CN108026527B - 确定的多偶联寡核苷酸 - Google Patents

确定的多偶联寡核苷酸 Download PDF

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CN108026527B
CN108026527B CN201680048179.5A CN201680048179A CN108026527B CN 108026527 B CN108026527 B CN 108026527B CN 201680048179 A CN201680048179 A CN 201680048179A CN 108026527 B CN108026527 B CN 108026527B
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isolated compound
cleavable
oligonucleotides
stranded
sirna
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CN108026527A (zh
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P.哈德维格
H-P.沃恩洛彻
J.M.布朗
J.E.达尔曼
K.K.H.纽曼
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MPEG LA LLC
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CN201680048179.5A 2015-06-15 2016-06-15 确定的多偶联寡核苷酸 Active CN108026527B (zh)

Applications Claiming Priority (15)

Application Number Priority Date Filing Date Title
US201562175718P 2015-06-15 2015-06-15
US201562175714P 2015-06-15 2015-06-15
US201562175709P 2015-06-15 2015-06-15
US62/175,709 2015-06-15
US62/175,718 2015-06-15
US62/175,714 2015-06-15
US201562203243P 2015-08-10 2015-08-10
US62/203,243 2015-08-10
US201562216318P 2015-09-09 2015-09-09
US201562216314P 2015-09-09 2015-09-09
US201562216317P 2015-09-09 2015-09-09
US62/216,318 2015-09-09
US62/216,314 2015-09-09
US62/216,317 2015-09-09
PCT/US2016/037685 WO2016205410A2 (en) 2015-06-15 2016-06-15 Defined multi-conjugate oligonucleotides

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CN108026527B true CN108026527B (zh) 2022-05-10

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EP (2) EP4541374A3 (https=)
JP (1) JP7033452B2 (https=)
KR (2) KR20250016526A (https=)
CN (1) CN108026527B (https=)
AU (3) AU2016280709B2 (https=)
CA (1) CA2988603A1 (https=)
HK (1) HK1252970A1 (https=)
IL (2) IL316159A (https=)
MX (2) MX2017016088A (https=)
WO (1) WO2016205410A2 (https=)

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AU2020319911A1 (en) * 2019-07-30 2022-02-24 Mpeg La, L.L.C. Subcutaneous delivery of multimeric oligonucleotides with enhanced bioactivity
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US12365894B2 (en) 2019-09-16 2025-07-22 University Of Massachusetts Branched lipid conjugates of siRNA for specific tissue delivery
CN111041025B (zh) 2019-12-17 2021-06-18 深圳市瑞吉生物科技有限公司 基于结合N-乙酰半乳糖胺多肽的mRNA靶向分子及其制备方法
CN112111524B (zh) * 2020-01-10 2024-02-27 深圳瑞吉生物科技有限公司 mRNA-GalNAc靶向分子的制备方法及其体内递送系统和应用
AU2021263932B2 (en) * 2020-04-30 2025-07-03 Mpeg La, L.L.C. Multimeric oligonucleotides with divided strands
CA3178559A1 (en) * 2020-05-19 2021-11-25 Jonathan Miles Brown Orthogonally linked multimeric oligonucleotides
WO2021242883A1 (en) 2020-05-26 2021-12-02 University Of Massachusetts Synthetic oligonucleotides having regions of block and cluster modifications
CN111744019B (zh) 2020-07-01 2023-08-04 深圳瑞吉生物科技有限公司 基于甘露糖的mRNA靶向递送系统及其应用
US20240318174A1 (en) * 2021-02-08 2024-09-26 Ractigen Therapeutics Multi-Valent Oligonucleotide Agent and Methods of Use Thereof
AU2022299169A1 (en) 2021-06-23 2024-02-08 Beth Israel Deaconess Medical Center, Inc. Optimized anti-flt1 oligonucleotide compounds for treatment of preeclampsia and other angiogenic disorders
CN115010794A (zh) * 2022-06-30 2022-09-06 武汉瑞佶生物科技有限公司 蛋白质介导的mRNA靶向分子及其制备方法和应用
JP2025531341A (ja) * 2022-09-19 2025-09-19 カイロンノヴァ （シャーメン） バイオファーマ カンパニー，リミテッド 炭水化物－オリゴヌクレオチド複合体、薬物組成物および治療への応用
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