HK1252970A1 - 确定的多偶联寡核苷酸 - Google Patents

确定的多偶联寡核苷酸 Download PDF

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Publication number
HK1252970A1
HK1252970A1 HK18112329.7A HK18112329A HK1252970A1 HK 1252970 A1 HK1252970 A1 HK 1252970A1 HK 18112329 A HK18112329 A HK 18112329A HK 1252970 A1 HK1252970 A1 HK 1252970A1
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Hong Kong
Prior art keywords
defined multi
conjugate
conjugate oligonucleotides
oligonucleotides
sirna
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HK18112329.7A
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English (en)
Chinese (zh)
Inventor
Philipp Hadwiger
Hans-Peter Vornlocher
Jonathan Miles Brown
James Everett DAHLMAN
Kristin K.H. NEUMAN
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Mpeg La, L.L.C.
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Application filed by Mpeg La, L.L.C. filed Critical Mpeg La, L.L.C.
Publication of HK1252970A1 publication Critical patent/HK1252970A1/zh

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
    • A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
    • C12N2310/3521—Methyl
    • C—CHEMISTRY; METALLURGY
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    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
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    • C12N2310/3533—Halogen
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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HK18112329.7A 2015-06-15 2016-06-15 确定的多偶联寡核苷酸 HK1252970A1 (zh)

Applications Claiming Priority (14)

Application Number Priority Date Filing Date Title
US201562175709P 2015-06-15 2015-06-15
US201562175714P 2015-06-15 2015-06-15
US201562175718P 2015-06-15 2015-06-15
US62/175,718 2015-06-15
US62/175,709 2015-06-15
US62/175,714 2015-06-15
US201562203243P 2015-08-10 2015-08-10
US62/203,243 2015-08-10
US201562216318P 2015-09-09 2015-09-09
US201562216317P 2015-09-09 2015-09-09
US201562216314P 2015-09-09 2015-09-09
US62/216,317 2015-09-09
US62/216,314 2015-09-09
US62/216,318 2015-09-09

Publications (1)

Publication Number Publication Date
HK1252970A1 true HK1252970A1 (zh) 2019-06-06

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US (3) US11352629B2 (https=)
EP (2) EP4541374A3 (https=)
JP (1) JP7033452B2 (https=)
KR (2) KR20250016526A (https=)
CN (1) CN108026527B (https=)
AU (3) AU2016280709B2 (https=)
CA (1) CA2988603A1 (https=)
HK (1) HK1252970A1 (https=)
IL (2) IL316159A (https=)
MX (2) MX2017016088A (https=)
WO (1) WO2016205410A2 (https=)

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CN112111524B (zh) * 2020-01-10 2024-02-27 深圳瑞吉生物科技有限公司 mRNA-GalNAc靶向分子的制备方法及其体内递送系统和应用
KR20230003579A (ko) * 2020-04-30 2023-01-06 엠펙 엘에이, 엘.엘.씨. 분할된 가닥을 갖는 다량체 올리고뉴클레오타이드
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JP2024506042A (ja) * 2021-02-08 2024-02-08 ラクティゲン セラピューティクス 多価オリゴヌクレオチド薬剤およびその使用方法
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