CN108026087B - 氨基嘧啶甲酮衍生物的柠檬酸盐 - Google Patents
氨基嘧啶甲酮衍生物的柠檬酸盐 Download PDFInfo
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- CN108026087B CN108026087B CN201680045214.8A CN201680045214A CN108026087B CN 108026087 B CN108026087 B CN 108026087B CN 201680045214 A CN201680045214 A CN 201680045214A CN 108026087 B CN108026087 B CN 108026087B
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
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| Application Number | Priority Date | Filing Date | Title |
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| EP15175066.8 | 2015-07-02 | ||
| EP15175066 | 2015-07-02 | ||
| PCT/US2016/040728 WO2017004537A1 (en) | 2015-07-02 | 2016-07-01 | (4-((3r,4r)-3-methoxytetrahydro-pyran-4-ylamino)piperidin-1-yl)(5-methyl-6-(((2r,6s)-6-(p-tolyl)tetrahydro-2h-pyran-2-yl)methylamino)pyrimidin-4yl)methanone citrate |
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| HRP20141143T1 (hr) | 2009-12-17 | 2015-01-02 | Boehringer Ingelheim International Gmbh | Novi antagonisti receptora ccr2 i njihove uporabe |
| BR112017028492B1 (pt) * | 2015-07-02 | 2023-12-26 | Centrexion Therapeutics Corporation | Citrato de (4-((3r,4r)-3-metoxitetra-hidro-piran-4- ilamino)piperidin-1-il) (5- metil-6-(((2r, 6s)-6-(p-tolil) tetra-hidro-2h-piran-2-il)metilamino)pirimidin-4-il) metanona, seu uso e seu método de preparação, e composição farmacêutica |
| WO2025228899A1 (en) | 2024-04-30 | 2025-11-06 | Boehringer Ingelheim International Gmbh | Further heterocyclic compounds as sting antagonists and the use thereof as medicament |
| WO2025228889A1 (en) | 2024-04-30 | 2025-11-06 | Boehringer Ingelheim International Gmbh | Monoarylic heterocyclic compounds as sting antagonists and the use thereof as medicament |
| WO2025228902A1 (en) | 2024-04-30 | 2025-11-06 | Boehringer Ingelheim International Gmbh | Heterocyclic acids as sting antagonists and the use thereof as medicament |
| US20250333398A1 (en) | 2024-04-30 | 2025-10-30 | Boehringer Ingelheim International Gmbh | Monoaryl and hetaryl substituted indazoles and benzimidazoles as sting antagonists and the use thereof as medicament |
| US20250333414A1 (en) | 2024-04-30 | 2025-10-30 | Boehringer Ingelheim International Gmbh | Hetaryl substituted indazoles and benzimidazoles as sting antagonists and the use thereof as medicament |
| WO2025228900A1 (en) | 2024-04-30 | 2025-11-06 | Boehringer Ingelheim International Gmbh | Arylamide substituted indazoles and the use thereof as medicament |
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| BR112017028492B1 (pt) * | 2015-07-02 | 2023-12-26 | Centrexion Therapeutics Corporation | Citrato de (4-((3r,4r)-3-metoxitetra-hidro-piran-4- ilamino)piperidin-1-il) (5- metil-6-(((2r, 6s)-6-(p-tolil) tetra-hidro-2h-piran-2-il)metilamino)pirimidin-4-il) metanona, seu uso e seu método de preparação, e composição farmacêutica |
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2016
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- 2016-07-01 PT PT168188985T patent/PT3317270T/pt unknown
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- 2016-07-01 MX MX2017017177A patent/MX383744B/es unknown
- 2016-07-01 CN CN201680045214.8A patent/CN108026087B/zh active Active
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- 2016-07-01 ES ES16818898T patent/ES2811098T3/es active Active
- 2016-07-01 CA CA2990460A patent/CA2990460C/en active Active
- 2016-07-01 WO PCT/US2016/040728 patent/WO2017004537A1/en not_active Ceased
- 2016-07-01 JP JP2017568018A patent/JP6917910B2/ja active Active
- 2016-07-01 AU AU2016287584A patent/AU2016287584B2/en active Active
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| CN102066359A (zh) * | 2008-06-18 | 2011-05-18 | 弗·哈夫曼-拉罗切有限公司 | 新的杂芳基甲酰胺衍生物 |
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| CA2990460A1 (en) | 2017-01-05 |
| PT3317270T (pt) | 2020-08-24 |
| US20200276197A1 (en) | 2020-09-03 |
| ES2811098T3 (es) | 2021-03-10 |
| US10568885B2 (en) | 2020-02-25 |
| US20220133723A1 (en) | 2022-05-05 |
| US20180207157A1 (en) | 2018-07-26 |
| US12076321B2 (en) | 2024-09-03 |
| CA2990460C (en) | 2023-10-17 |
| JP6917910B2 (ja) | 2021-08-11 |
| PL3317270T3 (pl) | 2020-11-16 |
| AU2016287584A1 (en) | 2018-04-19 |
| MX383744B (es) | 2025-03-14 |
| MX2017017177A (es) | 2018-11-09 |
| EP3317270A4 (en) | 2019-01-02 |
| EP3317270B1 (en) | 2020-05-13 |
| CN108026087A (zh) | 2018-05-11 |
| WO2017004537A1 (en) | 2017-01-05 |
| US10213428B2 (en) | 2019-02-26 |
| EP3317270A1 (en) | 2018-05-09 |
| HK1254741A1 (en) | 2019-07-26 |
| IL256530A (en) | 2018-02-28 |
| AU2016287584B2 (en) | 2020-03-26 |
| BR112017028492B1 (pt) | 2023-12-26 |
| US20190262339A1 (en) | 2019-08-29 |
| JP2018524342A (ja) | 2018-08-30 |
| BR112017028492A2 (pt) | 2018-08-28 |
| US11147814B2 (en) | 2021-10-19 |
| NZ738565A (en) | 2024-10-25 |
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