CN107922491B - 多价和多特异性结合dr5的融合蛋白 - Google Patents

多价和多特异性结合dr5的融合蛋白 Download PDF

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CN107922491B
CN107922491B CN201680041274.2A CN201680041274A CN107922491B CN 107922491 B CN107922491 B CN 107922491B CN 201680041274 A CN201680041274 A CN 201680041274A CN 107922491 B CN107922491 B CN 107922491B
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CN107922491A (zh
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J·C·蒂默
K·S·琼斯
A·S·拉扎伊
A·侯赛因
K·M·威利斯
Q·德沃拉克斯
B·P·艾克尔曼
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Yinxibi Bioscience Co ltd
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Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY200973A (en) 2017-04-11 2024-01-26 Inhibrx Inc Multispecific Polypeptide Constructs Having Constrained Cd3 Binding And Methods Of Using The Same
JP2021508478A (ja) * 2017-12-28 2021-03-11 ユリウス・マクシミリアンス−ウニヴェルジテート・ヴュルツブルクJulius Maximilians−Universitaet Wuerzburg FcγR非依存性アゴニスト活性がある腫瘍壊死因子(TNF)受容体スーパーファミリー(TNFRSF)受容体活性化抗体融合タンパク質(FcγR非依存性アゴニスト活性があるTNFRSF受容体活性化抗体融合タンパク質;TRAAFFIAA)
CN110305210B (zh) * 2018-03-27 2023-02-28 信达生物制药(苏州)有限公司 新型抗体分子、其制备方法及其用途
TW202010757A (zh) 2018-04-11 2020-03-16 美商英伊布里克斯公司 具有經受限cd3結合的多重特異性多肽構築體以及相關方法及用途
WO2020047705A1 (zh) * 2018-09-03 2020-03-12 安菲尼生命科技有限公司 Dr5单域抗体及其用途
GB201903767D0 (en) * 2019-03-19 2019-05-01 Quadrucept Bio Ltd Multimers, tetramers & octamers
AU2020358898B2 (en) * 2019-10-01 2025-10-16 Epsilogen Ltd Hybrid antibody
WO2022002038A1 (zh) * 2020-06-30 2022-01-06 和铂医药(上海)有限责任公司 免疫细胞衔接器多特异性结合蛋白及其制备和应用
EP4545569A3 (en) * 2020-06-30 2025-10-08 Harbour Biomed (Shanghai) Co., Ltd Binding protein having h2l2 and hcab structures
TWI818276B (zh) * 2020-06-30 2023-10-11 大陸商和鉑醫藥(上海)有限責任公司 Fab-HCAb結構的結合蛋白
CA3208641A1 (en) * 2021-02-19 2022-08-25 Ashraf AMANULLAH Formulations of dr5 binding polypeptides
WO2023196943A1 (en) * 2022-04-08 2023-10-12 Inhibrx, Inc. Dr5 agonist and plk1 inhibitor or cdk inhibitor combination therapy
EP4529455A1 (en) * 2022-05-23 2025-04-02 Inhibrx Biosciences, Inc. Dr5 agonist and iap antagonist combination therapy
CN117285644B (zh) * 2022-06-16 2026-05-15 清华大学 一种相变调节元件及其用途
CN120659804A (zh) 2022-09-28 2025-09-16 维连克治疗有限公司 多价蛋白质及筛选方法
KR20260032566A (ko) * 2023-06-29 2026-03-09 오디세이 테라퓨틱스, 인코포레이티드 항-trailr2 항원-결합 단백질 및 그의 용도

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101014623A (zh) * 2004-04-06 2007-08-08 健泰科生物技术公司 Dr5抗体及其用途
CN101717775A (zh) * 2009-11-13 2010-06-02 厦门大学 抗人死亡受体5的单链抗体基因
CN102884083A (zh) * 2010-02-10 2013-01-16 诺瓦提斯公司 Dr5 结合多肽激动剂
CN102924600A (zh) * 2012-11-14 2013-02-13 河南大学 死亡受体5激动性多价抗体及其在制备抗肿瘤药物中的应用

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE914504A1 (en) 1990-12-20 1992-07-01 Ixsys Optimization of binding proteins
US20020147140A1 (en) * 2000-01-31 2002-10-10 Rosen Craig A. Nucleic acids, proteins, and antibodies
BRPI0518994A2 (pt) 2004-12-31 2008-12-02 Biogen Idec Inc anticorpos ou polipeptÍdeos que se ligam a br3, seus usos e formulaÇÕes lÍquidas
CA2598889A1 (en) 2005-02-24 2006-08-31 Cemines, Inc. Compositions and methods for classifying biological samples
CA2619725C (en) 2005-08-18 2016-06-07 Ramot At Tel Aviv University Ltd. Single chain antibodies against beta-amyloid peptide
EP1966242A1 (en) 2005-12-06 2008-09-10 Domantis Limited Ligands that have binding specificity for egfr and/or vegf and methods of use therefor
DK1987178T3 (en) 2006-02-20 2015-04-20 Phylogica Ltd Process for the construction and screening of peptide structure libraries
JP2008133206A (ja) 2006-11-28 2008-06-12 Yokohama City Univ 緑膿菌に対して感染防御能を誘導できる医薬組成物
SG186017A1 (en) 2007-11-30 2012-12-28 Kalobios Pharmaceuticals Inc Antibodies to the pcrv antigen of pseudomonas aeruginosa
LT2285408T (lt) * 2008-06-05 2019-01-25 Ablynx N.V. Aminorūgščių sekos, nukreiptos prieš viruso apvalkalo baltymus, ir tokias sekas turintys polipeptidai, skirti virusinių ligų gydymui
US20110166076A1 (en) * 2008-09-10 2011-07-07 Bac Ip B.V. Antigen-binding proteins that inhibit superantigens for the treatment of skin diseases
EP2408475B1 (en) 2009-03-18 2017-11-15 Wake Forest University Health Sciences Flagellin fusion proteins and use thereof to induce immune responses against pseudomonas aeruginosa
US20100281003A1 (en) 2009-04-02 2010-11-04 New York University System and uses for generating databases of protein secondary structures involved in inter-chain protein interactions
HRP20251657T1 (hr) 2009-12-14 2026-02-13 Ablynx N.V. Imunoglobulinska protutijela s jednostrukom varijabilnom domenom protiv ox40l, konstrukti i njihova terapijska upotreba
US8623369B2 (en) 2010-04-27 2014-01-07 National Research Council Of Canada Anti-ICAM-1 single domain antibody and uses thereof
US8877899B2 (en) 2010-09-27 2014-11-04 Morphosys Ag Anti-CD38 antibody and lenalidomide or bortezomib for the treatment of multipe myeloma and NHL
CA2815888C (en) 2010-10-25 2020-06-30 National Research Council Of Canada Clostridium difficile-specific antibodies and uses thereof
CA2822684A1 (en) 2010-12-23 2012-06-28 Intercell Austria Ag Oprf/i agents and their use in hospitalized and other patients
MY167125A (en) 2011-08-17 2018-08-13 Glaxo Group Ltd Modified proteins and peptides
SMT202000091T1 (it) 2011-10-13 2020-05-08 Bristol Myers Squibb Co Polipeptidi anticorpali che antagonizzano cd40l
CN103906533A (zh) 2011-11-07 2014-07-02 米迪缪尼有限公司 多特异性和多价结合蛋白及其用途
CN104169304A (zh) 2011-12-20 2014-11-26 阿达拉塔合伙有限公司 作为pcsk9抑制剂的单域抗体
JP6415987B2 (ja) 2012-03-02 2018-10-31 アブリンクス エン.ヴェー. シュードモナス・エルギノーサのPcrVに結合する単一可変ドメイン抗体
WO2013167883A1 (en) 2012-05-07 2013-11-14 The University Court Of The University Of Aberdeen Single domain binding molecule
EP2684896A1 (en) * 2012-07-09 2014-01-15 International-Drug-Development-Biotech Anti-DR5 family antibodies, bispecific or multivalent anti-DR5 family antibodies and methods of use thereof
WO2014043509A2 (en) 2012-09-13 2014-03-20 Novartis Ag Antigen binding molecule with terminal modifications
US20150284450A1 (en) 2012-11-06 2015-10-08 Medimmune, Llc Combination therapies using anti-pseudomonas psl and pcrv binding molecules
WO2014111550A1 (en) 2013-01-17 2014-07-24 Glaxosmithkline Intellectual Property Development Limited Modified anti-serum albumin binding proteins
US9862777B2 (en) 2013-05-28 2018-01-09 Vib Vzw Single domain antibodies against SOD1 and their use in medicine
KR20160103007A (ko) * 2014-01-10 2016-08-31 각코호진 데이쿄 헤이세이 다이가쿠 재조합 편성 혐기성 그램 양성균

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101014623A (zh) * 2004-04-06 2007-08-08 健泰科生物技术公司 Dr5抗体及其用途
CN101717775A (zh) * 2009-11-13 2010-06-02 厦门大学 抗人死亡受体5的单链抗体基因
CN102884083A (zh) * 2010-02-10 2013-01-16 诺瓦提斯公司 Dr5 结合多肽激动剂
CN102924600A (zh) * 2012-11-14 2013-02-13 河南大学 死亡受体5激动性多价抗体及其在制备抗肿瘤药物中的应用

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Kyriakos P. Papadopoulos等.Unexpected hepatotoxicity in a phase I study of TAS266, a novel tetravalent agonistic Nanobody® targeting the DR5 receptor.《Cancer Chemother Pharmacol》.2015,第2015卷(第75期), *
Liposome-bound TRAIL induces superior DR5 clustering and andenhanced DISC recruitment in histiocytic lymphoma U937 cells;cellsDiego De Miguel等;《Leukemia Research》;20150404;第39卷(第6期);第657-666段 *
Multivalent nanobodies targeting death receptor 5 elicit superior tumor cell killing through efficient caspase induction;Heather A Huet等;《mAbs》;20141115;第6卷(第6期);第1561页左栏第2段 *

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