CN107624112B - 乳酸脱氢酶的小分子抑制剂及其使用方法 - Google Patents

乳酸脱氢酶的小分子抑制剂及其使用方法 Download PDF

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CN107624112B
CN107624112B CN201580077097.9A CN201580077097A CN107624112B CN 107624112 B CN107624112 B CN 107624112B CN 201580077097 A CN201580077097 A CN 201580077097A CN 107624112 B CN107624112 B CN 107624112B
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alkyl
phenyl
radical
cycloalkyl
halo
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CN107624112A (zh
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戴维·J·马洛尼
阿吉特·贾达夫
甘尼沙·雷·班图卡卢
凯勒·瑞安·布里马科姆
布赖恩·T·莫特
杨世明
丹尼尔·詹森·厄本
胡新
安顿·西梅奥诺夫
珍妮弗·L·库茨内特索瓦
亚历克斯·格雷戈里·沃特森
加里·艾伦·苏利科夫斯基
金光镐
普拉门·克里斯托夫
索姆纳特·贾纳
维克托·M·达利-乌斯马尔
威廉·J·穆尔
伦纳德·M·内克斯
希·V·丹格
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UAB Research Foundation
University of Pennsylvania Penn
Vanderbilt University
US Department of Health and Human Services
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University of Pennsylvania Penn
Vanderbilt University
US Department of Health and Human Services
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CN201580077097.9A 2014-12-29 2015-12-29 乳酸脱氢酶的小分子抑制剂及其使用方法 Active CN107624112B (zh)

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US201462097226P 2014-12-29 2014-12-29
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PCT/US2015/067895 WO2016109559A2 (en) 2014-12-29 2015-12-29 Small molecule inhibitors of lactate dehydrogenase and methods of use thereof

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US10662187B2 (en) * 2016-01-21 2020-05-26 Zibo Biopolar Changsheng Pharmaceutical Co. Ltd. Bruton's tyrosine kinase inhibitors
AU2017290233A1 (en) * 2016-06-29 2019-01-24 The Trustees Of The University Of Pennsylvania 1 H-pyrazol-1 -YL-thiazoles as inhibitors of lactate dehydrogenase and methods of use thereof
AU2018208422B2 (en) 2017-01-10 2021-11-11 Bayer Aktiengesellschaft Heterocyclene derivatives as pest control agents
BR112020003725A2 (pt) 2017-10-06 2020-11-03 Forma Therapeutics, Inc. inibição da peptidase 30 específica de ubiquitina
JP7449242B2 (ja) 2018-05-17 2024-03-13 フォーマ セラピューティクス,インコーポレイテッド ユビキチン特異的ペプチダーゼ30(usp30)阻害剤として有用な縮合二環化合物
WO2020030613A1 (en) 2018-08-07 2020-02-13 Kemijski Institut Small molecule-inhibitors of 6-phosphofructo-1-kinase for reducing lactate generation by cancer cells
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