CN107746834A - 用于制备普瑞巴林的方法和中间体 - Google Patents

用于制备普瑞巴林的方法和中间体 Download PDF

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Publication number
CN107746834A
CN107746834A CN201710882572.0A CN201710882572A CN107746834A CN 107746834 A CN107746834 A CN 107746834A CN 201710882572 A CN201710882572 A CN 201710882572A CN 107746834 A CN107746834 A CN 107746834A
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Chinese (zh)
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S·德巴尔热
D·T·厄德曼
P·M·奥尼尔
R·库玛
M·J·卡尔米洛维兹
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Pfizer Ireland Pharmaceuticals
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Pfizer Ireland Pharmaceuticals
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/001—Amines; Imines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B53/00—Asymmetric syntheses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/12—Formation of amino and carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/60—Two oxygen atoms, e.g. succinic anhydride
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/66—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/005—Amino acids other than alpha- or beta amino acids, e.g. gamma amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/04—Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04—Formation of amino groups in compounds containing carboxyl groups
    • C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
    • C07C227/08—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid by reaction of ammonia or amines with acids containing functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/74—Unsaturated compounds containing —CHO groups
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)

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  • Life Sciences & Earth Sciences (AREA)
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  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Furan Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Steroid Compounds (AREA)
CN201710882572.0A 2013-03-27 2014-03-25 用于制备普瑞巴林的方法和中间体 Pending CN107746834A (zh)

Applications Claiming Priority (3)

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US201361805786P 2013-03-27 2013-03-27
US61/805,786 2013-03-27
CN201480018083.5A CN105051022B (zh) 2013-03-27 2014-03-25 用于制备普瑞巴林的方法和中间体

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CN201480018083.5A Expired - Fee Related CN105051022B (zh) 2013-03-27 2014-03-25 用于制备普瑞巴林的方法和中间体
CN201710882572.0A Pending CN107746834A (zh) 2013-03-27 2014-03-25 用于制备普瑞巴林的方法和中间体

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CN201480018083.5A Expired - Fee Related CN105051022B (zh) 2013-03-27 2014-03-25 用于制备普瑞巴林的方法和中间体

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US (1) US20160024540A1 (enExample)
EP (2) EP2978748B1 (enExample)
JP (1) JP2016516744A (enExample)
KR (1) KR20150121202A (enExample)
CN (3) CN107556273A (enExample)
AU (2) AU2014240833B2 (enExample)
BR (2) BR112015024859A2 (enExample)
CA (1) CA2905411A1 (enExample)
CY (1) CY1118945T1 (enExample)
DK (1) DK2978748T3 (enExample)
ES (1) ES2630128T3 (enExample)
HU (1) HUE034834T2 (enExample)
IL (1) IL241438A0 (enExample)
MX (1) MX2015013589A (enExample)
PL (1) PL2978748T3 (enExample)
PT (1) PT2978748T (enExample)
RU (2) RU2017125261A (enExample)
SG (1) SG11201506998XA (enExample)
SI (1) SI2978748T1 (enExample)
WO (1) WO2014155291A1 (enExample)
ZA (1) ZA201506798B (enExample)

Cited By (1)

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CN111004102A (zh) * 2019-12-23 2020-04-14 万华化学集团股份有限公司 一种制备光学活性香茅醛的方法及用于该方法的催化剂

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DK2385983T3 (en) 2009-01-08 2018-02-12 Codexis Inc Transaminase POLYPEPTIDES
WO2016075082A1 (en) 2014-11-10 2016-05-19 Sandoz Ag Stereoselective reductive amination of alpha-chiral aldehydes using omega-transaminases for the synthesis of precursors of pregabalin and brivaracetam
US9958464B2 (en) 2015-03-03 2018-05-01 Ark Diagnostics, Inc. Pregabalin immunoassays
US11359183B2 (en) * 2017-06-14 2022-06-14 Codexis, Inc. Engineered transaminase polypeptides for industrial biocatalysis
AU2019300832B2 (en) 2018-07-09 2025-05-22 Merck Sharp & Dohme Llc Enzymatic synthesis of 4'-ethynyl nucleoside analogs
CN118772033A (zh) * 2024-06-11 2024-10-15 中国科学院成都生物研究所 一种普瑞巴林三聚体的合成方法

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WO2008127646A2 (en) * 2007-04-11 2008-10-23 Dsm Ip Assets B.V. Transaminase-based processes for preparation of pregabalin
CN101300224A (zh) * 2005-04-11 2008-11-05 特瓦制药工业有限公司 制备(s)-普瑞巴林的方法
CN101362696A (zh) * 2008-09-27 2009-02-11 开原亨泰精细化工厂 3-氨甲基-5-甲基己酸即混旋普瑞巴林的制备新方法
CN101821228A (zh) * 2007-08-10 2010-09-01 韩国科学技术院 制备普瑞巴林的新方法
CN102341494A (zh) * 2009-01-08 2012-02-01 科德克希思公司 转氨酶多肽

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Cited By (1)

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Publication number Priority date Publication date Assignee Title
CN111004102A (zh) * 2019-12-23 2020-04-14 万华化学集团股份有限公司 一种制备光学活性香茅醛的方法及用于该方法的催化剂

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EP2978748B1 (en) 2017-05-10
BR122017006144A2 (pt) 2019-09-03
CN105051022A (zh) 2015-11-11
AU2014240833A1 (en) 2015-10-01
HUE034834T2 (en) 2018-03-28
US20160024540A1 (en) 2016-01-28
DK2978748T3 (en) 2017-07-24
HK1213882A1 (zh) 2016-07-15
SG11201506998XA (en) 2015-10-29
WO2014155291A1 (en) 2014-10-02
ES2630128T3 (es) 2017-08-18
RU2015138545A (ru) 2017-05-03
AU2016203782B2 (en) 2017-06-01
CA2905411A1 (en) 2014-10-02
JP2016516744A (ja) 2016-06-09
BR112015024859A2 (pt) 2017-10-10
KR20150121202A (ko) 2015-10-28
ZA201506798B (en) 2019-05-29
AU2014240833B2 (en) 2016-07-07
CN105051022B (zh) 2017-10-27
EP3216863A1 (en) 2017-09-13
RU2017125261A (ru) 2019-01-31
PT2978748T (pt) 2017-07-06
IL241438A0 (en) 2015-11-30
MX2015013589A (es) 2016-06-23
CY1118945T1 (el) 2018-01-10
EP2978748A1 (en) 2016-02-03
SI2978748T1 (sl) 2017-07-31
PL2978748T3 (pl) 2017-09-29
RU2628298C2 (ru) 2017-08-15
AU2016203782A1 (en) 2016-06-23
CN107556273A (zh) 2018-01-09

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Application publication date: 20180302