CN108186801A - 一种香菇多糖保健口服液及其制备方法 - Google Patents
一种香菇多糖保健口服液及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种香菇多糖保健口服液及其制备方法,口服液的组分和重量百分含量为香菇多糖5%~15%、中药提取物5%~15%、甜味剂5%~15%、酸味剂2%~20%,余量为水,中药提取物由以下重量份的原料制成:木耳10份~30份、银耳10份~30份、枸杞子10份~30份、黄芪10份~30份和甘草1份~15份。制备方法包括香菇多糖的制备、中药提取物的制备、甜味剂的选取、酸味剂的选取、口服液混合液的制备以及混合液的灭菌、装瓶、包装。与现有技术相比,本发明的有益效果是具有增加免疫力的作用,且见效快。本发明的制备方法简单,原料来源广。
Description
技术领域
本发明属于保健品技术领域,特别涉及一种香菇多糖保健口服液及其制备方法。
背景技术
现代研究表明香菇多糖是一种抗肿瘤药,属于生物反应调节剂,具有免疫增强作用。香菇多糖在人体内虽无直接杀伤肿瘤细胞的作用,但是可以通过增强基体免疫功能,进而发挥抗肿瘤活性。香菇多糖与抗肿瘤药合用,可以起到曾敏作用;在体外使用时,香菇多糖可增强脱氧胸腺嘧啶核苷抗艾滋病毒的活性。香菇多糖对机体具有免疫调节作用,主要是由于其属于典型的T细胞激活剂,在体内能促进迟发超敏反应,同时还能诱导产生急性蛋白诱导因子等因子,从而产生相关免疫应答。有报道表明香菇多糖能够抑制小鼠S-180实体瘤的生长,同时对于治疗结肠癌、乳腺癌、肺癌、胃癌等都有良好的疗效,且能延长肿瘤患者的存活时间,也能够极大的减轻化疗带来的副作用;临床应用也发现,香菇多糖可改善乙肝患者的乏力、恶心、腹胀等常见症状,促进转氨酶和胆红素恢复正常;香菇多糖还对Abelson病毒、A2(H2N2)病毒、12型腺病毒及流感病毒等均有抑制作用。
市场上的香菇多糖主要分为两种,一种是用于临床,这种香菇多糖的纯度要求较高,特别是作为注射用药物,必须具有足够的纯度。另一种是应用在日常生活中,但这类香菇多糖产品大多是单独使用香菇多糖一种有效组分制成香菇多糖片、香菇多糖冲剂等饮品,由于这些制品中香菇多糖含量少,导致这些制品不能达到提高人体免疫力的效果。
发明内容
本发明的目的在于,针对现有香菇多糖在日常生活的应用中存在的上述问题,提供一种香菇多糖保健口服液及其制备方法。
为了实现上述目的,本申请采用的技术方案为:
一种香菇多糖保健口服液,所述口服液的组分和重量百分含量为香菇多糖5%~15%、中药提取物5%~15%、甜味剂5%~15%、酸味剂2%~20%,余量为水;
所述中药提取物由以下重量份的原料制成:木耳10份~30份、银耳10份~30份、枸杞子10份~30份、黄芪10份~30份和甘草1份~15份。
进一步的,所述甜味剂是蔗糖、木糖醇、低聚果糖和蜂蜜中的一种或两种;所述酸味剂为柠檬酸。
这种香菇多糖保健口服液的制备方法,包括如下步骤:
S1、香菇多糖的制备
a、取香菇,除杂洗净,沥干,切碎;
b、将步骤a中得到的香菇用6~12倍重量的水回流提取2~3次,每次提取2~3h,过滤,收集滤液备用;
c、将步骤b中的滤液进行超滤,将滤液浓缩至相对密度为1.1g/L~1.3g/L的浸膏,再向浸膏中加入乙醇,进行醇沉2~3次,每次醇沉均醇析16h~20h,4000r/min~4500r/min离心10min~20min,收集沉淀;
d、将步骤c中的沉淀依次用2~4倍重量的无水乙醇、丙酮分别洗涤,将洗涤后的沉淀用2~4倍蒸馏水溶解,过截留分子量为100万的中空纤维膜,收集浓缩液,然后将浓缩液过截留分子量为180万的中空纤维膜,收集透过液离心,过滤,取滤液备用;
e、将步骤d中得到的滤液干燥,得到香菇多糖;
S2、中药提取物的制备
称取所需重量份的木耳、银耳、枸杞子、黄芪和甘草,经混配、粉碎、热水浸提、离心、浓缩、真空干燥得到中药提取物。
S3、选取蔗糖、木糖醇、低聚果糖和蜂蜜中的一种或两种作为甜味剂;
S4、选取柠檬酸作为酸味剂;
S5、按照需要的重量百分含量称量S1中制备的香菇多糖、S2中制备的中药提取物、S3中选取的甜味剂、S4中选取的酸味剂与水进行混合得到混合液,所述混合液中各组分的重量含量为香菇多糖5%~15%、中药提取物5%~15%、甜味剂5%~10%、酸味剂5%~10%,余量为水;
S6、将S5得到的混合液进行灭菌、装瓶、密封、检验、包装即得到香菇多糖保健口服液。
进一步的,所述步骤c中的超滤时使用的是孔径为10nm~20nm的膜。
本发明的配方中主要成分为香菇多糖,香菇多糖具有抗肿瘤活性的作用,香菇多糖进入抗体后诱导产生一种具有免疫活性的细胞因子,在这些细胞因子的综合作用下,机体免疫系统增强,对肿瘤细胞起防御与杀伤作用,且香菇多糖也能够通过激活巨噬细胞,增强抗体依赖性细胞诱导的细胞毒,发挥抗肿瘤活性;此外香菇多糖还能够使肿瘤部位的血管扩张和出血,导致肿瘤出血坏死和完全退化。香菇多糖具有免疫调节的作用,它能促进淋巴细胞活化因子(LAE)的产生,释放各种辅助性T细胞因子,增强宿主腹腔巨噬细胞吞噬率,恢复或刺激辅助性T细胞的功能。另外,香菇多糖还能促进抗体生成,抑制巨噬细胞释放。香菇多糖还具有抗病毒活性和抗感染的作用。其中中药提取物的配伍原料木耳味甘,性平,具有很多药用功效。能益气强身,有活血效能,并可防治缺铁性贫血等;可养血驻颜,令人肌肤红润,容光焕发,能够疏通肠胃,润滑肠道,同时对高血压患者也有一定帮助。银耳具有强精、补肾、润肠、益胃、补气、和血、强心、壮身、补脑、提神、美容、嫩肤、延年益寿之功效。它能提高肝脏解毒能力,保护肝脏功能,它不但能增强机体抗肿瘤的免疫能力,还能增强肿瘤患者对放疗、化疗的耐受力。枸杞可调节机体免疫功能、能有效抑制肿瘤生长和细胞突变、具有延缓衰老、抗脂肪肝、调节血脂和血糖、促进造血功能等方面的作用。黄芪有增强机体免疫功能、保肝、利尿、抗衰老、抗应激、降压和较广泛的抗菌作用。甘草具有抗炎、抗病毒,和保肝解毒及增强免疫功能等作用。
与现有技术相比,本发明的有益效果是:具有提高机体免疫力的功效,且功效明显,见效快。而且本发明的制备方法简单,原料来源广,能够大规模生产。
具体实施方式
为了使本发明的技术手段、创作特征、达到目的与功效易于明白了解,下面将结合本发明的实施例,对本发明的技术方案进行清楚、完整地描述。
实施例1
一种香菇多糖保健口服液,包括香菇多糖5%、中药提取物5%、蔗糖和木糖醇共5%、柠檬酸2%和水83%;
中药提取物由以下重量份的原料制成:木耳10份、银耳10份、枸杞子10份、黄芪10份和甘草1份。
这种香菇多糖保健口服液制备方法,包括如下步骤:
S1、香菇多糖的制备
a、取香菇,除杂洗净,沥干,切碎;
b、将步骤a中得到的香菇用6倍重量的水回流提取2次,每次提取2h,过滤,收集滤液备用;
c、将步骤b中的滤液进行超滤,超滤时使用的是孔径为10nm~20nm的膜,将滤液浓缩至相对密度为1.1g/L~1.3g/L的浸膏,再向浸膏中加入乙醇,进行醇沉2次,每次醇沉均醇析16h,4000r/min离心10min,收集沉淀;
d、将步骤c中的沉淀依次用2倍重量的无水乙醇、丙酮分别洗涤,将洗涤后的沉淀用2倍蒸馏水溶解,过截留分子量为100万的中空纤维膜,收集浓缩液,然后将浓缩液过截留分子量为180万的中空纤维膜,收集透过液离心,过滤,取滤液备用;
e、将步骤d中得到的滤液干燥,得到香菇多糖;
S2、中药提取物的制备
称量木耳10份、银耳10份、枸杞子10份、黄芪10份和甘草1份,将上述原料混配,并粉碎成20目~80目的粉末;加入2倍重量热水浸提2h,离心取上层清夜,浓缩清夜得到浓缩液,真空干燥浓缩液,得到中药提取物。
S3、选取蔗糖和木糖醇作为甜味剂;
S4、选取柠檬酸作为酸味剂;
S5、按照所需的重量百分含量称量S1中制备的香菇多糖、S2中制备的中药提取物、S3中选取的甜味剂、S4中选取的酸味剂与水进行混合得到混合液,混合液中各组分的重量含量为香菇多糖5%、中药提取物5%、甜味剂5%、酸味剂2%和水83%;
S6、将S5得到的混合液进行灭菌、装瓶、密封、检验、包装即得到香菇多糖保健口服液。
实施例2
一种香菇多糖保健口服液,包括香菇多糖10%、中药提取物10%、低聚果糖和蜂蜜共10%、柠檬酸13%和水57%;
中药提取物由以下重量份的原料制成:木耳20份、银耳20份、枸杞子20份、黄芪20份和甘草7.5份。
这种香菇多糖保健口服液制备方法,包括如下步骤:
S1、香菇多糖的制备
a、取香菇,除杂洗净,沥干,切碎;
b、将步骤a中得到的香菇用9倍重量的水回流提取3次,每次提取2.5h,过滤,收集滤液备用;
c、将步骤b中的滤液进行超滤,超滤时使用的是孔径为10nm~20nm的膜,将滤液浓缩至相对密度为1.1g/L~1.3g/L的浸膏,再向浸膏中加入乙醇,进行醇沉3次,每次醇沉均醇析18h,4250r/min离心15min,收集沉淀;
d、将步骤c中的沉淀依次用3倍重量的无水乙醇、丙酮分别洗涤,将洗涤后的沉淀用3倍蒸馏水溶解,过截留分子量为100万的中空纤维膜,收集浓缩液,然后将浓缩液过截留分子量为180万的中空纤维膜,收集透过液离心,过滤,取滤液备用;
e、将步骤d中得到的滤液干燥,得到香菇多糖;
S2、中药提取物的制备
称量木耳20份、银耳20份、枸杞子20份、黄芪20份和甘草7.5份,将上述原料混配,并粉碎成20目~80目的粉末;加入3倍重量热水浸提2.5h,离心取上层清夜,浓缩清夜得到浓缩液,真空干燥浓缩液,得到中药提取物。
S3、选取低聚果糖和蜂蜜作为甜味剂;
S4、选取柠檬酸作为酸味剂;
S5、称量S1中制备的香菇多糖、S2中制备的中药提取物、S3中选取的甜味剂、S4中选取的酸味剂与水进行混合得到混合液,混合液中各组分的重量含量为香菇多糖10%、中药提取物10%、低聚果糖和蜂蜜共10%、柠檬酸13%和水57%;
S6、将S5得到的混合液进行灭菌、装瓶、密封、检验、包装即得到香菇多糖保健口服液。
实施例3
一种香菇多糖保健口服液,包括香菇多糖15%、中药提取物15%、蜂蜜15%、柠檬酸20%和水35%;
中药提取物由以下重量份的原料制成:木耳30份、银耳30份、枸杞子30份、黄芪30份和甘草15份。
这种香菇多糖保健口服液制备方法,包括如下步骤:
S1、香菇多糖的制备
a、取香菇,除杂洗净,沥干,切碎;
b、将步骤a中得到的香菇用12倍重量的水回流提取3次,每次提取3h,过滤,收集滤液备用;
c、将步骤b中的滤液进行超滤,超滤时使用的是孔径为10nm~20nm的膜,将滤液浓缩至相对密度为1.1g/L~1.3g/L的浸膏,再向浸膏中加入乙醇,进行醇沉3次,每次醇沉均醇析20h,4500r/min离心20min,收集沉淀;
d、将步骤c中的沉淀依次用4倍重量的无水乙醇、丙酮分别洗涤,将洗涤后的沉淀用4倍蒸馏水溶解,过截留分子量为100万的中空纤维膜,收集浓缩液,然后将浓缩液过截留分子量为180万的中空纤维膜,收集透过液离心,过滤,取滤液备用;
e、将步骤d中得到的滤液干燥,得到香菇多糖;
S2、中药提取物的制备
称量木耳30份、银耳30份、枸杞子30份、黄芪30份和甘草15份,将上述原料混配,并粉碎成20目~80目的粉末;加入3倍重量热水浸提3h,离心取上层清夜,浓缩清夜得到浓缩液,真空干燥浓缩液,得到中药提取物。
S3、选取蜂蜜作为甜味剂;
S4、选取柠檬酸作为酸味剂;
S5、称量S1中制备的香菇多糖、S2中制备的中药提取物、S3中选取的甜味剂、S4中选取的酸味剂与水进行混合得到混合液,混合液中各组分的重量含量为香菇多糖15%、中药提取物15%、蜂蜜15%、柠檬酸20%和水35%;
S6、将S5得到的混合液进行灭菌、装瓶、密封、检验、包装即得到香菇多糖保健口服液。
对比例
一种保健口服液,包括中药提取物15%、蜂蜜15%、柠檬酸20%和水50%;其中中药提取物由以下重量份的原料制成:木耳30份、银耳30份、枸杞子30份、黄芪30份和甘草15份。
这种保健口服液制备方法,包括如下步骤:
S1、中药提取物的制备
称量木耳30份、银耳30份、枸杞子30份、黄芪30份和甘草15份,将上述原料混配,并粉碎成20目~80目的粉末;加入3倍重量热水浸提3h,离心取上层清夜,浓缩清夜得到浓缩液,真空干燥浓缩液,得到中药提取物。
S2、选取蜂蜜作为甜味剂;
S3、选取柠檬酸作为酸味剂;
S4、称量S1中制备的中药提取物、S2中选取的甜味剂、S3中选取的酸味剂与水进行混合得到混合液,混合液中各组分的重量含量为中药提取物15%、蜂蜜15%、柠檬酸20%和水50%;
S5、将S4得到的混合液进行灭菌、装瓶、密封、检验、包装即得到一种保健口服液。
以实施例3制备得到的香菇多糖保健口服液为例,对其功能性进行检测,结果如下:
本发明以实施例3制备得到的香菇多糖保健口服液和对比例中的保健口服液为例,分别使用这两种口服液进行临床治疗。
选取200名免疫状态偏低的患者,其中100人为治疗组,另外一组100人为对比组,且两组的患者情况没有显著差别。
治疗组:每天早晚服用本发明的香菇多糖保健口服液,每次100mL,且每天均对患者进行抽血检查,检测患者淋巴细胞亚群(免疫五项)的情况。
对比组:每天早晚服用对比例中的保健口服液,每次100mL,且每天均对患者进行抽血检查,检测患者淋巴细胞亚群(免疫五项)的情况。
通过将两组患者的检测情况进行对比,发现治疗组在服用本发明的香菇多糖保健口服液一个月后,有患者的总淋巴细胞数、CD4+、NK细胞数均下降,且均下降到正常范围内,免疫力有所提高。而对比组在服用对比例中的口服液后45天后,才有患者的总淋巴细胞数、CD4+、NK细胞数均下降,且均下降到正常范围内,免疫力有所提高。
治疗组和对比组的患者在接受治疗三个月后,患者的免疫力提高效率如表1。判断指标为,通过检测每个患者的淋巴细胞亚群(免疫五项)的情况,当淋巴细胞亚群(免疫五项)均处于正常范围内时,说明患者的免疫力有显著的提高;当患者的淋巴细胞亚群(免疫五项)中只有三项指标处于正常范围内,说明患者的免疫力提高;当患者的淋巴细胞亚群(免疫五项)的指标中处于正常范围的数量小于等于两项,说明患者的免疫力没有提高。
表1治疗三个月后治疗组和对比组的治疗情况汇总
上述结果说明本发明的香菇多糖保健口服液具有增加免疫力的作用,且增强免疫力的效果明显,本发明的香菇多糖保健口服液适用于免疫力偏低的人群食用。
综上所述,本发明的香菇多糖保健口服液具有增加免疫力的作用。本发明的制备方法简单,原料来源广。
以上公开的仅为本发明的较佳实施例,但是,本发明实施例并非局限于此,任何本领域的技术人员能思之的变化都应落入本发明的保护范围。
Claims (4)
1.一种香菇多糖保健口服液,其特征在于,所述口服液组分和重量百分含量为香菇多糖5%~15%、中药提取物5%~15%、甜味剂5%~15%、酸味剂2%~20%,余量为水;
所述中药提取物由以下重量份的原料制成:木耳10份~30份、银耳10份~30份、枸杞子10份~30份、黄芪10份~30份和甘草1份~15份。
2.如权利要求1所述的一种香菇多糖保健口服液,其特征在于,所述甜味剂是蔗糖、木糖醇、低聚果糖和蜂蜜中的一种或两种;所述酸味剂为柠檬酸。
3.如权利要求1-2任一项所述的一种香菇多糖保健口服液的制备方法,其特征在于,包括如下步骤:
S1、香菇多糖的制备
a、取香菇,除杂洗净,沥干,切碎;
b、将步骤a中得到的香菇用6~12倍重量的水回流提取2~3次,每次提取2~3h,过滤,收集滤液备用;
c、将步骤b中的滤液进行超滤,将滤液浓缩至相对密度为1.1g/L~1.3g/L的浸膏,再向浸膏中加入乙醇,进行醇沉2~3次,每次醇沉均醇析16h~20h,4000r/min~4500r/min离心10min~20min,收集沉淀;
d、将步骤c中的沉淀依次用2~4倍重量的无水乙醇、丙酮分别洗涤,将洗涤后的沉淀用2~4倍蒸馏水溶解,过截留分子量为100万的中空纤维膜,收集浓缩液,然后将浓缩液过截留分子量为180万的中空纤维膜,收集透过液离心,过滤,取滤液备用;
e、将步骤d中得到的滤液干燥,得到香菇多糖;
S2、中药提取物的制备
称取所需重量份的木耳、银耳、枸杞子、黄芪和甘草,经混配、粉碎、热水浸提、离心、浓缩、真空干燥得到中药提取物。
S3、选取蔗糖、木糖醇、低聚果糖和蜂蜜中的一种或两种作为甜味剂;
S4、选取柠檬酸作为酸味剂;
S5、按照所需重量百分含量称量S1中制备的香菇多糖、S2中制备的中药提取物、S3中选取的甜味剂、S4中选取的酸味剂与水进行混合得到混合液;
S6、将S5得到的混合液进行灭菌、装瓶、密封、检验、包装即得到香菇多糖保健口服液。
4.如权利要求3所述的一种香菇多糖保健口服液的制备方法,其特征在于,所述步骤c中的超滤时使用的是孔径为10nm~20nm的膜。
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