-12-20 2002-06-04 Amphastar Pharmaceuticals, Inc. Propofol formulation with enhanced microbial inhibition
US20030027833A1 (en) 2001-05-07 2003-02-06 Cleary Gary W. Compositions and delivery systems for administration of a local anesthetic agent
TWI298257B (en) 2001-05-31 2008-07-01 Allergan Inc Hypotensive lipid and timolol compositions and methods of using same
US20040265362A1 (en) 2001-09-04 2004-12-30 Rudy Susilo Plaster for the treatment of dysfunctions and disorders of nail growth
JP2005523252A (ja) 2002-01-26 2005-08-04 マイクロ サイエンス テック コーポレーション リミテッド 牧丹皮抽出物を有効成分として含む組成物
CA2481394A1 (en) 2002-05-24 2003-12-04 Dr. Gerhard Mann Chem.-Pharm. Fabrik Gmbh Drop-forming ophthalmic gel preparation comprising diclofenamide and timolol
US20040033228A1 (en) 2002-08-16 2004-02-19 Hans-Juergen Krause Formulation of human antibodies for treating TNF-alpha associated disorders
US7074827B2 (en) 2002-10-24 2006-07-11 Sucampo Ag (Usa) Inc. Method for treating ocular hypertension and glaucoma
JP3998596B2 (ja) 2003-03-31 2007-10-31 日本ペイント株式会社 塗膜ムラの算出式算出方法及び塗膜ムラの数値化方法
JP2007503428A (ja) 2003-08-25 2007-02-22 フォーミックス エルティーディー． 浸透性医薬発泡剤
US20050079210A1 (en) 2003-10-09 2005-04-14 Gupta Shyam K. Liposomal delivery system for topical pharmaceutical, cosmeceutical, and cosmetic ingredients
AU2004283431B2 (en) 2003-10-10 2009-09-10 Antares Pharma Ipl Ag Transdermal pharmaceutical formulation for minimizing skin residues
EP1684724A4 (en) 2003-11-19 2008-04-02 Barnes Jewish Hospital IMPROVED DRUG DELIVERY
GB0408164D0 (en) 2004-04-13 2004-05-19 Immune Targeting Systems Ltd Antigen delivery vectors and constructs
US20080019926A1 (en) 2004-04-19 2008-01-24 Marie-Pierre Krafft Lung Surfactant Supplements
US20050288196A1 (en) 2004-06-08 2005-12-29 Ocularis Pharma, Inc. Silicone polymer contact lens compositions and methods of use
US7063241B2 (en) 2004-06-10 2006-06-20 Allergan, Inc. Dispensing tip
BRPI0512864B8 (pt) 2004-07-01 2021-05-25 Johnson & Johnson Vision Care composição oftálmica, uso de pelo menos um ácido graxo ômega-6 e pelo menos um ácido graxo ômega-3 e método para preparar a referida composição
US7740875B2 (en) 2004-10-08 2010-06-22 Mediquest Therapeutics, Inc. Organo-gel formulations for therapeutic applications
US20060078580A1 (en) 2004-10-08 2006-04-13 Mediquest Therapeutics, Inc. Organo-gel formulations for therapeutic applications
EP1688161A1 (en) 2004-11-02 2006-08-09 Switch Biotech Aktiengesellschaft Use of pirlindole for the treatment of diseases which are characterized by proliferation of t-lymphocytes and/or hyperproliferation of keratinocytes in particular atopic dermatitis and psoriasis
US7851504B2 (en) 2005-03-16 2010-12-14 Allergan, Inc. Enhanced bimatoprost ophthalmic solution
GB0511499D0 (en) 2005-06-06 2005-07-13 Medpharm Ltd Topical ungual formulations
WO2007008666A2 (en) 2005-07-08 2007-01-18 Ocularis Pharma, Inc. Compositions and methods for improving vision using adherent thin films
ATE420625T1 (de) 2005-08-05 2009-01-15 Bharat Serums & Vaccines Ltd Intravenöse propofol-emulsionszusammensetzungen mit konservierendem effekt
FR2892023B1 (fr) 2005-10-14 2009-09-25 Galderma Sa Composition pharmaceutique a base d'amorolfine et d'agent filmogene hydrosoluble pour application ungueale et peri-ungueale
DE102005050431A1 (de) 2005-10-21 2007-04-26 Lts Lohmann Therapie-Systeme Ag Transdermales therapeutisches System zur Verabreicherung lipophiler und/oder wenig hautpermeabler Wirkstoffe
DE102005055811A1 (de) * 2005-11-23 2007-05-31 Novaliq Gmbh Verwendung einer Zusammensetzung zur Konservierung von Organen und Gliedmaßen
TWI376239B (en) 2006-02-01 2012-11-11 Andrew Xian Chen Vitamin e succinate stabilized pharmaceutical compositions, methods for the preparation and the use thereof
US20070238732A1 (en) 2006-04-10 2007-10-11 Allergan, Inc. Brimonidine and timolol compositions
CN104434770A (zh) 2006-06-16 2015-03-25 瑞泽恩制药公司 适合玻璃体内施用的vegf拮抗剂的制剂
KR20090053892A (ko) 2006-07-25 2009-05-28 오스모티카 코프. 점안액
CN101516333A (zh) 2006-08-04 2009-08-26 英西斯治疗学股份有限公司 水性屈大麻酚制剂
US20080039807A1 (en) 2006-08-08 2008-02-14 Jerrold Scott Pine Ophthalmic Drug Dispensing Tip
CA2664879C (en) 2006-09-29 2015-03-24 Surmodics, Inc. Biodegradable ocular implants and methods for treating ocular conditions
US9000048B2 (en) 2006-11-28 2015-04-07 Wisconsin Alumni Research Foundation Fluoropolymer-based emulsions for the intravenous delivery of fluorinated volatile anesthetics
JP2010511577A (ja) 2006-12-07 2010-04-15 サン・ファーマ・アドバンスド・リサーチ・カンパニー・リミテッド マイクロリットル量の液体を液滴の形態で分注するための計量ドロップボトル
CN200977281Y (zh) 2006-12-08 2007-11-21 陈宇 带助滴器的滴眼瓶
US7959293B2 (en) * 2007-05-04 2011-06-14 Abbott Medical Optics Inc. Methods and devices for measuring tear film and diagnosing tear disorders
ITMI20070890A1 (it) 2007-05-04 2008-11-05 Sifi Spa Composizioni oftalmiche per il trattamento della ipertensione oculare e del glaucoma
EP2178502A2 (en) 2007-06-21 2010-04-28 Yale University Sustained delivery of drugs from biodegradable polymeric microparticles
FR2918891B1 (fr) 2007-07-20 2009-09-25 Thea Sa Lab Solution ophtalmique a base de prostaglandines sans conservateur
US8222292B2 (en) 2007-08-06 2012-07-17 Insys Therapeutics, Inc. Liquid cannabinoid formulations
DE102007055046A1 (de) 2007-11-19 2009-05-28 Fluoron Gmbh Infusionslösung
US20090136430A1 (en) 2007-11-27 2009-05-28 Dugger Harry A Antihistamine/Corticosteroid preparations for the treatment of atopic dermatitis
WO2009072007A2 (en) 2007-12-07 2009-06-11 Foamix Ltd. Carriers, formulations, methods for formulating unstable active agents for external application and uses thereof
CA3069576A1 (en) 2008-01-09 2009-07-16 The Schepens Eye Research Institute, Inc. Therapeutic compositions for treatment of ocular inflammatory disorders
DK2110126T3 (da) 2008-04-18 2012-02-27 Novaliq Gmbh Inhalations- og instillationsanvendelse af semifluorerede alkaner som aktiv bestanddel-bærere inden for det intrapulmonale område
US20100006600A1 (en) 2008-07-14 2010-01-14 Dascanio Gustavo A Fluid dispenser including hydrophobic ring
HUE032158T2 (en) 2008-10-31 2017-09-28 Univ Mississippi Process for the preparation of delta9-THC amino acid esters
JP2012509737A (ja) 2008-11-26 2012-04-26 サーモディクス，インコーポレイティド 埋め込み式の眼薬送達器具および眼薬送達方法
JP5670200B2 (ja) 2008-12-02 2015-02-18 ロート製薬株式会社 眼科用組成物
US8501800B2 (en) 2009-03-05 2013-08-06 Insite Vision Incorporated Controlled-release ophthalmic vehicles
IT1393419B1 (it) 2009-03-19 2012-04-20 Medivis S R L Composizioni oftalmiche a base di acidi grassi polinsaturi omega-3 e omega-6.
JP5872453B2 (ja) 2009-04-17 2016-03-01 ナタク ファルマ エセ．エレ． フィタン酸含量が低く、ω−３脂肪酸に富む組成物
WO2010146536A1 (en) 2009-06-18 2010-12-23 Koninklijke Philips Electronics N.V. Suspension of particles with drug
JP5736635B2 (ja) 2009-06-25 2015-06-17 ライオン株式会社 ドライアイ治療剤
JP5549669B2 (ja) 2009-06-25 2014-07-16 ライオン株式会社 眼科用組成物、ドライアイ治療剤及びビタミンａの安定化方法
PT2387391T (pt) 2009-07-24 2017-04-20 Mika Pharma Ges Für Die Entw Und Vermarktung Pharmazeutischer Produkte Mbh Processo para o desenvolvimento de uma composição líquida a ser aplicada na forma de espuma sobre a pele e composição de aplicação tópica
JP2011024841A (ja) 2009-07-28 2011-02-10 健太 ▲浜崎▼ 点眼補助具
AT509000B1 (de) 2009-10-23 2012-12-15 Rausch Peter Wasserlösliche zubereitungen von cannabinoiden und cannabispräparaten und deren anwendungen
US9149484B2 (en) 2009-11-09 2015-10-06 Allergan, Inc. Compositions and methods for stimulating hair growth
EP2332525A1 (en) 2009-11-23 2011-06-15 Novaliq GmbH Pharmaceutical composition comprising propofol
EP2335735A1 (en) 2009-12-14 2011-06-22 Novaliq GmbH Pharmaceutical composition for treatment of dry eye syndrome
US20110223208A1 (en) 2010-03-09 2011-09-15 Beth Hill Non-Aqueous High Concentration Reduced Viscosity Suspension Formulations
KR101656121B1 (ko) 2010-03-17 2016-09-08 노바리크 게엠베하 안압 증가를 치료하기 위한 약학 조성물
DE102010022567A1 (de) * 2010-06-02 2011-12-08 Fluoron Gmbh Zubereitung
HUP1000362A2 (en) 2010-07-12 2012-11-28 Egis Gyogyszergyar Nyrt Antiseptic and disinfecting compositions having reduced iodine content
EP2444063A1 (en) 2010-10-20 2012-04-25 Novaliq GmbH Liquid pharmaceutical compositions for the delivery of active ingredients
US20120100183A1 (en) 2010-10-23 2012-04-26 Joel Schlessinger Topical base and active agent-containing compositions, and methods for improving and treating skin
EP2462921A1 (en) 2010-11-11 2012-06-13 Novaliq GmbH Liquid pharmaceutical compositions for the treatment of a posterior eye disease
BR112013016661B1 (pt) 2011-01-04 2021-08-03 Novaliq Gmbh Emulsões de o/a compreendendo alcanos semifluorados
JP2014503555A (ja) 2011-01-13 2014-02-13 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 血管新生眼疾患を処置するためのｖｅｇｆアンタゴニストの使用
US20120219640A1 (en) 2011-02-25 2012-08-30 Wright Kenneth W Anti-infective solution for athlete's foot
KR101773648B1 (ko) 2011-05-25 2017-08-31 노바리크 게엠베하 조갑에 투여를 위한 제약학적 조성물
EP3311802B1 (en) 2011-05-25 2023-11-01 Dermaliq Therapeutics, Inc. Topical pharmaceutical composition based on semifluorinated alkanes
CN202136470U (zh) 2011-06-08 2012-02-08 天津市金亿达药用包装材料有限公司 便于滴药的眼药瓶
US8758826B2 (en) 2011-07-05 2014-06-24 Wet Inc. Cannabinoid receptor binding agents, compositions, and methods
WO2013106565A1 (en) 2012-01-10 2013-07-18 Allergan, Inc. Topical treatment for chemotherapy induced eyelash loss or hypotrichosis using prostamide f2 alpha agonists
MX361681B (es) 2012-01-23 2018-12-13 Novaliq Gmbh Composiciones de proteína estabilizadas basadas en alcanos semifluorados.
WO2013126602A1 (en) 2012-02-21 2013-08-29 Massachusetts Eye & Ear Infirmary Inflammatory eye disorders
NZ701915A (en) 2012-05-18 2016-11-25 Genentech Inc High-concentration monoclonal antibody formulations
WO2013188283A1 (en) 2012-06-12 2013-12-19 Bayer Healthcare Llc Topical ophthalmological pharmaceutical composition containing sunitinib
US9878000B2 (en) 2012-06-20 2018-01-30 University Of Waterloo Mucoadhesive nanoparticle composition comprising immunosuppresant and methods of use thereof
DK2895144T3 (en) 2012-09-12 2017-03-06 Novaliq Gmbh SEMIFLUORED ALKAN COMPOSITIONS
EP3100722B1 (en) 2012-09-12 2024-03-20 Novaliq GmbH Semifluorinated alkanes for use in solubilizing meibum
PL2708228T3 (pl) * 2012-09-12 2018-11-30 Novaliq Gmbh Kompozycje do przemywania oczu
EP2730291A1 (en) 2012-11-09 2014-05-14 Fluoron Gmbh Internal Tamponade Composition
EA201591176A1 (ru) 2012-12-18 2016-02-29 Новартис Аг Композиции и способы с использованием пептидной метки, связывающейся с гиалуронаном
EP2968650B1 (en) 2013-03-14 2019-01-16 PanOptica, Inc. Ocular formulations for drug-delivery to the posterior segment of the eye
EP2783703A1 (en) 2013-03-25 2014-10-01 B. Braun Melsungen AG Semifluorocarbon compound containing contrast agent
US10273298B2 (en) 2013-07-23 2019-04-30 Novaliq Gmbh Stabilized antibody compositions
WO2015053829A1 (en) 2013-10-09 2015-04-16 Johnson Living Trust Dated October 26, 2001, Leonidas A. Johnson, Trustee Methods and compositions for treating and preventing signs or symptoms of eye disease
CN203524843U (zh) 2013-10-20 2014-04-09 吕相瑜 自助滴眼液辅助支架
ES2784229T3 (es) 2013-11-20 2020-09-23 Panag Pharma Inc Composiciones y procedimientos para el tratamiento de la inflamación y el dolor ocular
FR3013977A1 (fr) 2013-12-03 2015-06-05 Oreal Composition cosmetique comprenant des filtres uv
ES2949040T3 (es) 2014-03-31 2023-09-25 Amcor Rigid Plastics Usa Llc Recipiente de liberación controlada
EP2944324A1 (de) * 2014-05-13 2015-11-18 LTS LOHMANN Therapie-Systeme AG Verwendung von semifluorierten Alkanen in transdermalen therapeutischen Systemen
US9186305B1 (en) 2014-05-19 2015-11-17 Shiseido Company, Ltd. Sunscreen products in which excessive whiteness due to titanium dioxide and zinc oxide is visually masked upon skin application
AU2015301761B2 (en) 2014-08-13 2020-05-21 University Of Florida Research Foundation, Inc. Preservative removal from eye drops
WO2016063184A1 (en) 2014-10-20 2016-04-28 Sentiss Pharma Private Limited Ophthalmic solution
WO2016082644A1 (en) 2014-11-26 2016-06-02 The University Of Hong Kong A semifluorinated alkane based cleaner for removing emulsified droplets in the eye to reduce the complications associated with the emulsification of silicone oil
WO2016108130A1 (en) 2014-12-30 2016-07-07 Sun Pharmaceutical Industries Limited Topical pharmaceutical compositions comprising nebivolol for the treatment of diabetic wounds
MA41299A (fr) 2014-12-30 2017-11-07 Axim Biotechnologies Inc Solutions ophtalmiques pour le traitement du glaucome et de la conjonctivite
US20170087100A1 (en) * 2015-09-30 2017-03-30 Novaliq Gmbh Semifluorinated compounds and their compositions
US11154513B2 (en) 2015-09-30 2021-10-26 Novaliq Gmbh Semifluorinated compounds
WO2017066429A1 (en) 2015-10-14 2017-04-20 Paul Gavaris Ophthalmic treatment composition and vehicle for delivery of pharmaceutical substances or therapeutic agents
MX2018006092A (es) 2015-11-18 2019-01-31 Formycon Ag Envase farmacéutico precargado que comprende una formulación líquida de un antagonista del vegf.
EP3400014A1 (en) 2016-01-08 2018-11-14 Clearside Biomedical, Inc. Methods and devices for treating posterior ocular disorderswith aflibercept and other biologics
JP2019504097A (ja) 2016-02-04 2019-02-14 ダイヤー, ゴードン, ウェーンDYER, Gordon, Wayne キャシー・バクスター状態を損なうための方法
JP2019517580A (ja) 2016-06-01 2019-06-24 ハロルド・リチャード・ヘルストロムＨａｒｏｌｄ Ｒｉｃｈａｒｄ ＨＥＬＬＳＴＲＯＭ 副交感神経薬および抗交感神経薬でのドライアイ疾患の処置
CA2983765C (en) 2016-06-08 2018-02-27 Majda Ficko Sun block formulation
JP2019520357A (ja) 2016-06-23 2019-07-18 ノバリック ゲーエムベーハー 局所投与方法
CN106176937A (zh) 2016-08-24 2016-12-07 刘艺鹏 湿疹、痤疮软膏
JP7012075B2 (ja) 2016-09-22 2022-01-27 ノバリック ゲーエムベーハー 眼瞼炎の治療に使用するための医薬組成物
JP6869336B2 (ja) 2016-09-23 2021-05-12 ノバリック ゲーエムベーハー シクロスポリンを含む眼科用組成物
US20190343793A1 (en) 2016-09-28 2019-11-14 Novaliq Gmbh Compositions comprising a cannabinoid receptor binding ligand
WO2018094316A1 (en) 2016-11-21 2018-05-24 Just Biotherapeutics, Inc. Aflibercept formulations and uses thereof
WO2018114557A1 (en) 2016-12-22 2018-06-28 Novaliq Gmbh Compositions comprising tacrolimus for the treatment of intraocular inflammatory eye diseases
PT3399962T (pt) 2016-12-23 2020-09-03 Novaliq Gmbh Composição oftálmica para o tratamento da doença do olho seco
ES2957559T3 (es) 2017-04-21 2024-01-22 Dermaliq Therapeutics Inc Composiciones de yodo
US20210069014A1 (en) 2017-05-06 2021-03-11 Novaliq Gmbh Drop dispenser
WO2018206656A1 (en) 2017-05-12 2018-11-15 Novaliq Gmbh Pharmaceutical compositions comprosing semifluorinated alkanes for the treatment of contact lense-related conditions
KR20200059272A (ko) 2017-09-27 2020-05-28 노바리크 게엠베하 안구 질환의 치료에서의 사용을 위한 라타노프로스트를 포함하는 안과적 조성물
US11896559B2 (en) 2017-10-04 2024-02-13 Novaliq Gmbh Opthalmic compositions comprising F6H8
JP7353292B2 (ja) 2018-03-02 2023-09-29 ノバリック ゲーエムベーハー ネビボロールを含む医薬組成物
JP7496778B2 (ja) 2018-03-28 2024-06-07 ノバリック ゲーエムベーハー チモロールを含む医薬組成物
US12226422B2 (en) 2018-04-27 2025-02-18 Novaliq Gmbh Ophthalmic compositions comprising tafluprost for the treatment of glaucoma
JP2022500461A (ja) 2018-09-22 2022-01-04 ノバリック ゲーエムベーハー 眼表面の損傷および乾燥の症状の治療のための眼科用組成物
CA3112031A1 (en) 2018-10-12 2020-04-16 Novaliq Gmbh Ophthalmic composition for treatment of dry eye disease
CN113164609A (zh) 2018-11-27 2021-07-23 诺瓦利克有限责任公司 包含ω-3脂肪酸乙酯的半氟化烷烃组合物
EP3914244A1 (en) 2019-01-21 2021-12-01 Novaliq GmbH Pharmaceutical composition for the treatment of ocular neovascularisation
US12397039B2 (en) 2019-02-13 2025-08-26 Novaliq Gmbh Compositions and methods for the treatment of ocular neovascularization
EP4009952A1 (en) 2019-08-09 2022-06-15 Dermaliq Therapeutics, Inc. Topical composition comprising a prostaglandin analogue
US12419933B2 (en) 2019-09-06 2025-09-23 Novaliq Gmbh Ophthalmic composition for the treatment of uveitis
EP4065082A1 (en) 2019-11-27 2022-10-05 Novaliq GmbH Suspension comprising a protein particle suspended in a non-aqueous vehicle

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005112667A1 (ja) * 2004-05-20 2005-12-01 Takashi Omori 健康食品
WO2012055769A1 (en) * 2010-10-25 2012-05-03 Alcatel Lucent CONTROL OF ACCESS NETWORK/ACCESS TECHNOLOGY SELECTION FOR THE ROUTING OF IP TRAFFIC BY A USER EQUIPMENT, AND QoS SUPPORT, IN A MULTI-ACCESS COMMUNICATION SYSTEM
US10349069B2 (en) * 2012-12-11 2019-07-09 Sony Interactive Entertainment Inc. Software hardware hybrid video encoder

Also Published As

Publication number Publication date
PT3355990T (pt) 2019-09-11
PL3355990T3 (pl) 2019-11-29
ES2743502T3 (es) 2020-02-19
US20220370377A1 (en) 2022-11-24
CN110403923A (zh) 2019-11-05
WO2017055454A1 (en) 2017-04-06
US20200338015A1 (en) 2020-10-29
US10682315B2 (en) 2020-06-16
EP3355990B1 (en) 2019-06-12
HK1257185A1 (zh) 2019-10-18
EP3495023B1 (en) 2020-04-22
JP6900442B2 (ja) 2021-07-07
US20190070125A1 (en) 2019-03-07
CN108348777A (zh) 2018-07-31
US11357738B2 (en) 2022-06-14
US12128010B2 (en) 2024-10-29
DE202016008738U1 (de) 2019-04-09
EP3355990A1 (en) 2018-08-08
JP6602964B2 (ja) 2019-11-06
DK3495023T3 (da) 2020-07-20
US20170087100A1 (en) 2017-03-30
JP2020023530A (ja) 2020-02-13
JP2018531233A (ja) 2018-10-25
CN120884568A (zh) 2025-11-04
HK1257183B (en) 2020-06-12
US20250017872A1 (en) 2025-01-16
CN111743882A (zh) 2020-10-09
DK3355990T3 (da) 2019-09-16
EP3495023A1 (en) 2019-06-12
CN110403923B (zh) 2021-09-21
CN120754071A (zh) 2025-10-10

Similar Documents

Publication Publication Date Title
US12128010B2 (en) Semifluorinated compounds and their compositions
CN108349855B (zh) 用于眼部给药的半氟化化合物
JP2018531233A6 (ja) 半フッ素化化合物およびその組成物
HK1257183A1 (en) Semifluorinated compounds and their compositions
HK40099432A (en) Semifluorinated compounds for ophthalmic administration
HK1257185B (en) Semifluorinated compounds and their compositions
HK40039482A (en) 2-perfluorobutyl pentane for ophthalmic administration
HK1257007B (en) Semifluorinated compounds for ophthalmic administration
HK1257007A1 (en) Semifluorinated compounds for ophthalmic administration
HK40006723B (en) Semifluorinated compounds and their compositions
HK40006723A (en) Semifluorinated compounds and their compositions

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1257185

Country of ref document: HK

GR01 Patent grant
GR01 Patent grant