CA2990460C - (4-((3r,4r)-3-methoxytetrahydro-pyran-4-ylamino)piperidin-1-yl)(5-methyl-6-(((2r,6s)-6-(p-tolyl)tetrahydro-2h-pyran-2-yl)methylamino)pyrimidin-4-yl)methanone citrate - Google Patents
(4-((3r,4r)-3-methoxytetrahydro-pyran-4-ylamino)piperidin-1-yl)(5-methyl-6-(((2r,6s)-6-(p-tolyl)tetrahydro-2h-pyran-2-yl)methylamino)pyrimidin-4-yl)methanone citrate Download PDFInfo
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- CA2990460C CA2990460C CA2990460A CA2990460A CA2990460C CA 2990460 C CA2990460 C CA 2990460C CA 2990460 A CA2990460 A CA 2990460A CA 2990460 A CA2990460 A CA 2990460A CA 2990460 C CA2990460 C CA 2990460C
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- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15175066.8 | 2015-07-02 | ||
| EP15175066 | 2015-07-02 | ||
| PCT/US2016/040728 WO2017004537A1 (en) | 2015-07-02 | 2016-07-01 | (4-((3r,4r)-3-methoxytetrahydro-pyran-4-ylamino)piperidin-1-yl)(5-methyl-6-(((2r,6s)-6-(p-tolyl)tetrahydro-2h-pyran-2-yl)methylamino)pyrimidin-4yl)methanone citrate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2990460A1 CA2990460A1 (en) | 2017-01-05 |
| CA2990460C true CA2990460C (en) | 2023-10-17 |
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| CA2990460A Active CA2990460C (en) | 2015-07-02 | 2016-07-01 | (4-((3r,4r)-3-methoxytetrahydro-pyran-4-ylamino)piperidin-1-yl)(5-methyl-6-(((2r,6s)-6-(p-tolyl)tetrahydro-2h-pyran-2-yl)methylamino)pyrimidin-4-yl)methanone citrate |
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| EP (1) | EP3317270B1 (enExample) |
| JP (1) | JP6917910B2 (enExample) |
| CN (1) | CN108026087B (enExample) |
| AU (1) | AU2016287584B2 (enExample) |
| BR (1) | BR112017028492B1 (enExample) |
| CA (1) | CA2990460C (enExample) |
| ES (1) | ES2811098T3 (enExample) |
| IL (1) | IL256530A (enExample) |
| MX (1) | MX383744B (enExample) |
| PL (1) | PL3317270T3 (enExample) |
| PT (1) | PT3317270T (enExample) |
| WO (1) | WO2017004537A1 (enExample) |
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| HRP20141143T1 (hr) | 2009-12-17 | 2015-01-02 | Boehringer Ingelheim International Gmbh | Novi antagonisti receptora ccr2 i njihove uporabe |
| BR112017028492B1 (pt) * | 2015-07-02 | 2023-12-26 | Centrexion Therapeutics Corporation | Citrato de (4-((3r,4r)-3-metoxitetra-hidro-piran-4- ilamino)piperidin-1-il) (5- metil-6-(((2r, 6s)-6-(p-tolil) tetra-hidro-2h-piran-2-il)metilamino)pirimidin-4-il) metanona, seu uso e seu método de preparação, e composição farmacêutica |
| WO2025228899A1 (en) | 2024-04-30 | 2025-11-06 | Boehringer Ingelheim International Gmbh | Further heterocyclic compounds as sting antagonists and the use thereof as medicament |
| WO2025228889A1 (en) | 2024-04-30 | 2025-11-06 | Boehringer Ingelheim International Gmbh | Monoarylic heterocyclic compounds as sting antagonists and the use thereof as medicament |
| WO2025228902A1 (en) | 2024-04-30 | 2025-11-06 | Boehringer Ingelheim International Gmbh | Heterocyclic acids as sting antagonists and the use thereof as medicament |
| US20250333398A1 (en) | 2024-04-30 | 2025-10-30 | Boehringer Ingelheim International Gmbh | Monoaryl and hetaryl substituted indazoles and benzimidazoles as sting antagonists and the use thereof as medicament |
| US20250333414A1 (en) | 2024-04-30 | 2025-10-30 | Boehringer Ingelheim International Gmbh | Hetaryl substituted indazoles and benzimidazoles as sting antagonists and the use thereof as medicament |
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| JP5658272B2 (ja) | 2009-12-17 | 2015-01-21 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃｃｒ２の新規アンタゴニスト及びこれらの使用 |
| WO2011109324A1 (en) | 2010-03-05 | 2011-09-09 | Boehringer Ingelheim International Gmbh | Tetrazole compounds which selectively modulate the cb2 receptor |
| WO2011141474A1 (en) | 2010-05-12 | 2011-11-17 | Boehringer Ingelheim International Gmbh | Novel ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments |
| US8946218B2 (en) | 2010-05-12 | 2015-02-03 | Boehringer Ingelheim International Gmbh | CCR2 receptor antagonists, method for producing the same, and use thereof as medicaments |
| EP2571870B1 (en) | 2010-05-17 | 2015-01-21 | Boehringer Ingelheim International GmbH | Ccr2 antagonists and uses thereof |
| EP2576542B1 (en) | 2010-05-25 | 2015-04-22 | Boehringer Ingelheim International GmbH | Cyclic amide derivatives of pyridazine-3-carboxylic acids and their use in the treatment of pulmonary, pain, immune related and cardiovascular diseases |
| JP5721242B2 (ja) | 2010-06-01 | 2015-05-20 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規ｃｃｒ２アンタゴニスト |
| WO2012171863A1 (en) | 2011-06-16 | 2012-12-20 | Boehringer Ingelheim International Gmbh | New selective ccr2 antagonists |
| WO2013010839A1 (en) | 2011-07-15 | 2013-01-24 | Boehringer Ingelheim International Gmbh | Novel and selective ccr2 antagonists |
| JP6229575B2 (ja) | 2014-03-31 | 2017-11-15 | 京セラドキュメントソリューションズ株式会社 | 画像処理装置 |
| BR112017028492B1 (pt) * | 2015-07-02 | 2023-12-26 | Centrexion Therapeutics Corporation | Citrato de (4-((3r,4r)-3-metoxitetra-hidro-piran-4- ilamino)piperidin-1-il) (5- metil-6-(((2r, 6s)-6-(p-tolil) tetra-hidro-2h-piran-2-il)metilamino)pirimidin-4-il) metanona, seu uso e seu método de preparação, e composição farmacêutica |
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2016
- 2016-07-01 BR BR112017028492-8A patent/BR112017028492B1/pt active IP Right Grant
- 2016-07-01 PT PT168188985T patent/PT3317270T/pt unknown
- 2016-07-01 EP EP16818898.5A patent/EP3317270B1/en active Active
- 2016-07-01 MX MX2017017177A patent/MX383744B/es unknown
- 2016-07-01 CN CN201680045214.8A patent/CN108026087B/zh active Active
- 2016-07-01 PL PL16818898T patent/PL3317270T3/pl unknown
- 2016-07-01 ES ES16818898T patent/ES2811098T3/es active Active
- 2016-07-01 CA CA2990460A patent/CA2990460C/en active Active
- 2016-07-01 WO PCT/US2016/040728 patent/WO2017004537A1/en not_active Ceased
- 2016-07-01 JP JP2017568018A patent/JP6917910B2/ja active Active
- 2016-07-01 AU AU2016287584A patent/AU2016287584B2/en active Active
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2017
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2021
- 2021-10-13 US US17/500,367 patent/US12076321B2/en active Active
Also Published As
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| CA2990460A1 (en) | 2017-01-05 |
| PT3317270T (pt) | 2020-08-24 |
| US20200276197A1 (en) | 2020-09-03 |
| ES2811098T3 (es) | 2021-03-10 |
| US10568885B2 (en) | 2020-02-25 |
| US20220133723A1 (en) | 2022-05-05 |
| US20180207157A1 (en) | 2018-07-26 |
| US12076321B2 (en) | 2024-09-03 |
| JP6917910B2 (ja) | 2021-08-11 |
| PL3317270T3 (pl) | 2020-11-16 |
| AU2016287584A1 (en) | 2018-04-19 |
| MX383744B (es) | 2025-03-14 |
| MX2017017177A (es) | 2018-11-09 |
| EP3317270A4 (en) | 2019-01-02 |
| EP3317270B1 (en) | 2020-05-13 |
| CN108026087A (zh) | 2018-05-11 |
| WO2017004537A1 (en) | 2017-01-05 |
| US10213428B2 (en) | 2019-02-26 |
| EP3317270A1 (en) | 2018-05-09 |
| HK1254741A1 (en) | 2019-07-26 |
| IL256530A (en) | 2018-02-28 |
| AU2016287584B2 (en) | 2020-03-26 |
| BR112017028492B1 (pt) | 2023-12-26 |
| US20190262339A1 (en) | 2019-08-29 |
| JP2018524342A (ja) | 2018-08-30 |
| BR112017028492A2 (pt) | 2018-08-28 |
| US11147814B2 (en) | 2021-10-19 |
| NZ738565A (en) | 2024-10-25 |
| CN108026087B (zh) | 2021-06-04 |
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