CN108271372B - Il-8-结合抗体及其应用 - Google Patents

Il-8-结合抗体及其应用 Download PDF

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CN108271372B
CN108271372B CN201680054135.3A CN201680054135A CN108271372B CN 108271372 B CN108271372 B CN 108271372B CN 201680054135 A CN201680054135 A CN 201680054135A CN 108271372 B CN108271372 B CN 108271372B
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antibody
amino acid
region
modification
antigen
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CN108271372A (zh
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井川智之
前田敦彦
中村元气
村冈优
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Chugai Pharmaceutical Co Ltd
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Chugai Pharmaceutical Co Ltd
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/235—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bordetella (G)
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CN201680054135.3A 2015-09-18 2016-08-05 Il-8-结合抗体及其应用 Active CN108271372B (zh)

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JP2015185254 2015-09-18
JP2015-185254 2015-09-18
PCT/JP2016/003616 WO2017046994A1 (en) 2015-09-18 2016-08-05 Il-8-binding antibodies and uses thereof

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EP (1) EP3350202A1 (ko)
JP (4) JP6266164B2 (ko)
KR (3) KR20230079500A (ko)
CN (2) CN108271372B (ko)
AR (1) AR105634A1 (ko)
AU (1) AU2016323088B2 (ko)
BR (1) BR112018002432A2 (ko)
CA (1) CA2993423C (ko)
CL (1) CL2018000699A1 (ko)
CO (1) CO2018004056A2 (ko)
CR (1) CR20180217A (ko)
HK (1) HK1252615A1 (ko)
IL (2) IL258088B2 (ko)
MA (1) MA42808A (ko)
MX (2) MX2018003005A (ko)
PE (1) PE20181336A1 (ko)
PH (1) PH12018500386A1 (ko)
RU (1) RU2728430C2 (ko)
TW (4) TWI814162B (ko)
UA (1) UA120981C2 (ko)
WO (1) WO2017046994A1 (ko)
ZA (1) ZA201800536B (ko)

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CN101874042B9 (zh) 2007-09-26 2019-01-01 中外制药株式会社 利用cdr的氨基酸取代来改变抗体等电点的方法
LT2708559T (lt) 2008-04-11 2018-06-11 Chugai Seiyaku Kabushiki Kaisha Antigeną surišanti molekulė, galinti pakartotinai prisijungti prie dviejų ar daugiau antigeno molekulių
EP2647706B1 (en) 2010-11-30 2023-05-17 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly
MX2014014678A (es) 2012-05-30 2015-02-10 Chugai Pharmaceutical Co Ltd Molecula de union al antigeno especifico para el tejido objetivo.
US11236168B2 (en) 2012-08-24 2022-02-01 Chugai Seiyaku Kabushiki Kaisha Mouse FcγammaRII-specific Fc antibody
AU2013306700B2 (en) 2012-08-24 2019-05-02 Chugai Seiyaku Kabushiki Kaisha FcgammaRIIb-specific Fc region variant
AU2014250434B2 (en) 2013-04-02 2019-08-08 Chugai Seiyaku Kabushiki Kaisha Fc region variant
EP3078744B1 (en) 2013-12-04 2020-08-26 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecules, the antigen-binding activity of which varies according to the concentration of compounds, and libraries of said molecules
SG11201700841QA (en) 2014-12-19 2017-03-30 Chugai Pharmaceutical Co Ltd Anti-myostatin antibodies, polypeptides containing variant fc regions, and methods of use
KR102605798B1 (ko) 2015-02-05 2023-11-23 추가이 세이야쿠 가부시키가이샤 이온 농도 의존적 항원 결합 도메인을 포함하는 항체, Fc 영역 개변체, IL-8에 결합하는 항체, 및 그들의 사용
PE20181336A1 (es) * 2015-09-18 2018-08-21 Chugai Pharmaceutical Co Ltd Anticuerpos que se unen a interleucina 8 (il-8) y sus usos
US11359009B2 (en) 2015-12-25 2022-06-14 Chugai Seiyaku Kabushiki Kaisha Anti-myostatin antibodies and methods of use
MX2019001448A (es) 2016-08-05 2019-09-13 Chugai Pharmaceutical Co Ltd Composicion para profilaxis o tratamiento de enfermedades relacionadas con interleucina 8 (il-8).
SG10201607778XA (en) 2016-09-16 2018-04-27 Chugai Pharmaceutical Co Ltd Anti-Dengue Virus Antibodies, Polypeptides Containing Variant Fc Regions, And Methods Of Use
KR20240056666A (ko) * 2017-06-05 2024-04-30 얀센 바이오테크 인코포레이티드 이중특이성 항체 생성을 위한 표면 전하 조작 방법
MX2020009296A (es) 2018-03-15 2020-11-13 Chugai Pharmaceutical Co Ltd Anticuerpos anti-virus del dengue que tienen reactividad cruzada con el virus zika y metodos de uso.
BR112021002037A2 (pt) 2018-08-10 2021-05-04 Chugai Seiyaku Kabushiki Kaisha molécula de ligação de antígeno anti-cd137 e uso da mesma
EP3956365A4 (en) * 2019-04-19 2023-07-05 Chugai Seiyaku Kabushiki Kaisha ANTIBODIES AND COMPOSITIONS FOR USE IN DETECTING OR CAPTURE OF A POLYPEPTIDE IN A SAMPLE AND METHODS OF DETECTING OR CAPTURE OF A POLYPEPTIDE IN A SAMPLE
CA3164818A1 (en) 2019-12-18 2021-06-24 F. Hoffmann-La Roche Ag Bispecific anti-ccl2 antibodies
KR20220134541A (ko) 2020-01-31 2022-10-05 추가이 세이야쿠 가부시키가이샤 착색을 억제한 폴리펩타이드를 포함하는 조성물의 제조 방법
TW202144395A (zh) 2020-02-12 2021-12-01 日商中外製藥股份有限公司 用於癌症之治療的抗cd137抗原結合分子
GB2595299B (en) * 2020-05-21 2022-08-03 Mabsolve Ltd Modified immunoglobulin FC regions
JPWO2022025030A1 (ko) * 2020-07-28 2022-02-03
EP4342984A1 (en) 2021-05-19 2024-03-27 Chugai Seiyaku Kabushiki Kaisha Method for predicting in vivo pharmacokinetics of molecule
AU2022295067A1 (en) 2021-06-18 2023-12-21 F. Hoffmann-La Roche Ag Bispecific anti-ccl2 antibodies

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US6025158A (en) * 1997-02-21 2000-02-15 Genentech, Inc. Nucleic acids encoding humanized anti-IL-8 monoclonal antibodies
US6458355B1 (en) * 1998-01-22 2002-10-01 Genentech, Inc. Methods of treating inflammatory disease with anti-IL-8 antibody fragment-polymer conjugates
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