CN108310326A - 一种治疗经行乳胀的药物及其制备方法 - Google Patents
一种治疗经行乳胀的药物及其制备方法 Download PDFInfo
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- CN108310326A CN108310326A CN201810401186.XA CN201810401186A CN108310326A CN 108310326 A CN108310326 A CN 108310326A CN 201810401186 A CN201810401186 A CN 201810401186A CN 108310326 A CN108310326 A CN 108310326A
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Abstract
本发明公开了一种治疗经行乳胀的药物及其制备方法,其是由枳壳、白芍、合欢皮、路路通、瓜蒌、延胡索、生地黄、青皮、刘寄奴、郁金、王不留行、小茴香、川贝母、山楂、茯苓、香附、木香、川楝子、益母草、川芎、茯神、山药、桔梗、橘叶按一定重量配比制备而成,本发明药物具有疏肝破气,散结消痰,固肾益精,降湿热的功能,用于治疗经行乳胀见效快、疗效好,不复发。
Description
技术领域
本发明涉及一种治疗经行乳胀的药物及其制备方法,属中药领域。
背景技术
经行乳胀是指每月行经前后,或正值经期,出现乳房胀痛,或乳头胀疼痛,甚至不能触衣者。中医则认为经行乳胀与肝郁气滞,肝肾亏虚,痰湿阻络有关。由于西药治疗副作用大,因此人们对有效治疗经行乳胀的中药药物存在极大的需求,至今为止,还没有发现关于本发明的有关报道。
发明内容
本发明人依据中医理论的研究和临床试验的反复验证,终于找到了有效治疗经行乳胀的药物,从而完成了本发明。
本发明的目的就是提供一种有效治疗经行乳胀的中药组合药物。
本发明的另一目的就是提供了该中药组合药物的制备方法。
本发明药物是选择枳壳、白芍、合欢皮、路路通、瓜蒌、延胡索、生地黄、青皮、刘寄奴、郁金、王不留行、小茴香、川贝母、山楂、茯苓、香附、木香、川楝子、益母草、川芎、茯神、山药、桔梗、橘叶、白芷、乌药、皂角刺进行组合制备的,将这些药物组合使得各药物功效产生协同作用,从而能够有效治疗经行乳胀。其中选用枳壳是因为其性味苦辛,凉,入肺、脾、大肠经,有破气,行痰,消积的功能,治胸膈痰滞,胸痞,胁胀,食积,噫气,呕逆,下痢后重,脱肛,子宫脱垂。选用白芍是因为其性味苦酸,凉,入肝、脾经,有养血柔肝,缓中止痛,敛阴收汗的功能,治胸腹胁肋疼痛,泻痢腹痛,自汗盗汗,阴虚发热,月经不调,崩漏,带下。选用合欢皮是因为其性味甘,平,入心、肝经,有解郁,和血,宁心,消痈肿的功能,治心神不安,忧郁失眠,肺痈,痈肿,瘰疬,筋骨折伤。选用路路通是因为其性味苦平,通行十二经,有祛风通络,利尿除湿的功能,治水肿,胀满,经闭,乳少,手足拘挛。选用瓜蒌是因为其性味甘、微苦,寒,归肺、胃、大肠经,有清热涤痰,宽胸散结,润燥滑肠的功能,治肺热咳嗽,痰浊黄稠,胸痹心痛,结胸痞满,乳痈,肠痈,大便秘结。选用延胡索是因为其性味辛苦,温,入肝、胃经,有活血,散瘀,理气,止痛的功能,治心腹腰膝诸痛,月经不调,癥瘕,崩中,产后血晕,恶露不尽,跌打损伤。选用生地黄是因为其性味甘,寒,归心、肝、肾经,有清热凉血,养阴,生津的功能,治热病烦渴,阴虚内热,骨蒸劳热,内热消渴,吐血,衄血,发斑发疹。选用青皮是因为其性味苦辛,微温,入肝、胆经,有疏肝破气,散结消痰的功能,治胸胁胃脘疼痛,疝气,食积,乳肿,乳核,久疟癖块。选用刘寄奴是因为其性味苦,温,入心、脾经,有破血通经,敛疮消肿的功能,治经闭癥瘕,胸腹胀痛,产后血瘀,跌打损伤,金疮出血,痈毒焮肿。选用郁金是因为其性味辛苦,凉,入心、肺、肝经,有行气解随,凉血破瘀的功能,治胸腹胁肋诸痛,失心癫狂,热病神昏,吐血,衄血,尿血,血淋,妇女倒经,黄疸。选用王不留行是因为其性味苦平,入肝、胃经,有行血通经,催生下乳,消肿敛疮的功能,治妇女经闭,乳汁不通,难产,血淋,痈肿,金疮出血。选用小茴香是因为其性味辛,温,归肝、肾、脾、胃经,有散寒止痛,理气和胃的功能,治寒疝腹痛,睾丸偏坠,痛经,少腹冷痛,脘腹胀满,食少吐泻,睾丸鞘膜积液。选用川贝母是因为其性味苦甘,凉,入肺经,有润肺散结,止嗽化痰的功能,治虚劳咳嗽,吐痰咯血,心胸郁结,肺痿,肺痈,瘿瘤,瘰疬,喉痹,乳痈。选用山楂是因为其性味酸甘,微温,入脾、胃、肝经,有消食积,散瘀血,驱绦虫的功能,治肉积,癥瘕,痰饮,痞满,吞酸,泻痢,肠风,腰痛,疝气,产后儿枕痛,恶露不尽,小儿乳食停滞。选用茯苓是因为其性味甘淡,平,入心、脾、肺经,有渗湿利水,益脾和胃,宁心安神的功能,治小便不利,水肿胀满,痰饮咳逆,呕哕,泄泻,遗精,淋浊,惊悸,健忘。选用香附是因为其性味辛微苦干,平,入肝、三焦经,有理气解郁,止痛调经的功能,治肝胃不和,气郁不舒,胸腹胁肋胀痛,痰饮痞满,月经不调,崩漏带下。选用木香是因为其性味辛苦,温,入肺、肝、脾经,有行气止痛,温中和胃的功能,治中寒气滞,胸腹胀痛,呕吐,泄泻,下痢里急后重,寒疝。选用川楝子是因为其性味苦,寒,有毒,入肝、胃、小肠经,有降湿热,清肝火,止痛,杀虫的功能,治热厥心痛,胁痛,疝痛,虫积腹痛。选用益母草是因为其性味辛苦,凉,入心包、肝经,有活血,祛瘀,调经,消水的功能,治月经不调,治漏难产,胞衣不下,产后血晕,瘀血腹痛,崩中漏下,尿血,泻血,痈肿疮疡。选用川芎是因为其性味辛,温,入肝、胆经,有行气开郁,祛风燥湿,活血止痛的功能,治风冷头痛旋晕,胁痛腹疼,寒痹筋挛,经闭,难产,产后瘀阻块痛,痈疽疮疡。选用茯神是因为其性味甘淡,平,入心、脾经,有宁心,安神,利水的功能,治心虚惊悸,健忘,失眠,惊癎,小便不利。选用山药是因为其性味甘,平,入肺、脾、肾经,有健脾,补肺,固肾,益精的功能,治脾虚泄泻,久痢,虚劳咳嗽,消渴,遗精、带下,小便频数。选用桔梗是因为其性味苦辛,平,入肺、胃经,有开宣肺气,祛痰排脓的功能,治外感咳嗽,咽喉肿痛,肺痈吐脓,胸满胁痛,痢疾腹痛。选用橘叶是因为其性味苦辛,平,入足厥阴肝经气分,有疏肝,行气,化痰,消肿毒的功能,治胁痛,乳痈,肺痈,咳嗽,胸膈痞满,疝气。选用白芷是因为其性味辛,温,入肺、脾、胃经,有祛风,燥湿,消肿,止痛的功能,治头痛,眉棱骨痛,齿痛,鼻渊,寒湿腹痛,肠风痔漏,赤白带下,痈疽疮疡,皮肤燥痒,疥癣。选用乌药是因为其性味辛,温,入脾、肺、肾、膀胱经,有顺气,开郁,散寒,止痛的功能,治气逆胸腹胀痛,宿食不满,反胃吐食,寒疝,脚气,小便频数。选用皂角刺是因为其性味辛,温,有搜风,拔毒,消肿,排脓的功能,治痈肿,疮毒,疠风,癣疮,胎衣不下。
具体实施方式
本发明组分的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下述重量范围内都具有较好的疗效:
枳壳10-15克,白芍10-20克,合欢皮5-15克,路路通5-15克,瓜蒌10-15克,延胡索10-15克,生地黄10-15克,青皮10-15克,刘寄奴5-15克,郁金5-15克,王不留行5-15克,小茴香5-10克,川贝母10-15克,山楂10-15克,茯苓10-20克,香附5-15克,木香10-15克,川楝子10-15克,益母草5-15克,川芎5-15克,茯神5-15克,山药10-15克,桔梗5-15克,橘叶10-20克,白芷5-10克,乌药10-15克,皂角刺10-15克。
优选为:
枳壳12克,白芍15克,合欢皮10克,路路通10克,瓜蒌12克,延胡索12克,生地黄12克,青皮12克,刘寄奴10克,郁金10克,王不留行10克,小茴香8克,川贝母12克,山楂12克,茯苓15克,香附10克,木香12克,川楝子12克,益母草10克,川芎10克,茯神10克,山药12克,桔梗10克,橘叶15克,白芷8克,乌药12克,皂角刺12克。
本发明药物的制备方法如下
一、备料
1、枳壳:除去瓤、核,冼净,稍浸,捞出,润软,以手能捏对折为好,切片,晾干;
2、白芍:拣去杂质,分开大小个,用水浸泡至八成透,捞出,晒晾,润至内外湿度均匀,切片,干燥;
3、合欢皮:清水浸泡洗净,捞出,闷润后先划成相等大的长条,再切块或切丝,干燥;
4、路路通:除去杂质,洗净,晒干;
5、瓜蒌:取原药材,除去杂质及果柄,洗净,压扁,切丝或小块,干燥;
6、延胡索:拣去杂质,用水浸泡,洗净,晒晾,润至内外湿度均匀,切片或打碎;
7、生地黄:取原药材,除去杂质,洗净,稍润,切厚片,干燥,筛去碎屑;
8、青皮:拣净杂质,用水浸泡,捞出,润透,切片,晒干;
9、刘寄奴:拣净杂质,去根,用水冼净,稍浸,切段,晒干;
10、郁金:用水浸泡,洗净,捞出晒晾,润透,切片,晒干;
11、王不留行:簸净杂质,置锅内,用文火炒至爆开白花六、七成时取出,放凉;
12、小茴香:取原药材,除去杂质;
13、川贝母:拣去杂质,用水稍泡,捞出,闷润,剥去心,晒干;
14、山楂:拣净杂质,筛去核;
15、茯苓:用水浸泡,洗净,捞出,闷透后,切片,晒干;
16、香附:拣去杂质,碾成碎粒,簸去细毛及细末;
17、木香:将原生药放清水内洗净,捞出,闷润12—24小时使软,切片,晒干;
18、川楝子:拣去杂质,洗净,烘干,轧碎或劈成两半;
19、益母草:拣去杂质,洗净,润透,切段,晒干;
20、川芎:拣去杂质,分开大、小个,用水浸泡,晒晾,闷润后切片,干燥;
21、茯神:取原药材,除去杂质,洗净,润透,切成正方形的厚生或块,阴干;
22、山药:拣净杂质,用水浸泡至山药中心部软化为度,捞出稍晾,切片晒干或烘干;
23、桔梗:拣净杂质,除去芦头,洗净捞出,润透后切片,晒干;
24、橘叶:拣净杂质,晒干;
25、白芷:拣净杂质,用水洗净,浸泡,捞出润透,略晒至外皮无滑腻感时,再闷润后,切片干燥;
26、乌药:拣去杂质,分开大小条,用水泡透,根据季节注意换水,防止发臭,及时捞出切片,筛去灰屑;
27、皂角刺:拣去杂质,用水浸泡,润透后切片,晒干。
二、制备
1、将所述重量的枳壳、白芍、合欢皮、路路通、瓜蒌、延胡索、生地黄、青皮、刘寄奴、郁金、王不留行、小茴香、川贝母、山楂、茯苓、香附、木香、川楝子、益母草、川芎、茯神、山药、桔梗、橘叶、白芷、乌药、皂角刺放入煎药容器内,第一次加水8倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
2、将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
3、将两次煎煮液混合搅拌均匀,分为3剂服用。
组方中青皮有疏肝破气,散结消痰的功能为君药;山药健脾,补肺,固肾,益精;橘叶有疏肝,行气,化痰的功能,二者为臣药,三味药共同发挥疏肝破气,散结消痰,固肾益精,健脾补肺的作用,治疗经行乳胀效力全面,且以疏肝破气,散结消痰,固肾益精为主可治本,乌药有顺气,开郁,散寒,止痛的功能为佐药,川楝子有降湿热,清肝火的功能为使药,与下余诸药是治标。
本发明药物具有疏肝破气,散结消痰,固肾益精,降湿热的功能,用于治疗经行乳胀,疗程短、见效快、治愈后不复发。
以下通过试验例来进一步阐述本发明所述药物的有益效果,这些试验例包括本发明药物的动物毒性试验报告和临床疗效观察资料。
[试验例1]本发明药物的动物毒性试验报告:
取家兔30只,雌雄兼用,体重2.0—2.5kg,分两组,每组15只,其中一组为超剂量试验组,另一组为正常量试验组。超常量组为20ml/kg,正常量为10ml/kg,给药方式为灌胃法给药,每天两次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常,药物无不良毒副作用。
[试验例2]本发明药物的临床疗效观察
1、一般资料
收治经行乳胀门诊患者共25例。
2、诊断标准
典型症状为乳房胀痛,或乳头胀疼痛。
3、治疗方法
选用上述药剂,给患者服用,每次服用1剂,每天早、晚各服1次,7天为一个疗程,连续服用2个疗程。
4、疗效评定标准
显效:经行乳胀症状消失,体质恢复正常,痊愈;
好转:患者乳房胀痛和乳头胀痛的现象减轻,经行乳胀症状明显好转,体质逐步恢复;
无效:达不到好转标准者。
5、治疗结果(见下表)
在上述治疗中,用本发明药物治疗经行乳胀患者25例,结果显效20例,显效率为80%,好转5例,好转率为20%,无效0例,总有效率为100%。
Claims (3)
1.一种治疗经行乳胀的药物,其特征在于:它是由下列重量范围内的原料药制成:
枳壳10-15克,白芍10-20克,合欢皮5-15克,路路通5-15克,瓜蒌10-15克,延胡索10-15克,生地黄10-15克,青皮10-15克,刘寄奴5-15克,郁金5-15克,王不留行5-15克,小茴香5-10克,川贝母10-15克,山楂10-15克,茯苓10-20克,香附5-15克,木香10-15克,川楝子10-15克,益母草5-15克,川芎5-15克,茯神5-15克,山药10-15克,桔梗5-15克,橘叶10-20克,白芷5-10克,乌药10-15克,皂角刺10-15克。
2.根据权利要求1所述的药物,其中各原料药的用量为:
枳壳12克,白芍15克,合欢皮10克,路路通10克,瓜蒌12克,延胡索12克,生地黄12克,青皮12克,刘寄奴10克,郁金10克,王不留行10克,小茴香8克,川贝母12克,山楂12克,茯苓15克,香附10克,木香12克,川楝子12克,益母草10克,川芎10克,茯神10克,山药12克,桔梗10克,橘叶15克,白芷8克,乌药12克,皂角刺12克。
3.根据权利要求1或2所述药物的制备方法,它包括下列步骤:
(一)备料
(1)枳壳:除去瓤、核,冼净,稍浸,捞出,润软,以手能捏对折为好,切片,晾干;
(2)白芍:拣去杂质,分开大小个,用水浸泡至八成透,捞出,晒晾,润至内外湿度均匀,切片,干燥;
(3)合欢皮:清水浸泡洗净,捞出,闷润后先划成相等大的长条,再切块或切丝,干燥;
(4)路路通:除去杂质,洗净,晒干;
(5)瓜蒌:取原药材,除去杂质及果柄,洗净,压扁,切丝或小块,干燥;
(6)延胡索:拣去杂质,用水浸泡,洗净,晒晾,润至内外湿度均匀,切片或打碎;
(7)生地黄:取原药材,除去杂质,洗净,稍润,切厚片,干燥,筛去碎屑;
(8)青皮:拣净杂质,用水浸泡,捞出,润透,切片,晒干;
(9)刘寄奴:拣净杂质,去根,用水冼净,稍浸,切段,晒干;
(10)郁金:用水浸泡,洗净,捞出晒晾,润透,切片,晒干;
(11)王不留行:簸净杂质,置锅内,用文火炒至爆开白花六、七成时取出,放凉;
(12)小茴香:取原药材,除去杂质;
(13)川贝母:拣去杂质,用水稍泡,捞出,闷润,剥去心,晒干;
(14)山楂:拣净杂质,筛去核;
(15)茯苓:用水浸泡,洗净,捞出,闷透后,切片,晒干;
(16)香附:拣去杂质,碾成碎粒,簸去细毛及细末;
(17)木香:将原生药放清水内洗净,捞出,闷润12—24小时使软,切片,晒干;
(18)川楝子:拣去杂质,洗净,烘干,轧碎或劈成两半;
(19)益母草:拣去杂质,洗净,润透,切段,晒干;
(20)川芎:拣去杂质,分开大、小个,用水浸泡,晒晾,闷润后切片,干燥;
(21)茯神:取原药材,除去杂质,洗净,润透,切成正方形的厚生或块,阴干;
(22)山药:拣净杂质,用水浸泡至山药中心部软化为度,捞出稍晾,切片晒干或烘干;
(23)桔梗:拣净杂质,除去芦头,洗净捞出,润透后切片,晒干;
(24)橘叶:拣净杂质,晒干;
(25)白芷:拣净杂质,用水洗净,浸泡,捞出润透,略晒至外皮无滑腻感时,再闷润后,切片干燥;
(26)乌药:拣去杂质,分开大小条,用水泡透,根据季节注意换水,防止发臭,及时捞出切片,筛去灰屑;
(27)皂角刺:拣去杂质,用水浸泡,润透后切片,晒干;
(二)制备
(1)将所述重量的枳壳、白芍、合欢皮、路路通、瓜蒌、延胡索、生地黄、青皮、刘寄奴、郁金、王不留行、小茴香、川贝母、山楂、茯苓、香附、木香、川楝子、益母草、川芎、茯神、山药、桔梗、橘叶、白芷、乌药、皂角刺放入煎药容器内,加水8倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
(2)将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
(3)将两次煎煮液混合搅拌均匀,分为3剂服用。
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