CN108026535A - 一种制备烟酰胺单核苷酸的方法 - Google Patents

一种制备烟酰胺单核苷酸的方法 Download PDF

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CN108026535A
CN108026535A CN201680003974.2A CN201680003974A CN108026535A CN 108026535 A CN108026535 A CN 108026535A CN 201680003974 A CN201680003974 A CN 201680003974A CN 108026535 A CN108026535 A CN 108026535A
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nampt
nicotinamide mononucleotide
prset
amino acid
mutant
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CN108026535B (zh
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傅荣昭
张琦
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Bontac Bio-Engineering (shenzhen) Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
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    • C12P19/00—Preparation of compounds containing saccharide radicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
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Abstract

本发明公开了一种制备烟酰胺单核苷酸的方法，以烟酰胺、ATP和AMP为原料，在烟酰胺磷酸核糖转移酶、核糖磷酸焦磷酸激酶以及AMP核苷酶的催化作用下发生反应，制得烟酰胺单核苷酸。

Description

PCT国内申请，说明书已公开。

Claims (1)

  1. PCT国内申请，权利要求书已公开。
CN201680003974.2A 2016-07-30 2016-07-30 一种制备烟酰胺单核苷酸的方法 Active CN108026535B (zh)

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PCT/CN2016/092460 WO2018023209A1 (zh) 2016-07-30 2016-07-30 一种制备烟酰胺单核苷酸的方法

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112646851A (zh) * 2019-10-10 2021-04-13 安徽古特生物科技有限公司 一种酶法快速制备β-烟酰胺单核苷酸的方法
CN114164190A (zh) * 2021-10-12 2022-03-11 南宁邦尔克生物技术有限责任公司 一种生产烟酰胺单核苷酸的融合酶及其应用
CN116004489A (zh) * 2022-07-04 2023-04-25 华熙生物科技股份有限公司 一种生产nmn的重组大肠杆菌及其应用

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* Cited by examiner, † Cited by third party
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EP3331894B1 (en) 2015-08-05 2021-02-17 Metro International Biotech, LLC Nicotinamide mononucleotide derivatives and their uses
GB2542881B (en) 2015-10-02 2020-01-01 Carr Andrew Crystal forms of ß-nicotinamide mononucleotide
US11180521B2 (en) 2018-01-30 2021-11-23 Metro International Biotech, Llc Nicotinamide riboside analogs, pharmaceutical compositions, and uses thereof
CN108949865A (zh) * 2018-08-17 2018-12-07 尚科生物医药（上海）有限公司 固定化全细胞一步酶法催化制备β-烟酰胺单核苷酸
US11939348B2 (en) 2019-03-22 2024-03-26 Metro International Biotech, Llc Compositions comprising a phosphorus derivative of nicotinamide riboside and methods for modulation of nicotinamide adenine dinucleotide
US10618927B1 (en) 2019-03-22 2020-04-14 Metro International Biotech, Llc Compositions and methods for modulation of nicotinamide adenine dinucleotide
CN112159831B (zh) * 2020-09-30 2022-06-03 湖州颐盛生物科技有限公司 一种制备烟酰胺单核苷酸的方法
CN113005162A (zh) * 2021-03-18 2021-06-22 绵阳晟氏健康科技有限公司 酶法生产烟酰胺单核苷酸的方法和用于该方法的转化体
WO2022251491A1 (en) 2021-05-27 2022-12-01 Metro International Biotech, Llc Crystalline solids of nicotinic acid mononucleotide and esters thereof and methods of making and use
JP7111878B1 (ja) 2021-10-27 2022-08-02 旭化成ファーマ株式会社 ニコチンアミドモノヌクレオチドの製造方法

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CN101601679A (zh) * 2009-03-17 2009-12-16 中国人民解放军第二军医大学 一种烟酰胺单核苷酸的应用
WO2015069860A1 (en) * 2013-11-06 2015-05-14 President And Fellows Of Harvard College Biological production of nad precursors and analogs
CN104814974A (zh) * 2015-03-16 2015-08-05 邦泰生物工程(深圳)有限公司 烟酰胺单核苷酸在制备抗衰老药物或保健品的应用

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WO2015069860A1 (en) * 2013-11-06 2015-05-14 President And Fellows Of Harvard College Biological production of nad precursors and analogs
CN104814974A (zh) * 2015-03-16 2015-08-05 邦泰生物工程(深圳)有限公司 烟酰胺单核苷酸在制备抗衰老药物或保健品的应用

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112646851A (zh) * 2019-10-10 2021-04-13 安徽古特生物科技有限公司 一种酶法快速制备β-烟酰胺单核苷酸的方法
CN112646851B (zh) * 2019-10-10 2023-03-28 安徽古特生物科技有限公司 一种酶法快速制备β-烟酰胺单核苷酸的方法
CN114164190A (zh) * 2021-10-12 2022-03-11 南宁邦尔克生物技术有限责任公司 一种生产烟酰胺单核苷酸的融合酶及其应用
CN114164190B (zh) * 2021-10-12 2023-11-21 南宁邦尔克生物技术有限责任公司 一种生产烟酰胺单核苷酸的融合酶及其应用
CN116004489A (zh) * 2022-07-04 2023-04-25 华熙生物科技股份有限公司 一种生产nmn的重组大肠杆菌及其应用

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