CN107635979A - 溴结构域抑制剂 - Google Patents
溴结构域抑制剂 Download PDFInfo
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- CN107635979A CN107635979A CN201580070259.6A CN201580070259A CN107635979A CN 107635979 A CN107635979 A CN 107635979A CN 201580070259 A CN201580070259 A CN 201580070259A CN 107635979 A CN107635979 A CN 107635979A
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| PL2571503T3 (pl) | 2010-05-14 | 2015-06-30 | Dana Farber Cancer Inst Inc | Kompozycje i sposoby leczenia nowotworu, choroby zapalnej i innych zaburzeń |
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| RS63733B1 (sr) | 2013-10-18 | 2022-12-30 | Celgene Quanticel Research Inc | Inhibitori bromodomena |
| MX379463B (es) | 2013-11-08 | 2025-03-10 | Dana Farber Cancer Inst Inc | Terapia de combinación para el cáncer usando inhibidores de la proteína bromodominio y extra-terminal. |
| JP2017506666A (ja) | 2014-02-28 | 2017-03-09 | テンシャ セラピューティクス，インコーポレイテッド | 高インスリン血症に関連した症状の処置 |
| US20180228907A1 (en) | 2014-04-14 | 2018-08-16 | Arvinas, Inc. | Cereblon ligands and bifunctional compounds comprising the same |
| EP3212654B1 (en) | 2014-10-27 | 2020-04-08 | Tensha Therapeutics, Inc. | Bromodomain inhibitors |
| CA2979070A1 (en) | 2015-03-18 | 2016-09-22 | Arvinas, Inc. | Compounds and methods for the enhanced degradation of targeted proteins |
| EP3337476A4 (en) | 2015-08-19 | 2019-09-04 | Arvinas, Inc. | Compounds and methods for the targeted degradation of bromodomain-containing proteins |
| US20190247302A1 (en) * | 2016-10-21 | 2019-08-15 | University Of Miami | Materials and methods for treating ophthalmic inflammation |
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| CN109503618A (zh) * | 2017-09-14 | 2019-03-22 | 成都海创药业有限公司 | 一种brd4抑制剂 |
| US11220515B2 (en) | 2018-01-26 | 2022-01-11 | Yale University | Imide-based modulators of proteolysis and associated methods of use |
| MX2020010571A (es) | 2018-04-13 | 2021-01-08 | Arvinas Operations Inc | Ligandos de cereblon y compuestos bifuncionales que los comprenden. |
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| CN112789281A (zh) * | 2018-09-11 | 2021-05-11 | 豪夫迈·罗氏有限公司 | 作为治疗癌症的溴结构域BRD4抑制剂的(S)-2-(4-(苯基)-6H-噻吩并[3，2-f][1，2，4]三唑并[4，3-a][1，4]二氮杂䓬-6-基)乙酸叔丁酯衍生物及相关化合物 |
| CN115175901B (zh) | 2019-12-19 | 2024-03-22 | 阿尔维纳斯运营股份有限公司 | 用于雄激素受体的靶向降解的化合物和方法 |
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| WO2025053994A1 (en) * | 2023-09-08 | 2025-03-13 | The Regents Of The University Of California | Small molecule enhancers of secreted clusterin (sclu) |
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| WO2014068402A2 (en) * | 2012-09-28 | 2014-05-08 | Oncoethix Sa | Pharmaceutical formulation containing thienotriazolodiazepine compounds |
| WO2014134583A2 (en) * | 2013-02-28 | 2014-09-04 | Washington University | Methods of treatment of human cytomegalovirus infection and diseases with bromodomain inhibitors |
| WO2014159392A1 (en) * | 2013-03-14 | 2014-10-02 | Dana-Farber Cancer Institute, Inc. | Bromodomain binding reagents and uses thereof |
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| BR112017008714A2 (pt) | 2017-12-19 |
| HK1243415A1 (en) | 2018-07-13 |
| CO2017004898A2 (es) | 2017-10-31 |
| KR20170068597A (ko) | 2017-06-19 |
| IL251784A0 (en) | 2017-06-29 |
| AU2015339511B2 (en) | 2020-05-14 |
| JP6715243B2 (ja) | 2020-07-01 |
| PE20171042A1 (es) | 2017-07-19 |
| MX2017005555A (es) | 2018-02-09 |
| EP3212654A1 (en) | 2017-09-06 |
| MX376748B (es) | 2025-03-07 |
| US10124009B2 (en) | 2018-11-13 |
| AU2015339511A1 (en) | 2017-05-18 |
| CA2965330A1 (en) | 2016-05-06 |
| EP3212654B1 (en) | 2020-04-08 |
| EA201790922A1 (ru) | 2017-08-31 |
| CL2017001046A1 (es) | 2018-01-26 |
| SG11201703414VA (en) | 2017-05-30 |
| CR20170219A (es) | 2017-08-14 |
| PH12017500745A1 (en) | 2017-10-30 |
| WO2016069578A1 (en) | 2016-05-06 |
| UA122130C2 (uk) | 2020-09-25 |
| EA033325B1 (ru) | 2019-09-30 |
| US20170333444A1 (en) | 2017-11-23 |
| JP2017531688A (ja) | 2017-10-26 |
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