MX2017016088A - Oligonucleotidos multi-conjugados definidos. - Google Patents

Oligonucleotidos multi-conjugados definidos.

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Publication number
MX2017016088A
MX2017016088A MX2017016088A MX2017016088A MX2017016088A MX 2017016088 A MX2017016088 A MX 2017016088A MX 2017016088 A MX2017016088 A MX 2017016088A MX 2017016088 A MX2017016088 A MX 2017016088A MX 2017016088 A MX2017016088 A MX 2017016088A
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MX
Mexico
Prior art keywords
defined multi
conjugate
conjugate oligonucleotides
oligonucleotides
sirna
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Application number
MX2017016088A
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English (en)
Inventor
Hadwiger Philipp
Peter Vornlocher Hans-
Miles Brown Jonathan
Everett Dahlman James
K H Neuman Kristin
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Mpeg La Llc
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Publication date
Application filed by Mpeg La Llc filed Critical Mpeg La Llc
Publication of MX2017016088A publication Critical patent/MX2017016088A/es

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    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
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Abstract

Se describen oligonucleótidos multi-conjugados definidos pueden tener tamaños y composiciones predeterminados. Por ejemplo, en diversas modalidades, los oligonucleótidos multi-conjugados definidos pueden tener propiedades adecuadas, por ejemplo en forma de siARN multi-conjugado definido (es decir, que incluye dos, tres o más siARN) que tiene administración intracelular potenciada y/o efectos de silenciamiento multigénico. En diversas modalidades, los oligonucleótidos multi-conjugados definidos pueden sintetizarse a través de nuevos intermedios sintéticos y métodos. Los oligonucleótidos multi-conjugados definidos pueden usarse, por ejemplo, para reducir la expresión génica, investigación biológica, tratar o prevenir afecciones médicas, o para producir fenotipos nuevos o alterados en células u organismos.
MX2017016088A 2015-06-15 2016-06-15 Oligonucleotidos multi-conjugados definidos. MX2017016088A (es)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US201562175718P 2015-06-15 2015-06-15
US201562175709P 2015-06-15 2015-06-15
US201562175714P 2015-06-15 2015-06-15
US201562203243P 2015-08-10 2015-08-10
US201562216317P 2015-09-09 2015-09-09
US201562216318P 2015-09-09 2015-09-09
US201562216314P 2015-09-09 2015-09-09
PCT/US2016/037685 WO2016205410A2 (en) 2015-06-15 2016-06-15 Defined multi-conjugate oligonucleotides

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MX2017016088A true MX2017016088A (es) 2018-04-11

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US (2) US11352629B2 (es)
EP (1) EP3307889A4 (es)
JP (1) JP7033452B2 (es)
KR (1) KR20180039621A (es)
CN (1) CN108026527B (es)
AU (2) AU2016280709B2 (es)
CA (1) CA2988603A1 (es)
HK (1) HK1252970A1 (es)
IL (1) IL256169A (es)
MX (1) MX2017016088A (es)
WO (1) WO2016205410A2 (es)

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